PROJECT INFORMATION
GOLD Project ID
Gp0038848  
Project Name
Homo sapiens  
Other Names
  
Legacy ER Project ID
44670  
Legacy GOLD ID
Gi0044670, Gc0044670  
NCBI BioProject Name Homo sapiens
NCBI BioProject Accession PRJNA31257
NCBI Locus Tag
  
NCBI BioSample Accession
PI William Kelly
Added By JGI automated process on 2013-04-02
Last Modified By Jyothi Mallajosyula on 2014-05-01
Project Comments
  
Project Status
Complete and Published  
Project Relevance
  
Sequencing Center Genome Reference Consortium
Collaborating Institute
  
Funding Agency
  
Project Description
  
Is JGI Project
No  
Project Information Visibility Public
PROJECT TYPE
Specimen Organism
Nucleic Acid DNA
Sequencing Strategy
Whole Genome Sequencing  
EXTERNAL PROJECT LINKS
JGI Data Utilization Status
  
JGI Award DOI
Genome Publications Nature Initial sequencing and analysis of the human genome.

Other Publications
  
Ignored Publications
  
Unassigned Publications Molecular biology of the cell 10(9):2847-59 Insulin-induced stimulation of Na+,K(+)-ATPase activity in kidney proximal tubule cells depends on phosphorylation of the alpha-subunit at Tyr-10.

J. Biol. Chem. 262(7):3082-5 Sulfation of a tyrosine residue in the plasmin-binding domain of alpha 2-antiplasmin.

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J. Biol. Chem. 275(35):27123-8 Matrix metalloproteinases cleave tissue factor pathway inhibitor. Effects on coagulation.

J. Biol. Chem. 275(19):14590-7 Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling.

J. Biol. Chem. 269(44):27715-8 Requirement for negative charge on "activation loop" of protein kinase C.

J. Biol. Chem. 273(46):30097-103 p40(phox) is phosphorylated on threonine 154 and serine 315 during activation of the phagocyte NADPH oxidase. Implication of a protein kinase c-type kinase in the phosphorylation process.

J. Biol. Chem. 279(3):1739-46 Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity.

J. Biol. Chem. 281(1):626-37 Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein.

J. Biol. Chem. 271(45):28502-8 Cysteines 153 and 154 of transmembrane transforming growth factor-alpha are palmitoylated and mediate cytoplasmic protein association.

Molecular and cellular biology 24(2):765-73 Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A.

J. Biol. Chem. 278(18):15886-96 Profile-based data base scanning for animal L-type lectins and characterization of VIPL, a novel VIP36-like endoplasmic reticulum protein.

Nucleic acids research 29(5):1027-33 Sp1 phosphorylation regulates inducible expression of platelet-derived growth factor B-chain gene via atypical protein kinase C-zeta.

J. Biol. Chem. 265(1):538-45 The amino terminus of muscle tropomyosin is a major determinant for function.

Journal of biochemistry 126(3):475-84 Mutational analysis of the regulatory mechanism of PKN: the regulatory region of PKN contains an arachidonic acid-sensitive autoinhibitory domain.

Molecular pharmacology 61(3):569-77 Caspase-dependent cleavage of carbamoyl phosphate synthetase II during apoptosis.

Genes & development 15(18):2343-60 Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails.

Proceedings of the National Academy of Sciences of the United States of America 92(24):11259-63 Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination.

Oncogene 22(23):3589-97 v-Src induces Shc binding to tyrosine 63 in the cytoplasmic domain of the LDL receptor-related protein 1.

Molecular cell 5(6):905-15 Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation.

J. Biol. Chem. 279(13):12220-31 Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398.

The Journal of cell biology 163(4):825-35 S100C/A11 is a key mediator of Ca(2+)-induced growth inhibition of human epidermal keratinocytes.

J. Biol. Chem. 277(42):39360-7 Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3.

Molecular and cellular biology 16(4):1295-304 Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation.

Thrombosis and haemostasis 80(4):645-8 Platelet glycoprotein Ia* is the processed form of multimerin--isolation and determination of N-terminal sequences of stored and released forms.

J. Biol. Chem. 271(39):23842-5 Elimination of potential sites of glycosylation fails to abrogate complement regulatory function of cell surface CD59.

J. Biol. Chem. 276(28):26237-42 Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity.

EMBO J. 23(2):312-21 Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins.

The Biochemical journal 365(Pt 1):79-87 Integrin-linked kinase phosphorylates the myosin phosphatase target subunit at the inhibitory site in platelet cytoskeleton.

Proceedings of the National Academy of Sciences of the United States of America 100(17):10032-7 Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease.

EMBO J. 22(4):797-806 Mad2 phosphorylation regulates its association with Mad1 and the APC/C.

Journal of molecular biology 329(4):631-44 Functional domains of FOXJ2.

J. Biol. Chem. 274(15):10086-93 Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase.

J. Biol. Chem. 278(8):5728-35 Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1.

J. Biol. Chem. 278(28):25277-80 Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate.

FEBS letters 421(2):125-30 Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin.

Arteriosclerosis, thrombosis, and vascular biology 22(5):759-64 Role of isoprenylcysteine carboxyl methyltransferase in tumor necrosis factor-alpha stimulation of expression of vascular cell adhesion molecule-1 in endothelial cells.

J. Biol. Chem. 275(34):26515-22 Synucleins are a novel class of substrates for G protein-coupled receptor kinases.

Molecular and cellular biology 26(7):2728-35 Uncleaved TFIIA is a substrate for taspase 1 and active in transcription.

Molecular and cellular biology 20(5):1678-91 Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav.

J. Biol. Chem. 266(14):8784-9 Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme.

Proceedings of the National Academy of Sciences of the United States of America 74(12):5377-81 Chemical evidence that proteolytic cleavage causes the heterogeneity present in human ceruloplasmin preparations.

EMBO J. 20(24):7052-9 Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression.

J. Biol. Chem. 272(13):8207-14 Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptor.

FEBS letters 409(1):57-62 Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases.

"Science (New York, N.Y.)" 278(5338):687-9 Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt.

Molecular cell 15(6):937-49 Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways.

The Journal of cell biology 160(7):1115-27 Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol.

J. Biol. Chem. 275(33):25585-94 Localization of disulfide bonds in the cystine knot domain of human von Willebrand factor.

J. Biol. Chem. 272(46):28962-70 Butylated hydroxyanisole and its metabolite tert-butylhydroquinone differentially regulate mitogen-activated protein kinases. The role of oxidative stress in the activation of mitogen-activated protein kinases by phenolic antioxidants.

Biochemistry 33(19):5791-6 Fluorescence studies of the location and membrane accessibility of the palmitoylation sites of rhodopsin.

Nature 405(6785):473-7 Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products.

J. Biol. Chem. 266(19):12266-71 In vitro phosphorylation of the adipocyte lipid-binding protein (p15) by the insulin receptor. Effects of fatty acid on receptor kinase and substrate phosphorylation.

Investigative ophthalmology & visual science 40(3):657-67 Modifications to rat lens major intrinsic protein in selenite-induced cataract.

Nature 434(7029):113-8 Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.

FEBS letters 266(1-2):167-70 Location and characterization of the three carbohydrate prosthetic groups of human protein HC.

Proceedings of the National Academy of Sciences of the United States of America 94(6):2350-5 Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain.

J. Biol. Chem. 281(1):36-42 In vitro transport of membrane proteins to peroxisomes by shuttling receptor Pex19p.

FEBS letters 236(1):201-4 A discontinuous epitope on p36, the major substrate of src tyrosine-protein-kinase, brings the phosphorylation site into the neighbourhood of a consensus sequence for Ca2+/lipid-binding proteins.

Molecular cell 5(6):917-26 Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14.

Nature 420(6916):636-42 Structural basis of BMP signalling inhibition by the cystine knot protein Noggin.

Biochem. Biophys. Res. Commun. 288(3):564-72 Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase, and PKCdelta.

Journal of biochemistry 138(4):485-91 Regulation of intracellular localization and transcriptional activity of FOXO4 by protein kinase B through phosphorylation at the motif sites conserved among the FOXO family.

Cytogenetic and genome research 159(1):12-18 Epigenetic Coactivation of MAGEA6 and CT-GABRA3 Defines Orientation of a Segmental Duplication in the Human X Chromosome.

J. Biol. Chem. 277(47):44962-8 Casein kinase 1 regulates connexin-43 gap junction assembly.

FEBS letters 482(1-2):44-8 MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells.

J. Biol. Chem. 277(2):1031-9 Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway.

J. Biol. Chem. 276(42):38480-6 Protein kinase C regulates the phosphorylation and cellular localization of occludin.

J. Biol. Chem. 277(41):38486-93 ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner.

J. Biol. Chem. 278(26):24018-25 CK2 phosphorylation of the armadillo repeat region of beta-catenin potentiates Wnt signaling.

Molecular and cellular biology 19(7):4843-54 BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site.

The Journal of cell biology 160(6):823-31 The RasGAP-associated endoribonuclease G3BP assembles stress granules.

J. Biol. Chem. 274(17):12171-6 Dual specificity protein kinase activity of testis-specific protein kinase 1 and its regulation by autophosphorylation of serine-215 within the activation loop.

J. Biol. Chem. 278(44):43541-9 T cell receptor engagement leads to the recruitment of IBP, a novel guanine nucleotide exchange factor, to the immunological synapse.

Oncogene 25(1):70-8 The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs.

"Science (New York, N.Y.)" 286(5445):1741-4 Phosphorylation and regulation of Raf by Akt (protein kinase B).

J. Biol. Chem. 272(40):25401-8 Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity.

J. Biol. Chem. 272(23):14850-9 The type II transforming growth factor-beta receptor autophosphorylates not only on serine and threonine but also on tyrosine residues.

Gastroenterology 115(5):1154-62 Modulation of the cleavage of the gastrin precursor by prohormone phosphorylation.

Journal of proteome research 4(5):1661-71 Phosphoproteome analysis of HeLa cells using stable isotope labeling with amino acids in cell culture (SILAC).

European journal of biochemistry 231(2):491-7 Human topoisomerase II alpha is phosphorylated in a cell-cycle phase-dependent manner by a proline-directed kinase.

Biochem. Biophys. Res. Commun. 169(3):896-904 Ca2(+)-calmodulin-dependent protein kinase II phosphorylates various types of non-epithelial intermediate filament proteins.

The Biochemical journal 394(Pt 2):379-87 Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity.

J. Biol. Chem. 271(10):5309-12 Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities.

EMBO J. 13(7):1610-9 Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.

J. Biol. Chem. 278(22):19642-8 In vivo identification of inducible phosphoacceptors in the IKKgamma/NEMO subunit of human IkappaB kinase.

Molecular and cellular biology 16(3):998-1005 Inhibition of Bcr serine kinase by tyrosine phosphorylation.

J. Biol. Chem. 271(38):23588-93 Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells.

J. Biol. Chem. 266(17):10820-4 Inactivation of DNA polymerase beta by in vitro phosphorylation with protein kinase C.

Molecular and cellular biology 20(6):2043-54 Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation.

Immunity 5(4):353-63 Protein kinase C mu (PKC mu) associates with the B cell antigen receptor complex and regulates lymphocyte signaling.

Endocrine journal 47(4):373-81 The functional significance of Shc in insulin signaling as a substrate of the insulin receptor.

Proceedings of the National Academy of Sciences of the United States of America 88(14):6142-6 Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation.

Nature 394(6694):697-700 Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta.

J. Biol. Chem. 280(42):35337-45 Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway.

Journal of immunology (Baltimore, Md. : 1950) 170(8):4170-7 Threonine phosphorylation sites in the beta 2 and beta 7 leukocyte integrin polypeptides.

Molecular cell 17(2):215-24 Regulation of Raf-1 by direct feedback phosphorylation.

Oncogene 21(43):6633-40 Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways.

J. Biol. Chem. 277(17):14408-16 Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727.

The Journal of cell biology 167(3):469-78 The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone.

European journal of biochemistry 175(2):331-8 Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase.

Oncogene 21(34):5335-45 Caspase-3 mediated cleavage of BRCA1 during UV-induced apoptosis.

Biochemistry 41(52):15845-53 Site-specific dephosphorylation of endothelial nitric oxide synthase by protein phosphatase 2A: evidence for crosstalk between phosphorylation sites.

Molecular cell 14(2):175-82 Gene-specific modulation of TAF10 function by SET9-mediated methylation.

J. Biol. Chem. 269(21):15337-43 Direct interaction between Shc and the platelet-derived growth factor beta-receptor.

J. Biol. Chem. 270(37):21765-71 Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits.

Molecular cancer research : MCR 1(8):598-609 Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation.

Cancer research 63(22):7619-23 Inactivation of a histone methyltransferase by mutations in human cancers.

The Biochemical journal 361(Pt 2):255-65 Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction.

J. Biol. Chem. 279(8):7048-54 Phosphorylation of vanilloid receptor 1 by Ca2+/calmodulin-dependent kinase II regulates its vanilloid binding.

Pharmacological reviews 51(1):7-61 The glutamate receptor ion channels.

J. Biol. Chem. 279(14):14391-7 Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor.

Molecular and cellular biology 21(4):1024-35 Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha.

J. Biol. Chem. 271(18):10816-20 Processing and activation of CMH-1 by granzyme B.

Biochim. Biophys. Acta 1477(1-2):90-7 S-nitrosylated human alpha(1)-protease inhibitor.

Molecular and cellular biology 16(3):1247-55 MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.

J. Biol. Chem. 278(19):17509-14 Phosphorylation-dependent regulation of Kv2.1 Channel activity at tyrosine 124 by Src and by protein-tyrosine phosphatase epsilon.

Proceedings of the National Academy of Sciences of the United States of America 94(24):12957-62 The phosphorylation state of the FIGQY tyrosine of neurofascin determines ankyrin-binding activity and patterns of cell segregation.

Oncogene 24(4):714-23 17beta-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo.

J. Biol. Chem. 273(3):1496-505 Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK.

J. Biol. Chem. 275(26):19567-76 Regulation of protein kinase D by multisite phosphorylation. Identification of phosphorylation sites by mass spectrometry and characterization by site-directed mutagenesis.

Nature 432(7020):988-94 The sequence and analysis of duplication-rich human chromosome 16.

J. Biol. Chem. 275(46):36143-51 cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains.

J. Biol. Chem. 277(30):27081-7 The presence of a single tyrosine residue at the carboxyl domain of vascular endothelial growth factor receptor-2/FLK-1 regulates its autophosphorylation and activation of signaling molecules.

J. Biol. Chem. 268(33):25001-8 Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha.

Biochemistry 31(17):4254-62 Recombinant human complement subcomponent C1s lacking beta-hydroxyasparagine, sialic acid, and one of its two carbohydrate chains still reassembles with C1q and C1r to form a functional C1 complex.

J. Biol. Chem. 275(31):24047-51 Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo.

Biochemistry 25(24):8089-94 A new acylphosphatase isoenzyme from human erythrocytes: purification, characterization, and primary structure.

European journal of biochemistry 196(3):743-50 Primary structure of a new actin-binding protein from human seminal plasma.

FEBS letters 536(1-3):203-8 Novel insights into cadherin processing by subtilisin-like convertases.

Journal of neurochemistry 86(6):1450-7 Physiological regulation of Munc18/nSec1 phosphorylation on serine-313.

J. Biol. Chem. 281(45):34009-20 Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF.

FEBS letters 492(3):204-9 A new family of small, palmitoylated, membrane-associated proteins, characterized by the presence of a cysteine-rich hydrophobic motif.

The Journal of cell biology 129(6):1677-89 The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion.

The Journal of social psychology 95(Second half):165-72 Symptoms of stress in four societies.

EMBO J. 18(1):270-9 Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.

Thrombosis and haemostasis 90(2):206-17 Biochemical importance of glycosylation of plasminogen activator inhibitor-1.

British journal of cancer 81(8):1269-73 Generation of angiostatin-like fragments from plasminogen by prostate-specific antigen.

Molecular carcinogenesis 22(2):110-9 Formation of a stable src-AFAP-110 complex through either an amino-terminal or a carboxy-terminal SH2-binding motif.

J. Biol. Chem. 275(44):34359-64 CREB-binding protein/p300 activates MyoD by acetylation.

J. Biol. Chem. 265(25):15341-5 Identification of membrane anchoring site of human renal dipeptidase and construction and expression of a cDNA for its secretory form.

Protein science : a publication of the Protein Society 4(4):791-803 Site-specific detection and structural characterization of the glycosylation of human plasma proteins lecithin:cholesterol acyltransferase and apolipoprotein D using HPLC/electrospray mass spectrometry and sequential glycosidase digestion.

Clinical cancer research : an official journal of the American Association for Cancer Research 9(2):594-600 Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis.

EMBO J. 22(1):47-59 Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor.

Biochem. Biophys. Res. Commun. 329(3):1108-17 Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain.

The Biochemical journal Human alpha-galactosidase A: glycosylation site 3 is essential for enzyme solubility.

American journal of human genetics 86(3):364-77 Worldwide population analysis of the 4q and 10q subtelomeres identifies only four discrete interchromosomal sequence transfers in human evolution.

Genes & development 12(19):2973-83 The complexity of p53 modulation: emerging patterns from divergent signals.

Molecular human reproduction 2(3):177-84 Cell-to-cell transfer of glycosylphosphatidylinositol-anchored membrane proteins during sperm maturation.

Molecular endocrinology (Baltimore, Md.) 16(2):367-77 Requirement of Ca(2+) and PKCdelta for Janus kinase 2 activation by angiotensin II: involvement of PYK2.

The Biochemical journal N-glycosylation of human acetylcholinesterase: effects on activity, stability and biosynthesis.

FEBS letters 549(1-3):105-9 S-nitrosation of Cys-800 of HIF-1alpha protein activates its interaction with p300 and stimulates its transcriptional activity.

Biochem. Biophys. Res. Commun. 291(5):1146-50 Nuclear receptor and apoptosis initiator NGFI-B is a substrate for kinase ERK2.

Nature 412(6844):346-51 TAK1 is a ubiquitin-dependent kinase of MKK and IKK.

Genes & development 16(8):919-32 SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.

J. Biol. Chem. 273(15):8691-8 Physical and functional interactions between receptor-like protein-tyrosine phosphatase alpha and p59fyn.

J. Biol. Chem. 277(1):528-34 Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway.

Proceedings of the National Academy of Sciences of the United States of America 87(19):7541-5 Identification and preliminary characterization of protein-cysteine farnesyltransferase.

Oncogene 18(39):5413-22 Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity.

J. Biol. Chem. 278(37):34897-909 A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases.

J. Biol. Chem. 276(43):39600-7 Dual regulation of mammalian myosin VI motor function.

Free radical biology & medicine 13(3):205-10 The site of nonenzymic glycation of human extracellular-superoxide dismutase in vitro.

Biochem. Biophys. Res. Commun. 178(2):764-72 Novel serine phosphorylation occurs in the fibroblast form of pp60c-src from Y79 retinoblastoma cells.

J. Biol. Chem. 271(34):20845-52 Cytoplasmic O-GlcNAc modification of the head domain and the KSP repeat motif of the neurofilament protein neurofilament-H.

J. Biol. Chem. 271(43):27099-106 The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32.

Nature 414(6859):36 Effect of DNA damage on a BRCA1 complex.

Biochemistry 35(6):1745-52 Mutagenesis of N-glycosylation sites in the human vasoactive intestinal peptide 1 receptor. Evidence that asparagine 58 or 69 is crucial for correct delivery of the receptor to plasma membrane.

The Biochemical journal 362(Pt 2):481-90 Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome.

Biophysical journal 64(3):792-802 Site-directed mutagenesis of alpha-tubulin. Reductive methylation studies of the Lys 394 region.

J. Biol. Chem. 277(35):32003-14 cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I.

EMBO J. 21(14):3694-703 Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition.

Biochem. Biophys. Res. Commun. 296(4):827-32 Functional analysis of calcium-binding EF-hand motifs of visinin-like protein-1.

EMBO J. 14(15):3679-86 Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase.

Nature 405(6784):360-4 Neurotoxicity induces cleavage of p35 to p25 by calpain.

The Biochemical journal 371(Pt 3):917-25 Protein kinase CK2 phosphorylates Hsp105 alpha at Ser509 and modulates its function.

Proceedings of the National Academy of Sciences of the United States of America 95(2):554-9 Modulation of cell death by Bcl-XL through caspase interaction.

Biochemistry 42(3):811-9 Phosphorylation of RGS14 by protein kinase A potentiates its activity toward G alpha i.

Protein expression and purification 22(2):258-66 [W206R]-procaspase 3: an inactivatable substrate for caspase 8.

J. Biol. Chem. 260(23):12492-9 Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3':5'-monophosphate-dependent protein kinase.

J. Biol. Chem. 273(27):16993-7 Human ADAM 12 (meltrin alpha) is an active metalloprotease.

FEBS letters 545(2-3):161-6 Occludin phosphorylation: identification of an occludin kinase in brain and cell extracts as CK2.

Molecular biology of the cell 18(4):1167-78 DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding.

Molecular and cellular biology 23(16):5526-39 p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD.

J. Biol. Chem. 277(41):38596-606 Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin.

EMBO J. 21(3):324-33 Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3.

J. Biol. Chem. 276(40):37529-36 The role of tyrosine residues in fibroblast growth factor receptor 1 signaling in PC12 cells. Systematic site-directed mutagenesis in the endodomain.

J. Biol. Chem. 267(1):555-63 Vertebrate lens alpha-crystallins are modified by O-linked N-acetylglucosamine.

FEBS letters 540(1-3):106-10 Stimulation of the alpha1A adrenergic receptor inhibits PDGF-induced PDGF beta receptor Tyr751 phosphorylation and PI 3-kinase activation.

J. Biol. Chem. 271(14):8075-81 Protein kinase A-dependent phosphorylation of GLUT2 in pancreatic beta cells.

European journal of immunology 23(10):2488-97 Association of the p56lck protein tyrosine kinase with the Fc gamma RIIIA/CD16 complex in human natural killer cells.

The Biochemical journal 358(Pt 1):185-92 Roles of the juxtamembrane and extracellular domains of angiotensin-converting enzyme in ectodomain shedding.

Journal of neurochemistry 67(2):699-707 In vitro phosphorylation of the cytoplasmic domain of the amyloid precursor protein by glycogen synthase kinase-3beta.

Nature cell biology 4(6):399-407 A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility.

J. Biol. Chem. 274(48):33851-4 Functional regulation of L-type calcium channels via protein kinase A-mediated phosphorylation of the beta(2) subunit.

J. Biol. Chem. 277(51):50131-6 Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes.

Journal of biochemistry 124(6):1237-44 Human erythrocyte bisphosphoglycerate mutase: inactivation by glycation in vivo and in vitro.

J. Biol. Chem. 274(49):34646-56 The novel kinase peptidylglycine alpha-amidating monooxygenase cytosolic interactor protein 2 interacts with the cytosolic routing determinants of the peptide processing enzyme peptidylglycine alpha-amidating monooxygenase.

Biochemistry 34(44):14594-600 Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal.

Cell 61(4):579-89 Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis.

Proceedings of the National Academy of Sciences of the United States of America 97(24):13103-7 Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin.

Nature 426(6966):579-84 Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly.

J. Biol. Chem. 269(1):588-92 Autocatalytic maturation of the prohormone convertase PC2.

Molecular and cellular biology 16(9):4710-6 A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9.

EMBO J. 26(1):209-20 Palmitoylation is required for efficient Fas cell death signaling.

J. Biol. Chem. 274(4):2097-106 Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase.

EMBO J. 25(5):932-42 Ubiquitylation of leptin receptor OB-Ra regulates its clathrin-mediated endocytosis.

J. Biol. Chem. 274(19):13229-34 Unusual sites of arginine methylation in Poly(A)-binding protein II and in vitro methylation by protein arginine methyltransferases PRMT1 and PRMT3.

Blood 77(3):644-8 Molecular characterization of erythrocyte glycophorin C variants.

J. Biol. Chem. 276(4):2544-50 Characterization of a prostate-specific tyrosine phosphatase by mutagenesis and expression in human prostate cancer cells.

Biochem. Biophys. Res. Commun. 294(2):324-8 Characterisation of the phosphorylation of beta-catenin at the GSK-3 priming site Ser45.

Cancer research 63(20):6758-62 Direct activation of pro-matrix metalloproteinase-2 by leukolysin/membrane-type 6 matrix metalloproteinase/matrix metalloproteinase 25 at the asn(109)-Tyr bond.

Journal of immunology (Baltimore, Md. : 1950) 164(3):1236-42 Phosphorylation of FADD/ MORT1 at serine 194 and association with a 70-kDa cell cycle-regulated protein kinase.

J. Biol. Chem. 269(20):14509-17 cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets.

Nucleic acids research 22(24):5173-6 Phosphorylation of the c-Fos and c-Jun HOB1 motif stimulates its activation capacity.

Biochim. Biophys. Acta 1593(1):45-55 Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase.

J. Biol. Chem. 277(50):48944-8 Regulation of ionizing radiation-induced Rad52 nuclear foci formation by c-Abl-mediated phosphorylation.

Journal of immunology (Baltimore, Md. : 1950) 159(4):1987-92 Selective conversion of big endothelins to tracheal smooth muscle-constricting 31-amino acid-length endothelins by chymase from human mast cells.

J. Biol. Chem. 276(42):38595-601 Four tyrosine residues in phospholipase C-gamma 2, identified as Btk-dependent phosphorylation sites, are required for B cell antigen receptor-coupled calcium signaling.

Blood 91(3):930-9 The p85 and p110 subunits of phosphatidylinositol 3-kinase-alpha are substrates, in vitro, for a constitutively associated protein tyrosine kinase in platelets.

FEBS letters 543(1-3):76-80 Heregulin and HER2 signaling selectively activates c-Src phosphorylation at tyrosine 215.

J. Biol. Chem. 273(15):9188-96 Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.

Biochim. Biophys. Acta 994(3):281-4 N-terminal sequence extension in the glycosylated forms of human pancreatic stone protein. The 5-oxoproline N-terminal chain is O-glycosylated on the 5th amino acid residue.

Genes & development 15(21):2852-64 Hierarchical phosphorylation of the translation inhibitor 4E-BP1.

Protein science : a publication of the Protein Society 11(10):2326-34 The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities.

Journal of neurochemistry 86(5):1181-8 Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B.

Journal of lipid research 37(8):1786-801 Functional and metabolic differences between elastase-generated fragments of human lipoprotein[a] and apolipoprotein[a].

Biochim. Biophys. Acta 1121(3):261-8 Human red cell acid phosphatase (ACP1): the primary structure of the two pairs of isozymes encoded by the ACP1*A and ACP1*C alleles.

Nucleic acids research 25(5):955-64 tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence.

Molecular & cellular proteomics : MCP 6(1):72-87 Mass spectrometric mapping of linker histone H1 variants reveals multiple acetylations, methylations, and phosphorylation as well as differences between cell culture and tissue.

J. Biol. Chem. 276(25):22788-96 Activation and functional characterization of the mosaic receptor SorLA/LR11.

Journal of immunology (Baltimore, Md. : 1950) 143(8):2589-94 The invariant chain is a phosphorylated subunit of class II molecules.

Oncogene 17(2):255-60 Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions.

J. Biol. Chem. 271(30):17957-60 Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein.

J. Biol. Chem. 277(33):29503-9 Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 signaling pathway.

Proceedings of the National Academy of Sciences of the United States of America 91(15):7335-9 Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.

J. Biol. Chem. 276(48):44873-80 Phosphorylation of Ser2078 modulates the Notch2 function in 32D cell differentiation.

Nature 440(7087):1045-9 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

Molecular and cellular biology 16(3):899-906 Casein kinase II phosphorylates I kappa B alpha at S-283, S-289, S-293, and T-291 and is required for its degradation.

The Biochemical journal 353(Pt 1):69-77 Novel properties of the protein kinase CK2-site-regulated nuclear- localization sequence of the interferon-induced nuclear factor IFI 16.

J. Biol. Chem. 274(10):6285-94 Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling.

Nature 408(6808):106-11 Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation.

Molecular and cellular biology 14(10):6674-82 Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation.

J. Biol. Chem. 271(33):20082-7 Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner.

Experimental cell research 256(2):522-32 The RGG domain in hnRNP A2 affects subcellular localization.

Molecular and cellular biology 23(15):5376-87 Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding.

European journal of immunology 34(12):3690-701 IREM-1 is a novel inhibitory receptor expressed by myeloid cells.

Molecular & cellular proteomics : MCP 6(4):575-88 Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells.

The Biochemical journal 254(2):531-7 Hydrolysis of alpha-human atrial natriuretic peptide in vitro by human kidney membranes and purified endopeptidase-24.11. Evidence for a novel cleavage site.

The Biochemical journal Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared with testis ACE despite cleavage at identical stalk sites.

Molecular cell 1(4):553-63 Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade.

J. Biol. Chem. 264(34):20778-85 Identification of sites phosphorylated in bovine cardiac troponin I and troponin T by protein kinase C and comparative substrate activity of synthetic peptides containing the phosphorylation sites.

Cell 80(5):729-38 Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals.

European journal of biochemistry 252(3):542-52 Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation.

J. Biol. Chem. 278(35):32929-35 Threonine 391 phosphorylation of the human prolactin receptor mediates a novel interaction with 14-3-3 proteins.

J. Biol. Chem. 259(22):13680-3 Phosphorylation of tyrosine hydroxylase by calmodulin-dependent multiprotein kinase.

Biochem. Biophys. Res. Commun. 252(1):46-50 Calcium/calmodulin-dependent protein kinase II controls integrin alpha5beta1-mediated cell adhesion through the integrin cytoplasmic domain associated protein-1alpha.

J. Biol. Chem. 264(30):18202-8 Normal rat kidney cells secrete both phosphorylated and nonphosphorylated forms of osteopontin showing different physiological properties.

The Journal of neuroscience : the official journal of the Society for Neuroscience 18(11):4008-21 Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M.

EMBO J. 20(20):5692-702 PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization.

Molecular biology of the cell 13(6):2016-30 The RNA binding activity of a ribosome biogenesis factor, nucleophosmin/B23, is modulated by phosphorylation with a cell cycle-dependent kinase and by association with its subtype.

Proceedings of the National Academy of Sciences of the United States of America 95(7):3792-7 NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176.

J. Biol. Chem. 272(31):19418-24 Phosphorylation by p34cdc2 protein kinase regulates binding of the kinesin-related motor HsEg5 to the dynactin subunit p150.

J. Biol. Chem. 254(18):8777-80 Carbohydrate of the human plasminogen variants. III. Structure of the O-glycosidically linked oligosaccharide unit.

European journal of immunology 31(3):699-707 Rapid inactivation of stromal cell-derived factor-1 by cathepsin G associated with lymphocytes.

J. Biol. Chem. 261(18):8334-41 Identification of lymphocyte integral membrane proteins as substrates for protein kinase C. Phosphorylation of the interleukin-2 receptor, class I HLA antigens, and T200 glycoprotein.

J. Biol. Chem. 275(22):16569-73 Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase.

European journal of immunology 30(12):3707-17 Induction, binding specificity and function of human ICOS.

EMBO J. 25(13):3078-88 FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2.

FEBS letters 364(2):223-8 Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells.

