Studies
|
53,971 |
|
Biosamples
|
170,233 |
|
Sequencing Projects
|
480,733 |
|
Analysis Projects
|
362,421 |
| Organisms | 467,884 |
| Biosamples: 83 Seq. Projects: 83 | |
| STUDY INFORMATION | |
|---|---|
|
GOLD Study ID
|
Gs0114003 |
|
Study Name
|
MetaHIT, a catalog of microbial genes of the intestinal tract |
|
Other Names
|
Metagenomics of the Human Intestinal Tract |
| NCBI Umbrella Bioproject Name |
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NCBI Umbrella Bioproject Accession
|
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| SRA Studies |
|
|
Legacy ER Study ID
|
|
|
Legacy GOLD ID
|
|
| Added By |
Jyothi Mallajosyula
on 2015-01-15 |
| Last Modified By |
Michelle Isbandi
on 2015-04-10 |
| PI | Ehrlich,S.D. |
|
Description
|
It is known that the number of our microbial companions exceeds by at least ten-fold those of cells of our own body and it was predicted that the number of unique genes they encode were at least 100-fold greater than the number of genes in our own genome. It is also known that this complex and dynamic microbiota has a profound influence on human physiology, nutrition, and immunity and that disruption in these human-associated microbial communities or alterations of the intimate cross-talk between these microbes and human cells may be a significant factor in many diseases.To understand the dynamic and variable nature of human microbial communities, we decided to focus on the microbiota of the intestine, which plays a particularly important role in human health and well-being and was believed to be the most complex of the microbial communities associated with humans.We chose to focuse on two pathologies, inflammatory bowel diseases and obesity, disorders of increasing social importance in Europe. We analyzed stool samples from 124 individuals that participated in our studies. They were of Danish and Spanish origin, some were healthy and some sick, suffering from IBD or obesity. In this way, we expected to identify the largest possible number of genes, not missing those that could possibly be less frequent or even absent in a given group of individuals that we were committed to study. We have identified at least 85 % of all the frequent genes that the 124 individuals carry, the value determined by an appropriate statistical analysis. Some 99 % of the genes are of bacterial origin, in keeping with the predominance of bacteria among the intestinal microbes. From the gene number we deduce that there are at least a 1000 frequent bacterial species in our gut. We identified over 19000 different functions in the genes present in our 124 samples and thus obtained an exhaustive view of the genetic potential of the bacteria from the human gut. |
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Relevance
|
Human Microbiome |
|
Study Information Visibility
|
Public |
| Metagenomic Study |
Yes |
| Publication |
|
| Is GEBA |
No |
| Is HMP |
No |
|
ECOSYSTEM CLASSIFICATION
|
|
| Ecosystem |
Host-associated |
| Ecosystem Category |
Mammals: Human |
| Ecosystem Type |
Digestive system |
| Ecosystem Subtype |
Large intestine |
| Specific Ecosystem |
Fecal |
| Ecosystem Path ID |
3920 |
| STUDY COMPOSITION | |
| Number of Biosamples |
83
|
| Number of Organisms | 0 |
| Number of Seq Projects |
83
|
| Number of Analysis Projects |
275
|
|
Number of Related Studies
|
0 |
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