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Study

Study Name: Oscillospiraceae bacterium CU972 genome sequencing

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Biosamples: 0 Seq. Projects: 1
STUDY INFORMATION
GOLD Study ID Gs0160918
Study Name Oscillospiraceae bacterium CU972 genome sequencing
Other Names
NCBI Umbrella Bioproject Name
NCBI Umbrella Bioproject Accession
SRA Studies
SRA Study Id ERP124561  (Link to NCBI )
Study Title Genome sequencing of commensal bacteria included in the protective mix ProBac
Study Abstract Multidrug resistant pathogens (MRP), including vancomycin-resistant Enterococcus (VRE), have become a major threat to public health. Some MRP strains can be resistant to all antibiotics available, thus alternative strategies to antibiotics are urgently needed to combat these challenging pathogens. MRP infections, including those produced by VRE, frequently start by colonization of the intestinal tract, a crucial step that is impaired by the presence of the intestinal microbiota. Despite its relevance, the members of the microbiota that suppress MRP gut colonization and the mechanisms of such protection are largely unknown.In the present study, we combined 16s rDNA sequencing of the gut microbiota to identify commensal bacteria associated with protection against VRE colonization. We next assembled a consortium containing five of the putative protective commensals and showed that administration of these bacteria was sufficient to restrict VRE gut colonization in antibiotic treated mice. Finally, we combined sequencing of the putative probiotic genomes with metatranscriptomics, targeted metabolomics and in vivo assays to identify the mechanism by which the bacterial consortium inhibits VRE growth.
  
Legacy ER Study ID
Legacy GOLD ID
Added By JGI automated process on 2023-01-20
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PI Unknown
Description
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Study Information Visibility Public
Metagenomic Study No
Publication
Is GEBA
Is HMP
ECOSYSTEM CLASSIFICATION
Ecosystem
Ecosystem Category
Ecosystem Type
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Specific Ecosystem
Ecosystem Path ID 1
STUDY COMPOSITION
Number of Biosamples 0
Number of Organisms 1
Number of Seq Projects 1
Number of Analysis Projects 1
Number of Related Studies 0

 

 

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