SRA STUDY
SRA Study Id ERP115428  (Link to NCBI )
Study Title Lactobacilli have a niche in the human nose.
SRA Experiments
SRA Experiment Id ERX4655655  (Link to NCBI )
Experiment Title Illumina MiSeq paired end sequencing; Raw reads: AMBR158
Exp Library Strategy WGS
Library Source GENOMIC
Library Selection RANDOM PCR
Library Layout PAIRED
Library Instrument ILLUMINA_MI_SEQ
   
SRA Experiment Id ERX4655606  (Link to NCBI )
Experiment Title Illumina MiSeq paired end sequencing; Raw reads: AMBR074
Exp Library Strategy WGS
Library Source GENOMIC
Library Selection RANDOM PCR
Library Layout PAIRED
Library Instrument ILLUMINA_MI_SEQ
   
SRA Experiment Id ERX4651506  (Link to NCBI )
Experiment Title Illumina MiSeq paired end sequencing; Raw reads: AMBR037
Exp Library Strategy WGS
Library Source GENOMIC
Library Selection RANDOM PCR
Library Layout PAIRED
Library Instrument ILLUMINA_MI_SEQ
   
SRA Experiment Id ERX4651507  (Link to NCBI )
Experiment Title Illumina MiSeq paired end sequencing; Raw reads: AMBR047
Exp Library Strategy WGS
Library Source GENOMIC
Library Selection RANDOM PCR
Library Layout PAIRED
Library Instrument ILLUMINA_MI_SEQ
   
SRA Experiment Id ERX4651504  (Link to NCBI )
Experiment Title Illumina MiSeq paired end sequencing; Raw reads: AMBR024
Exp Library Strategy WGS
Library Source GENOMIC
Library Selection RANDOM PCR
Library Layout PAIRED
Library Instrument ILLUMINA_MI_SEQ
   
SRA Experiment Id ERX4652737  (Link to NCBI )
Experiment Title Illumina MiSeq paired end sequencing; Raw reads: AMBR055
Exp Library Strategy WGS
Library Source GENOMIC
Library Selection RANDOM PCR
Library Layout PAIRED
Library Instrument ILLUMINA_MI_SEQ
   
SRA Experiment Id ERX4647289  (Link to NCBI )
Experiment Title Illumina MiSeq paired end sequencing
Exp Library Strategy WGS
Library Source GENOMIC
Library Selection RANDOM PCR
Library Name AMBR12
Library Layout PAIRED
Library Instrument ILLUMINA_MI_SEQ
   
SRA Experiment Id ERX4655650  (Link to NCBI )
Experiment Title Illumina MiSeq paired end sequencing; Raw reads: AMBR075
Exp Library Strategy WGS
Library Source GENOMIC
Library Selection RANDOM PCR
Library Layout PAIRED
Library Instrument ILLUMINA_MI_SEQ
Study Abstract While an increasing number of beneficial microbiome members is characterized for the human gut and vagina, beneficial microbes are underexplored for the human upper respiratory tract (URT). In this study, we demonstrate that taxa from the beneficial Lactobacillus genus might have a role as keystone species in the healthy URT. Several URT-specific Lactobacillus isolates were cultured, characterized, and further explored for their genetic and functional properties related to adaptation to the URT. Catalase genes were found in the identified Lactobacillus taxa, which is a unique feature within this mostly facultative anaerobic genus. Moreover, one of our isolated strains, Lactobacillus casei AMBR2, contained unique fimbriae enabling strong adherence to URT epithelium, inhibited the growth and virulence of several URT pathogens, and successfully colonized nasal epithelium of healthy volunteers. This study thus demonstrates that specific Lactobacillus taxa are adapted to the URT and could have a beneficial keystone function in this habitat.
Alias ena-STUDY-UANTW-23-05-2019-12:18:07:883-293
External Id PRJEB32716