J. Biol. Chem. 276(30):28006-13 Identification of Src phosphorylation sites in the catenin p120ctn.

EMBO reports 3(2):177-82 An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells.

Archives of biochemistry and biophysics 407(1):103-16 Phosphorylation of the stress-activated protein kinase, MEKK3, at serine 166.

J. Biol. Chem. 269(49):31097-106 Visualization and function of vimentin phosphorylation by cdc2 kinase during mitosis.

J. Biol. Chem. 269(47):29746-51 Serine 1524 is a major site of phosphorylation on human topoisomerase II alpha protein in vivo and is a substrate for casein kinase II in vitro.

J. Biol. Chem. 268(35):26428-34 Proteolytic release of human angiotensin-converting enzyme. Localization of the cleavage site.

J. Biol. Chem. 276(22):19469-82 Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.

Journal of immunology (Baltimore, Md. : 1950) 165(6):3226-31 Serine 6 of Lck tyrosine kinase: a critical site for Lck myristoylation, membrane localization, and function in T lymphocytes.

Cancer research 55(18):4000-3 Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein.

Molecular and cellular biology 24(7):2986-97 A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin.

Growth regulation 4(4):164-72 Biochemical analysis of prostate specific antigen-proteolyzed insulin-like growth factor binding protein-3.

Immunogenetics 60(1):1-18 Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project.

Neuroscience 115(3):829-37 Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5.

Biochem. Biophys. Res. Commun. 315(2):471-6 Interaction of human MUC1 and beta-catenin is regulated by Lck and ZAP-70 in activated Jurkat T cells.

J. Biol. Chem. 267(7):5005-12 Proteolytic inactivation of alpha 1-proteinase inhibitor and alpha 1-antichymotrypsin by oxidatively activated human neutrophil metalloproteinases.

J. Biol. Chem. 279(3):1922-31 Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling.

Gut 47(2):242-50 Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells.

The Journal of cell biology 152(2):375-84 A novel chromatin protein, distantly related to histone H2A, is largely excluded from the inactive X chromosome.

J. Biol. Chem. 269(25):17311-9 Molecular structure of pulmonary surfactant protein D (SP-D).

J. Biol. Chem. 276(44):41237-44 Identification of a caspase-9 substrate and detection of its cleavage in programmed cell death during mouse development.

J. Biol. Chem. 273(8):4734-9 Transgenic approaches to define the functional role of dual site phospholamban phosphorylation.

Am. J. Pathol. 162(4):1183-90 Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer.

J. Biol. Chem. 270(32):19166-72 Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo.

The Biochemical journal 367(Pt 1):31-40 Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysis.

J. Biol. Chem. 275(44):34592-6 Association of immature hypophosphorylated protein kinase cepsilon with an anchoring protein CG-NAP.

Biochem. Biophys. Res. Commun. 296(4):911-7 Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation.

European journal of immunology 31(3):812-22 Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo.

Biochemistry 35(24):8035-44 Cell cycle-dependent phosphorylation of nucleoporins and nuclear pore membrane protein Gp210.

Oncogene 15(3):285-90 Involvement of caspase-4(-like) protease in Fas-mediated apoptotic pathway.

Biochem. Biophys. Res. Commun. 270(2):488-94 Skeletal muscle CaMKII enriches in nuclei and phosphorylates myogenic factor SRF at multiple sites.

Neuron 38(3):375-87 Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice.

Nature 428(6982):529-35 The DNA sequence and biology of human chromosome 19.

"Science (New York, N.Y.)" 286(5449):2514-7 Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation.

Genes to cells : devoted to molecular & cellular mechanisms 10(8):835-50 Transcriptional activity of megakaryoblastic leukemia 1 (MKL1) is repressed by SUMO modification.

FEBS letters 510(3):211-5 Decreased intracellular degradation of insulin-like growth factor binding protein-3 in cathepsin L-deficient fibroblasts.

EMBO J. 25(24):5670-82 GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome.

J. Biol. Chem. 278(42):40514-20 CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation.

Oncogene 19(7):858-69 The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP.

J. Biol. Chem. 282(22):16232-43 Biochemical and functional characterization of Orai proteins.

Molecular and cellular biology 13(2):801-8 Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1.

Proceedings of the National Academy of Sciences of the United States of America 103(9):3316-21 Proteinase 3 is an IL-32 binding protein.

Proceedings of the National Academy of Sciences of the United States of America 101(37):13489-94 Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.

J. Biol. Chem. 274(23):15971-4 Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases.

The Journal of cell biology 156(6):951-7 CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae.

J. Biol. Chem. 277(8):6490-6 Protein kinase C (PKC)eta-mediated PKC mu activation modulates ERK and JNK signal pathways.

J. Biol. Chem. 261(4):1868-72 Amino acid sequence of protein B23 phosphorylation site.

Nature 429(6990):375-81 The DNA sequence and comparative analysis of human chromosome 10.

Molecular and cellular biology 19(12):8469-78 BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

FEBS letters 577(3):555-62 Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl.

Cell 122(6):887-900 Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR.

J. Biol. Chem. 269(16):12220-8 Insulin stimulates the phosphorylation of Tyr538 and the catalytic activity of PTP1C, a protein tyrosine phosphatase with Src homology-2 domains.

Molecular biology of the cell 9(2):301-9 Recognition signal for C-mannosylation of Trp-7 in RNase 2 consists of sequence Trp-x-x-Trp.

Molecular and cellular biology 19(4):2986-97 Role for caspase-mediated cleavage of Rad51 in induction of apoptosis by DNA damage.

Carcinogenesis 21(8):1537-46 A potential mechanism for fumonisin B(1)-mediated hepatocarcinogenesis: cyclin D1 stabilization associated with activation of Akt and inhibition of GSK-3beta activity.

European journal of biochemistry 209(3):945-50 Specific phosphorylation of the acidic central region of the N-myc protein by casein kinase II.

The Biochemical journal Post-translational processing of progastrin: inhibition of cleavage, phosphorylation and sulphation by brefeldin A.

J. Biol. Chem. 271(13):7265-8 Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin.

J. Biol. Chem. 261(4):1786-93 Identification of the site of sulfation of the fourth component of human complement.

Biochem. Biophys. Res. Commun. 279(3):744-50 Glycosylation effect on membrane domain (GEM) involved in cell adhesion and motility: a preliminary note on functional alpha3, alpha5-CD82 glycosylation complex in ldlD 14 cells.

J. Biol. Chem. 273(39):25436-42 A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis.

J. Biol. Chem. 274(33):23426-36 Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease.

Proceedings of the National Academy of Sciences of the United States of America 80(10):2894-8 HLA-A2 and HLA-B7 antigens are phosphorylated in vitro by rous sarcoma virus kinase (pp60v-src) at a tyrosine residue encoded in a highly conserved exon of the intracellular domain.

The Biochemical journal 368(Pt 3):875-84 Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes.

Oncogene 18(5):1131-8 Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis.

Proceedings of the National Academy of Sciences of the United States of America 91(25):12253-7 Amino-terminal basic residues of Src mediate membrane binding through electrostatic interaction with acidic phospholipids.

Oncogene 22(5):746-55 Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1).

FEBS letters 42(3):249-52 The amino acid sequences of the phosphorylated sites in troponin-I from rabbit skeletal muscle.

Nature immunology 4(1):44-8 Tyrosine phosphorylation of VHR phosphatase by ZAP-70.

J. Biol. Chem. 270(39):23119-25 Phosphorylation of Gz alpha by protein kinase C blocks interaction with the beta gamma complex.

Nature 420(6916):691-5 Signal-dependent regulation of splicing via phosphorylation of Sam68.

Journal of cell science 115(Pt 24):4787-99 Lasp-1 binds to non-muscle F-actin in vitro and is localized within multiple sites of dynamic actin assembly in vivo.

Archives of biochemistry and biophysics 327(1):61-70 Glycosylation in human thyroglobulin: location of the N-linked oligosaccharide units and comparison with bovine thyroglobulin.

Molecular and cellular biology 21(1):88-99 Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop.

Oncogene 9(10):3005-11 p56/p53lyn tyrosine kinase activation in mammalian cells treated with mitomycin C.

The Biochemical journal The regulation of AMP-activated protein kinase by phosphorylation.

J. Biol. Chem. 277(27):24809-17 Autophosphorylation of the mammalian multifunctional protein that initiates de novo pyrimidine biosynthesis.

Biochemistry 37(9):3196-202 Galpha12 requires acylation for its transforming activity.

Acta crystallographica. Section D, Biological crystallography 57(Pt 3):378-84 Structure of fibroblast growth factor 9 shows a symmetric dimer with unique receptor- and heparin-binding interfaces.

Current biology : CB 14(16):1425-35 aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity.

Journal of neurochemistry 75(3):1085-91 Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5.

FEBS letters 314(1):85-8 Natural human tumor necrosis factor beta (lymphotoxin). Variable O-glycosylation at Thr7, proteolytic processing, and allelic variation.

J. Biol. Chem. 273(27):17186-91 Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor.

The Biochemical journal 375(Pt 1):207-13 Adaptor signalling proteins Grb2 and Grb7 are recruited by human G6f, a novel member of the immunoglobulin superfamily encoded in the MHC.

J. Biol. Chem. 276(40):37223-9 Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase.

FEBS letters 506(3):207-10 Signalling of GPI-anchored CD157 via focal adhesion kinase in MCA102 fibroblasts.

Molecular and cellular biology 19(1):229-40 Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression.

J. Biol. Chem. 276(3):1911-5 Phosphorylation of GRK2 by protein kinase C abolishes its inhibition by calmodulin.

EMBO J. 22(12):3062-72 Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.

J. Biol. Chem. 269(27):18134-40 Activation of human interstitial procollagenase through direct cleavage of the Leu83-Thr84 bond by mast cell chymase.

The Journal of neuroscience : the official journal of the Society for Neuroscience 22(16):6972-9 Protective role of phosphorylation in turnover of glial fibrillary acidic protein in mice.

Analytical chemistry 77(17):5693-9 Identification of phosphorylation sites in insulin receptor substrate-1 by hypothesis-driven high-performance liquid chromatography-electrospray ionization tandem mass spectrometry.

Molecular immunology 30(12):1089-96 Efficient complement-mediated lysis of cells containing the CAMPATH-1 (CDw52) antigen.

Circulation research 89(6):480-7 Proteomic analysis of pharmacologically preconditioned cardiomyocytes reveals novel phosphorylation of myosin light chain 1.

Developmental cell 2(6):831-7 The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

J. Biol. Chem. 276(3):1961-7 The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation.

Biochemistry 30(9):2311-4 Tissue plasminogen activator has an O-linked fucose attached to threonine-61 in the epidermal growth factor domain.

Experimental cell research 299(2):343-55 Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1.

Cell 70(5):777-89 Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity.

Current biology : CB 9(10):522-9 Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex.

"Science (New York, N.Y.)" 281(5381):1360-3 Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate.

J. Biol. Chem. 273(40):25770-6 The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells.

The Biochemical journal The 50 kDa protein subunit of assembly polypeptide (AP) AP-2 adaptor from clathrin-coated vesicles is phosphorylated on threonine-156 by AP-1 and a soluble AP50 kinase which co-purifies with the assembly polypeptides.

J. Biol. Chem. 275(4):2513-9 Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase.

Oncogene 14(5):507-13 Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site.

Molecular biology of the cell 8(2):287-301 Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation.

FEBS letters 567(2-3):248-52 Suppression of the caspase cleavage of beta-amyloid precursor protein by its cytoplasmic phosphorylation.

Molecular and cellular biology 23(4):1239-50 Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle.

European journal of biochemistry 186(1-2):273-86 Carbohydrate structure of recombinant human uterine tissue plasminogen activator expressed in mouse epithelial cells.

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 9(4):241-53 Inflammation-related neutrophil proteases, cathepsin G and elastase, function as insulin-like growth factor binding protein proteases.

J. Biol. Chem. 270(5):2092-8 Characterization of a mitochondrial metallopeptidase reveals neurolysin as a homologue of thimet oligopeptidase.

Oncogene 24(34):5333-43 Adhesion signaling by a novel mitotic substrate of src kinases.

Journal of immunology (Baltimore, Md. : 1950) 161(10):5276-83 Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B cell activation includes a site that negatively regulates signaling.

Nature 395(6705):863-9 Structural basis for activation of the titin kinase domain during myofibrillogenesis.

Archives of biochemistry and biophysics 314(1):99-106 Identification, assay, and purification of a Cdc2-activating threonine-161 protein kinase from human cells.

Stem cells (Dayton, Ohio) 16(5):322-8 Native thrombopoietin: structure and function.

J. Biol. Chem. 277(22):19521-9 Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity.

J. Virol. 65(1):170-9 Structural elements that regulate pp59c-fyn catalytic activity, transforming potential, and ability to associate with polyomavirus middle-T antigen.

J. Biol. Chem. 266(36):24249-52 CSK: a protein-tyrosine kinase involved in regulation of src family kinases.

Journal of lipid research 28(12):1405-9 Molecular cloning of a human apoC-III variant: Thr 74----Ala 74 mutation prevents O-glycosylation.

Journal of cell science 115(Pt 3):575-85 Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function.

J. Biol. Chem. 271(28):16526-34 Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation.

Journal of molecular biology 226(4):1051-72 Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine heart mitochondria. Application of a novel strategy for sequencing proteins using the polymerase chain reaction.

The Journal of experimental medicine 194(9):1263-76 Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling.

BMC biochemistry Phosphorylation-facilitated sumoylation of MEF2C negatively regulates its transcriptional activity.

J. Biol. Chem. 266(2):1250-7 Glycophospholipid membrane anchor attachment. Molecular analysis of the cleavage/attachment site.

FEBS letters 232(2):391-4 Role of N-linked oligosaccharides attached to human renin expressed in COS cells.

J. Biol. Chem. 272(11):7408-11 Evidence for a novel O-linked sialylated trisaccharide on Ser-248 of human plasminogen 2.

J. Biol. Chem. 272(18):11928-36 Phosphorylation and O-glycosylation sites of bovine chromogranin A from adrenal medullary chromaffin granules and their relationship with biological activities.

International journal of cancer 81(3):438-42 Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1.

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie 320(8):621-8 Proteolytic fragments of insulin-like growth factor binding protein-3: N-terminal sequences and relationships between structure and biological activity.

J. Biol. Chem. 276(24):20913-23 Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation.

The Biochemical journal Heterogeneity in utilization of N-glycosylation sites Asn624 and Asn138 in human lactoferrin: a study with glycosylation-site mutants.

Neuron 35(5):907-20 Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex.

Molecular cell 7(6):1221-31 Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300.

J. Biol. Chem. 278(5):3363-71 Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas.

Blood 94(6):1933-42 Identification of a 14-3-3 binding sequence in the common beta chain of the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors that is serine-phosphorylated by GM-CSF.

Nature genetics 23(2):147 Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA.

Oncogene 16(10):1229-39 Identification of Tyr-762 in the platelet-derived growth factor alpha-receptor as the binding site for Crk proteins.

Oncogene 19(25):2895-903 Identification of Grb10 as a direct substrate for members of the Src tyrosine kinase family.

J. Biol. Chem. 272(51):32547-50 The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus.

J. Biol. Chem. 265(26):15860-6 Protein kinase A phosphorylates retinal phosducin on serine 73 in situ.

J. Biol. Chem. 280(11):10264-76 SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.

J. Biol. Chem. 274(26):18821-6 ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix.

J. Biol. Chem. 277(2):1531-7 Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action.

J. Biol. Chem. 278(42):40973-9 Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites.

EMBO J. 16(8):1970-81 Positive and negative regulation of type II TGF-beta receptor signal transduction by autophosphorylation on multiple serine residues.

J. Biol. Chem. 274(45):32274-8 Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells.

Biochim. Biophys. Acta 1594(1):191-8 Mutational analysis of sites in sepiapterin reductase phosphorylated by Ca2+/calmodulin-dependent protein kinase II.

Molecular and cellular biology 18(6):3540-51 Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments.

Journal of cell science Role of glycosylation in the expression of human procathepsin D.

Cell 77(2):261-71 A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family.

Proceedings of the National Academy of Sciences of the United States of America 98(24):13631-6 Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription.

EMBO J. 21(8):1889-98 14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity.

FEBS letters 328(3):285-90 Determination of the disulphide bridge arrangement of bovine histidine-rich glycoprotein.

J. Biol. Chem. 276(21):18090-5 Identification of new JNK substrate using ATP pocket mutant JNK and a corresponding ATP analogue.

J. Biol. Chem. 259(12):7673-81 Amino acid sequence of the phosphorylation site of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

Molecular and cellular biochemistry Preparation and functional characterization of a catalytically active fragment of phosphorylase kinase.

The Journal of clinical endocrinology and metabolism 86(8):3675-85 Characterization of human FSH isoforms reveals a nonglycosylated beta-subunit in addition to the conventional glycosylated beta-subunit.

J. Biol. Chem. 276(29):26753-61 HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 ((3D)HSP27).

J. Biol. Chem. 278(48):47434-40 PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation.

J. Biol. Chem. 272(46):29238-42 Dentatorubral pallidoluysian atrophy (DRPLA) protein is cleaved by caspase-3 during apoptosis.

International journal of impotence research 17(4):320-5 3',5'-cyclic nucleotide phosphodiesterase 11A: localization in human tissues.

European journal of biochemistry 268(7):2099-106 Human phosphatidylinositol 4-kinase isoform PI4K92. Expression of the recombinant enzyme and determination of multiple phosphorylation sites.

BMC cell biology A p130Cas tyrosine phosphorylated substrate domain decoy disrupts v-crk signaling.

J. Biol. Chem. 262(22):10434-7 Phosphorylation site of eukaryotic initiation factor 4E.

Protein science : a publication of the Protein Society 3(5):822-30 Conserved phosphorylation of serines in the Ser-X-Glu/Ser(P) sequences of the vitamin K-dependent matrix Gla protein from shark, lamb, rat, cow, and human.

Biochemistry 38(12):3549-58 Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments.

Cell death and differentiation 7(9):843-50 Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis.

J. Biol. Chem. 277(35):32348-52 Natural truncation of the chemokine MIP-1 beta /CCL4 affects receptor specificity but not anti-HIV-1 activity.

Proceedings of the National Academy of Sciences of the United States of America 81(2):390-4 Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule.

FEBS letters 312(2-3):152-6 Prothymosin alpha is phosphorylated by casein kinase-2.

J. Biol. Chem. 275(46):36311-5 Phosphorylation of the beta-galactoside-binding protein galectin-3 modulates binding to its ligands.

J. Biol. Chem. 278(34):32227-35 Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways.

European journal of biochemistry 267(24):7170-5 Identification of IkappaBalpha as a substrate of Fas-associated phosphatase-1.

J. Biol. Chem. 268(9):6714-20 Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation.

Proceedings of the National Academy of Sciences of the United States of America 90(6):2207-11 Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.

European journal of biochemistry 107(2):529-37 Glycogen synthase from rabbit skeletal muscle. Amino acid sequence at the sites phosphorylated by glycogen synthase kinase-3, and extension of the N-terminal sequence containing the site phosphorylated by phosphorylase kinase.

Cell 94(4):481-90 Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors.

Biochemistry 43(20):6182-9 Protein phosphorylation of human brain glutamic acid decarboxylase (GAD)65 and GAD67 and its physiological implications.

Proceedings of the National Academy of Sciences of the United States of America 75(8):3588-92 Specific phosphorylation at serine-283 of alpha tropomyosin from frog skeletal and rabbit skeletal and cardiac muscle.

Urology 48(2):317-25 Alteration of the hormonal bioactivity of parathyroid hormone-related protein (PTHrP) as a result of limited proteolysis by prostate-specific antigen.

J. Biol. Chem. 275(27):20880-6 Selective attenuation of metabolic branch of insulin receptor down-signaling by high glucose in a hepatoma cell line, HepG2 cells.

Molecular cancer research : MCR 1(2):155-63 Regulation of Lck and Fyn tyrosine kinase activities by transmembrane protein tyrosine phosphatase leukocyte common antigen-related molecule.

J. Biol. Chem. 277(19):16733-43 ERK8, a new member of the mitogen-activated protein kinase family.

Biochemistry 36(13):3811-9 Characterization of prostate-specific antigen proteolytic activity on its major physiological substrate, the sperm motility inhibitor precursor/semenogelin I.

Blood 90(3):1065-74 Human neutrophil elastase activates human factor V but inactivates thrombin-activated human factor V.

J. Biol. Chem. 275(42):33008-13 Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XII.

J. Biol. Chem. 276(36):33665-74 SET-related cell division autoantigen-1 (CDA1) arrests cell growth.

J. Biol. Chem. 277(44):41835-42 Protein kinase A site-specific phosphorylation regulates ATP-binding cassette A1 (ABCA1)-mediated phospholipid efflux.

Oncogene 22(2):220-32 Protein kinase CK2 regulates CDC25B phosphatase activity.

J. Biol. Chem. 278(9):7390-6 Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells.

FEBS letters 403(3):254-8 Identification of Raf-1 Ser621 kinase activity from NIH 3T3 cells as AMP-activated protein kinase.

Proceedings of the National Academy of Sciences of the United States of America 91(25):11963-7 Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A.

"Science (New York, N.Y.)" 296(5576):2215-8 Identification of signal peptide peptidase, a presenilin-type aspartic protease.

EMBO J. 19(20):5324-31 Post-translational hydroxylation at the N-terminus of the prion protein reveals presence of PPII structure in vivo.

Molecular and cellular biology 22(13):4535-43 c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs.

J. Biol. Chem. 273(12):7162-8 p125Fak focal adhesion kinase is a substrate for the insulin and insulin-like growth factor-I tyrosine kinase receptors.

EMBO J. 17(4):1087-95 Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300.

Rheumatology (Oxford, England) 42(1):154-61 Autoantibodies to dsDNA cross-react with the arginine-glycine-rich domain of heterogeneous nuclear ribonucleoprotein A2 (hnRNP A2) and promote methylation of hnRNP A2.

BMC cell biology Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL.

J. Biol. Chem. 277(27):24169-79 Inhibition of interleukin-1beta -induced NF-kappa B activation by calcium/calmodulin-dependent protein kinase kinase occurs through Akt activation associated with interleukin-1 receptor-associated kinase phosphorylation and uncoupling of MyD88.

J. Biol. Chem. 268(19):14294-300 Phosphorylation of connexin-32 by protein kinase C prevents its proteolysis by mu-calpain and m-calpain.

J. Biol. Chem. 281(8):4762-70 Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells.

J. Biol. Chem. 273(52):35273-81 Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323.

Molecular and cellular biology 24(11):4955-67 Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity.

J. Biol. Chem. 266(12):7549-55 Identification of phosphorylated sites in the mouse glucocorticoid receptor.

Proceedings of the National Academy of Sciences of the United States of America 101(8):2625-30 Regulation of canonical transient receptor potential isoform 3 (TRPC3) channel by protein kinase G.

J. Biol. Chem. 274(21):15101-9 Regulated interaction of protein kinase Cdelta with the heterogeneous nuclear ribonucleoprotein K protein.

International journal of molecular medicine 10(2):221-5 Molecular cloning and characterization of OSR1 on human chromosome 2p24.

J. Biol. Chem. 280(9):7581-7 Modulation of erythrocyte membrane mechanical function by protein 4.1 phosphorylation.

Molecular and cellular biology 16(3):977-89 Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction.

American journal of physiology. Heart and circulatory physiology 283(1):H77-84 Role of glycosylation in cell surface expression and stability of HERG potassium channels.

J. Biol. Chem. 276(40):37659-64 Acetylation of steroidogenic factor 1 protein regulates its transcriptional activity and recruits the coactivator GCN5.

European journal of biochemistry 268(17):4647-52 The role of Thr160 phosphorylation of Cdk2 in substrate recognition.

Molecular and cellular biology 17(11):6508-16 STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation.

J. Biol. Chem. 267(28):20317-25 Casein kinase II phosphorylates p34cdc2 kinase in G1 phase of the HeLa cell division cycle.

J. Biol. Chem. 272(39):24475-9 Posttranslational modifications of the 5'-AMP-activated protein kinase beta1 subunit.

Oncogene 9(1):49-57 Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor).

J. Biol. Chem. 279(51):53071-7 MUC1 membrane trafficking is modulated by multiple interactions.

American journal of physiology. Endocrinology and metabolism 290(3):E500-8 Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue.

J. Biol. Chem. 274(20):14376-81 Activation of C3G guanine nucleotide exchange factor for Rap1 by phosphorylation of tyrosine 504.

Cell 96(6):795-806 Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance.

J. Biol. Chem. 278(15):12737-44 Palmitoylated peptides from the cysteine-rich domain of SNAP-23 cause membrane fusion depending on peptide length, position of cysteines, and extent of palmitoylation.

J. Biol. Chem. 272(1):17-9 LSP1 is the major substrate for mitogen-activated protein kinase-activated protein kinase 2 in human neutrophils.

EMBO J. 19(24):6778-91 TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins.

J. Biol. Chem. 269(47):29520-9 Identification by electrospray ionization mass spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70.

Proceedings of the National Academy of Sciences of the United States of America 97(10):5261-6 5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases.

J. Biol. Chem. 276(18):14602-6 Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40.

EMBO J. 25(15):3618-26 A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics.

EMBO J. 21(1-2):72-82 PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2.

Neurobiology of disease 3(4):325-37 Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.

Proceedings of the National Academy of Sciences of the United States of America 98(12):6650-5 Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4.

Molecular biology of the cell 14(2):349-60 Integrin-mediated tyrosine phosphorylation of Shc in T cells is regulated by protein kinase C-dependent phosphorylations of Lck.

FEBS letters 447(1):87-90 The cleavage site specificity of human prostate specific antigen for insulin-like growth factor binding protein-3.

J. Biol. Chem. 278(38):36410-7 Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis.

Biochemical and molecular medicine 61(1):47-51 Comparison of the hydrolysis of the three types of natriuretic peptides by human kidney neutral endopeptidase 24.11.

Proceedings of the National Academy of Sciences of the United States of America 96(4):1321-6 Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization.

"Science (New York, N.Y.)" 289(5482):1202-6 Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3.

"Science (New York, N.Y.)" 255(5052):1705-7 An amino acid mutation in a potassium channel that prevents inhibition by protein kinase C.

Experimental cell research 287(2):219-27 Cofilin phosphorylation and actin polymerization by NRK/NESK, a member of the germinal center kinase family.

Biochim. Biophys. Acta 1380(2):177-82 Characterization of tau phosphorylation in glycogen synthase kinase-3beta and cyclin dependent kinase-5 activator (p23) transfected cells.

EMBO J. 22(6):1302-12 Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome.

Biochem. Biophys. Res. Commun. 323(4):1197-202 ATR-dependent phosphorylation of ATRIP in response to genotoxic stress.

J. Biol. Chem. 270(11):6338-44 Limited and defined truncation at the C terminus enhances receptor binding and degranulation activity of the neutrophil-activating peptide 2 (NAP-2). Comparison of native and recombinant NAP-2 variants.

Human molecular genetics 6(5):717-26 alpha-Mannosidosis: functional cloning of the lysosomal alpha-mannosidase cDNA and identification of a mutation in two affected siblings.

J. Biol. Chem. 265(30):18601-7 Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon.

J. Biol. Chem. 267(18):12742-52 Phosphorylation of the cystic fibrosis transmembrane conductance regulator.

J. Biol. Chem. 280(2):1037-43 Interleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR).

The Biochemical journal The low-density-lipoprotein receptor-related protein (LRP) is processed by furin in vivo and in vitro.

EMBO J. 19(16):4298-309 Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein.

J. Biol. Chem. 270(23):14192-200 Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells.

Molecular and cellular biology 25(6):2227-41 Removal of C-terminal SRC kinase from the immune synapse by a new binding protein.

J. Biol. Chem. 273(50):33443-8 Regulation of TFII-I activity by phosphorylation.

Biochem. Biophys. Res. Commun. 296(5):1215-21 Molecular cloning of a novel immunoglobulin superfamily gene preferentially expressed by brain and testis.

J. Biol. Chem. 273(25):15533-9 Identification and characterization of the major phosphorylation sites of the B-type natriuretic peptide receptor.

J. Biol. Chem. 276(6):4398-408 Caveolin-1 binding to endoplasmic reticulum membranes and entry into the regulated secretory pathway are regulated by serine phosphorylation. Protein sorting at the level of the endoplasmic reticulum.

The Journal of cell biology 117(3):583-93 PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18.

J. Biol. Chem. 276(21):18513-8 Sumo-1 modification regulates the DNA binding activity of heat shock transcription factor 2, a promyelocytic leukemia nuclear body associated transcription factor.

FEBS letters 392(3):209-14 A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress.

J. Biol. Chem. 273(10):5858-68 DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139.

Journal of cell science 117(Pt 12):2523-31 Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition.

J. Biol. Chem. 275(27):20754-61 Identification of p130cas as an in vivo substrate of receptor protein-tyrosine phosphatase alpha.

J. Biol. Chem. 278(35):32662-72 A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates.

J. Biol. Chem. 280(5):3414-25 Src phosphorylation of Alix/AIP1 modulates its interaction with binding partners and antagonizes its activities.

The Biochemical journal 355(Pt 3):597-607 The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site.

Proceedings of the National Academy of Sciences of the United States of America 99(12):7900-5 Shotgun identification of protein modifications from protein complexes and lens tissue.

Proceedings of the National Academy of Sciences of the United States of America 97(26):14400-5 Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5.

Proceedings of the National Academy of Sciences of the United States of America 97(17):9712-7 BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.

J. Biol. Chem. 282(3):1797-804 FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity.

Nature 396(6710):478-82 Functional interaction between InsP3 receptors and store-operated Htrp3 channels.

Thrombosis research 33(5):487-98 The location of a second in vivo phosphorylation site in the A alpha-chain of human fibrinogen.

Proceedings of the National Academy of Sciences of the United States of America 85(17):6337-41 Ca2+/calmodulin-dependent protein kinase II: identification of threonine-286 as the autophosphorylation site in the alpha subunit associated with the generation of Ca2+-independent activity.

EMBO J. 22(9):2091-103 Cdc2-mediated phosphorylation of Kid controls its distribution to spindle and chromosomes.

European journal of biochemistry 268(23):6076-82 ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3).

J. Biol. Chem. 277(29):25904-13 Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor.

J. Biol. Chem. 275(10):7416-23 FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions.

J. Biol. Chem. 277(33):29484-9 The role of post-translational modifications of the CXCR4 amino terminus in stromal-derived factor 1 alpha association and HIV-1 entry.

American journal of physiology. Lung cellular and molecular physiology 280(5):L983-90 Regulation of endothelial cell barrier function by calcium/calmodulin-dependent protein kinase II.

J. Biol. Chem. 274(46):32580-7 Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase.

Nature 421(6923):601-7 The DNA sequence and analysis of human chromosome 14.

Genes to cells : devoted to molecular & cellular mechanisms 7(2):91-7 Phosphorylation and reorganization of vimentin by p21-activated kinase (PAK).

Nature neuroscience 1(3):185-91 Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition.

Biochemistry 34(45):14693-702 Isolation and structural characterization of different isoforms of the hypusine-containing protein eIF-5A from HeLa cells.

Proceedings of the National Academy of Sciences of the United States of America 92(26):12090-4 Palmitoylation of the GluR6 kainate receptor.

