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Study

Study Name: A unified sequence catalogue of the human gut microbiome

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Biosamples: 0 Seq. Projects: 223
STUDY INFORMATION
GOLD Study ID Gs0146605
Study Name A unified sequence catalogue of the human gut microbiome
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NCBI Umbrella Bioproject Name
NCBI Umbrella Bioproject ID
SRA Studies
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Added By JGI automated process on 2020-07-02
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PI
Description Comprehensive reference data is essential for accurate taxonomic and functional characterisation of the human gut microbiome. Here we present the Unified Human Gastrointestinal Genome (UHGG) collection, a resource combining 286,997 genomes representing 4,644 prokaryotic species from the human gut. These genomes contain over 625 million protein sequences used to generate the Unified Human Gastrointestinal Protein (UHGP) catalogue, a collection that more than doubles the number of gut protein clusters over the Integrated Gene Catalogue. We find that a large portion of the human gut microbiome remains to be fully explored, with over 70% of the UHGG species lacking cultured representatives, and 40% of the UHGP missing meaningful functional annotations. Intra-species genomic variation analyses revealed a large reservoir of accessory genes and single-nucleotide variants, many of which were specific to individual human populations. These freely available genomic resources should greatly facilitate investigations into the human gut microbiome.
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Is GEBA
Is HMP
ECOSYSTEM CLASSIFICATION
Ecosystem
Ecosystem Category
Ecosystem Type
Ecosystem Subtype
Specific Ecosystem
STUDY COMPOSITION
Number of Biosamples 0
Number of Organisms 223
Number of Seq Projects 223
Number of Analysis Projects 223
Number of Related Studies 0

 

 

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