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Study

Study Name: Bacteroides acidifaciens NZ_B_acidifaciens_9G3_hyb genome sequencing

Projects

Biosamples

Organisms

Biosamples: 0 Seq. Projects: 1
STUDY INFORMATION
GOLD Study ID Gs0161017
Study Name Bacteroides acidifaciens NZ_B_acidifaciens_9G3_hyb genome sequencing
Other Names
NCBI Umbrella Bioproject Name
NCBI Umbrella Bioproject Accession
SRA Studies
SRA Study Id ERP118964  (Link to NCBI )
Study Title Combined prebiotic and microbial intervention improves oral cholera vaccination responses in a mouse model of childhood undernutrition
Study Abstract Undernourished children in low-income countries often exhibit poor responses to oral vaccination. Perturbed microbiota development is linked to undernutrition but whether and how microbiota changes affect vaccine responsiveness remain unclear. Here, we show that gnotobiotic mice colonized with microbiota from undernourished Bangladeshi children and fed a Bangladeshi diet exhibited microbiota- dependent differences in mucosal IgA responses to oral vaccination with cholera toxin (CT). Supplementation with a nutrient-rich diet consisting of spirulina, amaranth, flaxseed and micronutrients augmented CT-IgA production. Mice initially colonized with a microbiota associated with poor CT responses exhibited improved immunogenicity upon invasion of bacterial taxa from cagemates colonized with a more 'responsive' microbiota. Additionally, a consortium of five cultured bacterial invaders conferred augmented CT-IgA responses in mice fed the supplemented diet and colonized with the 'hypo- responsive' community. These results provide preclinical proof-of-concept that diet and microbiota influence mucosal immune responses to CT vaccination and identify a candidate synbiotic formulation.
  
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Legacy GOLD ID
Added By JGI automated process on 2023-01-20
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Description
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Study Information Visibility Public
Metagenomic Study No
Publication
Is GEBA
Is HMP
ECOSYSTEM CLASSIFICATION
Ecosystem
Ecosystem Category
Ecosystem Type
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Specific Ecosystem
Ecosystem Path ID 1
STUDY COMPOSITION
Number of Biosamples 0
Number of Organisms 1
Number of Seq Projects 1
Number of Analysis Projects 1
Number of Related Studies 0

 

 

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