Molecular cell 9(3):481-91 Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication.

J. Biol. Chem. 274(52):37385-90 Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase.

Biochemistry 35(12):3704-11 Phosphorylation of beta III-tubulin.

Molecular and cellular biology 16(4):1305-15 Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk.

Molecular pharmacology 58(5):1050-6 Identification of G protein-coupled receptor kinase 2 phosphorylation sites responsible for agonist-stimulated delta-opioid receptor phosphorylation.

J. Biol. Chem. 276(23):19770-7 Phosphorylation and regulation of G-protein-activated phospholipase C-beta 3 by cGMP-dependent protein kinases.

Nature 416(6878):345-7 TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2.

European journal of biochemistry 166(3):565-74 Amino-acid sequence of human alpha 2-antiplasmin.

EMBO J. 20(4):792-801 Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis.

Proceedings of the National Academy of Sciences of the United States of America 95(7):4007-12 Mechanism of nicotinic acetylcholine receptor cluster formation by rapsyn.

Protein expression and purification 9(3):363-71 Purification, characterization, and in vitro phosphorylation of the neuron-specific membrane-associated protein SCG10.

Proceedings of the National Science Council, Republic of China. Part B, Life sciences 23(4):175-80 Arginine methylation of a glycine and arginine rich peptide derived from sequences of human FMRP and fibrillarin.

J. Biol. Chem. 279(30):31251-8 BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage.

FEBS letters 318(3):331-4 Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr-15 by human cdc25B phosphatase.

Am. J. Pathol. 163(1):243-51 ASK1 associates with troponin T and induces troponin T phosphorylation and contractile dysfunction in cardiomyocytes.

Nature neuroscience 6(6):564-71 AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists.

J. Biol. Chem. 277(20):17616-22 Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling.

J. Biol. Chem. 279(26):27542-8 Proteolysis of the mismatch repair protein MLH1 by caspase-3 promotes DNA damage-induced apoptosis.

Immunity 9(3):377-83 The structure of HLA-DM, the peptide exchange catalyst that loads antigen onto class II MHC molecules during antigen presentation.

J. Biol. Chem. 275(7):5031-6 Apoptotic cleavage of scaffold attachment factor A (SAF-A) by caspase-3 occurs at a noncanonical cleavage site.

J. Biol. Chem. 272(8):5175-82 Targeting of SCG10 to the area of the Golgi complex is mediated by its NH2-terminal region.

Cell 107(2):149-59 hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences 354(1389):1601-9 Control of NF-kappa B transcriptional activation by signal induced proteolysis of I kappa B alpha.

J. Biol. Chem. 278(22):19579-82 Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX.

J. Biol. Chem. 276(5):3310-8 Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases.

EMBO J. 22(23):6299-309 Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene.

EMBO reports 8(3):265-70 Interferons induce tyrosine phosphorylation of the eIF2alpha kinase PKR through activation of Jak1 and Tyk2.

Current biology : CB 9(8):393-404 PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

J. Biol. Chem. 276(3):1865-72 Regulation of apoptosis by phosphatidylinositol 4,5-bisphosphate inhibition of caspases, and caspase inactivation of phosphatidylinositol phosphate 5-kinases.

Protein science : a publication of the Protein Society 9(1):170-9 Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry.

J. Biol. Chem. 277(38):35168-75 Peptide substrate specificities and protein cleavage sites of human endometase/matrilysin-2/matrix metalloproteinase-26.

The Biochemical journal Dynamic palmitoylation of lymphoma proprotein convertase prolongs its half-life, but is not essential for trans-Golgi network localization.

Molecular and cellular biology 18(12):7499-509 Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control.

Molecular and cellular biology 11(7):3652-9 Mutation of serum response factor phosphorylation sites and the mechanism by which its DNA-binding activity is increased by casein kinase II.

EMBO J. 15(11):2760-70 Selective interaction of JNK protein kinase isoforms with transcription factors.

Brain research. Molecular brain research 47(1-2):59-66 Molecular characterization and pharmacological properties of the human P2X3 purinoceptor.

European journal of biochemistry 253(1):67-75 Activation of the precursor of human stromelysin 2 and its interactions with other matrix metalloproteinases.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 19(1):89-99 Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts.

J. Biol. Chem. 271(5):2769-75 Identification of important regions in the cytoplasmic juxtamembrane domain of type I receptor that separate signaling pathways of transforming growth factor-beta.

European journal of biochemistry 198(1):13-20 Nuclear transition protein 1 from ram elongating spermatids. Mass spectrometric characterization, primary structure and phosphorylation sites of two variants.

J. Biol. Chem. 273(7):3799-802 Regulation of Rad51 function by c-Abl in response to DNA damage.

Molecular and cellular biology 11(5):2511-6 The epidermal growth factor receptor phosphorylates GTPase-activating protein (GAP) at Tyr-460, adjacent to the GAP SH2 domains.

The Biochemical journal 374(Pt 2):423-31 Phosphorylation of BATF regulates DNA binding: a novel mechanism for AP-1 (activator protein-1) regulation.

American journal of human genetics 93(3):411-21 Mapping the human reference genome's missing sequence by three-way admixture in Latino genomes.

J. Biol. Chem. 271(37):22315-20 CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails.

J. Biol. Chem. 276(50):47460-7 The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism.

Carcinogenesis 17(12):2661-71 Structural characterization by mass spectrometry of hemoglobin adducts formed after in vivo exposure to methyl bromide.

Experimental cell research 257(2):245-54 Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization.

The Biochemical journal 353(Pt 3):621-6 Phosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+/calmodulin-independent activity.

J. Biol. Chem. 277(36):33501-8 p38 kinase regulates nitric oxide-induced apoptosis of articular chondrocytes by accumulating p53 via NFkappa B-dependent transcription and stabilization by serine 15 phosphorylation.

Biochemistry 23(16):3701-7 Tissue plasminogen activator: peptide analyses confirm an indirectly derived amino acid sequence, identify the active site serine residue, establish glycosylation sites, and localize variant differences.

J. Biol. Chem. 272(39):24550-5 Identification of serine 643 of protein kinase C-delta as an important autophosphorylation site for its enzymatic activity.

The Journal of cell biology 142(2):485-97 Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons.

Gene 302(1-2):21-9 Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1).

Lymphokine research 9(1):67-79 Closely related glycosylation patterns of recombinant human IL-2 expressed in a CHO cell line and natural IL-2.

Biochem. Biophys. Res. Commun. 262(1):198-205 The DNA-binding and transcriptional activities of MAZ, a myc-associated zinc finger protein, are regulated by casein kinase II.

The Biochemical journal Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase.

The Journal of cell biology 154(6):1111-6 S-Nitrosylation of mitochondrial caspases.

J. Biol. Chem. 279(49):50850-6 Arginine 260 of the amino-terminal domain of NR1 subunit is critical for tissue-type plasminogen activator-mediated enhancement of N-methyl-D-aspartate receptor signaling.

J. Biol. Chem. 278(21):19023-31 Serine phosphorylation negatively regulates RhoA in vivo.

Journal of immunology (Baltimore, Md. : 1950) 166(8):5058-67 Identification of novel functional regions important for the activity of HOXB7 in mammalian cells.

J. Biol. Chem. 268(36):27363-70 Iron-responsive element-binding protein. Phosphorylation by protein kinase C.

Oncogene 24(13):2218-28 Cooperation and selectivity of the two Grb2 binding sites of p52Shc in T-cell antigen receptor signaling to Ras family GTPases and Myc-dependent survival.

Nature 442(7104):814-7 Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology.

J. Biol. Chem. 278(4):2731-9 Oligomerization and trafficking of the human dopamine transporter. Mutational analysis identifies critical domains important for the functional expression of the transporter.

Biochemistry 38(20):6699-705 Regulation of PTP1B via glutathionylation of the active site cysteine 215.

J. Biol. Chem. 277(49):46852-7 Acyl-enzyme complexes between tissue-type plasminogen activator and neuroserpin are short-lived in vitro.

J. Biol. Chem. 278(13):11536-45 Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma.

Biochim. Biophys. Acta 996(1-2):82-8 Degradation of human gastrin and CCK by endopeptidase 24.11: differential behaviour of the sulphated and unsulphated peptides.

J. Biol. Chem. 277(25):22798-805 c-Src-dependent transcriptional activation of TFII-I.

"Science (New York, N.Y.)" 284(5411):147-51 Two distinct cytokines released from a human aminoacyl-tRNA synthetase.

J. Biol. Chem. 275(34):26477-83 Src-mediated tyrosine phosphorylation of NR2 subunits of N-methyl-D-aspartate receptors protects from calpain-mediated truncation of their C-terminal domains.

Proteomics 4(3):587-98 Identification and characterization of phosphorylated proteins in the human pituitary.

Journal of cell science 117(Pt 25):6085-94 PKA phosphorylation of Src mediates Rap1 activation in NGF and cAMP signaling in PC12 cells.

Proceedings of the National Academy of Sciences of the United States of America 100(26):16006-11 Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3.

Nature medicine 5(5):577-81 Enhanced inhibition of hepatitis B virus production by asialoglycoprotein receptor-directed interferon.

Oncogene 12(8):1727-36 A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn.

"Science (New York, N.Y.)" 277(5331):1497-501 Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25.

Journal of molecular biology 337(1):115-28 Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1.

The Biochemical journal Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor.

J. Biol. Chem. 275(49):38633-9 Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways.

FEBS letters 447(2-3):241-6 Biochemical analysis of interleukin-2 receptor beta chain phosphorylation by p56(lck).

J. Biol. Chem. 271(40):24880-4 Regulation of the Lck SH2 domain by tyrosine phosphorylation.

Molecular and cellular biology 17(4):1824-31 Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation.

Proceedings of the National Academy of Sciences of the United States of America 96(11):6193-8 Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6.

Nature 399(6736):601-5 Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation.

European journal of biochemistry 194(2):541-7 Amino acid sequence of in vivo phosphorylation sites in the main intrinsic protein (MIP) of lens membranes.

J. Biol. Chem. 275(39):30451-7 Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules.

Circulation research 87(5):E1-9 A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9.

J. Biol. Chem. 272(46):29083-90 Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates.

FEBS letters 547(1-3):145-50 Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif.

J. Biol. Chem. 271(20):11831-7 Phosphorylation of eIF-4E on serine 209 by protein kinase C is inhibited by the translational repressors, 4E-binding proteins.

Nature 393(6687):809-12 Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization.

Proceedings of the National Academy of Sciences of the United States of America 101(13):4419-24 M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.

Cell 89(5):693-702 A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway.

J. Biol. Chem. 275(14):10379-87 Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4.

J. Biol. Chem. 271(7):3863-8 Phosphorylation of caveolin by src tyrosine kinases. The alpha-isoform of caveolin is selectively phosphorylated by v-Src in vivo.

J. Biol. Chem. 276(48):45456-61 Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathway.

J. Biol. Chem. 276(10):7366-75 Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling.

J. Biol. Chem. 271(17):10183-7 A novel Ca2+-binding protein, p22, is required for constitutive membrane traffic.

Biochem. Biophys. Res. Commun. 229(3):845-51 Casein kinase 2 phosphorylates recombinant human spermidine/spermine N1-acetyltransferase on both serine and threonine residues.

J. Biol. Chem. 274(13):8539-45 Correlations in palmitoylation and multiple phosphorylation of rat bradykinin B2 receptor in Chinese hamster ovary cells.

Molecular and cellular biology 17(9):5648-55 Dual requirement for a newly identified phosphorylation site in p70s6k.

Endocrinology 142(5):1835-40 The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II.

The Biochemical journal The C-terminus of NIPP1 (nuclear inhibitor of protein phosphatase-1) contains a novel binding site for protein phosphatase-1 that is controlled by tyrosine phosphorylation and RNA binding.

J. Biol. Chem. 274(19):13085-90 Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit.

Proceedings of the National Academy of Sciences of the United States of America 100(16):9185-90 Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product.

J. Biol. Chem. 276(46):42714-21 Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids.

Biochemistry 34(50):16456-66 In vitro phosphorylation of the epidermal growth factor receptor autophosphorylation domain by c-src: identification of phosphorylation sites and c-src SH2 domain binding sites.

Proceedings of the National Academy of Sciences of the United States of America 97(19):10389-94 Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.

Bone 31(3):359-65 Calcitonin induces dephosphorylation of Pyk2 and phosphorylation of focal adhesion kinase in osteoclasts.

J. Biol. Chem. 275(13):9314-23 Identification of caspase 3-mediated cleavage and functional alteration of eukaryotic initiation factor 2alpha in apoptosis.

Molecular cell 10(1):151-62 Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.

Human molecular genetics 11(8):961-9 Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder.

Molecular and cellular biology 25(18):8273-84 Rapid estrogen-induced phosphorylation of the SRC-3 coactivator occurs in an extranuclear complex containing estrogen receptor.

Experimental hematology 31(5):398-405 Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway.

J. Biol. Chem. 275(19):14046-55 Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-alpha convertase activity but does not activate pro-MMP2.

J. Biol. Chem. 278(19):17218-27 Signal transduction pathways regulated by prolactin and Src result in different conformations of activated Stat5b.

Oncogene 23(31):5301-15 MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol.

Journal of neurochemistry 76(4):1221-32 Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry.

J. Biol. Chem. 281(3):1692-7 DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM.

J. Biol. Chem. 273(43):28524-32 Differential and cooperative polysialylation of the neural cell adhesion molecule by two polysialyltransferases, PST and STX.

J. Biol. Chem. 269(21):14853-6 Dephosphorylation of osteopontin and bone sialoprotein by osteoclastic tartrate-resistant acid phosphatase. Modulation of osteoclast adhesion in vitro.

J. Biol. Chem. 275(52):40946-51 Phosphorylation of p300 at serine 89 by protein kinase C.

Proceedings of the National Academy of Sciences of the United States of America 87(22):8960-4 Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine.

Cell 42(3):849-57 Protein kinase C phosphorylates pp60src at a novel site.

The Journal of experimental medicine 189(11):1747-56 BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.

Molecular and cellular biology 20(11):4149-58 Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer.

Biochemistry 41(50):14645-51 S-methylated cysteines in human lens gamma S-crystallins.

Cellular and molecular life sciences : CMLS 60(1):198-211 Regulation of caldesmon activity by Cdc2 kinase plays an important role in maintaining membrane cortex integrity during cell division.

Neuroscience 96(1):121-9 The neuronal EF-hand calcium-binding protein visinin-like protein-3 is expressed in cerebellar Purkinje cells and shows a calcium-dependent membrane association.

Molecular systems biology Phosphotyrosine interactome of the ErbB-receptor kinase family.

Nature 443(7108):230-3 Orai1 is an essential pore subunit of the CRAC channel.

J. Biol. Chem. 275(5):3577-82 Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop.

FEBS letters 302(3):223-6 Phosphorylation sequences in h-caldesmon from phorbol ester-stimulated canine aortas.

Journal of molecular biology 282(1):195-208 A model of Cdc25 phosphatase catalytic domain and Cdk-interaction surface based on the presence of a rhodanese homology domain.

Journal of biomedical science 10(6 Pt 1):617-24 Identification and functional analysis of truncated human glutamic acid decarboxylase 65.

J. Biol. Chem. 275(52):41439-46 Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines.

J. Biol. Chem. 267(36):25660-3 Function of the alpha 1 beta 2 gamma 2S gamma-aminobutyric acid type A receptor is modulated by protein kinase C via multiple phosphorylation sites.

J. Biol. Chem. 270(46):27653-60 Characterization of the mitotic specific phosphorylation site of histone H1. Absence of a consensus sequence for the p34cdc2/cyclin B kinase.

J. Biol. Chem. 276(11):8118-24 Identification of internal autoproteolytic cleavage sites within the prosegments of recombinant procathepsin B and procathepsin S. Contribution of a plausible unimolecular autoproteolytic event for the processing of zymogens belonging to the papain family.

Molecular and cellular biology 21(18):6181-8 Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBP.

J. Biol. Chem. 278(28):26265-74 Ca2+-dependent phosphorylation of syntaxin-1A by the death-associated protein (DAP) kinase regulates its interaction with Munc18.

J. Biol. Chem. 279(35):36192-200 Argininosuccinate synthetase is reversibly inactivated by S-nitrosylation in vitro and in vivo.

Biochemistry 44(16):6286-92 Phosphorylation of the human Fhit tumor suppressor on tyrosine 114 in Escherichia coli and unexpected steady state kinetics of the phosphorylated forms.

J. Biol. Chem. 276(13):10025-31 Phosphorylation of tau is regulated by PKN.

EMBO J. 16(12):3563-71 Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.

J. Biol. Chem. 275(29):22574-82 Phosphorylation of human gp130 at Ser-782 adjacent to the Di-leucine internalization motif. Effects on expression and signaling.

Journal of cell science Retargeting of cytosolic proteins to the plasma membrane by the Lck protein tyrosine kinase dual acylation motif.

The Biochemical journal 14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation.

J. Biol. Chem. 277(24):21922-9 Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation.

J. Biol. Chem. 274(34):24392-400 Protein kinase C delta associates with and phosphorylates Stat3 in an interleukin-6-dependent manner.

Proceedings of the National Academy of Sciences of the United States of America 88(12):5222-6 Phosphorylation of protein 4.1 on tyrosine-418 modulates its function in vitro.

Nature 396(6707):180-3 The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338.

FEBS letters 463(3):312-6 Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15.

Biochim. Biophys. Acta 1541(3):231-8 Caspase 7 can cleave tumor necrosis factor receptor-I (p60) at a non-consensus motif, in vitro.

J. Biol. Chem. 277(49):46871-6 Ca2+-stimulated Ca2+ oscillations produced by the Ca2+-sensing receptor require negative feedback by protein kinase C.

J. Biol. Chem. 271(48):30847-57 Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1.

The Journal of physiology 546(Pt 3):879-89 Phosphorylation of the myosin phosphatase targeting subunit and CPI-17 during Ca2+ sensitization in rabbit smooth muscle.

J. Biol. Chem. 278(10):8468-75 Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody.

Blood 101(7):2804-9 Felic (CIP4b), a novel binding partner with the Src kinase Lyn and Cdc42, localizes to the phagocytic cup.

J. Biol. Chem. 273(18):10914-8 Regulation of syndecan-4 phosphorylation in vivo.

Molecular and cellular biology 23(5):1546-57 The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation.

EMBO J. 22(21):5780-92 Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities.

J. Biol. Chem. 269(47):29943-8 Tyrosine 1356 in the carboxyl-terminal tail of the HGF/SF receptor is essential for the transduction of signals for cell motility and morphogenesis.

J. Biol. Chem. 276(46):43305-12 Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.

Proceedings of the National Academy of Sciences of the United States of America 101(16):5898-903 Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress.

J. Biol. Chem. 267(35):25282-8 Unique autolytic cleavage of human myeloperoxidase. Implications for the involvement of active site MET409.

Archives of biochemistry and biophysics 304(1):144-53 N-linked sugar chain structure of recombinant human lymphotoxin produced by CHO cells: the functional role of carbohydrate as to its lectin-like character and clearance velocity.

Molecular and cellular biology 18(4):2282-97 Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2.

Blood 88(11):4159-65 CD10/neutral endopeptidase 24.11 is phosphorylated by casein kinase II and coassociates with other phosphoproteins including the lyn src-related kinase.

EMBO J. 18(15):4280-91 Residues phosphorylated by TFIIH are required for E2F-1 degradation during S-phase.

J. Biol. Chem. 266(30):20380-9 Phosphorylation of the beta subunit of casein kinase II in human A431 cells. Identification of the autophosphorylation site and a site phosphorylated by p34cdc2.

J. Biol. Chem. 268(2):1125-31 Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101.

American journal of physiology. Endocrinology and metabolism 285(4):E854-63 Potential role of leucine metabolism in the leucine-signaling pathway involving mTOR.

Biochem. Biophys. Res. Commun. 191(3):1028-33 In vitro tyrosine phosphorylation of PLC-gamma 1 and PLC-gamma 2 by src-family protein tyrosine kinases.

EMBO reports 5(2):154-60 p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 17(8):1401-7 Induction of transcriptional activity of the cyclic adenosine monophosphate response element binding protein by parathyroid hormone and epidermal growth factor in osteoblastic cells.

Oncogene 12(4):863-73 Differential phosphorylations of Spi-B and Spi-1 transcription factors.

Molecular and cellular biology 18(1):130-40 Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization.

Molecular and cellular biology 18(10):5899-907 Molecular determinants of NF-kappaB-inducing kinase action.

EMBO J. 16(2):332-42 Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factors.

EMBO J. 25(20):4784-94 The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression.

J. Biol. Chem. 259(23):14537-43 The enzyme that cleaves apolipoprotein A-II upon in vitro incubation of human plasma high-density lipoprotein-3 with blood polymorphonuclear cells is an elastase.

J. Biol. Chem. 275(36):28222-9 Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha.

J. Biol. Chem. 269(2):1437-48 Dominant inhibitory mutants of ARF1 block endoplasmic reticulum to Golgi transport and trigger disassembly of the Golgi apparatus.

J. Biol. Chem. 275(37):29042-52 Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks.

J. Biol. Chem. 278(52):52021-31 SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/degradation downstream of the prolactin receptor.

Oncogene 18(30):4287-94 Evidence for an important role of serine 16 and its phosphorylation in the stabilization of c-Mos.

EMBO J. 15(22):6231-40 Phosphorylation of Ser165 in TGF-beta type I receptor modulates TGF-beta1-induced cellular responses.

J. Biol. Chem. 271(35):21108-13 Site-specific phosphorylation of synapsin I by mitogen-activated protein kinase and Cdk5 and its effects on physiological functions.

J. Biol. Chem. 273(44):28733-9 Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity.

J. Biol. Chem. 274(15):10505-10 Regulation of the transcriptional activity of the peroxisome proliferator-activated receptor alpha by phosphorylation of a ligand-independent trans-activating domain.

J. Biol. Chem. 272(46):28823-5 Angiostatin-converting enzyme activities of human matrilysin (MMP-7) and gelatinase B/type IV collagenase (MMP-9).

Biochem. Biophys. Res. Commun. 250(3):635-41 Gustin from human parotid saliva is carbonic anhydrase VI.

J. Biol. Chem. 279(7):5405-12 Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP).

Journal of neurochemistry 61(2):451-6 Purification and chemical characterization of beta-trace protein from human cerebrospinal fluid: its identification as prostaglandin D synthase.

Nature cell biology 4(12):993-7 DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.

Molecular endocrinology (Baltimore, Md.) 10(10):1249-60 Identification of growth hormone receptor (GHR) tyrosine residues required for GHR phosphorylation and JAK2 and STAT5 activation.

American journal of physiology. Cell physiology 285(4):C823-30 Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-beta-induced nuclear accumulation.

Experimental eye research 77(3):383-5 Expression of betaA2-crystallin in human lenses.

Nature neuroscience 4(5):457-8 Beam me up, Scottie! TREK channels swing both ways.

J. Biol. Chem. 275(51):40048-56 Identification and cloning of Kidins220, a novel neuronal substrate of protein kinase D.

J. Biol. Chem. 273(33):21267-75 Protein kinase C phosphorylation of threonine at position 888 in Ca2+o-sensing receptor (CaR) inhibits coupling to Ca2+ store release.

J. Biol. Chem. 276(40):37472-81 Actin cytoskeletal association of cytohesin-1 is regulated by specific phosphorylation of its carboxyl-terminal polybasic domain.

Molecular and cellular biology 16(11):6295-302 Autophosphorylation sites participate in the activation of the double-stranded-RNA-activated protein kinase PKR.

Leukemia 13(9):1374-82 SHC and SHIP phosphorylation and interaction in response to activation of the FLT3 receptor.

Blood 99(7):2418-26 Adducin in platelets: activation-induced phosphorylation by PKC and proteolysis by calpain.

J. Biol. Chem. 278(14):12530-6 Nuclear localization of the cell cycle regulator CDH1 and its regulation by phosphorylation.

EMBO reports 7(7):727-33 c-Abl acetylation by histone acetyltransferases regulates its nuclear-cytoplasmic localization.

Proceedings of the National Academy of Sciences of the United States of America 83(8):2363-7 Amino acid sequence of human plasma alpha 1B-glycoprotein: homology to the immunoglobulin supergene family.

Journal of cell science 118(Pt 23):5661-73 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.

Oncogene 18(4):1033-40 Phosphorylation of the DNA repair protein APE/REF-1 by CKII affects redox regulation of AP-1.

The Biochemical journal Structural elements within the methylation loop (residues 112-117) and EF hands III and IV of calmodulin are required for Lys(115) trimethylation.

J. Biol. Chem. 268(22):16679-87 Glycosylation of mammalian neurofilaments. Localization of multiple O-linked N-acetylglucosamine moieties on neurofilament polypeptides L and M.

Journal of immunology (Baltimore, Md. : 1950) 160(12):5922-8 HLA-G isoforms produced by placental cytotrophoblasts and found in amniotic fluid are due to unusual glycosylation.

EMBO J. 22(4):893-904 STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPbeta.

Journal of neurochemistry 68(5):2220-3 Phosphorylation and activation of brain tryptophan hydroxylase: identification of serine-58 as a substrate site for protein kinase A.

Life sciences 64(6-7):471-7 Muscarinic cholinergic signaling in cardiac myocytes: dynamic targeting of M2AChR to sarcolemmal caveolae and eNOS activation.

J. Biol. Chem. 270(29):17616-21 Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation.

Biol. Reprod. 66(2):407-14 Proteolytic processing of human zona pellucida proteins.

J. Biol. Chem. 269(29):19074-80 Identification of nuclear beta II protein kinase C as a mitotic lamin kinase.

The Journal of experimental medicine 192(8):1165-74 FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation.

J. Biol. Chem. 274(13):8875-85 Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus.

J. Biol. Chem. 276(37):34458-64 Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme.

Circulation 111(15):1946-53 Phosphorylation of GATA2 by Akt increases adipose tissue differentiation and reduces adipose tissue-related inflammation: a novel pathway linking obesity to atherosclerosis.

J. Biol. Chem. 271(21):12632-8 Phosphorylation of human fascin inhibits its actin binding and bundling activities.

European journal of biochemistry 175(2):347-54 Analysis of sites phosphorylated on acetyl-CoA carboxylase in response to insulin in isolated adipocytes. Comparison with sites phosphorylated by casein kinase-2 and the calmodulin-dependent multiprotein kinase.

Canadian journal of physiology and pharmacology 75(6):757-61 Characterization of kininogenase activity of an acidic proteinase isolated from human kidney.

J. Biol. Chem. 272(32):20291-8 Phosphorylation and calmodulin binding of the metabotropic glutamate receptor subtype 5 (mGluR5) are antagonistic in vitro.

J. Biol. Chem. 273(8):4449-58 Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells.

Oncogene 17(9):1097-108 The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R.

Molecular and cellular biology 25(20):8834-43 Abl kinases regulate actin comet tail elongation via an N-WASP-dependent pathway.

The Biochemical journal Protein kinase C and cyclic AMP-dependent protein kinase phosphorylate phospholemman, an insulin and adrenaline-regulated membrane phosphoprotein, at specific sites in the carboxy terminal domain.

J. Biol. Chem. 278(15):12813-9 Specific nitration at tyrosine 430 revealed by high resolution mass spectrometry as basis for redox regulation of bovine prostacyclin synthase.

Molecular and cellular biology 23(21):7875-86 Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling.

J. Biol. Chem. 261(28):13333-41 Sequence analysis of phospholamban. Identification of phosphorylation sites and two major structural domains.

J. Biol. Chem. 275(36):27933-9 Torsin A and its torsion dystonia-associated mutant forms are lumenal glycoproteins that exhibit distinct subcellular localizations.

J. Biol. Chem. 277(13):10767-74 The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase.

J. Biol. Chem. 272(9):5647-58 Sequence-specific DNA binding and transcription factor phosphorylation by Ku Autoantigen/DNA-dependent protein kinase. Phosphorylation of Ser-527 of the rat glucocorticoid receptor.

Molecular cell 7(2):401-9 NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100.

The Biochemical journal 370(Pt 2):567-78 Effect of mutation of two critical glutamic acid residues on the activity and stability of human carboxypeptidase M and characterization of its signal for glycosylphosphatidylinositol anchoring.

Molecular and cellular biology 16(10):5674-82 Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2.

J. Biol. Chem. 275(5):3603-9 Regulation of protein kinase Ctheta function during T cell activation by Lck-mediated tyrosine phosphorylation.

J. Biol. Chem. 275(31):23973-80 Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse.

Cell cycle (Georgetown, Tex.) 1(6):424-9 Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2.

Oncogene 21(46):6992-7000 Tyr-863 phosphorylation enhances focal adhesion kinase autophosphorylation at Tyr-397.

Nature neuroscience 7(11):1204-12 Focal adhesion kinase in netrin-1 signaling.

J. Biol. Chem. 273(41):26675-82 Identification of three major sentrinization sites in PML.

J. Biol. Chem. 278(35):33029-38 Regulation of A + U-rich element-directed mRNA turnover involving reversible phosphorylation of AUF1.

J. Biol. Chem. 268(5):3494-8 Analysis of Gz alpha by site-directed mutagenesis. Sites and specificity of protein kinase C-dependent phosphorylation.

European journal of biochemistry 246(2):433-9 Sequence specificity of C-terminal Src kinase (CSK)--a comparison with Src-related kinases c-Fgr and Lyn.

Proceedings of the National Academy of Sciences of the United States of America 88(19):8425-9 Endocytosis by the asialoglycoprotein receptor is independent of cytoplasmic serine residues.

J. Biol. Chem. 276(9):6485-98 C-mannosylation and O-fucosylation of the thrombospondin type 1 module.

Journal of biochemistry 133(2):165-71 Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells.

The international journal of biochemistry & cell biology 35(12):1645-57 Inhibition of the catalytic activity of rhodanese by S-nitrosylation using nitric oxide donors.

J. Biol. Chem. 267(26):18991-8 Identification of the autophosphorylation sites in rhodopsin kinase.

Proceedings of the National Academy of Sciences of the United States of America 103(1):63-8 Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase.

Biochemistry 16(16):3507-13 Primary structure of human J chain: alignment of peptides from chemical and enzymatic hydrolyses.

J. Biol. Chem. 274(38):27168-76 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.

J. Biol. Chem. 264(16):9638-42 Phosphorylation modulates the activity of glycine N-methyltransferase, a folate binding protein. In vitro phosphorylation is inhibited by the natural folate ligand.

J. Biol. Chem. 276(11):8087-93 TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis.

Molecular and cellular biology 21(22):7747-60 RasGAP-associated endoribonuclease G3Bp: selective RNA degradation and phosphorylation-dependent localization.

Molecular and cellular biology 22(13):4851-62 Caspase processing and nuclear export of CTP:phosphocholine cytidylyltransferase alpha during farnesol-induced apoptosis.

Molecular and cellular biology 23(19):7030-43 Phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by extracellular signal-regulated kinase mediates the transcriptional activation of AP-1 and cellular transformation induced by platelet-derived growth factor.

FEBS letters 351(1):35-7 Identification and hypotensive activity of proadrenomedullin N-terminal 20 peptide (PAMP).

The Biochemical journal 357(Pt 3):843-50 Ca(2+)/calmodulin-dependent protein kinase mediates the phosphorylation of CD44 required for cell migration on hyaluronan.

