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Study

Study Name: MetaHIT, a catalog of microbial genes of the intestinal tract

Projects

Biosamples

Organisms

Biosamples: 83 Seq. Projects: 83
STUDY INFORMATION
GOLD Study ID Gs0114003
Study Name MetaHIT, a catalog of microbial genes of the intestinal tract
Other Names Metagenomics of the Human Intestinal Tract
NCBI Umbrella Bioproject Name
NCBI Umbrella Bioproject ID
SRA Studies
Legacy ER Study ID
Legacy GOLD ID
Added By Jyothi Mallajosyula on 2015-01-15
Last Modified By Michelle Isbandi on 2015-04-10
PI Ehrlich,S.D.
Description It is known that the number of our microbial companions exceeds by at least ten-fold those of cells of our own body and it was predicted that the number of unique genes they encode were at least 100-fold greater than the number of genes in our own genome. It is also known that this complex and dynamic microbiota has a profound influence on human physiology, nutrition, and immunity and that disruption in these human-associated microbial communities or alterations of the intimate cross-talk between these microbes and human cells may be a significant factor in many diseases.To understand the dynamic and variable nature of human microbial communities, we decided to focus on the microbiota of the intestine, which plays a particularly important role in human health and well-being and was believed to be the most complex of the microbial communities associated with humans.We chose to focuse on two pathologies, inflammatory bowel diseases and obesity, disorders of increasing social importance in Europe. We analyzed stool samples from 124 individuals that participated in our studies. They were of Danish and Spanish origin, some were healthy and some sick, suffering from IBD or obesity. In this way, we expected to identify the largest possible number of genes, not missing those that could possibly be less frequent or even absent in a given group of individuals that we were committed to study. We have identified at least 85 % of all the frequent genes that the 124 individuals carry, the value determined by an appropriate statistical analysis. Some 99 % of the genes are of bacterial origin, in keeping with the predominance of bacteria among the intestinal microbes. From the gene number we deduce that there are at least a 1000 frequent bacterial species in our gut. We identified over 19000 different functions in the genes present in our 124 samples and thus obtained an exhaustive view of the genetic potential of the bacteria from the human gut.
Relevance Human Microbiome
Study Information Link
Study Information Visibility Public
Metagenomic Study Yes
Publication
Is GEBA No
Is HMP No
ECOSYSTEM CLASSIFICATION
Ecosystem Host-associated
Ecosystem Category Human
Ecosystem Type Digestive system
Ecosystem Subtype Large intestine
Specific Ecosystem Fecal
STUDY COMPOSITION
Number of Biosamples 83
Number of Organisms 0
Number of Seq Projects 83
Number of Analysis Projects 275
Number of Related Studies 0

 

 

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