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Study

Study Name: Lactobacilli have a niche in the human nose.

Projects

Biosamples

Organisms

Biosamples: 0 Seq. Projects: 18
STUDY INFORMATION
GOLD Study ID Gs0155894
Study Name Lactobacilli have a niche in the human nose.
Other Names
NCBI Umbrella Bioproject Name
NCBI Umbrella Bioproject Accession
SRA Studies
SRA Study Id ERP115428  (Link to NCBI )
Study Title Lactobacilli have a niche in the human nose.
Study Abstract While an increasing number of beneficial microbiome members is characterized for the human gut and vagina, beneficial microbes are underexplored for the human upper respiratory tract (URT). In this study, we demonstrate that taxa from the beneficial Lactobacillus genus might have a role as keystone species in the healthy URT. Several URT-specific Lactobacillus isolates were cultured, characterized, and further explored for their genetic and functional properties related to adaptation to the URT. Catalase genes were found in the identified Lactobacillus taxa, which is a unique feature within this mostly facultative anaerobic genus. Moreover, one of our isolated strains, Lactobacillus casei AMBR2, contained unique fimbriae enabling strong adherence to URT epithelium, inhibited the growth and virulence of several URT pathogens, and successfully colonized nasal epithelium of healthy volunteers. This study thus demonstrates that specific Lactobacillus taxa are adapted to the URT and could have a beneficial keystone function in this habitat.
  
Legacy ER Study ID
Legacy GOLD ID
Added By JGI automated process on 2021-12-23
Last Modified By
PI
Description
Relevance
Study Information Visibility Public
Metagenomic Study No
Publication
Is GEBA
Is HMP
ECOSYSTEM CLASSIFICATION
Ecosystem
Ecosystem Category
Ecosystem Type
Ecosystem Subtype
Specific Ecosystem
Ecosystem Path ID 1
STUDY COMPOSITION
Number of Biosamples 0
Number of Organisms 18
Number of Seq Projects 18
Number of Analysis Projects 18
Number of Related Studies 0

 

 

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