EMBO J. 25(6):1207-18 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation.

Immunity 4(5):515-25 Regulation of Btk function by a major autophosphorylation site within the SH3 domain.

Archives of biochemistry and biophysics 356(2):187-96 Caspase-mediated fragmentation of calpain inhibitor protein calpastatin during apoptosis.

Protein and peptide letters 16(10):1244-8 Glycosylation of tetraspanin Tspan-1 at four distinct sites promotes its transition through the endoplasmic reticulum.

Oncogene 17(12):1587-95 Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation.

Radiation research 160(3):309-17 Dephosphorylation of histone gamma-H2AX during repair of DNA double-strand breaks in mammalian cells and its inhibition by calyculin A.

Cell 128(2):295-308 PRAK is essential for ras-induced senescence and tumor suppression.

J. Biol. Chem. 275(26):19831-8 Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells.

J. Biol. Chem. 273(52):34850-6 Characterization of human glycogenin-2, a self-glucosylating initiator of liver glycogen metabolism.

J. Biol. Chem. 274(47):33654-60 The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family.

EMBO J. 22(8):1790-800 PKA phosphorylates the p75 receptor and regulates its localization to lipid rafts.

Biochemistry 42(47):13909-18 Functional diversity of endothelin pathways in human lung fibroblasts may be based on structural diversity of the endothelin receptors.

Hepatology (Baltimore, Md.) 40(2):459-66 Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease.

Molecular cell 1(7):949-57 Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization.

FEBS letters 434(3):431-6 Tyrosine phosphorylation of the Wiskott-Aldrich syndrome protein by Lyn and Btk is regulated by CDC42.

J. Biol. Chem. 281(2):782-91 Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding.

J. Biol. Chem. 272(8):5128-32 Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site.

J. Biol. Chem. 261(4):1624-8 Distribution of gamma-carboxyglutamic acid residues in partially carboxylated human prothrombins.

J. Biol. Chem. 276(37):35150-8 Palmitoylation of caveolin-1 at a single site (Cys-156) controls its coupling to the c-Src tyrosine kinase: targeting of dually acylated molecules (GPI-linked, transmembrane, or cytoplasmic) to caveolae effectively uncouples c-Src and caveolin-1 (TYR-14).

J. Biol. Chem. 276(19):16456-63 Mitotic reorganization of the intermediate filament protein nestin involves phosphorylation by cdc2 kinase.

Molecular cell 7(2):249-62 Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway.

J. Biol. Chem. 273(32):20487-93 Tyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activation.

J. Biol. Chem. 277(4):2973-86 PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASP.

Biochemistry 34(26):8433-40 Partial glycosylation of antithrombin III asparagine-135 is caused by the serine in the third position of its N-glycosylation consensus sequence and is responsible for production of the beta-antithrombin III isoform with enhanced heparin affinity.

Cell 129(5):903-14 Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity.

The Biochemical journal 367(Pt 2):475-81 Evidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulin.

J. Biol. Chem. 275(12):9047-54 The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307).

J. Biol. Chem. 276(1):729-37 Regulation of Cbl molecular interactions by the co-receptor molecule CD43 in human T cells.

J. Biol. Chem. 276(13):9817-24 Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance.

Proceedings of the National Academy of Sciences of the United States of America 100(3):928-33 The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation.

Journal of cellular biochemistry 78(2):241-50 Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4.

EMBO J. 16(11):3133-44 IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase.

J. Biol. Chem. 277(35):31988-93 Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35.

The Journal of experimental medicine 176(2):587-92 Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils.

Pituitary 9(2):109-20 Phosphoproteomic analysis of the human pituitary.

Molecular cell 7(3):551-8 CREB binding protein recruitment to the transcription complex requires growth factor-dependent phosphorylation of its GF box.

Biol. Reprod. 66(3):735-44 SAMP32, a testis-specific, isoantigenic sperm acrosomal membrane-associated protein.

Biochem. Biophys. Res. Commun. 211(3):928-34 Phorbol ester stimulates rapid intracellular phosphorylation of glia maturation factor.

Oncogene 25(6):827-37 Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA.

Biochemistry 41(17):5613-24 Identification of in vivo phosphorylation sites of MLK3 by mass spectrometry and phosphopeptide mapping.

Biochem. Biophys. Res. Commun. 307(3):459-65 Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C.

Blood 99(6):1894-901 Processing of the lipocalin alpha(1)-microglobulin by hemoglobin induces heme-binding and heme-degradation properties.

Molecular and cellular biology 13(10):6260-73 A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity.

J. Biol. Chem. 267(9):6205-12 Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein.

EMBO J. 24(2):294-304 Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK.

European journal of biochemistry 220(2):359-68 Cell-cycle-regulated phosphorylation of oncoprotein 18 on Ser16, Ser25 and Ser38.

Neuroreport 11(16):3479-84 Postsynaptic targeting of MAGUKs mediated by distinct N-terminal domains.

Proceedings of the National Academy of Sciences of the United States of America 89(13):5779-83 Identification of Tyr-185 as the site of tyrosine autophosphorylation of recombinant mitogen-activated protein kinase p42mapk.

Nature 431(7011):931-45 Finishing the euchromatic sequence of the human genome.

Journal of immunology (Baltimore, Md. : 1950) 162(5):2906-11 Mutations of the type A domain of complement factor B that promote high-affinity C3b-binding.

Molecular and cellular biology 22(2):567-77 PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells.

European journal of biochemistry 250(2):354-63 Human amyloid precursor-like protein 1--cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid.

Nature cell biology 1(5):305-11 Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase.

Analytical chemistry 81(1):94-104 Profiling of endogenous serum phosphorylated peptides by titanium (IV) immobilized mesoporous silica particles enrichment and MALDI-TOFMS detection.

Endocrinology 140(11):5102-11 Role of N-linked glycosylation on the function and expression of the human secretin receptor.

Cell 84(6):853-62 Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity.

Proceedings of the National Academy of Sciences of the United States of America 80(3):765-9 Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor.

The Biochemical journal 368(Pt 2):507-16 Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.

Experimental cell research 288(1):110-8 Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk.

J. Biol. Chem. 279(37):38649-57 Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk.

Biochemistry 26(2):338-43 Functional role of proteolytic cleavage at arginine-275 of human tissue plasminogen activator as assessed by site-directed mutagenesis.

The Journal of experimental medicine 179(6):1809-21 Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular "heads" of C1q.

J. Biol. Chem. 274(20):13933-7 The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate.

J. Biol. Chem. 271(8):4273-9 The sequence of human betaB1-crystallin cDNA allows mass spectrometric detection of betaB1 protein missing portions of its N-terminal extension.

EMBO J. 13(18):4361-9 Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription.

J. Biol. Chem. 281(44):33276-82 Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function.

Leukemia 11(4):497-503 Antisense src expression inhibits tyrosine phosphorylation of Shc and its association with Grb2 and Sos which leads to MAP kinase activation in U937 human leukemia cells.

Current biology : CB 10(11):671-4 Cyclic AMP regulates the HERG K(+) channel by dual pathways.

J. Biol. Chem. 273(27):17102-8 Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide.

The Biochemical journal 368(Pt 1):243-51 Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase.

International archives of allergy and immunology 118(2-4):422-5 Novel autocrine and paracrine loops of the stem cell factor/chymase network.

The Biochemical journal 368(Pt 2):495-505 Glycosylation of human proteinase-activated receptor-2 (hPAR2): role in cell surface expression and signalling.

J. Biol. Chem. 264(36):21748-59 Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase II.

Molecular pharmacology 57(4):778-83 Agonist-dependent modulation of G protein-coupled receptor kinase 2 by mitogen-activated protein kinases.

FEBS letters 506(3):196-200 The AP-1 repressor, JDP2, is a bona fide substrate for the c-Jun N-terminal kinase.

J. Biol. Chem. 278(41):39609-14 Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases.

J. Biol. Chem. 272(7):4043-9 Interactions of mast cell tryptase with thrombin receptors and PAR-2.

Protein science : a publication of the Protein Society 11(4):862-74 Mass spectrometric analysis of the kinetics of in vivo rhodopsin phosphorylation.

Proceedings of the National Academy of Sciences of the United States of America 94(25):13850-5 Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity.

Molecular carcinogenesis 43(1):1-12 Involvement of protein kinase PKN1 in G2/M delay caused by arsenite.

Genes & development 16(9):1066-76 Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway.

J. Biol. Chem. 278(17):15056-64 Activation of pro-gelatinase B by endometase/matrilysin-2 promotes invasion of human prostate cancer cells.

J. Biol. Chem. 265(8):4722-9 Phosphorylation sites linked to glial filament disassembly in vitro locate in a non-alpha-helical head domain.

Journal of protein chemistry 16(8):747-53 The unusual amino acid triplet Asn-Ile-Cys is a glycosylation consensus site in human alpha-lactalbumin.

Molecular and cellular biology 23(23):8528-41 Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain.

J. Biol. Chem. 275(27):20374-81 Thrombocidins, microbicidal proteins from human blood platelets, are C-terminal deletion products of CXC chemokines.

FEBS letters 489(2-3):254-8 Identification of the main ubiquitination site in human erythroid alpha-spectrin.

Biochemistry 39(20):6012-21 Effects of the N-linked glycans on the 3D structure of the free alpha-subunit of human chorionic gonadotropin.

Molecular and cellular biology 17(3):1129-43 Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes.

"Science (New York, N.Y.)" 256(5060):1217-21 Heteromeric NMDA receptors: molecular and functional distinction of subtypes.

J. Biol. Chem. 272(43):27116-23 Biosynthesis, distinct post-translational modifications, and functional characterization of lymphoma proprotein convertase.

J. Biol. Chem. 274(38):26705-12 Protein phosphatase 2C inactivates F-actin binding of human platelet moesin.

The Biochemical journal 361(Pt 3):587-95 The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis.

American journal of human genetics 92(4):530-46 Complete haplotype sequence of the human immunoglobulin heavy-chain variable, diversity, and joining genes and characterization of allelic and copy-number variation.

Immunity 6(2):155-64 Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2.

Neuron 22(3):497-509 Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifs.

Proceedings of the National Academy of Sciences of the United States of America 92(7):2597-601 Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells.

Current biology : CB 9(20):1173-6 Regulation of ARNO nucleotide exchange by a PH domain electrostatic switch.

Biochemistry 44(14):5420-9 N-Linked glycosylation of the human ABC transporter ABCG2 on asparagine 596 is not essential for expression, transport activity, or trafficking to the plasma membrane.

FEBS letters 470(2):161-6 Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors.

Genes & development 13(7):804-16 A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras.

J. Biol. Chem. 276(38):35368-74 Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.

J. Biol. Chem. 277(15):13312-20 KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine.

J. Biol. Chem. 277(35):31818-25 The specificity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphatases.

Molecular cell 31(3):371-82 Ubc9 sumoylation regulates SUMO target discrimination.

Blood 80(4):942-52 Role of individual gamma-carboxyglutamic acid residues of activated human protein C in defining its in vitro anticoagulant activity.

Molecular & cellular proteomics : MCP 5(9):1610-27 Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation by epidermal growth factor using Extended Range Proteomic Analysis (ERPA).

J. Biol. Chem. 277(16):14227-37 Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2+ signal transduction.

EMBO J. 22(7):1676-87 Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint.

FEBS letters 412(1):161-4 Multiple tyrosine residues in the intracellular domain of the common beta subunit of the interleukin 5 receptor are involved in activation of STAT5.

Archives of biochemistry and biophysics 420(1):55-67 Functional characterization of Narc 1, a novel proteinase related to proteinase K.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 12(3):447-55 Identification of peptide fragments generated by digestion of bovine and human osteocalcin with the lysosomal proteinases cathepsin B, D, L, H, and S.

EMBO reports 3(1):39-44 Methylation at arginine 17 of histone H3 is linked to gene activation.

J. Biol. Chem. 279(36):37716-25 Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B.

Proteomics 4(2):454-65 Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

J. Biol. Chem. 264(15):9094-101 Glycosylation of human apolipoprotein E. The carbohydrate attachment site is threonine 194.

Proceedings of the National Academy of Sciences of the United States of America 100(4):2029-34 cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1.

Molecular and cellular biology 15(2):835-42 Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS.

J. Biol. Chem. 269(8):6016-25 Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution.

Oncogene 10(8):1647-51 B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222.

Biochem. Biophys. Res. Commun. 333(3):742-9 TSSK5, a novel member of the testis-specific serine/threonine kinase family, phosphorylates CREB at Ser-133, and stimulates the CRE/CREB responsive pathway.

Current biology : CB 5(9):986-9 Cell signalling. Receptor orphans find a family.

Journal of cell science 114(Pt 5):987-98 Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97.

Proceedings of the National Academy of Sciences of the United States of America 94(20):10669-74 Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells.

EMBO J. 21(8):2009-18 Regulation of the ubiquitin-conjugating enzyme hHR6A by CDK-mediated phosphorylation.

Genes to cells : devoted to molecular & cellular mechanisms 7(8):835-50 MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation.

J. Biol. Chem. 277(51):49417-21 Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding.

Proceedings of the National Academy of Sciences of the United States of America 90(10):4616-20 Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast.

J. Biol. Chem. 277(28):25583-91 Intracellular activation of human adamalysin 19/disintegrin and metalloproteinase 19 by furin occurs via one of the two consecutive recognition sites.

J. Biol. Chem. 278(32):30028-36 Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA).

Biochem. Biophys. Res. Commun. 214(3):888-94 Development of a rapid approach to identification of tyrosine phosphorylation sites: application to PKC delta phosphorylated upon activation of the high affinity receptor for IgE in rat basophilic leukemia cells.

J. Biol. Chem. 274(20):14229-37 Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck.

J. Biol. Chem. 272(48):30491-7 Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta.

Molecular cell 21(6):749-60 Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1.

Proceedings of the National Academy of Sciences of the United States of America 82(14):4673-7 The nucleotide sequence of the gene for human protein C.

J. Biol. Chem. 270(1):66-72 Hepsin, a putative membrane-associated serine protease, activates human factor VII and initiates a pathway of blood coagulation on the cell surface leading to thrombin formation.

Oncogene 19(43):4961-9 The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function.

Biochemistry 42(5):1301-8 Basal and hydrogen peroxide stimulated sites of phosphorylation in heterogeneous nuclear ribonucleoprotein C1/C2.

Molecular and cellular biology 22(7):2099-110 Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway.

J. Biol. Chem. 266(30):20198-204 Thyroglobulin processing by thyroidal proteases. Major sites of cleavage by cathepsins B, D, and L.

Experimental cell research 230(1):84-93 Inhibition of protein dephosphorylation results in the accumulation of splicing snRNPs and coiled bodies within the nucleolus.

The Journal of cell biology 154(4):815-27 v-Src phosphorylation of connexin 43 on Tyr247 and Tyr265 disrupts gap junctional communication.

Molecular biology of the cell 13(8):2881-93 The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells.

Nature biotechnology 21(6):660-6 Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

J. Biol. Chem. 282(2):888-96 Phosphorylation of a threonine unique to the short C-terminal isoform of betaII-spectrin links regulation of alpha-beta spectrin interaction to neuritogenesis.

Proceedings of the National Academy of Sciences of the United States of America 99(8):5567-72 IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase.

Nature 361(6413):637-41 Phosphorylation and modulation of recombinant GluR6 glutamate receptors by cAMP-dependent protein kinase.

Endocrinology 139(10):4182-8 A protease-resistant form of insulin-like growth factor (IGF) binding protein 4 inhibits IGF-1 actions.

J. Biol. Chem. 274(11):7207-15 Disulfide bond structure and N-glycosylation sites of the extracellular domain of the human interleukin-6 receptor.

Molecular and cellular biology 23(13):4598-610 Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707.

Cancer research 60(1):56-9 A novel form of prostate-specific antigen transcript produced by alternative splicing.

Journal of immunology (Baltimore, Md. : 1950) 163(3):1321-6 CD45 negatively regulates lyn activity by dephosphorylating both positive and negative regulatory tyrosine residues in immature B cells.

J. Biol. Chem. 272(36):22377-80 Phosphorylation of the PEST domain of IkappaBbeta regulates the function of NF-kappaB/IkappaBbeta complexes.

Current biology : CB 8(2):69-81 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro.

Biochemistry 35(20):6267-75 Identification of insulin-stimulated phosphorylation sites on calmodulin.

Receptor 5(1):71-80 Glycosylation sites encoded by exon 2 of the human insulin receptor gene are not required for the oligomerization, ligand binding, or kinase activity of the insulin receptor.

Biochemistry 39(11):3023-33 Detailed analysis of the phosphorylation of the human La (SS-B) autoantigen. (De)phosphorylation does not affect its subcellular distribution.

J. Biol. Chem. 274(45):31981-6 The role of DOC-2/DAB2 protein phosphorylation in the inhibition of AP-1 activity. An underlying mechanism of its tumor-suppressive function in prostate cancer.

J. Biol. Chem. 269(35):22162-8 Critical phosphorylation sites for acetyl-CoA carboxylase activity.

EMBO J. 20(16):4360-9 A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta.

Molecular and cellular biology 22(6):1693-703 Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells.

FEBS letters 461(3):323-8 Kinetic mechanism and ATP-binding site reactivity of p38gamma MAP kinase.

Biochem. Biophys. Res. Commun. 310(2):612-8 Proteolytic processing of IGFBP-related protein-1 (TAF/angiomodulin/mac25) modulates its biological activity.

Proceedings of the National Academy of Sciences of the United States of America 101(29):10578-83 Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13.

Biology of the cell 96(7):509-17 Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit.

EMBO J. 20(21):5919-28 Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak.

Molecular and cellular biology 20(5):1886-96 Posttranslational modification of Bcl-2 facilitates its proteasome-dependent degradation: molecular characterization of the involved signaling pathway.

J. Biol. Chem. 277(28):24967-75 Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor.

Molecular and cellular biology 19(11):7539-48 JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway.

Blood 97(1):130-8 Posttranslational modifications of recombinant myotube-synthesized human factor IX.

EMBO J. 22(11):2788-97 MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14.

EMBO J. 21(21):5911-20 Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability.

Blood 102(1):254-61 Ser727/Tyr701-phosphorylated Stat1 is required for the regulation of c-Myc, cyclins, and p27Kip1 associated with ATRA-induced G0/G1 arrest of U-937 cells.

J. Biol. Chem. 274(6):3531-40 Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity.

The Journal of endocrinology 160(3):379-87 Characterisation of recombinant glycosylation variants of insulin-like growth factor binding protein-3.

European journal of biochemistry 262(3):781-9 Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors.

Gut 46(4):454-9 The human two domain trefoil protein, TFF2, is glycosylated in vivo in the stomach.

J. Biol. Chem. 278(47):46533-40 Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells.

Oncogene 18(44):6029-36 The physical association and phosphorylation of Cdc25C protein phosphatase by Prk.

Blood 93(6):2003-12 Involvement of wiskott-aldrich syndrome protein in B-cell cytoplasmic tyrosine kinase pathway.

The Journal of cell biology 155(7):1147-57 CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis.

Biochemistry 41(2):603-8 The Protein-tyrosine-phosphatase SHP2 is phosphorylated on serine residues 576 and 591 by protein kinase C isoforms alpha, beta 1, beta 2, and eta.

Oncogene 18(51):7370-7 Caspase-mediated cleavage and functional changes of hematopoietic progenitor kinase 1 (HPK1).

Prostate 57(2):140-51 Effect of carbohydrate moieties on the folate hydrolysis activity of the prostate specific membrane antigen.

Journal of immunology (Baltimore, Md. : 1950) 164(6):3123-31 Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines.

J. Biol. Chem. 276(29):27709-15 Sequential activation of Rac-1, SEK-1/MKK-4, and protein kinase Cdelta is required for interleukin-6-induced STAT3 Ser-727 phosphorylation and transactivation.

Journal of neurochemistry 73(1):12-20 Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain.

Journal of immunology (Baltimore, Md. : 1950) 169(1):286-91 Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation.

J. Biol. Chem. 278(39):37223-30 Oxidative damage to mitochondrial complex I due to peroxynitrite: identification of reactive tyrosines by mass spectrometry.

FEBS letters 416(1):45-50 Disturbed progastrin processing in carboxypeptidase E-deficient fat mice.

J. Biol. Chem. 272(8):5183-6 Protein kinase A (PKA)- and protein kinase C-phosphorylated glia maturation factor promotes the catalytic activity of PKA.

FEBS letters 313(3):307-13 Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins.

FEBS letters 407(3):257-60 Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association.

Molecular cell 8(5):971-82 Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1.

Nature 372(6508):786-91 Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase.

"Science (New York, N.Y.)" 292(5516):464-8 HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.

J. Biol. Chem. 278(4):2654-60 The cytokine-inducible Scr homology domain-containing protein negatively regulates signaling by promoting apoptosis in erythroid progenitor cells.

International journal of oncology 19(5):977-82 Molecular cloning and characterization of human WNT3.

Canadian journal of biochemistry 55(7):755-60 Human pituitary thyrotropin. The primary structure of the alpha and beta subunits.

J. Biol. Chem. 255(7):3120-7 Sites of nonenzymatic glycosylation of human hemoglobin A.

J. Biol. Chem. 274(26):18173-80 CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells.

J. Biol. Chem. 276(40):37459-71 Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity.

Oncogene 19(12):1509-18 Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis.

J. Biol. Chem. 276(40):37520-8 Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1.

J. Biol. Chem. 276(42):38940-8 In vivo tyrosine phosphorylation sites of activated ephrin-B1 and ephB2 from neural tissue.

Journal of immunology (Baltimore, Md. : 1950) 162(4):1879-83 Cutting edge: the CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes.

Oncogene 19(42):4906-16 The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation.

Cancer biology & therapy 1(3):277-83 p53 Antiproliferative function is enhanced by aspartate substitution at threonine 18 and serine 20.

Journal of cell science 119(Pt 14):2847-50 Identification of phosphorylation sites in GIT1.

Proceedings of the National Academy of Sciences of the United States of America 93(9):4170-4 The phosphatase activity of carbonic anhydrase III is reversibly regulated by glutathiolation.

J. Biol. Chem. 272(34):21067-74 Activation of type IV procollagenases by human tumor-associated trypsin-2.

The Biochemical journal 356(Pt 2):461-71 Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells.

Proceedings of the National Academy of Sciences of the United States of America 100(11):6529-34 Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate.

Biochem. Biophys. Res. Commun. 303(2):700-6 Transcriptional activity and DNA binding of heat shock factor-1 involve phosphorylation on threonine 142 by CK2.

J. Biol. Chem. 277(17):14838-43 Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase.

Journal of pharmaceutical sciences 72(4):432-5 Kinetics of the rapid modification of human serum albumin with trinitrobenzenesulfonate and localization of its site.

Genes & development 11(11):1464-78 Cyclin E-CDK2 is a regulator of p27Kip1.

European journal of cell biology 86(2):111-23 Modulation of beta-catenin by cyclin-dependent kinase 6 in Wnt-stimulated cells.

The Journal of cell biology 157(1):149-60 Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling.

Cell 128(2):281-94 p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2.

Proceedings of the National Academy of Sciences of the United States of America 102(14):5056-61 Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage.

Human molecular genetics 9(1):125-32 Ser298 of MITF, a mutation site in Waardenburg syndrome type 2, is a phosphorylation site with functional significance.

Nature 398(6728):630-4 Direct control of the Forkhead transcription factor AFX by protein kinase B.

Nature 364(6432):70-3 Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain.

J. Biol. Chem. 276(18):15369-77 Unique disulfide bond structures found in ST8Sia IV polysialyltransferase are required for its activity.

The international journal of biochemistry & cell biology 31(11):1327-37 In vitro processing of amyloid precursor protein by cathepsin D.

Seminars in cell & developmental biology 11(4):235-42 Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic beta-cell.

J. Biol. Chem. 270(13):7420-6 Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine.

J. Biol. Chem. 278(2):1186-94 Phosphorylation of spinophilin modulates its interaction with actin filaments.

J. Biol. Chem. 259(21):13504-10 HLA-A2 antigen phosphorylation in vitro by cyclic AMP-dependent protein kinase. Sites of phosphorylation and segmentation in class i major histocompatibility complex gene structure.

BMC Immunol. Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk.

Proceedings of the National Academy of Sciences of the United States of America 97(10):5450-5 Molecular basis for a link between complement and the vascular complications of diabetes.

J. Biol. Chem. 279(22):22857-65 Regulation of Smad4 sumoylation and transforming growth factor-beta signaling by protein inhibitor of activated STAT1.

Journal of neurochemistry 92(1):93-102 Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin.

Cell cycle (Georgetown, Tex.) 5(5):519-21 CDK9 phosphorylates p53 on serine residues 33, 315 and 392.

J. Biol. Chem. 281(38):28387-96 STOP-like protein 21 is a novel member of the STOP family, revealing a Golgi localization of STOP proteins.

Journal of neurochemistry 70(2):540-9 Peripherin is tyrosine-phosphorylated at its carboxyl-terminal tyrosine.

Current biology : CB 15(9):815-23 RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration.

J. Biol. Chem. 277(22):20104-12 Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site.

J. Biol. Chem. 278(35):32683-91 Reversal of the deoxyhypusine synthesis reaction. Generation of spermidine or homospermidine from deoxyhypusine by deoxyhypusine synthase.

Journal of neurochemistry 74(4):1587-95 Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta.

American journal of human genetics 90(4):599-613 Resolving the breakpoints of the 17q21.31 microdeletion syndrome with next-generation sequencing.

The Biochemical journal 358(Pt 1):137-45 Polyamine analogues inhibit the ubiquitination of spermidine/spermine N1-acetyltransferase and prevent its targeting to the proteasome for degradation.

The Journal of experimental medicine 189(8):1181-94 SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation.

J. Biol. Chem. 276(10):7609-13 Protein kinase C activation modulates alpha-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor complex.

Genome biology 10(6):R60 Closing gaps in the human genome using sequencing by synthesis.

EMBO J. 19(24):6792-803 P/CAF-mediated acetylation regulates the function of the basic helix-loop-helix transcription factor TAL1/SCL.

European journal of biochemistry 267(16):4998-5004 Processing of synthetic pro-islet amyloid polypeptide (proIAPP) 'amylin' by recombinant prohormone convertase enzymes, PC2 and PC3, in vitro.

Oncogene 14(21):2553-61 Recognition of activated CSF-1 receptor in breast carcinomas by a tyrosine 723 phosphospecific antibody.

J. Biol. Chem. 269(2):1075-82 Enzymatic methylation of recombinant heterogeneous nuclear RNP protein A1. Dual substrate specificity for S-adenosylmethionine:histone-arginine N-methyltransferase.

J. Biol. Chem. 272(38):23896-904 Sites of UV-induced phosphorylation of the p34 subunit of replication protein A from HeLa cells.

Biochemistry 38(41):13584-91 Partial glycosylation of Asn2181 in human factor V as a cause of molecular and functional heterogeneity. Modulation of glycosylation efficiency by mutagenesis of the consensus sequence for N-linked glycosylation.

Thrombosis and haemostasis 89(1):122-31 Plasma membrane Ca2+-ATPase isoform 4b is phosphorylated on tyrosine 1176 in activated human platelets.

Molecular & cellular proteomics : MCP 1(7):517-27 A mass spectrometry-based proteomic approach for identification of serine/threonine-phosphorylated proteins by enrichment with phospho-specific antibodies: identification of a novel protein, Frigg, as a protein kinase A substrate.

Molecular and cellular biology 18(4):1978-84 pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167.

Journal of immunology (Baltimore, Md. : 1950) 163(11):5753-7 Cutting edge: SLP-76 cooperativity with FYB/FYN-T in the Up-regulation of TCR-driven IL-2 transcription requires SLP-76 binding to FYB at Tyr595 and Tyr651.

J. Biol. Chem. 266(8):5147-52 Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (Pro-uPA).

Journal of cell science 115(Pt 17):3479-90 Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells.

The Journal of cell biology 161(6):1067-79 The localization and phosphorylation of p47 are important for Golgi disassembly-assembly during the cell cycle.

Nature 437(7058):551-5 DNA sequence and analysis of human chromosome 18.

EMBO J. 25(23):5614-25 MDMX regulation of p53 response to ribosomal stress.

Oncogene 22(28):4398-405 Lats2, a putative tumor suppressor, inhibits G1/S transition.

Molecular cell 2(6):877-85 PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis.

J. Biol. Chem. 279(21):22131-7 Proteasomal degradation of N-acetyltransferase 1 is prevented by acetylation of the active site cysteine: a mechanism for the slow acetylator phenotype and substrate-dependent down-regulation.

FEBS letters 531(2):132-6 Identification and functional analysis of novel phosphorylation sites in Cx43 in rat primary granulosa cells.

Neuron 37(1):7-10 Pathways to Parkinsonism.

J. Biol. Chem. 272(22):14470-6 SHP1 and SHP2 protein-tyrosine phosphatases associate with betac after interleukin-3-induced receptor tyrosine phosphorylation. Identification of potential binding sites and substrates.

J. Biol. Chem. 276(44):40411-6 Phosphorylation of Ser(19) alters the conformation of tyrosine hydroxylase to increase the rate of phosphorylation of Ser(40).

J. Biol. Chem. 278(13):11032-40 Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex.

Oncogene 13(7):1379-85 Proline-rich sequences mediate the interaction of the Arg protein tyrosine kinase with Crk.

J. Biol. Chem. 270(14):7864-8 CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB.

Biochem. Biophys. Res. Commun. 257(1):100-5 Identification of NEDD8-conjugation site in human cullin-2.

Molecular and cellular biology 21(10):3534-46 Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.

Molecular and cellular biology 17(10):5771-83 Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation.

"Science (New York, N.Y.)" 281(5376):572-5 Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation.

FEBS letters 579(3):615-20 Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells.

Molecular and cellular biology 21(14):4441-52 Phosphorylation of MafA is essential for its transcriptional and biological properties.

J. Biol. Chem. 282(10):7522-31 Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1.

"Science (New York, N.Y.)" 316(5828):1160-6 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

Nature 440(7082):346-51 The finished DNA sequence of human chromosome 12.

Biochem. Biophys. Res. Commun. 244(3):756-62 Mutations which abolish phosphorylation of the TRAF-binding domain of TNF receptor 2 enhance receptor-mediated NF-kappa B activation.

J. Biol. Chem. 277(35):31567-76 Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization.

Molecular and cellular biology 23(8):2953-68 Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1.

J. Biol. Chem. 269(23):16311-7 The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo.

Archives of biochemistry and biophysics 399(1):1-5 Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1.

J. Biol. Chem. 276(21):17672-8 Proteolytic activation of ETK/Bmx tyrosine kinase by caspases.

Biochemistry 36(26):8100-6 Serine-578 is a major phosphorylation locus in human plasma plasminogen.

Naunyn-Schmiedeberg's archives of pharmacology 369(1):23-37 Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry.

J. Biol. Chem. 274(45):32198-203 The interferon-induced double-stranded RNA-activated protein kinase PKR will phosphorylate serine, threonine, or tyrosine at residue 51 in eukaryotic initiation factor 2alpha.

American journal of physiology. Cell physiology 285(5):C1188-96 Mutagenesis of the N-glycosylation site of hNaSi-1 reduces transport activity.

