The following elements will have their visibility changed, please review the list before confirming the visibility change

Study

Study Name: Comparative genomics of a livestock cohort of Chlamydia suis

Projects

Biosamples

Organisms

Biosamples: 0 Seq. Projects: 32
STUDY INFORMATION
GOLD Study ID Gs0132803
Study Name Comparative genomics of a livestock cohort of Chlamydia suis
Other Names
NCBI Umbrella Bioproject Name
NCBI Umbrella Bioproject ID
SRA Studies
SRA Study Id ERP019897
Study Title Chlamydia suis demonstrates unprecedented genome diversity, plasticity and mobile antibiotic resistance: comparative genomics of a recent livestock cohort
Study Abstract Background: Chlamydia suis is an endemic pig pathogen, belonging to a fascinating genus of obligate intracellular pathogens. Of particular interest, this is the only chlamydial species have naturally acquired genes encoding for antibiotic resistance. To date the distribution and mobility of the Tet-island is not well understood. Our study focused on whole genome sequencing of C. suis isolates from a recent porcine cohort within Switzerland, combined with data from USA tetracycline-resistant isolates.Results: The genome of C. suis has unprecedented diversity and shows a high rate of recombination. Very distinct strains circulate within Europe, and even within individual Swiss farms, whereas New World isolates have more restricted diversity and appear to derive from European isolates. There are several possibilities as to the origins of the Tet-island within C. suis, with recombination a major factor in its transmission. The architecture of the Tet-island is variable, but the tetA(C) gene is always intact. Selective pressure from tetracycline use within pigs leads to a higher number of Tet-island carrying isolates, which tend to be lost in the absence of such pressure.Conclusions: C. suis has a very plastic genome, highly affected by recombination and plasmid exchange. A large diversity of isolates are found circulating in Swiss farms, suggesting that C. suis originated around Europe and historical strain transfers to the USA have occurred. Under antibiotic pressure, strain replacement occurs rather than loss or gain of the Tet-island. The Tet-island appears to be a recent import into the genome of C.suis, with an American origin possible.
  
Legacy ER Study ID
Legacy GOLD ID
Added By JGI automated process on 2017-11-09
Last Modified By JGI automated process on 2019-09-06
PI
Description
Relevance
Study Information Link
Study Information Visibility Public
Metagenomic Study No
Publication
Is GEBA
Is HMP
ECOSYSTEM CLASSIFICATION
Ecosystem
Ecosystem Category
Ecosystem Type
Ecosystem Subtype
Specific Ecosystem
STUDY COMPOSITION
Number of Biosamples 0
Number of Organisms 32
Number of Seq Projects 32
Number of Analysis Projects 38
Number of Related Studies 0

 

 

  You are going to add the following user to ALL Sequencing Projects, Biosamples and Analysis Projects that
sit under this study (a cascading permission update).

 

Contact Name/Email:

Do you want to continue?

 

 

  You are going to remove permissions for the following user to all Sequencing Projects,
Biosamples and Analysis Projects under this study.

 

Contact Name/Email:

Do you want to continue?