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Study

Study Name: Infant fecal microbial communities from breast milk and formula fed babies in Texas, USA

Projects

Biosamples

Organisms

Biosamples: 12 Seq. Projects: 12
STUDY INFORMATION
GOLD Study ID Gs0141814
Study Name Infant fecal microbial communities from breast milk and formula fed babies in Texas, USA
Other Names
NCBI Umbrella Bioproject Name
NCBI Umbrella Bioproject ID
SRA Studies
SRA Study Id ERP001038  (Link to NCBI )
Study Title Mutualism between gut microbiota and the host as revealed in a comparative study of breast-fed versus formula-fed infants.
Study Abstract In this study, we examined the host intestinal mRNA gene expression and microbial DNA profiles in full term 3 month-old infants exclusively formula fed (FF; n=6) or breast fed (BF; n=6) from birth to 3 months. Host mRNA microarray measurements were performed on intact sloughed epithelial cells in stool samples collected at 3 months. Microbial composition from the same stool samples was assessed by metagenomic pyrosequencing. Both host mRNA expression and bacterial microbiome phylogenetic profiles provided strong feature sets that classified the two groups of babies (FF and BF). To determine the relationship between epithelial cell gene expression and the bacterial colony profiles, the host transcriptome and functionally profiled microbiome data were analyzed in a multivariate manner. From a functional perspective, analysis of the gut microbiota's metagenome revealed that virulence characteristics differed between the FF and BF babies. Using canonical correlation analysis, evidence of multivariate structure relating eleven host immunity/mucosal defense-related genes and microbiome virulence characteristics was observed. These results, for the first time, provide insight into the integrated responses of the host and microbiome to dietary substrates in the early neonatal period.
  
Legacy ER Study ID
Legacy GOLD ID
Added By JGI automated process on 2019-01-30
Last Modified By
PI Robert Chapkin
Description Mutualism between gut microbiota and the host as revealed in a comparative study of breast-fed versus formula-fed infants
Relevance
Study Information Link
Study Information Visibility Public
Metagenomic Study Yes
Publication
Is GEBA
Is HMP
ECOSYSTEM CLASSIFICATION
Ecosystem Host-associated
Ecosystem Category Human
Ecosystem Type Digestive system
Ecosystem Subtype Large intestine
Specific Ecosystem Fecal
STUDY COMPOSITION
Number of Biosamples 12
Number of Organisms 0
Number of Seq Projects 12
Number of Analysis Projects 0
Number of Related Studies 0

 

 

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