Cell 92(4):573-85 Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

Biochim. Biophys. Acta 1492(2-3):369-76 Functional cloning and mutational analysis of the human cDNA for phosphoacetylglucosamine mutase: identification of the amino acid residues essential for the catalysis.

Journal of biochemistry 114(4):473-7 Determination of carboxyl-terminal residue and disulfide bonds of MACIF (CD59), a glycosyl-phosphatidylinositol-anchored membrane protein.

Biochemistry 41(30):9462-9 The tumor necrosis factor-alpha converting enzyme (TACE): a unique metalloproteinase with highly defined substrate selectivity.

Electrophoresis 19(10):1803-7 Rab11a is modified in vivo by isoprenoid geranylgeranyl.

Molecular and cellular biology 14(4):2713-21 Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase.

EMBO J. 25(19):4423-35 A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking.

J. Biol. Chem. 274(43):30896-905 Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.

BMC cell biology Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity.

Biochim. Biophys. Acta 1066(1):70-6 Three regions of erythrocyte band 3 protein are phosphorylated on tyrosines: characterization of the phosphorylation sites by solid phase sequencing combined with capillary electrophoresis.

J. Biol. Chem. 273(38):24805-13 Phosphorylation of vitronectin by casein kinase II. Identification of the sites and their promotion of cell adhesion and spreading.

"Science (New York, N.Y.)" 227(4685):427-9 Amino terminal myristylation of the protein kinase p60src, a retroviral transforming protein.

J. Biol. Chem. 271(29):17519-25 Autophosphorylation of the Fes tyrosine kinase. Evidence for an intermolecular mechanism involving two kinase domain tyrosine residues.

Analytical chemistry 75(22):6043-9 A proteomic approach for quantitation of phosphorylation using stable isotope labeling in cell culture.

J. Biol. Chem. 277(47):45162-71 The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex.

J. Biol. Chem. 278(48):47713-23 Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with Hck.

Molecular and cellular biology 17(5):2497-501 Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop.

EMBO J. 21(20):5457-66 Control of CBP co-activating activity by arginine methylation.

J. Biol. Chem. 271(42):26276-80 Dephosphorylation of serine 3 regulates nuclear translocation of cofilin.

Genes & development 18(5):512-27 Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells.

J. Biol. Chem. 276(12):8631-4 BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase.

Oncogene 23(9):1645-55 Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation.

J. Biol. Chem. 271(44):27879-87 Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase.

Journal of immunology (Baltimore, Md. : 1950) 160(7):3305-14 Asymmetrical phosphorylation and function of immunoreceptor tyrosine-based activation motif tyrosines in B cell antigen receptor signal transduction.

Proteomics 2(11):1586-600 The spectrum of endogenous human chromogranin A-derived peptides identified using a modified proteomic strategy.

J. Biol. Chem. 274(7):3988-93 Truncation of macrophage-derived chemokine by CD26/ dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction.

Nature methods 9(11):1107-12 DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution.

Nature 411(6840):969-74 ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses.

Molecular and cellular biology 21(16):5591-604 SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis.

J. Biol. Chem. 272(40):24961-5 Agonist-induced desensitization of the mu opioid receptor is determined by threonine 394 preceded by acidic amino acids in the COOH-terminal tail.

European journal of biochemistry 218(1):153-63 Identification of O-linked oligosaccharide chains in the activation peptides of blood coagulation factor X. The role of the carbohydrate moieties in the activation of factor X.

J. Biol. Chem. 276(27):24946-58 Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop.

J. Biol. Chem. 280(45):37610-5 A protein kinase C/Ras/ERK signaling pathway activates myeloid fibronectin receptors by altering beta1 integrin sialylation.

J. Biol. Chem. 279(11):10765-75 Mutual regulation of protein-tyrosine phosphatase 20 and protein-tyrosine kinase Tec activities by tyrosine phosphorylation and dephosphorylation.

Proceedings of the National Academy of Sciences of the United States of America 96(20):11156-60 Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation.

J. Virol. 76(12):6382-6 Fatty acid modification of the coxsackievirus and adenovirus receptor.

J. Biol. Chem. 278(42):40717-22 Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1.

EMBO J. 20(21):6095-103 A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300.

Molecular and cellular biology 21(5):1854-65 HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression.

Cancer science 96(2):134-41 Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage.

Journal of immunology (Baltimore, Md. : 1950) 147(9):2964-9 IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha.

J. Biol. Chem. 276(17):14400-6 Inhibition of insulin-induced activation of Akt by a kinase-deficient mutant of the epsilon isozyme of protein kinase C.

Biochemistry 35(20):6450-9 Amino acid sequence and carbohydrate structure of a recombinant human tissue factor pathway inhibitor expressed in Chinese hamster ovary cells: one N-and two O-linked carbohydrate chains are located between Kunitz domains 2 and 3 and one N-linked carbohydrate chain is in Kunitz domain 2.

Genome biology 8(6):R114 Detailed analysis of 15q11-q14 sequence corrects errors and gaps in the public access sequence to fully reveal large segmental duplications at breakpoints for Prader-Willi, Angelman, and inv dup(15) syndromes.

EMBO J. 20(13):3484-94 Rsk2 allosterically activates estrogen receptor alpha by docking to the hormone-binding domain.

Nature genetics 42(9):745-50 A large and complex structural polymorphism at 16p12.1 underlies microdeletion disease risk.

Journal of neurochemistry 73(1):418-28 Glycosylation sites flank phosphorylation sites on synapsin I: O-linked N-acetylglucosamine residues are localized within domains mediating synapsin I interactions.

Molecular biology of the cell 14(9):3664-74 Spy1 interacts with p27Kip1 to allow G1/S progression.

Biochemistry 32(30):7818-23 Specific glycosylation site mutations of the insulin receptor alpha subunit impair intracellular transport.

Biochem. Biophys. Res. Commun. 252(1):14-9 Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4.

J. Biol. Chem. 276(13):10556-63 The angiotensin II-dependent nuclear translocation of Stat1 is mediated by the Jak2 protein motif 231YRFRR.

J. Biol. Chem. 276(18):15192-9 Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79.

J. Biol. Chem. 268(28):20801-7 Cloning and characterization of the gene encoding the human platelet glycoprotein V. A member of the leucine-rich glycoprotein family cleaved during thrombin-induced platelet activation.

Archives of biochemistry and biophysics 357(2):299-309 Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules.

J. Biol. Chem. 278(27):24644-50 Identification of MCM4 as a target of the DNA replication block checkpoint system.

Journal of immunology (Baltimore, Md. : 1950) 160(8):4034-41 Posttranslational modifications affect the activity of the human monocyte chemotactic proteins MCP-1 and MCP-2: identification of MCP-2(6-76) as a natural chemokine inhibitor.

Biochemistry 38(6):1829-37 Factor VIIa/tissue factor generates a form of factor V with unchanged specific activity, resistance to activation by thrombin, and increased sensitivity to activated protein C.

Molecular and cellular biology 26(1):63-76 Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation.

J. Biol. Chem. 275(12):8324-30 The roles of carbohydrate chains of the beta-subunit on the functional expression of gastric H(+),K(+)-ATPase.

Molecular biology of the cell 14(1):274-87 Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1.

Clinical and experimental hypertension. Part A, Theory and practice 10(6):1147-55 Characterization of N-linked oligosaccharides attached to human renin expressed in COS cells.

J. Biol. Chem. 274(46):32786-94 The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues.

J. Biol. Chem. 277(17):14793-800 Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2).

J. Biol. Chem. 272(3):1777-85 The regulatory Ser262 of microtubule-associated protein tau is phosphorylated by phosphorylase kinase.

Molecular & cellular proteomics : MCP 6(6):1103-9 Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications.

J. Biol. Chem. 276(11):8244-53 Determination of the disulfide structure and N-glycosylation sites of the extracellular domain of the human signal transducer gp130.

The Journal of cell biology 161(5):911-21 BMPs signal alternately through a SMAD or FRAP-STAT pathway to regulate fate choice in CNS stem cells.

FEBS letters 304(2-3):170-8 Heterogeneous expression of four MAP kinase isoforms in human tissues.

J. Biol. Chem. 269(22):15885-91 Regulation of c-Fgr protein kinase by c-Src kinase (CSK) and by polycationic effectors.

Archives of biochemistry and biophysics 304(2):352-8 Isolation and biochemical characterization of procathepsin E from human erythrocyte membranes.

J. Biol. Chem. 275(2):1247-60 Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin.

Oncogene 21(25):3978-87 CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation.

J. Biol. Chem. 277(30):27217-26 Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members.

Biochim. Biophys. Acta 1264(3):303-11 Expression of recombinant elongation factor 1 beta from rabbit in Escherichia coli. Phosphorylation by casein kinase II.

J. Biol. Chem. 266(30):19945-52 Phosphorylation by cdc2 kinase modulates DNA binding activity of high mobility group I nonhistone chromatin protein.

Oncogene 15(7):817-26 Ligand-independent activation of fibroblast growth factor receptor-2 by carboxyl terminal alterations.

Molecular and cellular biology 17(11):6472-80 O glycosylation of an Sp1-derived peptide blocks known Sp1 protein interactions.

J. Biol. Chem. 278(40):38980-90 Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo.

J. Biol. Chem. 265(16):8975-8 Phosphorylation of smooth myosin light chain kinase by smooth muscle Ca2+/calmodulin-dependent multifunctional protein kinase.

Proceedings of the National Academy of Sciences of the United States of America 87(2):728-32 G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells.

Nature 367(6460):243-9 The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1.

Biochemistry 39(36):11084-91 N-terminal sequences direct the autophosphorylation states of the FER tyrosine kinases in vivo.

Biochemistry 39(5):1169-79 Phosphorylation of recombinant human ATP:citrate lyase by cAMP-dependent protein kinase abolishes homotropic allosteric regulation of the enzyme by citrate and increases the enzyme activity. Allosteric activation of ATP:citrate lyase by phosphorylated sugars.

Proceedings of the National Academy of Sciences of the United States of America 100(5):2328-33 The C-terminal domain phosphatase and transcription elongation activities of FCP1 are regulated by phosphorylation.

J. Biol. Chem. 259(11):7224-9 A vascular smooth muscle alpha-isoactin biosynthetic intermediate in BC3H1 cells. Identification of acetylcysteine at the NH2 terminus.

J. Biol. Chem. 269(25):17056-61 Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766.

Biochim. Biophys. Acta 1117(2):207-15 Site-specific glycation of lens crystallins by ascorbic acid.

EMBO J. 26(8):2115-26 A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis.

FEBS letters 464(3):164-8 Phosphorylation of the Spi-B transcription factor reduces its intrinsic stability.

Nature 446(7133):333-7 A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate.

EMBO J. 25(20):4752-62 Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2.

The Journal of clinical investigation 97(3):761-8 Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage.

J. Biol. Chem. 270(32):19173-80 Truncated forms of the human prion protein in normal brain and in prion diseases.

J. Biol. Chem. 258(23):14521-6 Phosphorylation of human choriogonadotropin. Stoichiometry and sites of phosphate incorporation.

Structure (London, England : 1993) 7(3):319-30 Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis.

Molecular cell 16(1):93-105 Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin.

"Science (New York, N.Y.)" 273(5277):959-63 Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase.

Nature 386(6622):296-9 Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation.

J. Biol. Chem. 270(38):22208-17 Identification of a putative Syp substrate, the PDGF beta receptor.

The Journal of experimental medicine 194(11):1661-73 Sialylated O-glycans and sulfated tyrosines in the NH2-terminal domain of CC chemokine receptor 5 contribute to high affinity binding of chemokines.

J. Biol. Chem. 251(23):7593-9 Post-proline cleaving enzyme. Purification of this endopeptidase by affinity chromatography.

Human immunology 61(12):1202-18 N-linked carbohydrate on human leukocyte antigen-C and recognition by natural killer cell inhibitory receptors.

J. Biol. Chem. 277(38):35176-82 Nuclear localization of CDC25B1 and serine 146 integrity are required for induction of mitosis.

Glycobiology 1(4):393-404 Site-specific N-glycosylation of human chorionic gonadotrophin--structural analysis of glycopeptides by one- and two-dimensional 1H NMR spectroscopy.

J. Biol. Chem. 269(37):23185-91 Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes.

The Biochemical journal Phosphorylation by protein kinase C and cyclic AMP-dependent protein kinase of synthetic peptides derived from the linker region of human P-glycoprotein.

J. Biol. Chem. 276(15):12356-61 Phosphorylation of the oncofetal variant of the human bile salt-dependent lipase. identification of phosphorylation site and relation with secretion process.

J. Biol. Chem. 270(29):17582-7 Reactivation of phosphorylated actin depolymerizing factor and identification of the regulatory site.

Proceedings of the National Academy of Sciences of the United States of America 98(13):7200-5 Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.

J. Biol. Chem. 266(16):10544-51 Phosphorylation of neuromodulin (GAP-43) by casein kinase II. Identification of phosphorylation sites and regulation by calmodulin.

J. Biol. Chem. 276(32):29839-45 Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family.

Genes & development 12(18):2831-41 DNA damage activates p53 through a phosphorylation-acetylation cascade.

J. Biol. Chem. 267(2):1129-40 Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase.

Molecular and cellular biology 23(6):2096-108 Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP.

EMBO J. 20(12):3101-13 Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation.

Blood 96(5):1844-52 Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity.

Nature cell biology 8(8):803-14 FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling.

J. Biol. Chem. 280(14):13304-14 Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types.

J. Biol. Chem. 270(11):5706-9 14-3-3 alpha and delta are the phosphorylated forms of raf-activating 14-3-3 beta and zeta. In vivo stoichiometric phosphorylation in brain at a Ser-Pro-Glu-Lys MOTIF.

Journal of lipid research 43(9):1496-507 The N-linked oligosaccharides at the amino terminus of human apoB are important for the assembly and secretion of VLDL.

American journal of human genetics 81(5):884-94 Specific sequence variations within the 4q35 region are associated with facioscapulohumeral muscular dystrophy.

J. Biol. Chem. 268(14):10425-32 Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase.

Cell 98(1):69-80 Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi.

J. Biol. Chem. 276(20):17387-94 Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi network.

J. Biol. Chem. 278(38):35979-87 M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex.

European journal of biochemistry 191(3):563-9 Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form.

Molecular & cellular proteomics : MCP 3(5):456-65 Improved detection of hydrophilic phosphopeptides using graphite powder microcolumns and mass spectrometry: evidence for in vivo doubly phosphorylated dynamin I and dynamin III.

Journal of cell science 119(Pt 14):2851-3 Cortactin phosphorylation sites mapped by mass spectrometry.

The Journal of physiology 537(Pt 3):659-65 Phosphorylation of Ser(982) in the sodium bicarbonate cotransporter kNBC1 shifts the HCO(3)(-) : Na(+) stoichiometry from 3 : 1 to 2 : 1 in murine proximal tubule cells.

J. Biol. Chem. 278(20):18658-63 The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor.

Oncogene 21(15):2309-19 Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway.

The Journal of neuroscience : the official journal of the Society for Neuroscience 24(7):1561-4 Decreased phosphorylation of NMDA receptor type 1 at serine 897 in brains of patients with Schizophrenia.

J. Biol. Chem. 281(33):23611-9 Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP.

J. Biol. Chem. 268(28):21147-54 The carboxyl-terminal transactivation domain of human serum response factor contains DNA-activated protein kinase phosphorylation sites.

J. Biol. Chem. 272(52):33260-70 The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr.

The Biochemical journal Evaluation of the extent of the binding site in human tissue kallikrein by synthetic substrates with sequences of human kininogen fragments.

Molecular cell 11(5):1163-76 Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype.

Endocrinology 141(2):564-70 The effect of phosphorylation by casein kinase 2 on the activity of insulin-like growth factor-binding protein-3.

Molecular and cellular biology 22(11):3892-904 Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases.

Journal of molecular biology 300(3):503-18 The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A.

Biochemistry 24(22):6185-90 Ia-associated invariant chain is fatty acylated before addition of sialic acid.

Cell 96(5):667-76 Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry.

Cancer cell 3(3):247-58 Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

J. Biol. Chem. 276(30):28261-7 Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin).

European journal of immunology 24(9):2168-74 Interleukin-7 induces the association of phosphatidylinositol 3-kinase with the alpha chain of the interleukin-7 receptor.

Biochem. Biophys. Res. Commun. 174(2):735-41 Mapping of carbohydrate sites on the human insulin receptor.

J. Biol. Chem. 278(34):32448-56 Activation of ERK induces phosphorylation of MAPK phosphatase-7, a JNK specific phosphatase, at Ser-446.

J. Biol. Chem. 271(19):11222-7 Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action.

Biochem. Biophys. Res. Commun. 285(2):235-43 A novel secreted tumor antigen with a glycosylphosphatidylinositol-anchored structure ubiquitously expressed in human cancers.

Genes & development 13(19):2514-26 Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis.

EMBO J. 20(21):6028-36 Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress.

Molecular and cellular biology 21(7):2373-83 p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression.

Biochemistry 32(22):5773-80 Insulin receptor autophosphorylation. II. Determination of autophosphorylation sites by chemical sequence analysis and identification of the juxtamembrane sites.

Diabetes 42(7):966-74 Glycosylation of Asn397 or Asn418 is required for normal insulin receptor biosynthesis and processing.

J. Biol. Chem. 277(23):21007-16 p59Hck isoform induces F-actin reorganization to form protrusions of the plasma membrane in a Cdc42- and Rac-dependent manner.

J. Biol. Chem. 266(6):3968-72 Phosphorylation and subcellular distribution of calpastatin in human hematopoietic system cells.

J. Biol. Chem. 278(13):11579-89 Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation.

The Biochemical journal 382(Pt 3):957-66 The plasma membrane translocation of diacylglycerol kinase delta1 is negatively regulated by conventional protein kinase C-dependent phosphorylation at Ser-22 and Ser-26 within the pleckstrin homology domain.

FEBS letters 378(3):227-31 Processing of pro-islet amyloid polypeptide (proIAPP) by the prohormone convertase PC2.

Circulation research 78(4):635-42 Removal of Arg141 from the alpha chain of human hemoglobin by carboxypeptidases N and M.

J. Biol. Chem. 281(39):28919-31 CFBP is a novel tyrosine-phosphorylated protein that might function as a regulator of CIN85/CD2AP.

Journal of immunology (Baltimore, Md. : 1950) 173(6):3962-71 Phosphorylation of Grb2-associated binder 2 on serine 623 by ERK MAPK regulates its association with the phosphatase SHP-2 and decreases STAT5 activation.

FEBS letters 579(21):4635-41 The role of PKCalpha and RLIP76 in transport-mediated doxorubicin-resistance in lung cancer.

FEBS letters 579(21):4763-8 Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.

Blood 101(11):4423-9 A predominant role for cAMP-dependent protein kinase in the cGMP-induced phosphorylation of vasodilator-stimulated phosphoprotein and platelet inhibition in humans.

Biochemistry 43(49):15494-502 Requirements for pYXXM motifs in Cbl for binding to the p85 subunit of phosphatidylinositol 3-kinase and Crk, and activation of atypical protein kinase C and glucose transport during insulin action in 3T3/L1 adipocytes.

J. Biol. Chem. 277(51):49408-16 Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation.

J. Biol. Chem. 271(45):28533-40 Antibacterial activity of glycosylated and phosphorylated chromogranin A-derived peptide 173-194 from bovine adrenal medullary chromaffin granules.

Molecular and cellular biology 23(5):1590-601 Phosphorylation of stem-loop binding protein (SLBP) on two threonines triggers degradation of SLBP, the sole cell cycle-regulated factor required for regulation of histone mRNA processing, at the end of S phase.

Biochemistry 38(8):2377-85 Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization.

Nature 353(6342):361-3 Myc rescue of a mutant CSF-1 receptor impaired in mitogenic signalling.

Blood 96(4):1550-7 Sequential phosphorylation of protein band 3 by Syk and Lyn tyrosine kinases in intact human erythrocytes: identification of primary and secondary phosphorylation sites.

EMBO J. 17(8):2224-34 Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1.

J. Biol. Chem. 276(19):15886-92 Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity.

Molecular and cellular biology 18(12):7336-43 Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.

J. Biol. Chem. 274(25):17635-42 Calnexin interaction with N-glycosylation mutants of a polytopic membrane glycoprotein, the human erythrocyte anion exchanger 1 (band 3).

Molecular & cellular proteomics : MCP 1(10):791-804 Mapping sites of O-GlcNAc modification using affinity tags for serine and threonine post-translational modifications.

Journal of immunology (Baltimore, Md. : 1950) 158(2):580-90 Analysis of CD28 cytoplasmic tail tyrosine residues as regulators and substrates for the protein tyrosine kinases, EMT and LCK.

Molecular human reproduction 8(12):1117-24 Expression and subcellular distribution of the active form of c-Src tyrosine kinase in differentiating human endometrial stromal cells.

J. Biol. Chem. 267(16):10976-81 Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites.

Molecular and cellular biology 20(4):1140-8 Extracellular signal-regulated kinase binds to TFII-I and regulates its activation of the c-fos promoter.

Proceedings of the National Academy of Sciences of the United States of America 93(21):11681-6 The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner.

Archives of biochemistry and biophysics 320(2):315-22 Carbonic anhydrase IV: role of removal of C-terminal domain in glycosylphosphatidylinositol anchoring and realization of enzyme activity.

The Biochemical journal 373(Pt 2):505-13 Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes.

Proceedings of the National Academy of Sciences of the United States of America 96(15):8511-5 Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins.

Biopolymers 60(1):61-75 Preparation and application of antibodies to phosphoamino acid sequences.

J. Biol. Chem. 276(52):49043-52 Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology.

Molecular and cellular biology 21(13):4292-301 Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family.

Nature cell biology 3(5):439-44 Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain.

J. Biol. Chem. 280(48):40025-31 Regulation of the interaction of Pak2 with Cdc42 via autophosphorylation of serine 141.

The Journal of experimental medicine 194(4):529-39 B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1.

Proceedings of the National Academy of Sciences of the United States of America 95(16):9214-9 Autoregulation of the Raf-1 serine/threonine kinase.

J. Biol. Chem. 278(18):15601-7 Actin binding of human LIM and SH3 protein is regulated by cGMP- and cAMP-dependent protein kinase phosphorylation on serine 146.

J. Biol. Chem. 269(42):26259-66 Phorbol ester stimulates phosphorylation on serine 1327 of the human insulin receptor.

Molecular and cellular biology 21(3):952-65 Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a).

Molecular pharmacology 62(2):379-88 Oxidative stress decreases G protein-coupled receptor kinase 2 in lymphocytes via a calpain-dependent mechanism.

The Biochemical journal 213(2):467-71 Action of human liver cathepsin B on the oxidized insulin B chain.

Klinische Wochenschrift Relationships between structure and function of tissue-type plasminogen activator.

Proceedings of the National Academy of Sciences of the United States of America 99(23):14795-800 Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.

J. Biol. Chem. 281(11):7489-97 Phosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2.

J. Biol. Chem. 277(27):24274-9 Striatal enriched phosphatase 61 dephosphorylates Fyn at phosphotyrosine 420.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 7(12):1589-97 Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584.

European journal of biochemistry 127(3):473-81 Phosphorylation of the type-II regulatory subunit of cyclic-AMP-dependent protein kinase by glycogen synthase kinase 3 and glycogen synthase kinase 5.

Biochem. Biophys. Res. Commun. 291(3):628-34 Phosphorylation of Fanconi anemia protein, FANCA, is regulated by Akt kinase.

J. Biol. Chem. 276(33):30987-94 Heterogeneous fatty acylation of Src family kinases with polyunsaturated fatty acids regulates raft localization and signal transduction.

EMBO J. 16(9):2342-51 Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets.

EMBO J. 19(23):6427-39 Transmembrane transforming growth factor-alpha tethers to the PDZ domain-containing, Golgi membrane-associated protein p59/GRASP55.

J. Biol. Chem. 279(18):18392-400 p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor.

The Biochemical journal 357(Pt 2):563-7 Autocatalytic tyrosine-phosphorylation of protein kinase CK2 alpha and alpha' subunits: implication of Tyr182.

J. Biol. Chem. 277(30):27200-9 Polypyrimidine tract-binding proteins are cleaved by caspase-3 during apoptosis.

Cell death and differentiation 9(3):322-8 Yeast two-hybrid screening using constitutive-active caspase-7 as bait in the identification of PA28gamma as an effector caspase substrate.

J. Biol. Chem. 273(40):25937-43 Two forms of collagen XVII in keratinocytes. A full-length transmembrane protein and a soluble ectodomain.

Molecular and cellular biology 19(6):4200-8 Expression of the p56(Lck) Y505F mutation in CD45-deficient mice rescues thymocyte development.

J. Biol. Chem. 281(3):1746-54 Phosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase x Src complex and promote cell migration.

Molecular and cellular biology 19(12):8433-41 Glycogen synthase kinase 3 is an insulin-regulated C/EBPalpha kinase.

Proceedings of the National Academy of Sciences of the United States of America 96(24):13813-8 An Eph receptor regulates integrin activity through R-Ras.

The Biochemical journal 397(1):223-31 Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.

Proceedings of the National Academy of Sciences of the United States of America 102(9):3489-94 Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5).

EMBO J. 26(4):1105-16 Role of activation of PIP5Kgamma661 by AP-2 complex in synaptic vesicle endocytosis.

J. Biol. Chem. 269(49):31034-40 Identification of phosphorylation sites unique to the B form of human progesterone receptor. In vitro phosphorylation by casein kinase II.

Cell 71(7):1181-94 FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains.

Neuron 36(3):493-505 Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning.

"Science (New York, N.Y.)" 171(3971):579-81 Specific enzymic methylation of an arginine in the experimental allergic encephalomyelitis protein from human myelin.

J. Biol. Chem. 275(43):33321-8 Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes. Cross-talk via trans-activation of the tyrosine kinase c-kit receptor.

Molecular human reproduction 3(11):957-63 The role of N-terminal glycosylation in the human oxytocin receptor.

"Science (New York, N.Y.)" 316(5828):1194-8 Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.

J. Biol. Chem. 270(13):7679-88 Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262.

Journal of proteome research 4(4):1339-46 Global phosphoproteome of HT-29 human colon adenocarcinoma cells.

The Biochemical journal 368(Pt 1):317-24 N-glycosylation is required for full enzymic activity of the murine galactosylceramide sulphotransferase.

Journal of cellular biochemistry 80(3):346-52 Differences in phosphorylation of human and chicken stathmin by MAP kinase.

Molecular cell 16(3):387-97 Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint.

J. Biol. Chem. 266(1):380-5 Multisite phosphorylation of a synthetic peptide derived from the carboxyl terminus of the ribosomal protein S6.

J. Biol. Chem. 261(21):9614-21 Clathrin-coated vesicles contain two protein kinase activities. Phosphorylation of clathrin beta-light chain by casein kinase II.

Journal of immunology (Baltimore, Md. : 1950) 171(7):3734-41 Eosinophil major basic protein stimulates neutrophil superoxide production by a class IA phosphoinositide 3-kinase and protein kinase C-zeta-dependent pathway.

Cell 129(5):969-82 The tumor suppressor PP2A Abeta regulates the RalA GTPase.

Archives of biochemistry and biophysics 394(1):54-60 Purification and characterization of the human PDE4A catalytic domain (PDE4A330-723) expressed in Sf9 cells.

The Journal of pharmacology and experimental therapeutics 304(3):1120-8 Selective tryptic cleavage at the tethered ligand site of the amino terminal domain of proteinase-activated receptor-2 in intact cells.

Molecular and cellular biology 22(1):270-85 Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2.

Nature 378(6559):785-9 Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.

Oncogene 21(46):7067-76 The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn).

Biochemistry 42(34):10333-41 N-Glycosylation and conserved cysteine residues in RAMP3 play a critical role for the functional expression of CRLR/RAMP3 adrenomedullin receptor.

"Science (New York, N.Y.)" 291(5506):1040-3 An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome.

FEBS letters 535(1-3):6-10 Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells.

Journal of immunology (Baltimore, Md. : 1950) 171(1):267-73 Activation of protein kinase C delta by IFN-gamma.

Oncogene 8(12):3199-209 Phosphorylation sites mapping in the N-terminal domain of c-myc modulate its transforming potential.

J. Biol. Chem. 273(52):34663-6 Phosphorylation of moesin by rho-associated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structures.

J. Biol. Chem. 275(24):18534-40 Big mitogen-activated kinase regulates multiple members of the MEF2 protein family.

J. Biol. Chem. 280(1):146-55 Sumoylation of MITF and its related family members TFE3 and TFEB.

Genes to cells : devoted to molecular & cellular mechanisms 3(12):789-800 Tip60 acetylates six lysines of a specific class in core histones in vitro.

J. Biol. Chem. 278(3):2072-80 Tyrosine phosphorylation of I kappa B alpha activates NF kappa B through a redox-regulated and c-Src-dependent mechanism following hypoxia/reoxygenation.

Amino acids 15(4):291-306 Recent advances in protein methylation: enzymatic methylation of nucleic acid binding proteins.

Biochemistry 33(19):5759-65 Glycosylation of human corticosteroid-binding globulin. Differential processing and significance of carbohydrate chains at individual sites.

Nature genetics 29(3):279-86 The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men.

Molecular cell 6(3):539-50 Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity.

Molecular and cellular biology 22(11):3599-609 APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes.

J. Biol. Chem. 277(6):4395-405 Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1.

Proceedings of the National Academy of Sciences of the United States of America 99(15):9745-9 Glutathionylation of human thioredoxin: a possible crosstalk between the glutathione and thioredoxin systems.

Nature genetics 46(12):1293-302 Palindromic GOLGA8 core duplicons promote chromosome 15q13.3 microdeletion and evolutionary instability.

J. Biol. Chem. 271(29):17124-31 Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme.

J. Biol. Chem. 278(51):51372-9 Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B.

Cancer research 63(7):1458-63 The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity.

J. Biol. Chem. 280(8):7080-7 BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan.

Oncogene 9(9):2733-6 Protein kinase A phosphorylates cyclin D1 at three distinct sites within the cyclin box and at the C-terminus.

J. Biol. Chem. 274(18):12748-52 Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl.

Molecular and cellular biology 19(9):6286-96 Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt.

Biochem. Biophys. Res. Commun. 251(1):117-23 The Src-like tyrosine kinase Hck is activated by granulocyte colony-stimulating factor (G-CSF) and docks to the activated G-CSF receptor.

J. Biol. Chem. 275(48):37542-51 Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases.

Biochim. Biophys. Acta 1583(1):99-107 Early-glycation of apolipoprotein E: effect on its binding to LDL receptor, scavenger receptor A and heparan sulfates.

J. Biol. Chem. 277(6):3943-9 Phosphorylation of beta3 integrin controls ligand binding strength.

J. Biol. Chem. 279(49):50643-6 Phosphorylation of annexin I by TRPM7 channel-kinase.

Biochemistry 35(40):13040-6 Disulfide structure and N-glycosylation sites of an extracellular domain of granulocyte-colony stimulating factor receptor.

J. Biol. Chem. 277(11):9437-46 Endosomal proteolysis of internalized insulin at the C-terminal region of the B chain by cathepsin D.

