Biosamples: 0 Seq. Projects: 892 | |
STUDY INFORMATION | |
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GOLD Study ID
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Gs0146605 |
Study Name
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A unified sequence catalogue of the human gut microbiome |
Other Names
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NCBI Umbrella Bioproject Accession
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SRA Studies |
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Legacy ER Study ID
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Added By | JGI automated process on 2020-07-02 |
Last Modified By | |
PI | Unknown |
Description
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Comprehensive reference data is essential for accurate taxonomic and functional characterisation of the human gut microbiome. Here we present the Unified Human Gastrointestinal Genome (UHGG) collection, a resource combining 286,997 genomes representing 4,644 prokaryotic species from the human gut. These genomes contain over 625 million protein sequences used to generate the Unified Human Gastrointestinal Protein (UHGP) catalogue, a collection that more than doubles the number of gut protein clusters over the Integrated Gene Catalogue. We find that a large portion of the human gut microbiome remains to be fully explored, with over 70% of the UHGG species lacking cultured representatives, and 40% of the UHGP missing meaningful functional annotations. Intra-species genomic variation analyses revealed a large reservoir of accessory genes and single-nucleotide variants, many of which were specific to individual human populations. These freely available genomic resources should greatly facilitate investigations into the human gut microbiome. |
Relevance
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Study Information Visibility
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Public |
Metagenomic Study |
No |
Publication |
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Is HMP |
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ECOSYSTEM CLASSIFICATION
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Ecosystem |
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Ecosystem Type |
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Specific Ecosystem |
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Ecosystem Path ID |
1 |
STUDY COMPOSITION | |
Number of Biosamples | 0 |
Number of Organisms |
892
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Number of Seq Projects |
892
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Number of Analysis Projects |
892
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Number of Related Studies
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0 |
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