EMBO J. 12(5):1937-46 Multi-site phosphorylation of the protein tyrosine phosphatase, PTP1B: identification of cell cycle regulated and phorbol ester stimulated sites of phosphorylation.

J. Biol. Chem. 267(4):2190-9 The predominant form of secreted colony stimulating factor-1 is a proteoglycan.

J. Biol. Chem. 278(11):9134-41 A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3.

J. Biol. Chem. 269(3):1668-73 Membrane topology of aquaporin CHIP. Analysis of functional epitope-scanning mutants by vectorial proteolysis.

J. Biol. Chem. 277(49):47572-80 SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei.

"Science (New York, N.Y.)" 256(5055):370-3 Calcium-regulated phosphorylation within the leucine zipper of C/EBP beta.

Journal of neurochemistry 68(6):2514-22 Functional role of amino-terminal serine16 and serine27 of G alphaZ in receptor and effector coupling.

Nucleic acids research 34(1):217-31 Functional role of NF-IL6beta and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene.

Genes & development 12(22):3499-511 Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.

EMBO J. 25(4):739-51 P38MAPK-dependent phosphorylation and degradation of SRC-3/AIB1 and RARalpha-mediated transcription.

Molecular and cellular biology 22(8):2673-86 SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription.

Biochemistry 39(21):6459-65 Monoclonal antibody light chain with prothrombinase activity.

Nature medicine 8(10):1145-52 PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.

Oncogene 17(21):2787-98 Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins.

Circulation research 88(11):E68-75 Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity.

The Journal of experimental medicine 176(4):1053-62 Myristyl acylation of the tumor necrosis factor alpha precursor on specific lysine residues.

FEBS letters 581(8):1542-8 Modulation of p300 binding by posttranslational modifications of the C-terminal activation domain of hypoxia-inducible factor-1alpha.

Journal of biochemistry 107(2):292-7 Structure of recombinant human interleukin 5 produced by Chinese hamster ovary cells.

"Science (New York, N.Y.)" 275(5308):1930-4 Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3.

Biochim. Biophys. Acta 1448(3):363-71 Ribonucleotide reductase R2 protein is phosphorylated at serine-20 by P34cdc2 kinase.

J. Biol. Chem. 275(30):23065-73 Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta.

The Journal of cell biology 153(5):893-904 Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration.

Molecular and cellular biology 18(12):7216-24 Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin.

J. Biol. Chem. 267(3):1517-21 Patterns of prohormone processing. Order revealed by a new procholecystokinin-derived peptide.

J. Biol. Chem. 271(30):18217-23 Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1.

Nature 421(6922):499-506 DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.

The Journal of experimental medicine 199(4):503-14 N-linked glycosylation is required for optimal function of Kaposi's sarcoma herpesvirus-encoded, but not cellular, interleukin 6.

Nature 405(6785):477-82 ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response.

Molecular biology of the cell 12(6):1811-7 Mitotic phosphorylation of Golgi reassembly stacking protein 55 by mitogen-activated protein kinase ERK2.

Biological chemistry 383(1):93-9 Apolipoprotein(a): structure-function relationship at the lysine-binding site and plasminogen activator cleavage site.

The Biochemical journal 358(Pt 1):69-77 Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites.

J. Biol. Chem. 278(28):25568-76 Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305.

J. Biol. Chem. 270(9):4805-12 Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity.

Oncogene 23(39):6581-9 The M-CSF receptor substrate and interacting protein FMIP is governed in its subcellular localization by protein kinase C-mediated phosphorylation, and thereby potentiates M-CSF-mediated differentiation.

Journal of inflammation 45(3):152-60 Phosphorylation of the 26 kDa TNF precursor in monocytic cells and in transfected HeLa cells.

Biochem. Biophys. Res. Commun. 268(2):249-54 Evidence for the carboxyl methylation of nuclear lamin-B in the pancreatic beta cell.

J. Biol. Chem. 265(20):11682-91 Phosphorylation of tyrosine hydroxylase in situ at serine 8, 19, 31, and 40.

EMBO J. 25(14):3323-34 Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation.

Proceedings of the National Academy of Sciences of the United States of America 97(8):4040-5 Membrane-associated GAIP is a phosphoprotein and can be phosphorylated by clathrin-coated vesicles.

Oncogene 21(6):867-77 MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts.

Molecular biology of the cell 9(6):1495-512 The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease.

Proceedings of the National Academy of Sciences of the United States of America 96(17):9677-82 Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction.

Blood 100(2):467-73 Prostaglandin-E2 enhances EPO-mediated STAT5 transcriptional activity by serine phosphorylation of CREB.

FEBS letters 443(1):48-52 Prorenin processing by cathepsin B in vitro and in transfected cells.

Molecular and cellular biology 22(8):2810-20 HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A.

Molecular cell 10(3):483-93 Control of Smad7 stability by competition between acetylation and ubiquitination.

FEBS letters 178(2):213-6 Amino acid sequence of the N-terminal region of human hemopexin.

Journal of immunology (Baltimore, Md. : 1950) 176(6):3603-10 Signaling through mutants of the IgA receptor CD89 and consequences for Fc receptor gamma-chain interaction.

BioEssays : news and reviews in molecular, cellular and developmental biology 24(6):502-11 Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor.

Proceedings of the National Academy of Sciences of the United States of America 100(5):2432-7 JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis.

J. Biol. Chem. 273(15):9158-67 Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.

J. Biol. Chem. 278(38):36966-72 Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway.

EMBO J. 18(8):2137-48 Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation.

J. Biol. Chem. 281(3):1495-505 Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase.

Biochemistry 37(8):2291-8 Human mast cell tryptase fibrinogenolysis: kinetics, anticoagulation mechanism, and cell adhesion disruption.

Molecular cell 6(1):127-37 Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7.

The Journal of cell biology 116(2):405-22 A strategy for isolation of cDNAs encoding proteins affecting human intestinal epithelial cell growth and differentiation: characterization of a novel gut-specific N-myristoylated annexin.

Molecular and cellular biology 23(16):5692-705 The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization.

Current biology : CB 10(8):467-70 Acetylation of importin-alpha nuclear import factors by CBP/p300.

J. Biol. Chem. 277(29):26642-51 Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor.

J. Biol. Chem. 279(21):22715-26 Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes.

Molecular and cellular biology 24(19):8374-85 Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5.

J. Biol. Chem. 271(41):25157-66 Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C.

Biochem. Biophys. Res. Commun. 298(2):185-92 High-affinity Src-SH2 ligands which do not activate Tyr(527)-phosphorylated Src in an experimental in vivo system.

Molecular & cellular proteomics : MCP 4(7):975-83 Post-translational modification of nuclear co-repressor receptor-interacting protein 140 by acetylation.

J. Biol. Chem. 276(22):19656-63 Cdc42 is a substrate for caspases and influences Fas-induced apoptosis.

J. Biol. Chem. 278(7):4713-8 Tip60 acetyltransferase activity is controlled by phosphorylation.

J. Biol. Chem. 268(35):26712-8 L-29, a soluble lactose-binding lectin, is phosphorylated on serine 6 and serine 12 in vivo and by casein kinase I.

The Journal of neuroscience : the official journal of the Society for Neuroscience 22(18):7948-58 A new activity of doublecortin in recognition of the phospho-FIGQY tyrosine in the cytoplasmic domain of neurofascin.

Human mutation 18(5):397-410 Mutation screening at the RNA level of the STK11/LKB1 gene in Peutz-Jeghers syndrome reveals complex splicing abnormalities and a novel mRNA isoform (STK11 c.597(insertion mark)598insIVS4).

Biochem. Biophys. Res. Commun. 286(2):322-7 The N-terminal internal region of BLM is required for the formation of dots/rod-like structures which are associated with SUMO-1.

Cancer research 62(22):6475-80 14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s).

Structure (London, England : 1993) 8(11):1105-13 Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail.

Cell 105(2):257-67 Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation.

"Science (New York, N.Y.)" 271(5250):822-5 Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases.

J. Biol. Chem. 278(15):13061-8 Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein.

Immunity 9(2):239-46 LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation.

J. Biol. Chem. 278(16):13663-71 The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.

J. Biol. Chem. 272(38):23623-30 Membrane topology of the multidrug resistance protein (MRP). A study of glycosylation-site mutants reveals an extracytosolic NH2 terminus.

Physiological reviews 83(3):731-801 The calpain system.

J. Biol. Chem. 264(34):20320-5 Identification of a disaccharide (Xyl-Glc) and a trisaccharide (Xyl2-Glc) O-glycosidically linked to a serine residue in the first epidermal growth factor-like domain of human factors VII and IX and protein Z and bovine protein Z.

J. Biol. Chem. 281(16):11002-10 Identification of substrates of human protein-tyrosine phosphatase PTPN22.

Immunogenetics 50(1-2):1-7 Cloning of a new lectin-like receptor expressed on human NK cells.

Immunity 8(4):451-60 Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis.

J. Biol. Chem. 277(29):26573-80 Deciphering the phosphorylation "code" of the glucocorticoid receptor in vivo.

J. Biol. Chem. 271(16):9313-9 Phosphorylation of the ATP-sensitive, inwardly rectifying K+ channel, ROMK, by cyclic AMP-dependent protein kinase.

Journal of biochemistry 102(5):1113-20 Phosphorylation sites of bovine brain myelin basic protein phosphorylated with Ca2+-calmodulin-dependent protein kinase from rat brain.

J. Biol. Chem. 277(48):45793-802 Bi-functional, substrate mimicking RNA inhibits MSK1-mediated cAMP-response element-binding protein phosphorylation and reveals magnesium ion-dependent conformational changes of the kinase.

American journal of physiology. Endocrinology and metabolism 286(3):E411-7 5'-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle.

J. Biol. Chem. 276(34):31620-6 Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf.

J. Biol. Chem. 278(10):8184-9 Nitric oxide, NOC-12, and S-nitrosoglutathione modulate the skeletal muscle calcium release channel/ryanodine receptor by different mechanisms. An allosteric function for O2 in S-nitrosylation of the channel.

Journal of immunology (Baltimore, Md. : 1950) 162(8):4438-46 Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase.

J. Biol. Chem. 266(1):559-66 Phosphorylation of the 48-kDa subunit of the glycine receptor by protein kinase C.

European journal of pharmacology 386(2-3):305-12 Palmitoylation occurs at cysteine 347 and cysteine 351 of the dopamine D(1) receptor.

Journal of immunology (Baltimore, Md. : 1950) 165(3):1197-209 FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells.

J. Biol. Chem. 279(39):40475-83 Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus.

Biochim. Biophys. Acta 1269(1):69-78 The protein kinase from mitotic human cells that phosphorylates Ser-209 on the casein kinase II beta-subunit is p34cdc2.

Proceedings of the National Academy of Sciences of the United States of America 103(14):5391-6 Phosphoproteome analysis of the human mitotic spindle.

J. Biol. Chem. 263(35):18920-8 Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences.

EMBO J. 12(1):75-85 Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15.

J. Biol. Chem. 277(39):35787-90 Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphatase.

Protein science : a publication of the Protein Society 13(6):1627-35 Identification of the N-glycosylation sites on glutamate carboxypeptidase II necessary for proteolytic activity.

The Biochemical journal Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2.

Journal of lipid research 34(8):1355-66 Fatty acid-binding protein from rat heart is phosphorylated on Tyr19 in response to insulin stimulation.

J. Biol. Chem. 275(50):39090-5 Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells.

Biochem. Biophys. Res. Commun. 298(3):309-16 Dissociation of AMPK activity and ACCbeta phosphorylation in human muscle during prolonged exercise.

The FEBS journal 273(6):1224-39 Site-specific phosphorylation of MCM4 during the cell cycle in mammalian cells.

The Journal of urology 156(2 Pt 1):526-31 Prostate specific antigen cleaves parathyroid hormone-related protein in the PTH-like domain: inactivation of PTHrP-stimulated cAMP accumulation in mouse osteoblasts.

J. Biol. Chem. 268(29):21478-81 Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor.

Proceedings of the National Academy of Sciences of the United States of America 100(15):8776-81 Protein kinase A phosphorylation modulates transport of the polypyrimidine tract-binding protein.

FEBS letters 474(2-3):141-5 Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1.

Molecular cell 12(2):381-92 Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation.

American journal of physiology. Cell physiology 279(1):C266-73 VACM-1, a cullin gene family member, regulates cellular signaling.

J. Biol. Chem. 279(12):11129-36 Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily.

J. Biol. Chem. 262(30):14600-5 Structure of the carbohydrate moiety of human interferon-beta secreted by a recombinant Chinese hamster ovary cell line.

Current biology : CB 7(10):776-89 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.

Biology of the cell 96(2):125-32 Alpha- and beta- cleavages of the amino-terminus of the cellular prion protein.

J. Biol. Chem. 277(26):23658-63 SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities.

The Biochemical journal 371(Pt 1):15-27 Positive and negative regulation of T-cell activation through kinases and phosphatases.

Nature structural & molecular biology 13(2):140-6 Structural basis for the methylation site specificity of SET7/9.

Journal of neurochemistry 70(5):1839-49 Palmitoylation of neurofascin at a site in the membrane-spanning domain highly conserved among the L1 family of cell adhesion molecules.

FEBS letters 385(3):241-3 Site-directed mutagenesis but not gamma-carboxylation of Glu-35 in factor VIIa affects the association with tissue factor.

FEBS letters 576(3):401-7 N-glycosylation is required for efficient secretion of a novel human secreted glycoprotein, hPAP21.

Molecular biology of the cell 18(3):1107-17 Aurora-B regulates RNA methyltransferase NSUN2.

Biochem. Biophys. Res. Commun. 280(4):1085-92 Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125.

The Journal of cell biology 145(2):347-61 Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility.

Proceedings of the National Academy of Sciences of the United States of America 95(15):8532-7 A cloning method for caspase substrates that uses the yeast two-hybrid system: cloning of the antiapoptotic gene gelsolin.

Oncogene 20(23):2918-26 Sequential two-step cleavage of the retinoblastoma protein by caspase-3/-7 during etoposide-induced apoptosis.

Journal of immunology (Baltimore, Md. : 1950) 165(12):6872-9 The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19.

Cell 76(6):1025-37 JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain.

European journal of biochemistry 257(1):242-8 Caspase 3 specifically cleaves p21WAF1/CIP1 in the earlier stage of apoptosis in SK-HEP-1 human hepatoma cells.

J. Biol. Chem. 276(33):31216-28 Transcription factor STAT5A is a substrate of Bruton's tyrosine kinase in B cells.

Molecular and cellular biology 18(9):5229-38 14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity.

Cell 128(1):59-70 Modeling of a human circadian mutation yields insights into clock regulation by PER2.

Biochemistry 36(21):6270-82 Structure and assembly of the catalytic region of human complement protease C1r: a three-dimensional model based on chemical cross-linking and homology modeling.

Molecular endocrinology (Baltimore, Md.) 16(10):2382-92 Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation.

J. Biol. Chem. 277(22):19389-95 Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain.

J. Biol. Chem. 276(25):23173-8 Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase.

J. Biol. Chem. 276(34):31858-62 Regulation of Akt/PKB activation by tyrosine phosphorylation.

Molecular and cellular biochemistry 221(1-2):147-54 Phosphorylation and activation of protein tyrosine phosphatase (PTP) 1B by insulin receptor.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 9(3):197-208 C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding.

Molecular biology of the cell 11(9):2901-14 Exposure at the cell surface is required for gas3/PMP22 To regulate both cell death and cell spreading: implication for the Charcot-Marie-Tooth type 1A and Dejerine-Sottas diseases.

EMBO J. 20(11):2723-41 Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility.

Cell 108(6):837-47 Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism.

Journal of cell science 120(Pt 17):3034-44 Calcineurin is essential for depolarization-induced nuclear translocation and tyrosine phosphorylation of PYK2 in neurons.

Biochemistry 27(10):3682-90 Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C.

Cell 93(5):851-61 Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1.

J. Biol. Chem. 274(17):11693-700 Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP).

J. Biol. Chem. 275(27):20436-43 Histone deacetylases specifically down-regulate p53-dependent gene activation.

Biochemistry 32(20):5472-9 Expression of glycosylated and nonglycosylated human transferrin in mammalian cells. Characterization of the recombinant proteins with comparison to three commercially available transferrins.

Proceedings of the National Academy of Sciences of the United States of America 97(23):12577-82 Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein.

Biochemistry 41(42):12850-7 Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2.

Molecular & cellular proteomics : MCP 1(8):567-78 Mapping and structural dissection of human 20 S proteasome using proteomic approaches.

The international journal of biochemistry & cell biology 32(8):805-15 Structure-function and biological role of betacellulin.

EMBO J. 20(14):3716-27 Positive and negative regulation of Raf kinase activity and function by phosphorylation.

Journal of cell science 115(Pt 18):3609-18 A novel chk1-dependent G1/M checkpoint in fission yeast.

Nucleic acids research 21(5):1289-95 c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif.

Proceedings of the National Academy of Sciences of the United States of America 98(6):3416-21 The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation.

EMBO J. 21(14):3715-27 Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation.

Proceedings of the National Academy of Sciences of the United States of America 100(16):9470-5 A Ras activation pathway dependent on Syk phosphorylation of protein kinase C.

Cell cycle (Georgetown, Tex.) 2(5):473-8 Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint.

J. Biol. Chem. 276(29):27462-9 Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343.

J. Biol. Chem. 280(45):37623-33 Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties.

J. Biol. Chem. 279(44):45603-12 Protein kinase Cdelta regulates apoptosis via activation of STAT1.

Molecular and cellular biology 17(2):571-83 The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex.

Cell 78(5):799-811 Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa protein.

PloS one 5(12):e15115 Different patterns of evolution in the centromeric and telomeric regions of group A and B haplotypes of the human killer cell Ig-like receptor locus.

Molecular & cellular proteomics : MCP 5(1):194-203 Mapping post-translational modifications of the histone variant MacroH2A1 using tandem mass spectrometry.

"Science (New York, N.Y.)" 286(5442):1162-6 Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.

J. Biol. Chem. 272(50):31865-71 Regulation of leukotriene A4 hydrolase activity in endothelial cells by phosphorylation.

J. Steroid Biochem. Mol. Biol. 75(2-3):147-58 Glycosylation of the murine estrogen receptor-alpha.

European journal of biochemistry 225(1):29-41 A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex.

FEBS letters 453(3):387-90 Mutational analysis of sites in the translational regulator, PHAS-I, that are selectively phosphorylated by mTOR.

EMBO J. 25(13):3179-90 Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange.

FEBS letters 280(2):211-5 Inactivation of human cystatin C and kininogen by human cathepsin D.

The Biochemical journal Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7.

Nature structural & molecular biology 11(4):308-15 Regulation of the p300 HAT domain via a novel activation loop.

Nature genetics 30(3):285-9 BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage.

J. Biol. Chem. 269(24):16589-96 Phosphorylation of the erythroid transcription factor GATA-1.

EMBO J. 17(21):6250-62 Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation.

The Biochemical journal 358(Pt 3):705-15 Targeting of the transcription factor Max during apoptosis: phosphorylation-regulated cleavage by caspase-5 at an unusual glutamic acid residue in position P1.

Neuron 24(2):377-87 A phospho-switch controls the dynamic association of synapsins with synaptic vesicles.

Molecular cancer research : MCR 2(3):170-82 The interaction of specific peptide aptamers with the DNA binding domain and the dimerization domain of the transcription factor Stat3 inhibits transactivation and induces apoptosis in tumor cells.

J. Biol. Chem. 270(41):24116-26 Structural analysis of the oligosaccharides derived from glycodelin, a human glycoprotein with potent immunosuppressive and contraceptive activities.

Neurology 56(2):207-14 Cognitive impairment in Coffin-Lowry syndrome correlates with reduced RSK2 activation.

The Biochemical journal 370(Pt 3):881-9 The N-terminus of the human copper transporter 1 (hCTR1) is localized extracellularly, and interacts with itself.

Biochim. Biophys. Acta 1539(1-2):131-9 Glycosylation of human CRLR at Asn123 is required for ligand binding and signaling.

J. Biol. Chem. 271(17):10379-84 Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane.

J. Biol. Chem. 277(23):20367-71 Protein kinase C (PKC) delta regulates PKCalpha activity in a Syndecan-4-dependent manner.

J. Biol. Chem. 264(34):20526-31 Structure of human lysosomal membrane glycoprotein 1. Assignment of disulfide bonds and visualization of its domain arrangement.

J. Biol. Chem. 278(17):14926-35 Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs.

J. Biol. Chem. 275(44):34710-8 Mitotic phosphorylation of DNA topoisomerase II alpha by protein kinase CK2 creates the MPM-2 phosphoepitope on Ser-1469.

Biochim. Biophys. Acta 1151(2):149-52 Identification of the phosphorylation site on human erythrocyte band 7 integral membrane protein: implications for a monotopic protein structure.

J. Biol. Chem. 272(34):21010-7 Activation of caspase-2 in apoptosis.

J. Biol. Chem. 268(10):7107-17 The alpha-type 85-kDa subunit of phosphatidylinositol 3-kinase is phosphorylated at tyrosines 368, 580, and 607 by the insulin receptor.

The American journal of physiology 263(2 Pt 1):L249-56 Generation of the neutrophil-activating peptide-2 by cathepsin G and cathepsin G-treated human platelets.

The Journal of cell biology 136(5):1023-35 Rapid plasma membrane anchoring of newly synthesized p59fyn: selective requirement for NH2-terminal myristoylation and palmitoylation at cysteine-3.

J. Biol. Chem. 279(16):16394-402 Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase.

J. Biol. Chem. 269(47):29351-4 Phosphorylation of the desmoplakin COOH terminus negatively regulates its interaction with keratin intermediate filament networks.

J. Biol. Chem. 277(16):13430-7 Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria.

The Biochemical journal Stat1 associates with c-kit and is activated in response to stem cell factor.

Molecular and cellular biology 13(8):4679-90 Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1.

Current biology : CB 5(12):1394-1403 Protein kinase C is regulated in vivo by three functionally distinct phosphorylations.

J. Biol. Chem. 268(24):18234-42 N-glycosylation of prostaglandin endoperoxide synthases-1 and -2 and their orientations in the endoplasmic reticulum.

Molecular and cellular endocrinology 175(1-2):149-56 KN-93 inhibition of G protein signaling is independent of the ability of Ca2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser.

The Journal of cell biology 142(6):1547-58 Active MAP kinase in mitosis: localization at kinetochores and association with the motor protein CENP-E.

J. Biol. Chem. 276(15):11939-48 Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor.

J. Biol. Chem. 278(46):45994-8 Phosphorylation of serine 337 of NF-kappaB p50 is critical for DNA binding.

"Science (New York, N.Y.)" 278(5343):1638-41 Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway.

Cell 115(3):293-303 Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression.

Biochemistry 39(44):13551-7 Mutations of serine 236-237 and tyrosine 302 residues in the human lipoxin A4 receptor intracellular domains result in sustained signaling.

Archives of biochemistry and biophysics 298(1):150-8 Post-translational processing of membrane-associated recombinant human stem cell factor expressed in Chinese hamster ovary cells.

Molecular endocrinology (Baltimore, Md.) 12(4):544-55 N-glycosylation of the prolactin receptor is not required for activation of gene transcription but is crucial for its cell surface targeting.

J. Biol. Chem. 269(16):11962-6 Identification of the phosphorylation site in vitro for cAMP-dependent protein kinase on the rat adipocyte cGMP-inhibited cAMP phosphodiesterase.

EMBO J. 20(24):7008-21 Polarized trafficking and surface expression of the AQP4 water channel are coordinated by serial and regulated interactions with different clathrin-adaptor complexes.

Molecular cell 11(2):437-44 The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.

J. Biol. Chem. 277(2):883-6 p21-activated kinase links Rac/Cdc42 signaling to merlin.

J. Biol. Chem. 271(11):5961-4 Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction.

J. Biol. Chem. 276(18):14909-15 Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis.

Molecular biology of the cell 13(6):2031-44 Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding.

EMBO J. 12(10):3903-11 Multiple and cooperative phosphorylation events regulate the CREM activator function.

J. Biol. Chem. 274(11):6823-6 Nitric oxide inhibits caspase-3 by S-nitrosation in vivo.

Nature 391(6668):703-7 Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells.

The Biochemical journal Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor 4E-binding protein 1 on the rapamycin-insensitive site (serine-111).

Biochemistry 44(50):16475-90 Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase.

J. Biol. Chem. 281(5):2551-61 Binding of manumycin A inhibits IkappaB kinase beta activity.

The Journal of cell biology 150(4):905-12 Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis.

J. Biol. Chem. 276(34):31738-44 Gas6 anti-apoptotic signaling requires NF-kappa B activation.

J. Biol. Chem. 280(15):15340-7 Protein kinase CK1alpha regulates mRNA binding by heterogeneous nuclear ribonucleoprotein C in response to physiologic levels of hydrogen peroxide.

EMBO J. 4(13B):3735-42 Phosphorylation and activation of hamster carbamyl phosphate synthetase II by cAMP-dependent protein kinase. A novel mechanism for regulation of pyrimidine nucleotide biosynthesis.

J. Biol. Chem. 276(7):4709-16 Heterologous activation of protein kinase C stimulates phosphorylation of delta-opioid receptor at serine 344, resulting in beta-arrestin- and clathrin-mediated receptor internalization.

Gene 186(2):189-95 The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals.

"Science (New York, N.Y.)" 282(5392):1318-21 Regulation of cell death protease caspase-9 by phosphorylation.

FEBS letters 580(21):5096-104 CRM1 mediates nuclear export of HDAC7 independently of HDAC7 phosphorylation and association with 14-3-3s.

J. Biol. Chem. 279(30):31164-70 Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function.

Journal of cell science 115(Pt 23):4433-45 A developmentally regulated ARF-like 5 protein (ARL5), localized to nuclei and nucleoli, interacts with heterochromatin protein 1.

EMBO reports 4(4):412-8 Proteolytic cleavage of PDZD2 generates a secreted peptide containing two PDZ domains.

J. Biol. Chem. 278(51):51479-83 Modification of promyelocytic leukemia zinc finger protein (PLZF) by SUMO-1 conjugation regulates its transcriptional repressor activity.

J. Biol. Chem. 281(10):6236-45 Phosphorylation of serine 526 is required for MEKK3 activity, and association with 14-3-3 blocks dephosphorylation.

J. Biol. Chem. 252(12):4326-9 Limited pepsin digestion of human plasma albumin.

FEBS letters 580(15):3624-30 Polo-like kinase 1 regulates mitotic arrest after UV irradiation through dephosphorylation of p53 and inducing p53 degradation.

J. Biol. Chem. 275(1):423-8 Akt protein kinase inhibits Rac1-GTP binding through phosphorylation at serine 71 of Rac1.

J. Biol. Chem. 275(33):25723-32 Regulation of human endothelial cell focal adhesion sites and migration by cGMP-dependent protein kinase I.

Molecular cell 8(5):1063-73 An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF.

Molecular and cellular biology 16(10):5623-33 Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases.

Molecular and cellular biology 18(1):616-28 Pex19p, a farnesylated protein essential for peroxisome biogenesis.

Glycobiology 11(11):997-1008 The polysialyltransferase ST8Sia II/STX: posttranslational processing and role of autopolysialylation in the polysialylation of neural cell adhesion molecule.

J. Biol. Chem. 277(16):13840-7 IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2.

J. Biol. Chem. 278(37):35702-9 Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival.

British journal of cancer 82(12):1938-45 ATM protein and p53-serine 15 phosphorylation in ataxia-telangiectasia (AT) patients and at heterozygotes.

J. Biol. Chem. 271(40):24408-12 Stimulation of tumor cell motility linked to phosphodiesterase catalytic site of autotaxin.

Genomics 47(1):125-30 Sequence characterization of a newly identified human alpha-tubulin gene (TUBA2).

Molecular and cellular biology 23(4):1379-89 Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling.

Journal of andrology 16(1):64-74 Secretory leucocyte protease inhibitor in the male genital tract: PSA-induced proteolytic processing in human semen and tissue localization.

J. Biol. Chem. 277(46):44115-20 Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase.

Journal of biochemistry 107(3):486-92 Structural characterization of natural and recombinant human granulocyte colony-stimulating factors.

J. Biol. Chem. 281(2):915-26 Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling.

Nature 444(7119):629-32 Repression of p53 activity by Smyd2-mediated methylation.

J. Biol. Chem. 274(12):8022-8 Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation.

J. Biol. Chem. 275(36):27845-50 SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells.

Developmental biology 213(2):283-300 Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis.

J. Biol. Chem. 277(33):29792-802 The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation.

J. Biol. Chem. 270(47):28357-63 Cell cycle phase-specific phosphorylation of human topoisomerase II alpha. Evidence of a role for protein kinase C.

J. Biol. Chem. 272(51):32221-9 Separate domains of the human fas ligand dictate self-association and receptor binding.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 16(2):210-2 Multiple phosphorylation of alpha-synuclein by protein tyrosine kinase Syk prevents eosin-induced aggregation.

Cell death and differentiation 8(5):443-50 Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis.

J. Biol. Chem. 268(32):23933-9 Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases.

Oncogene 15(14):1727-36 p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs.

J. Biol. Chem. 265(11):6030-4 Kinetic determination of the effects of ADP-ribosylation on the interaction of eukaryotic elongation factor 2 with ribosomes.

EMBO J. 19(17):4565-76 Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes.

Biochemistry 35(47):14849-61 Peptide, disulfide, and glycosylation mapping of recombinant human thrombopoietin from ser1 to Arg246.

European journal of biochemistry 262(3):644-51 Site-directed removal of N-glycosylation sites in human gastric lipase.

Molecular and cellular biology 24(19):8576-85 FANCG is phosphorylated at serines 383 and 387 during mitosis.

FEBS letters 126(2):257-60 The site in human antithrombin for functional proteolytic cleavage by human thrombin.

J. Biol. Chem. 276(16):12932-7 MAP kinases mediate UVB-induced phosphorylation of histone H3 at serine 28.

DNA and cell biology 13(2):87-95 Cloning and expression of the gene for the melanoma-associated ME20 antigen.

J. Biol. Chem. 275(31):23549-58 Control sites of ribosomal S6 kinase B and persistent activation through tumor necrosis factor.

Molecular cell 2(2):233-9 SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation.

FEBS letters 569(1-3):185-90 Interaction of filamin A with the integrin beta 7 cytoplasmic domain: role of alternative splicing and phosphorylation.

J. Biol. Chem. 272(23):14562-70 Characterization of Lnk. An adaptor protein expressed in lymphocytes.

Nature 440(7088):1194-8 The DNA sequence, annotation and analysis of human chromosome 3.

Human molecular genetics 10(18):1971-82 Structure-function analysis of phytanoyl-CoA 2-hydroxylase mutations causing Refsum's disease.

Developmental cell 5(1):127-38 A role for Plk1 phosphorylation of NudC in cytokinesis.

J. Biol. Chem. 270(20):11820-7 Identification and mutational analysis of the glycosylation sites of human keratin 18.

J. Biol. Chem. 271(9):5215-24 Structural and enzymatic aspects of rhodopsin phosphorylation.

Molecular and cellular biology 26(3):955-64 Inhibition of DNA binding by differential sumoylation of heat shock factors.

EMBO J. 21(9):2263-71 Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion.

J. Biol. Chem. 254(14):6211-4 Sequence of two phosphorylated sites in the catalytic subunit of bovine cardiac muscle adenosine 3':5'-monophosphate-dependent protein kinase.

J. Biol. Chem. 257(2):592-5 The complete amino acid sequence of the rabbit P2 protein.

The Biochemical journal 367(Pt 3):907-11 Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptor.

J. Biol. Chem. 278(4):2432-6 The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6.

J. Biol. Chem. 272(11):7556-64 Phosphorylation of human keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431.

J. Biol. Chem. 275(8):5504-11 Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle.

J. Biol. Chem. 278(7):5062-71 The p34cdc2-related cyclin-dependent kinase 11 interacts with the p47 subunit of eukaryotic initiation factor 3 during apoptosis.

Journal of neurochemistry 63(4):1416-25 Protein kinase FA/glycogen synthase kinase-3 alpha after heparin potentiation phosphorylates tau on sites abnormally phosphorylated in Alzheimer's disease brain.

J. Biol. Chem. 277(37):34367-74 Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis.

Peptides 17(4):601-7 The in vivo metabolism of cholecystokinin (CCK-8) is essentially ensured by aminopeptidase A.

The Biochemical journal Structural composition and functional characterization of soluble CD59: heterogeneity of the oligosaccharide and glycophosphoinositol (GPI) anchor revealed by laser-desorption mass spectrometric analysis.

Nature structural biology 9(5):365-9 SH3-dependent stimulation of Src-family kinase autophosphorylation without tail release from the SH2 domain in vivo.

EMBO J. 17(12):3258-68 Mapping the interaction between GRASP65 and GM130, components of a protein complex involved in the stacking of Golgi cisternae.

FEBS letters 467(2-3):150-4 Prothymosin alpha fragmentation in apoptosis.

Cancer research 59(20):5376-85 Signaling pathways and structural domains required for phosphorylation of EMS1/cortactin.

Cell 128(2):269-80 Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases.

Biochim. Biophys. Acta 1313(3):283-9 Mapping of a regulatory important site for protein kinase C phosphorylation in the N-terminal domain of annexin II.

DNA and cell biology 12(4):291-8 Glycosylation of active human renin is necessary for secretion: effect of targeted modifications of Asn-5 and Asn-75.

Cancer research 61(16):5985-91 Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K.

EMBO J. 18(20):5745-54 The replication factory targeting sequence/PCNA-binding site is required in G(1) to control the phosphorylation status of DNA ligase I.

Journal of cell science 116(Pt 19):3879-91 The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity.

Biochemistry 25(9):2410-7 Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats.

EMBO J. 16(8):1943-52 D-myo-inositol 1,4,5-trisphosphate 3-kinase A is activated by receptor activation through a calcium:calmodulin-dependent protein kinase II phosphorylation mechanism.

Biochem. Biophys. Res. Commun. 240(2):399-404 Tyrosine residues 239 and 240 of Shc are phosphatidylinositol 4,5-bisphosphate-dependent phosphorylation sites by c-Src.

J. Biol. Chem. 276(11):8364-70 Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor. Implications for a novel mode of ligand recognition by a major histocompatibility complex class 1-type receptor.

J. Biol. Chem. 272(23):14762-8 Rhodopsin phosphorylation sites and their role in arrestin binding.

Blood 100(10):3710-8 Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties.

J. Biol. Chem. 277(23):20438-45 Regulation of metallothionein transcription by the metal-responsive transcription factor MTF-1: identification of signal transduction cascades that control metal-inducible transcription.

J. Biol. Chem. 278(52):52195-202 The SH3 domain-containing adaptor HIP-55 mediates c-Jun N-terminal kinase activation in T cell receptor signaling.

Proceedings of the National Academy of Sciences of the United States of America 98(10):5746-51 Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis.

Oncogene 18(17):2690-702 The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro.

J. Biol. Chem. 276(36):33444-51 Serum response factor cleavage by caspases 3 and 7 linked to apoptosis in human BJAB cells.

J. Biol. Chem. 276(22):18681-7 Exposure on cell surface and extensive arginine methylation of ewing sarcoma (EWS) protein.

J. Biol. Chem. 270(11):6088-99 Primary structure of CD52.

FEBS letters 580(3):813-21 Induction of apoptosis by p110C requires mitochondrial translocation of the proapoptotic BCL-2 family member BAD.

Molecular cell 1(5):627-37 Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT.

J. Biol. Chem. 273(51):34558-67 Identification of the sites of N-linked glycosylation on the human calcium receptor and assessment of their role in cell surface expression and signal transduction.

European journal of biochemistry 267(4):1083-91 Changes in integrity and association of eukaryotic protein synthesis initiation factors during apoptosis.

J. Biol. Chem. 259(14):9235-40 Human and murine class I MHC antigens share conserved serine 335, the site of HLA phosphorylation in vivo.

EMBO J. 16(23):7054-66 BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C.

Molecular and cellular biology 18(7):3966-73 Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation.

Molecular pharmacology 62(3):672-9 Activation of phospholipase Cgamma2 by tyrosine phosphorylation.

Proceedings of the National Academy of Sciences of the United States of America 101(40):14390-5 Prohaptoglobin is proteolytically cleaved in the endoplasmic reticulum by the complement C1r-like protein.

Biochemistry 34(7):2212-9 Purification and structure-function analysis of native, PNGase F-treated, and endo-beta-galactosidase-treated CHIP28 water channels.

J. Biol. Chem. 275(8):5600-5 The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01.

Journal of lipid research 42(11):1727-39 Role of apoA-II in lipid metabolism and atherosclerosis: advances in the study of an enigmatic protein.

Molecular cell 14(2):207-19 A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor.

J. Biol. Chem. 268(20):15039-47 Serine 25 of oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase.

J. Biol. Chem. 274(17):11643-6 Suppression of Kir2.3 activity by protein kinase C phosphorylation of the channel protein at threonine 53.

Protein science : a publication of the Protein Society 8(1):234-41 Identification of Tyr438 as the major in vitro c-Src phosphorylation site in human gelsolin: a mass spectrometric approach.

Nature cell biology 5(5):401-9 Chk2 activates E2F-1 in response to DNA damage.

J. Biol. Chem. 273(31):19411-8 Cytoplasmic domains of the human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor beta chain (hbetac) responsible for human GM-CSF-induced myeloid cell differentiation.

Proceedings of the National Academy of Sciences of the United States of America 84(24):8793-5 Structure and formation of microplasmin.

Nature cell biology 2(12):893-8 Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1.

J. Biol. Chem. 275(47):36720-5 Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease.

Acta biologica et medica Germanica 40(9):1139-43 Action of rat liver cathepsin L on glucagon.

Trends in biochemical sciences 27(7):327-9 Wnt signal transduction: kinase cogs in a nano-machine?

J. Biol. Chem. 281(33):23686-97 Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity.

Molecular cell 4(6):1087-92 Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha.

"Science (New York, N.Y.)" 248(4952):217-20 Differential phosphorylation of c-Abl in cell cycle determined by cdc2 kinase and phosphatase activity.

Cell 94(5):625-34 A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth.

The Journal of neuroscience : the official journal of the Society for Neuroscience 21(20):7985-92 An NMDA receptor signaling complex with protein phosphatase 2A.

J. Biol. Chem. 277(37):34556-67 Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1.

Molecular and cellular biology 22(16):5662-8 Identification of a nuclear Stat1 protein tyrosine phosphatase.

J. Biol. Chem. 263(12):5499-501 Identification of the phosphorylation sites of clathrin light chain LCb.

Molecular and cellular biology 22(10):3237-46 Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259.

Cancer research 60(12):3299-304 Role for ATM in DNA damage-induced phosphorylation of BRCA1.

The Journal of neuroscience : the official journal of the Society for Neuroscience 25(28):6584-93 Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase.

The Biochemical journal 367(Pt 2):525-32 Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways.

Analytical chemistry 77(16):5243-50 Mapping of phosphorylation sites by a multi-protease approach with specific phosphopeptide enrichment and NanoLC-MS/MS analysis.

J. Biol. Chem. 277(32):29162-71 Molecular characterization of hCTR1, the human copper uptake protein.

J. Biol. Chem. 276(25):23092-6 Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha.

Proceedings of the National Academy of Sciences of the United States of America 101(39):14180-5 A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-gamma activation.

EMBO J. 16(21):6346-54 The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis.

Structure (London, England : 1993) 11(9):1123-31 The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain.

The Biochemical journal 393(Pt 3):715-24 Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation.

J. Biol. Chem. 260(24):12895-8 The primary structure of human tissue amyloid P component from a patient with primary idiopathic amyloidosis.

J. Biol. Chem. 271(39):24231-5 Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo.

Nature medicine 9(12):1506-12 Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure.

Molecular cell 9(2):265-77 Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription.

J. Biol. Chem. 268(20):14687-93 Characterization of rabbit skeletal muscle glycogenin. Tyrosine 194 is essential for function.

Nature cell biology 3(5):512-6 PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor.

Immunity 16(3):479-92 TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator.

J. Biol. Chem. 279(15):14772-83 Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epithelia.

Current biology : CB 10(15):877-85 Dab1 tyrosine phosphorylation sites relay positional signals during mouse brain development.

J. Biol. Chem. 274(38):26697-704 The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B.

EMBO J. 21(17):4571-82 Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling.

Cell 83(7):1159-69 Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo.

J. Biol. Chem. 273(46):30622-9 Casein kinase II catalyzes a mitotic phosphorylation on threonine 1342 of human DNA topoisomerase IIalpha, which is recognized by the 3F3/2 phosphoepitope antibody.

Proceedings of the National Academy of Sciences of the United States of America 90(15):6939-43 The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp.

Biochimie 79(6):373-84 The BASP1 family of myristoylated proteins abundant in axonal termini. Primary structure analysis and physico-chemical properties.

Journal of neurochemistry 72(1):51-7 Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties.

EMBO J. 22(23):6234-44 The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic.

Cancer research 66(6):2997-3005 Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation.

EMBO J. 15(24):7060-9 The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2.

J. Biol. Chem. 272(43):27369-77 The prooncoprotein EWS binds calmodulin and is phosphorylated by protein kinase C through an IQ domain.

J. Biol. Chem. 277(26):23747-54 Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII.

Acta urologica Belgica 45(4):327-31 Cystitis emphysematosa.

Cellular signalling 11(4):245-52 Intensification of growth factor receptor signalling by phorbol treatment of ligand-primed cells implies a dimer-stabilizing effect of protein kinase C-dependent juxtamembrane domain phosphorylation.

J. Biol. Chem. 276(44):40431-40 Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function.

Archives of biochemistry and biophysics 411(1):19-26 Functional analysis of site-directed glycosylation mutants of the human equilibrative nucleoside transporter-2.

Molecular and cellular biology 19(8):5523-34 Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.

Molecular and cellular biology 22(8):2871-81 MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts.

J. Biol. Chem. 280(26):24680-9 Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation.

Biochemistry 40(33):9860-9 Purification and characterization of a soluble bioactive amino-terminal extracellular domain of the human thyrotropin receptor.

Molecular cancer research : MCR 1(7):541-50 Protein tyrosine phosphatase epsilon inhibits signaling by mitogen-activated protein kinases.

Genes to cells : devoted to molecular & cellular mechanisms 6(11):1003-15 Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha.

Proteomics 2(6):642-8 Identification of the phosphotyrosine proteome from thrombin activated platelets.

J. Biol. Chem. 274(10):6741-6 Intracellular proteolytic processing of the heavy chain of rat pre-alpha-inhibitor. The COOH-terminal propeptide is required for coupling to bikunin.

J. Biol. Chem. 278(45):44369-76 Phosphorylation of SNAP-23 in activated human platelets.

J. Biol. Chem. 262(13):6055-9 The reactive site of human alpha 2-antiplasmin.

Molecular and cellular biology 25(20):9063-72 Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination.

Biochem. Biophys. Res. Commun. 319(1):130-7 Phosphorylation of the mitochondrial protein Sab by stress-activated protein kinase 3.

Analytical biochemistry 317(1):26-33 Stable isotope phospho-profiling of fibrinogen and fetuin subunits by element mass spectrometry coupled to capillary liquid chromatography.

Proceedings of the National Academy of Sciences of the United States of America 82(12):4080-4 Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor phosphorylation at threonine-654.

Biochemistry 38(39):12926-34 Transient palmitoylation supports H-Ras membrane binding but only partial biological activity.

EMBO J. 21(8):1967-77 Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation.

Genes & development 16(11):1356-70 Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation.

J. Biol. Chem. 278(52):52188-94 Physical and functional interaction between Hck tyrosine kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domain.

J. Biol. Chem. 271(2):1061-4 The beta-adrenergic receptor is a substrate for the insulin receptor tyrosine kinase.

European journal of biochemistry 269(15):3619-31 Phosphorylation of calmodulin. Functional implications.

Molecular and cellular biology 20(3):1030-43 Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3.

Molecular cell 12(5):1225-37 PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation.

Science's STKE : signal transduction knowledge environment 2002(163):pe53 Mono-ADP-ribosylation: a tool for modulating immune response and cell signaling.

J. Biol. Chem. 274(13):8949-57 ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling.

J. Biol. Chem. 270(45):27127-35 Repetitive Ser-Gly sequences enhance heparan sulfate assembly in proteoglycans.

The Journal of cell biology 114(6):1285-94 Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10.

J. Biol. Chem. 278(51):51693-702 Characterization of recombinant skeletal muscle (Ser-2843) and cardiac muscle (Ser-2809) ryanodine receptor phosphorylation mutants.

Molecular cell 1(1):35-45 Differential roles of p300 and PCAF acetyltransferases in muscle differentiation.

J. Biol. Chem. 266(15):9778-85 Glycosylation of human protein C affects its secretion, processing, functional activities, and activation by thrombin.

J. Biol. Chem. 278(43):42330-9 Processing and localization of ADAMTS-1 and proteolytic cleavage of versican during cumulus matrix expansion and ovulation.

J. Biol. Chem. 273(34):22096-104 Tyrosine phosphorylation of c-ErbB-2 is regulated by the cellular form of prostatic acid phosphatase in human prostate cancer cells.

Journal of immunology (Baltimore, Md. : 1950) 167(11):6292-302 The IL-15R alpha chain signals through association with Syk in human B cells.

Oncogene 11(5):921-31 Mutation at tyrosine residue 1337 abrogates ligand-dependent transforming capacity of the FLT4 receptor.

J. Biol. Chem. 272(19):12738-46 Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases.

J. Biol. Chem. 275(3):1793-801 Architecture of high mobility group protein I-C.DNA complex and its perturbation upon phosphorylation by Cdc2 kinase.

Glycobiology 13(4):227-44 Glycosylation of human pancreatic ribonuclease: differences between normal and tumor states.

Journal of immunology (Baltimore, Md. : 1950) 162(3):1270-7 Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases.

Genomics 80(5):456-60 Identification and characterization of novel members of the CREG family, putative secreted glycoproteins expressed specifically in brain.

Proceedings of the National Academy of Sciences of the United States of America 103(23):8798-803 Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation.

International journal of oncology 26(4):1135-9 Molecular evolution of Wnt2b orthologs.

Advances in enzyme regulation Phosphorylation of cAMP-dependent protein kinase subunits.

J. Biol. Chem. 272(33):20811-9 Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356.

Nature 389(6651):618-22 Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1.

The Journal of experimental medicine 186(4):561-8 Src homology 2 protein tyrosine phosphatase (SHPTP2)/Src homology 2 phosphatase 2 (SHP2) tyrosine phosphatase is a positive regulator of the interleukin 5 receptor signal transduction pathways leading to the prolongation of eosinophil survival.

J. Biol. Chem. 270(11):6156-62 Protein kinase C delta-specific phosphorylation of the elongation factor eEF-alpha and an eEF-1 alpha peptide at threonine 431.

Journal of biochemistry 126(5):957-61 Neuron-specific Cdk5 kinase is responsible for mitosis-independent phosphorylation of c-Src at Ser75 in human Y79 retinoblastoma cells.

Molecular biology of the cell 5(5):565-74 Adhesive properties of osteopontin: regulation by a naturally occurring thrombin-cleavage in close proximity to the GRGDS cell-binding domain.

J. Biol. Chem. 269(3):2041-7 In vitro analysis of microtubule assembly of isotypically pure tubulin dimers. Intrinsic differences in the assembly properties of alpha beta II, alpha beta III, and alpha beta IV tubulin dimers in the absence of microtubule-associated proteins.

J. Biol. Chem. 271(14):8313-20 Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites.

Biochem. Biophys. Res. Commun. 335(1):232-9 Pleiotrophin stimulates tyrosine phosphorylation of beta-adducin through inactivation of the transmembrane receptor protein tyrosine phosphatase beta/zeta.

Molecular and cellular biology 19(8):5363-72 Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha.

J. Biol. Chem. 272(17):11198-204 Regulation by cAMP of post-translational processing and subcellular targeting of endothelial nitric-oxide synthase (type 3) in cardiac myocytes.

J. Biol. Chem. 275(7):5131-5 Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases.

Biochem. Biophys. Res. Commun. 325(1):314-9 Tyrosine phosphatase epsilonM stimulates migration and survival of porcine aortic endothelial cells by activating c-Src.

Infection and immunity 73(12):8179-87 Ectophosphorylation of CD36 regulates cytoadherence of Plasmodium falciparum to microvascular endothelium under flow conditions.

J. Biol. Chem. 278(30):27495-501 AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability.

Proceedings of the National Academy of Sciences of the United States of America 95(10):5584-9 Plasma membrane localization is required for RGS4 function in Saccharomyces cerevisiae.

J. Biol. Chem. 275(24):18399-406 Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation.

J. Biol. Chem. 271(3):1270-3 Association of a 85-kDa serine kinase with activated fibroblast growth factor receptor-4.

Molecular and cellular biology 22(16):5835-45 Regulation of estrogen receptor nuclear export by ligand-induced and p38-mediated receptor phosphorylation.

Journal of proteome research 3(3):426-33 Identification of phosphorylation sites in protein kinase A substrates using artificial neural networks and mass spectrometry.

Oncogene 21(50):7630-41 Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation.

J. Biol. Chem. 270(12):6691-7 Matrix metalloproteinase 7 (matrilysin) from human rectal carcinoma cells. Activation of the precursor, interaction with other matrix metalloproteinases and enzymic properties.

EMBO J. 24(18):3235-46 Phosphorylation of EEA1 by p38 MAP kinase regulates mu opioid receptor endocytosis.

J. Biol. Chem. 274(45):32063-70 Identification of inhibitory autophosphorylation sites in casein kinase I epsilon.

Proceedings of the National Academy of Sciences of the United States of America 90(8):3675-9 Lipid modifications of G proteins: alpha subunits are palmitoylated.

J. Biol. Chem. 276(20):17347-53 The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity.

J. Biol. Chem. 276(37):34408-18 Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization.

J. Biol. Chem. 269(50):31869-80 The mechanism of inactivation of human factor V and human factor Va by activated protein C.

FEBS letters 434(1-2):155-9 Biosynthetic processing and quaternary interactions of proprotein convertase SPC4 (PACE4).

The Biochemical journal The two forms of bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase result from alternative splicing.

Biochemistry 27(12):4227-31 Human tissue factor contains thioester-linked palmitate and stearate on the cytoplasmic half-cystine.

The European journal of neuroscience 12(7):2224-34 Localization and targeting of SCG10 to the trans-Golgi apparatus and growth cone vesicles.

Cell 89(2):175-84 DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis.

J. Biol. Chem. 276(50):47733-41 Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation.

J. Biol. Chem. 280(14):13442-9 Distinct turnover of alternatively spliced isoforms of the RET kinase receptor mediated by differential recruitment of the Cbl ubiquitin ligase.

FEBS letters 257(1):101-4 Identification of sites on chromosomal protein HMG-I phosphorylated by casein kinase II.

Biochemistry 44(24):8841-9 Identification of tyrosine residues on ELMO1 that are phosphorylated by the Src-family kinase Hck.

J. Biol. Chem. 276(44):41049-58 Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2.

Biochem. Biophys. Res. Commun. 300(3):637-44 GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3.

Proceedings of the National Academy of Sciences of the United States of America 80(24):7395-9 cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure.

J. Biol. Chem. 277(16):13375-8 Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues.

Proceedings of the National Academy of Sciences of the United States of America 92(26):12338-42 Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region.

J. Biol. Chem. 269(3):1815-20 Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase.

J. Biol. Chem. 274(10):6536-45 Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals.

Proceedings of the National Academy of Sciences of the United States of America 98(7):3690-4 Akt phosphorylates and regulates the orphan nuclear receptor Nur77.

Proceedings of the National Academy of Sciences of the United States of America 95(9):5051-6 Activation of protein tyrosine kinase PYK2 by the m1 muscarinic acetylcholine receptor.

Oncogene 19(3):403-9 Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product.

J. Biol. Chem. 277(11):9415-21 Distinct residues in the carboxyl tail mediate agonist-induced desensitization and internalization of the human dopamine D1 receptor.

Biochem. Biophys. Res. Commun. 260(3):658-64 Casein kinase 2 binds to and phosphorylates BRCA1.

J. Biol. Chem. 271(10):5617-22 Requirements for calcium and calmodulin in the calmodulin kinase activation cascade.

Oncogene 22(30):4617-26 Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases.

J. Biol. Chem. 272(9):5915-20 Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes.

The Journal of cell biology 127(1):161-71 Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization.

"Science (New York, N.Y.)" 261(5129):1744-6 A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma.

J. Biol. Chem. 277(15):12838-45 Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability.

Nature 404(6779):778-82 NAK is an IkappaB kinase-activating kinase.

Nature 410(6830):842-7 The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis.

J. Biol. Chem. 277(40):37401-5 Structure of mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export.

Molecular and cellular endocrinology 113(1):99-108 The post-translational processing and intracellular sorting of carboxypeptidase H in the islets of Langerhans.

Nature cell biology 4(12):913-20 Interaction of FANCD2 and NBS1 in the DNA damage response.

J. Biol. Chem. 269(45):27791-4 Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family.

Nature methods 4(7):583-8 Determination of the sites of tyrosine O-sulfation in peptides and proteins.

FEBS letters 530(1-3):225-32 Beta-helical catalytic domains in glycoside hydrolase families 49, 55 and 87: domain architecture, modelling and assignment of catalytic residues.

The Journal of cell biology 149(3):603-12 Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis.

Molecular & cellular proteomics : MCP 5(1):97-113 Hyperphosphorylation of JNK-interacting protein 1, a protein associated with Alzheimer disease.

Molecular and cellular biology 24(24):10593-610 PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73.

J. Biol. Chem. 272(10):6752-9 Phosphorylation of a vesicular monoamine transporter by casein kinase II.

European journal of biochemistry 253(1):114-22 Delayed production of biologically active O-glycosylated forms of human eotaxin by tumor-necrosis-factor-alpha-stimulated dermal fibroblasts.

Current biology : CB 9(18):1057-60 Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation.

Biochem. Biophys. Res. Commun. 348(3):826-31 Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation.

Molecular and cellular endocrinology 160(1-2):157-63 Additional N-glycosylation at Asn(13) rescues the human LHbeta-subunit from disulfide-linked aggregation.

J. Biol. Chem. 276(45):41620-8 Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation.

Proceedings of the National Academy of Sciences of the United States of America 95(4):1432-7 RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1.

Molecular cell 10(6):1519-26 CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.

J. Biol. Chem. 280(27):25485-90 Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase.

American journal of physiology. Endocrinology and metabolism 284(5):E855-62 Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs.

American journal of physiology. Renal physiology 279(5):F793-801 Molecular and functional properties of two-pore-domain potassium channels.

Biochemistry 30(8):2204-16 Protein-induced inactivation and phosphorylation of rabbit muscle phosphofructokinase.

Biochem. Biophys. Res. Commun. 204(2):613-20 Matrilysin is much more efficient than other matrix metalloproteinases in the proteolytic inactivation of alpha 1-antitrypsin.

J. Biol. Chem. 275(31):23620-6 Deletion of the serotonin 5-HT2C receptor PDZ recognition motif prevents receptor phosphorylation and delays resensitization of receptor responses.

J. Biol. Chem. 277(23):20631-9 Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases: their implication in vascular endothelial growth factor gene transcription.

Nature 342(6246):189-92 Ionomycin-regulated phosphorylation of the myeloid calcium-binding protein p14.

J. Biol. Chem. 268(23):17309-16 Identification of the major phosphorylation sites of the Raf-1 kinase.

Molecular and cellular biology 20(22):8458-67 Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation.

Journal of molecular biology 317(4):577-89 The role of MeH73 in actin polymerization and ATP hydrolysis.

J. Biol. Chem. 273(13):7594-603 Protein kinase C-theta phosphorylation of moesin in the actin-binding sequence.

Oncogene 20(56):8075-84 Phosphorylation and structure-based functional studies reveal a positive and a negative role for the activation loop of the c-Abl tyrosine kinase.

J. Biol. Chem. 272(45):28328-34 Phosphorylation by neuronal cdc2-like protein kinase promotes dimerization of Tau protein in vitro.

Molecular and cellular biology 20(10):3558-67 Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression.

"Science (New York, N.Y.)" 281(5385):2042-5 Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.

The Biochemical journal 370(Pt 2):429-38 Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform.

J. Biol. Chem. 242(10):2333-42 The peptide chains of human plasmin. Mechanism of activation of human plasminogen to plasmin.

Biochemistry 35(12):3782-9 Phosphorylation of C8 and C9 subunits of the multicatalytic proteinase by casein kinase II and identification of the C8 phosphorylation sites by direct mutagenesis.

Proceedings of the National Academy of Sciences of the United States of America 95(20):11566-71 Proteolytic activation of PKN by caspase-3 or related protease during apoptosis.

J. Biol. Chem. 272(37):23340-6 Identification of the membrane receptor binding domain of thyroglobulin. Insights into quality control of thyroglobulin biosynthesis.

J. Biol. Chem. 274(15):10019-23 Macrophage metalloelastase, MMP-12, cleaves human apolipoprotein(a) in the linker region between kringles IV-4 and IV-5. Potential relevance to lipoprotein(a) biology.

EMBO J. 8(4):1111-9 Myc oncoproteins are phosphorylated by casein kinase II.

J. Biol. Chem. 275(43):33536-41 KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells.

J. Biol. Chem. 275(10):6945-55 SPACRCAN, a novel human interphotoreceptor matrix hyaluronan-binding proteoglycan synthesized by photoreceptors and pinealocytes.

J. Biol. Chem. 278(15):13265-70 Signaling between focal adhesion kinase and trio.

J. Biol. Chem. 277(16):14336-42 Peroxynitrite-induced nitration of tyrosine hydroxylase: identification of tyrosines 423, 428, and 432 as sites of modification by matrix-assisted laser desorption ionization time-of-flight mass spectrometry and tyrosine-scanning mutagenesis.

J. Biol. Chem. 267(20):14470-6 Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the beta 1, gamma 2S, and gamma 2L subunits of the gamma-aminobutyric acid type A receptor.

Molecular & cellular proteomics : MCP 4(9):1240-50 Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.

Biochem. Biophys. Res. Commun. 259(3):533-8 Identification and characterization of a myristylated and palmitylated serine/threonine protein kinase.

J. Biol. Chem. 276(40):37556-63 DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor.

Human molecular genetics 11(15):1687-96 PTEN blocks insulin-mediated ETS-2 phosphorylation through MAP kinase, independently of the phosphoinositide 3-kinase pathway.

Blood 96(8):2673-81 Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact.

J. Biol. Chem. 279(28):29409-17 Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation.

J. Biol. Chem. 277(8):6399-405 Identification of a novel phosphorylation site, Ser-170, as a regulator of bad pro-apoptotic activity.

Journal of proteome research 3(6):1219-27 Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry.

EMBO J. 24(22):3869-80 Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCtheta in T lymphocytes.

FEBS letters 449(2-3):101-4 Cysteine 29 is the major palmitoylation site on stomatin.

FEBS letters 352(3):389-92 Identification of serines-1035/1037 in the kinase domain of the insulin receptor as protein kinase C alpha mediated phosphorylation sites.

J. Biol. Chem. 280(12):11869-75 CK2 phosphorylates SSRP1 and inhibits its DNA-binding activity.

J. Biol. Chem. 281(20):14288-95 Posttranslational N-myristoylation is required for the anti-apoptotic activity of human tGelsolin, the C-terminal caspase cleavage product of human gelsolin.

Proceedings of the National Academy of Sciences of the United States of America 103(49):18562-7 Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology.

The Biochemical journal 374(Pt 1):199-206 Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization.

Proceedings of the National Academy of Sciences of the United States of America 99(19):12114-9 Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleus.

EMBO J. 20(14):3800-10 Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1.

The Journal of cell biology 134(3):771-82 Identification of stromal cell products that interact with pre-B cells.

J. Biol. Chem. 272(28):17565-73 Stress, apoptosis, and mitosis induce phosphorylation of human keratin 8 at Ser-73 in tissues and cultured cells.

The Biochemical journal 380(Pt 3):939-49 The T-cell protein tyrosine phosphatase is phosphorylated on Ser-304 by cyclin-dependent protein kinases in mitosis.

International journal of oncology 19(6):1117-26 FAS-associated factor 1 interacts with protein kinase CK2 in vivo upon apoptosis induction.

J. Biol. Chem. 270(3):1130-7 Phosphorylation of the N-formyl peptide receptor carboxyl terminus by the G protein-coupled receptor kinase, GRK2.

Molecular cell 6(1):41-51 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation.

American journal of hematology 54(1):1-11 Lineage- and differentiation stage-specific expression of LSM-1 (LPAP), a possible substrate for CD45, in human hematopoietic cells.

J. Biol. Chem. 276(35):32875-82 Interaction of farnesylated PRL-2, a protein-tyrosine phosphatase, with the beta-subunit of geranylgeranyltransferase II.

The Biochemical journal The m3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase.

J. Biol. Chem. 272(24):15113-9 Regulation of platelet plasma membrane Ca2+-ATPase by cAMP-dependent and tyrosine phosphorylation.

J. Biol. Chem. 274(44):31341-8 Serine 19 of human 6-pyruvoyltetrahydropterin synthase is phosphorylated by cGMP protein kinase II.

J. Biol. Chem. 272(49):31051-7 Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1.

EMBO J. 22(13):3291-302 Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins.

Nature cell biology 9(6):683-90 Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair.

EMBO J. 22(24):6505-15 Growth inhibition by the mammalian SWI-SNF subunit Brm is regulated by acetylation.

Molecular and cellular biology 20(14):5010-8 Phosphorylation of the PTEN tail regulates protein stability and function.

Biochemistry and molecular biology international 32(2):349-57 The amino acid sequence and phosphorylation sites of a boar transition protein 1.

J. Biol. Chem. 278(15):12696-702 Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity.

Acta neurochirurgica 31(3-4):273 Proceedings: Aneurysmal bone cysts of the spine.

J. Biol. Chem. 277(7):5596-602 Biosynthetic processing of the pro-alpha 1(V)2pro-alpha 2(V) collagen heterotrimer by bone morphogenetic protein-1 and furin-like proprotein convertases.

Neurobiology of disease 8(1):162-72 Proapoptotic effects of tau cleavage product generated by caspase-3.

Biochemistry 39(35):10812-22 Proteolysis of the exodomain of recombinant protease-activated receptors: prediction of receptor activation or inactivation by MALDI mass spectrometry.

Molecular cell 8(5):995-1004 Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein.

J. Biol. Chem. 278(52):52154-65 Constitutively active Galpha16 stimulates STAT3 via a c-Src/JAK- and ERK-dependent mechanism.

Oncogene 23(42):7067-75 Regulation of caspase-6 and FLIP by the AMPK family member ARK5.

EMBO J. 15(17):4629-42 FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2.

Molecular cell 8(3):601-11 Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8.

J. Biol. Chem. 266(1):391-8 Phosphorylation of cardiac and skeletal muscle calsequestrin isoforms by casein kinase II. Demonstration of a cluster of unique rapidly phosphorylated sites in cardiac calsequestrin.

Biochem. Biophys. Res. Commun. 293(4):1191-6 Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction.

J. Biol. Chem. 279(34):35726-34 B23/nucleophosmin serine 4 phosphorylation mediates mitotic functions of polo-like kinase 1.

J. Biol. Chem. 267(15):10856-65 Sequencing, cloning, and expression of human red cell-type acid phosphatase, a cytoplasmic phosphotyrosyl protein phosphatase.

J. Biol. Chem. 274(45):32127-36 Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers.

J. Biol. Chem. 261(29):13542-5 Nonenzymatic glycosylation of albumin in vivo. Identification of multiple glycosylated sites.

Biochemistry 40(34):10243-53 Mechanistic effects of autophosphorylation on receptor tyrosine kinase catalysis: enzymatic characterization of Tie2 and phospho-Tie2.

Biochemistry 12(14):2711-24 Structure of 1 -acid glycoprotein. The complete amino acid sequence, multiple amino acid substitutions, and homology with the immunoglobulins.

J. Biol. Chem. 272(17):11079-87 Polymorphonuclear cells isolated from human peripheral blood cleave lipoprotein(a) and apolipoprotein(a) at multiple interkringle sites via the enzyme elastase. Generation of mini-Lp(a) particles and apo(a) fragments.

Molecular cell 4(5):725-34 Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program.

Journal of cell science 116(Pt 20):4169-79 The UIM domain of Hrs couples receptor sorting to vesicle formation.

EMBO J. 20(10):2487-96 Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.

FEBS letters 267(2):181-2 Two phosphorylation sites on eIF-2 alpha.

Genome research 26(11):1453-1467 Interchromosomal core duplicons drive both evolutionary instability and disease susceptibility of the Chromosome 8p23.1 region.

Biochem. Biophys. Res. Commun. 284(3):836-44 Identification of a novel phosphorylation site in human androgen receptor by mass spectrometry.

FEBS letters 499(1-2):127-32 Proposed lipocalin fold for apolipoprotein M based on bioinformatics and site-directed mutagenesis.

J. Biol. Chem. 272(45):28712-9 Characterization of the phosphorylation sites involved in G protein-coupled receptor kinase- and protein kinase C-mediated desensitization of the alpha1B-adrenergic receptor.

J. Biol. Chem. 277(46):44278-84 Protein kinase C (PKC)-induced phosphorylation of ROMK1 is essential for the surface expression of ROMK1 channels.

Molecular and cellular biology 23(7):2287-97 p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction.

Proceedings of the National Academy of Sciences of the United States of America 99(9):5971-6 Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma.

J. Biol. Chem. 267(13):9059-64 GAP-43, a protein associated with axon growth, is phosphorylated at three sites in cultured neurons and rat brain.

J. Biol. Chem. 277(7):5094-100 Different domains of the mitogen-activated protein kinases ERK3 and ERK2 direct subcellular localization and upstream specificity in vivo.

European journal of cell biology 62(2):237-47 Functional analysis of phosphorylation sites in human lamin A controlling lamin disassembly, nuclear transport and assembly.

Cancer cell 10(1):25-38 HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors.

J. Biol. Chem. 279(16):15805-13 A novel proteomic approach for specific identification of tyrosine kinase substrates using [13C]tyrosine.

European journal of biochemistry 269(3):977-88 Tyrosine sulfation and N-glycosylation of human heparin cofactor II from plasma and recombinant Chinese hamster ovary cells and their effects on heparin binding.

Proceedings of the National Academy of Sciences of the United States of America 100(2):443-8 Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.

J. Biol. Chem. 265(25):14971-8 Substrate- and kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMP.

Biosci. Biotechnol. Biochem. 62(8):1612-4 Effects of glycosylation of the residue at position 14 in ovine angiotensinogen on the human renin reaction.

Nature structural biology 8(7):593-6 Structure of GSK3beta reveals a primed phosphorylation mechanism.

Molecular biology of the cell 14(2):600-10 Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexes.

J. Biol. Chem. 277(18):16229-40 Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2.

J. Biol. Chem. 275(52):41201-9 p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).

Nature 414(6866):865-71 The DNA sequence and comparative analysis of human chromosome 20.

Molecular biology of the cell 12(1):1-12 Serine phosphorylation of focal adhesion kinase in interphase and mitosis: a possible role in modulating binding to p130(Cas).

FEBS letters 535(1-3):82-6 Ezrin is a substrate for Lck in T cells.

J. Biol. Chem. 277(47):45680-7 Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain.

Journal of neurochemistry 72(2):614-24 Differential phosphorylation of syntaxin and synaptosome-associated protein of 25 kDa (SNAP-25) isoforms.

The Journal of cell biology 149(7):1503-12 Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication.

Oncogene 9(5):1437-46 Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity.

Brain research. Molecular brain research 87(1):12-21 Influence of the somatostatin receptor sst2 on growth factor signal cascades in human glioma cells.

J. Biol. Chem. 269(16):11691-4 Identification of covalently bound amino-terminal myristic acid in endothelial nitric oxide synthase.

Molecular cell 11(5):1389-96 Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding.

Molecular and cellular biology 21(3):743-54 The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.

J. Biol. Chem. 275(14):10342-8 Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity.

J. Biol. Chem. 270(45):27213-21 Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif.

European journal of biochemistry 217(2):715-22 Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2.

Proceedings of the National Academy of Sciences of the United States of America 81(7):2021-5 Structure of human hemopexin: O-glycosyl and N-glycosyl sites and unusual clustering of tryptophan residues.

J. Biol. Chem. 269(47):29367-70 Regulation of p68 RNA helicase by calmodulin and protein kinase C.

J. Biol. Chem. 273(38):24839-46 Phosphotyrosine 1173 mediates binding of the protein-tyrosine phosphatase SHP-1 to the epidermal growth factor receptor and attenuation of receptor signaling.

Methods in enzymology Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulations.

J. Biol. Chem. 276(35):32828-34 Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10).

Molecular human reproduction 7(9):811-8 Expression and function of the HSD-3.8 gene encoding a testis-specific protein.

Microscopy research and technique 57(1):14-22 Functional interaction of G protein-coupled receptors of the adrenomedullin peptide family with accessory receptor-activity-modifying proteins (RAMP).

European journal of biochemistry 260(2):384-91 Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb.

Molecular and cellular biology 16(9):4735-43 In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation.

Molecular and cellular biology 20(14):5285-99 The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR.

FEBS letters 521(1-3):190-4 Activation of Pyk2/RAFTK induces tyrosine phosphorylation of alpha-synuclein via Src-family kinases.

Molecular and cellular biology 19(7):4819-24 Tyrosine phosphorylation of the proto-oncoprotein Raf-1 is regulated by Raf-1 itself and the phosphatase Cdc25A.

Human molecular genetics 10(3):179-88 Congenital insensitivity to pain with anhidrosis (CIPA): effect of TRKA (NTRK1) missense mutations on autophosphorylation of the receptor tyrosine kinase for nerve growth factor.

Molecular and cellular biology 19(2):1202-9 p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage.

J. Biol. Chem. 279(21):21866-72 Phosphorylation of histone H2A inhibits transcription on chromatin templates.

J. Biol. Chem. 271(47):30077-82 Threonine 1342 in human topoisomerase IIalpha is phosphorylated throughout the cell cycle.

Endocrine reviews 20(2):189-206 The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family.

Molecular and cellular biology 22(17):6209-21 Plk phosphorylation regulates the microtubule-stabilizing protein TCTP.

Nature 399(6738):814-7 p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage.

Cell 111(5):709-20 Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation.

J. Biol. Chem. 275(16):11610-7 Phosphorylation of dynamin I on Ser-795 by protein kinase C blocks its association with phospholipids.

J. Biol. Chem. 276(45):42070-6 G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2.

Biochem. Biophys. Res. Commun. 299(5):880-5 Identification and characterization of P15RS, a novel P15(INK4b) related gene on G1/S progression.

J. Biol. Chem. 277(45):42987-96 Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation.

EMBO J. 14(9):1878-91 Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle.

J. Biol. Chem. 278(11):9019-26 Phosphorylation of tyrosine 319 of the angiotensin II type 1 receptor mediates angiotensin II-induced trans-activation of the epidermal growth factor receptor.

J. Biol. Chem. 278(13):11221-6 Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition.

Life sciences 72(7):747-57 Biosynthesis and processing of pro CCK: recent progress and future challenges.

Chemistry 7(5):1129-32 Chemical synthesis of lymphotactin: a glycosylated chemokine with a C-terminal mucin-like domain.

Journal of neurochemistry 68(5):2129-39 The neuronal calcium-sensor protein VILIP modulates cyclic AMP accumulation in stably transfected C6 glioma cells: amino-terminal myristoylation determines functional activity.

Cell 127(3):635-48 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

J. Biol. Chem. 270(21):12665-9 Components of a new human protein kinase signal transduction pathway.

Nature cell biology 5(8):701-10 Cdk5 is essential for synaptic vesicle endocytosis.

Progress in brain research Molecular pharmacology and modeling of vasopressin receptors.

J. Biol. Chem. 269(2):944-54 Molecular mechanism of the synergistic phosphorylation of phosphatase inhibitor-2. Cloning, expression, and site-directed mutagenesis of inhibitor-2.

Current biology : CB 12(6):446-53 The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3.

FEBS letters 230(1-2):1-5 Two adjacent cysteine residues in the C-terminal cytoplasmic fragment of bovine rhodopsin are palmitylated.

J. Biol. Chem. 277(44):41361-8 Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase.

Molecular and cellular biology 19(3):2180-8 Activation of IkappaB kinase beta by protein kinase C isoforms.

Cell 129(5):915-28 L3MBTL1, a histone-methylation-dependent chromatin lock.

J. Biol. Chem. 275(40):30996-1000 The low pH in trans-Golgi triggers autocatalytic cleavage of pre-alpha -inhibitor heavy chain precursor.

The Biochemical journal 347(Pt 2):501-9 The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells.

Journal of chromatography. B, Biomedical sciences and applications 759(1):1-15 Characterization of glycated hemoglobin in diabetic patients: usefulness of electrospray mass spectrometry in monitoring the extent and distribution of glycation.

The Biochemical journal 368(Pt 3):939-45 Differential targeting of the stress mitogen-activated protein kinases to the c-Jun dimerization protein 2.

FEBS letters 570(1-3):133-7 Calcium/calmodulin-dependent protein kinase I inhibits neuronal nitric-oxide synthase activity through serine 741 phosphorylation.

FEBS letters 579(25):5473-80 HIPK2 inhibits both MDM2 gene and protein by, respectively, p53-dependent and independent regulations.

EMBO J. 14(23):5920-30 Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2.

Oncogene 23(20):3580-8 Phosphorylation of p53 on Thr55 by ERK2 is necessary for doxorubicin-induced p53 activation and cell death.

Biulleten' eksperimental'noi biologii i meditsiny 82(8):961-2 [Study of the heterogenetic antigens in vaccinal preparations of V. cholerae].

Molecular cancer research : MCR 5(4):393-401 Growth stimulation of non-small cell lung cancer cell lines by antibody against epidermal growth factor receptor promoting formation of ErbB2/ErbB3 heterodimers.

Cell 101(4):365-76 PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.

EMBO J. 23(24):4835-46 Phosphorylation of XPB helicase regulates TFIIH nucleotide excision repair activity.

Molecular & cellular proteomics : MCP 3(11):1093-101 Phosphoproteomic analysis of the developing mouse brain.

Molecular and cellular biology 22(11):3717-28 Cyclic AMP blocks cell growth through Raf-1-dependent and Raf-1-independent mechanisms.

The Biochemical journal 355(Pt 3):609-15 The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase.

Molecular biology of the cell 13(12):4497-507 Calcium regulation of GM-CSF by calmodulin-dependent kinase II phosphorylation of Ets1.

Cell 30(1):153-61 Alpha chain of HLA-DR transplantation antigens is a member of the same protein superfamily as the immunoglobulins.

EMBO J. 17(7):1892-906 Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins.

J. Biol. Chem. 279(16):15719-22 Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status.

The Biochemical journal Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1.

Oncogene 8(1):117-24 Phosphorylation of Src mutants at Tyr 527 in fibroblasts does not correlate with in vitro phosphorylation by CSK.

Proceedings of the National Academy of Sciences of the United States of America 100(8):4574-9 Processing, localization, and requirement of human separase for normal anaphase progression.

Journal of molecular biology 355(3):590-603 Phosphorylation on Ser106 modulates the cellular functions of the SHOX homeodomain protein.

Oncogene 14(18):2175-88 ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

"Science (New York, N.Y.)" 284(5412):309-13 Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.

Genes & development 17(24):3048-61 SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression.

J. Biol. Chem. 275(7):4897-905 Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha.

Biochemistry 40(14):4372-80 Posttranslational modifications of microfibril associated glycoprotein-1 (MAGP-1).

J. Biol. Chem. 275(20):14992-9 Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding.

Circulation research 92(4):411-8 Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle.

Rapid communications in mass spectrometry : RCM 19(1):57-71 Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites.

J. Biol. Chem. 268(24):18157-66 Phosphorylation of the insulin receptor substrate IRS-1 by casein kinase II.

J. Biol. Chem. 277(42):40020-6 Sumoylation of topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecin.

Cancer cell 10(6):473-86 Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint.

Molecular endocrinology (Baltimore, Md.) 9(1):24-33 Phosphorylation of the human estrogen receptor on tyrosine 537 in vivo and by src family tyrosine kinases in vitro.

Molecular cell 7(2):355-65 RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation.

J. Biol. Chem. 275(40):30901-6 Threonine phosphorylation of the beta 3 integrin cytoplasmic tail, at a site recognized by PDK1 and Akt/PKB in vitro, regulates Shc binding.

EMBO J. 20(15):4132-42 Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads.

J. Biol. Chem. 276(31):28984-90 c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1.

Biochemistry 44(24):8890-7 Phosphorylation of Grb10 by mitogen-activated protein kinase: identification of Ser150 and Ser476 of human Grb10zeta as major phosphorylation sites.

J. Biol. Chem. 277(5):3286-92 Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest.

J. Biol. Chem. 261(21):9591-4 Human preproapolipoprotein C-II. Analysis of major plasma isoforms.

The Biochemical journal Mechanisms of platelet activation by a stimulatory antibody: cross-linking of a novel platelet receptor for monoclonal antibody F11 with the Fc gamma RII receptor.

Cancer research 64(19):7156-68 Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence.

British journal of cancer 87(6):645-53 Biological activity of the thyroid TRK-T3 oncogene requires signalling through Shc.

J. Biol. Chem. 271(15):8951-8 ERK3 is a constitutively nuclear protein kinase.

J. Biol. Chem. 280(21):20793-803 Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of TRPM7/ChaK1.

Oncogene 19(22):2664-77 Interaction between protein tyrosine phosphatase and protein tyrosine kinase is involved in androgen-promoted growth of human prostate cancer cells.

Molecular cell 8(3):693-704 Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis.

Oncogene 21(16):2555-63 Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain.

Zoological science 22(2):169-75 Receptor-type protein tyrosine phosphatase epsilon (PTPepsilonM) is a negative regulator of insulin signaling in primary hepatocytes and liver.

J. Biol. Chem. 270(13):7773-81 Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors.

Molecular and cellular biology 22(19):6719-25 Cdc42/Rac1-mediated activation primes PAK2 for superactivation by tyrosine phosphorylation.

Molecular and cellular biology 15(1):505-16 Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27.

J. Biol. Chem. 272(20):13255-61 Contraction-induced changes in acetyl-CoA carboxylase and 5'-AMP-activated kinase in skeletal muscle.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 16(9):983-92 N-glycans of sphingosine 1-phosphate receptor Edg-1 regulate ligand-induced receptor internalization.

EMBO J. 18(11):3024-33 Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway.

J. Biol. Chem. 277(18):15499-506 Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function betwenn LRP and the PDGF.

J. Biol. Chem. 276(45):41898-905 DNA damage-dependent and -independent phosphorylation of the hRad9 checkpoint protein.

"Science (New York, N.Y.)" 295(5556):858-61 Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch.

Biochem. Biophys. Res. Commun. 223(3):539-43 Proadrenomedullin N-terminal 20 peptide is rapidly cleaved by neutral endopeptidase.

J. Biol. Chem. 275(49):38885-90 Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites.

FEBS letters 571(1-3):74-80 hOLF44, a secreted glycoprotein with distinct expression pattern, belongs to an uncharacterized olfactomedin-like subfamily newly identified by phylogenetic analysis.

Molecular and cellular biology 23(19):6922-35 Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms.

Carcinogenesis 25(7):1165-75 Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1.

J. Biol. Chem. 272(45):28557-62 Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein.

Cell 120(1):137-49 GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity.

Molecular cell 15(4):511-21 Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation.

Molecular and cellular biology 25(2):819-29 Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP.

J. Biol. Chem. 279(36):37282-90 Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase.

J. Biol. Chem. 278(20):17969-76 Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation.

J. Biol. Chem. 276(16):12660-6 Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor.

J. Biol. Chem. 278(9):7240-6 Sialic acid capping of CD8beta core 1-O-glycans controls thymocyte-major histocompatibility complex class I interaction.

Nature immunology 4(2):106-8 Granzyme A: the road less traveled.

Oncogene 18(26):3919-22 Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma.

EMBO reports 3(3):268-73 PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays.

J. Biol. Chem. 278(13):11520-7 Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress.

Molecular biology of the cell 12(4):931-42 Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation.

J. Biol. Chem. 278(12):10588-93 Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1.

Oncogene 22(19):2897-909 ARHI is a Ras-related small G-protein with a novel N-terminal extension that inhibits growth of ovarian and breast cancers.

Biochem. Biophys. Res. Commun. 185(2):524-30 Phosphorylation of interleukin-6 at serine54: an early event in the secretory pathway in human fibroblasts.

J. Biol. Chem. 278(11):9441-7 Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA.

J. Biol. Chem. 278(21):18714-9 Activation of transforming growth factor-beta signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4.

Molecular and cellular biology 18(12):6951-61 Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity.

J. Biol. Chem. 269(41):25742-6 Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures.

J. Biol. Chem. 268(33):24808-12 The phosphorylation and DNA binding of the DNA-binding domain of the orphan nuclear receptor NGFI-B.

J. Biol. Chem. 277(49):47804-9 Unusual proteolytic activation of pro-hepatocyte growth factor by plasma kallikrein and coagulation factor XIa.

Biochem. Biophys. Res. Commun. 280(3):776-81 Frap-dependent serine phosphorylation of IRS-1 inhibits IRS-1 tyrosine phosphorylation.

The Biochemical journal Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo.

J. Biol. Chem. 276(44):41175-81 The fate of desmosomal proteins in apoptotic cells.

J. Biol. Chem. 268(15):11256-64 Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor.

J. Biol. Chem. 278(20):18682-8 Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activation.

EMBO J. 20(23):6712-23 Nuclear export of phosphorylated C/EBPbeta mediates the inhibition of albumin expression by TNF-alpha.

EMBO J. 21(14):3782-93 Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38.

Proceedings of the National Academy of Sciences of the United States of America 93(14):6898-901 The stress response to ionizing radiation involoves c-Abl-dependent phosphorylation of SHPTP1.

J. Biol. Chem. 268(25):18898-904 Myristoylation of hippocalcin is linked to its calcium-dependent membrane association properties.

Cell 119(4):517-28 Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases.

Journal of protein chemistry 22(2):177-81 Thr94 in bovine myelin basic protein is a second phosphorylation site for 42-kDa mitogen-activated protein kinase (ERK2).

Proceedings of the National Academy of Sciences of the United States of America 94(2):604-9 BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement.

J. Biol. Chem. 276(31):28676-85 The cytoskeletal/non-muscle isoform of alpha-actinin is phosphorylated on its actin-binding domain by the focal adhesion kinase.

Biochem. Biophys. Res. Commun. 333(3):818-26 Phosphorylation and binding partner analysis of the TSC1-TSC2 complex.

FEBS letters 580(27):6405-12 Regulation of RKIP binding to the N-region of the Raf-1 kinase.

The Biochemical journal The principal site of glycation of human complement factor B.

J. Biol. Chem. 270(16):9437-42 The role of N-glycosylation in the targeting and activity of the GLYT1 glycine transporter.

J. Biol. Chem. 280(28):26233-40 Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells.

Journal of cell science Ubiquitin-activating enzyme, E1, is phosphorylated in mammalian cells by the protein kinase Cdc2.

J. Biol. Chem. 271(30):17896-902 An activated epidermal growth factor receptor/Lck chimera restores early T cell receptor-mediated calcium response in a CD45-deficient T cell line.

J. Biol. Chem. 272(44):27678-85 TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling.

Biochemistry 40(6):1671-8 Human recombinant pro-dipeptidyl peptidase I (cathepsin C) can be activated by cathepsins L and S but not by autocatalytic processing.

Nature 409(6818):349-54 CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling.

J. Biol. Chem. 279(31):32586-91 VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX.

J. Biol. Chem. 269(8):5989-6000 Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis.

J. Biol. Chem. 276(4):2459-65 Domain-dependent function of the rasGAP-binding protein p62Dok in cell signaling.

J. Biol. Chem. 278(51):51957-67 Identification and characterization of GCP16, a novel acylated Golgi protein that interacts with GCP170.

Proceedings of the National Academy of Sciences of the United States of America 98(13):7218-23 Mutations within a furin consensus sequence block proteolytic release of ectodysplasin-A and cause X-linked hypohidrotic ectodermal dysplasia.

Proceedings of the National Academy of Sciences of the United States of America 97(4):1456-60 Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein.

The Biochemical journal LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo.

The Journal of cell biology 149(6):1193-206 Relationship between contact inhibition and intranuclear S100C of normal human fibroblasts.

J. Biol. Chem. 276(26):24422-31 Inhibition of the catalytic activity of cell adhesion kinase beta by protein-tyrosine phosphatase-PEST-mediated dephosphorylation.

J. Biol. Chem. 274(43):31055-61 Serine phosphorylation and negative regulation of Stat3 by JNK.

The Biochemical journal Palmitoylation of the recombinant human A1 adenosine receptor: enhanced proteolysis of palmitoylation-deficient mutant receptors.

J. Biol. Chem. 276(44):40903-9 Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding.

Molecular and cellular biology 25(16):7092-106 WW domains provide a platform for the assembly of multiprotein networks.

Nature genetics 32(2):235-6 Facioscapulohumeral muscular dystrophy is uniquely associated with one of the two variants of the 4q subtelomere.

J. Biol. Chem. 266(14):9078-85 Protein kinase C phosphorylates the carboxyl terminus of the plasma membrane Ca(2+)-ATPase from human erythrocytes.

Molecular cell 4(6):1029-40 Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1.

Molecular and cellular biology 21(3):893-901 Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1.

"Science (New York, N.Y.)" 283(5410):2083-5 Inhibition of myosin light chain kinase by p21-activated kinase.

Biochem. Biophys. Res. Commun. 299(5):857-62 Characterization of the cysteine-rich calcium-binding S100A3 protein from human hair cuticles.

The Biochemical journal Complex formation between deoxyhypusine synthase and its protein substrate, the eukaryotic translation initiation factor 5A (eIF5A) precursor.

J. Biol. Chem. 272(21):13489-95 Casein kinase II-mediated phosphorylation of the C terminus of Sp1 decreases its DNA binding activity.

J. Biol. Chem. 268(6):4530-3 Identification of 40 S ribosomal protein S6 phosphorylation sites in Swiss mouse 3T3 fibroblasts stimulated with serum.

Journal of cell science 115(Pt 24):4743-53 Protein kinase CKII regulates the interaction of beta-catenin with alpha-catenin and its protein stability.

Molecular and cellular biology 23(13):4511-21 Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action.

J. Biol. Chem. 273(33):20996-1002 Mutation of a Shc binding site tyrosine residue in ErbB3/HER3 blocks heregulin-dependent activation of mitogen-activated protein kinase.

FEBS letters 528(1-3):246-50 Anaphase specific auto-cleavage of separase.

Biochem. Biophys. Res. Commun. 296(4):870-6 Interaction of the developmental regulator SALL1 with UBE2I and SUMO-1.

J. Biol. Chem. 276(43):40268-73 Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis.

The Biochemical journal Characterization of iduronate sulphatase mutants affecting N-glycosylation sites and the cysteine-84 residue.

Molecular and cellular endocrinology 175(1-2):185-91 Regulation of the ErbB3 binding protein Ebp1 by protein kinase C.

J. Biol. Chem. 275(15):11514-20 Acetylation of novel sites in the nucleosomal binding domain of chromosomal protein HMG-14 by p300 alters its interaction with nucleosomes.

Molecular and cellular biology 20(24):9391-8 Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination.

J. Biol. Chem. 279(15):14961-6 Role of glycosylation in the organic anion transporter OAT1.

Molecular and cellular biology 21(10):3387-97 JAK2 activates TFII-I and regulates its interaction with extracellular signal-regulated kinase.

J. Biol. Chem. 277(31):27839-49 Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo.

Nature 430(6996):226-31 Cyclin-dependent kinases regulate the antiproliferative function of Smads.

FEBS letters 580(26):6269-74 PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners.

Nature 424(6945):157-64 The DNA sequence of human chromosome 7.

Archives of biochemistry and biophysics 397(1):77-83 Release and degradation of angiotensin I and angiotensin II from angiotensinogen by neutrophil serine proteinases.

Developmental cell 5(1):33-43 Fertility and taxon-specific sperm binding persist after replacement of mouse sperm receptors with human homologs.

J. Biol. Chem. 275(24):18210-8 c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity.

FEBS letters 580(1):305-10 Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon.

J. Biol. Chem. 278(42):40815-28 Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints.

J. Biol. Chem. 271(42):26395-403 Beta1,4-N-acetylgalactosaminyltransferase (GM2 synthase) is released from Golgi membranes as a neuraminidase-sensitive, disulfide-bonded dimer by a cathepsin D-like protease.

The Biochemical journal PC8 [corrected], a new member of the convertase family.

Journal of immunology (Baltimore, Md. : 1950) 147(3):921-6 Proteolysis of C3 on U937 cell plasma membranes. Purification of cathepsin G.

Nature 405(6783):195-200 ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation.

J. Biol. Chem. 276(1):670-6 Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase.

Nucleic acids research 30(5):1154-62 Phosphorylation of mammalian translation initiation factor 5 (eIF5) in vitro and in vivo.

Molecular and cellular biology 23(14):5090-106 Cdk5 regulates the organization of Nestin and its association with p35.

The Biochemical journal Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor.

Nature 402(6762):669-71 Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons.

Molecular cell 6(6):1413-23 Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation.

J. Biol. Chem. 267(19):13593-7 Identification of palmitoylation sites on CD4, the human immunodeficiency virus receptor.

Annual review of genomics and human genetics Apolipoprotein E: far more than a lipid transport protein.

J. Biol. Chem. 252(16):5864-70 Effects of altered thyroid function on galactosyl diacylglycerol metabolism in myelinating rat brain.

FEBS letters 529(2-3):319-24 WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis.

Oncogene 16(20):2657-70 Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region.

BMC biochemistry The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site.

Oncogene 15(11):1247-53 Phosphorylation of the Src substrate Sam68 by Cdc2 during mitosis.

Biochim. Biophys. Acta 1175(2):193-206 Phosphorylation of serine 2843 in ryanodine receptor-calcium release channel of skeletal muscle by cAMP-, cGMP- and CaM-dependent protein kinase.

Genes & development 14(3):289-300 The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

J. Biol. Chem. 277(27):24220-4 Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP).

Molecular biology of the cell 10(11):3607-22 Mechanisms of G2 arrest in response to overexpression of p53.

J. Biol. Chem. 277(24):22093-102 Mitosis-specific activation of LIM motif-containing protein kinase and roles of cofilin phosphorylation and dephosphorylation in mitosis.

Nature cell biology 5(7):647-54 Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK.

EMBO J. 18(17):4766-78 NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes.

Molecular and cellular biology 23(17):6243-54 Acetylation-mediated transcriptional activation of the ETS protein ER81 by p300, P/CAF, and HER2/Neu.

Cancer cell 5(6):575-85 Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes.

Biochemistry 43(43):13694-706 Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27).

Molecular and cellular biology 14(3):1680-8 Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src.

J. Biol. Chem. 279(12):11354-63 Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response.

J. Biol. Chem. 262(35):16969-72 Glycation and inactivation of human Cu-Zn-superoxide dismutase. Identification of the in vitro glycated sites.

Nature cell biology 4(1):11-9 Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

J. Biol. Chem. 277(40):36955-61 A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta.

EMBO J. 20(16):4349-59 Eukaryotic initiation factor 2B: identification of multiple phosphorylation sites in the epsilon-subunit and their functions in vivo.

J. Biol. Chem. 277(41):38087-94 Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells.

J. Biol. Chem. 278(20):18617-27 Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide.

Molecular biology of the cell 11(2):721-34 Palmitoylation of apolipoprotein B is required for proper intracellular sorting and transport of cholesteroyl esters and triglycerides.

EMBO J. 25(6):1196-206 Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.

J. Biol. Chem. 270(35):20775-80 Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor.

J. Biol. Chem. 276(23):20774-80 Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplication.

Molecular & cellular proteomics : MCP 6(3):537-47 Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.

Proceedings of the National Academy of Sciences of the United States of America 93(5):2077-82 Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation.

J. Biol. Chem. 275(28):21099-106 Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties.

J. Biol. Chem. 276(26):24380-7 Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2.

Nature 439(7074):331-5 DNA sequence and analysis of human chromosome 8.

J. Biol. Chem. 272(16):10333-6 Phosphorylation of glial fibrillary acidic protein at the same sites by cleavage furrow kinase and Rho-associated kinase.

Proceedings of the National Academy of Sciences of the United States of America 95(22):12906-11 Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics.

J. Biol. Chem. 280(34):30175-84 Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels.

Molecular and cellular biology 15(2):954-63 Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases.

Proceedings of the National Academy of Sciences of the United States of America 101(13):4401-6 Functional association between Wwox tumor suppressor protein and p73, a p53 homolog.

Molecular and cellular biology 17(8):4509-16 Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling.

Molecular and cellular biology 20(21):8103-11 Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II.

Proceedings of the National Academy of Sciences of the United States of America 84(21):7518-22 Amino acid sequences surrounding the cAMP-dependent and calcium/calmodulin-dependent phosphorylation sites in rat and bovine synapsin I.

FEBS letters 478(1-2):173-7 Acylation of Galpha(13) is important for its interaction with thrombin receptor, transforming activity and actin stress fiber formation.

J. Biol. Chem. 276(19):16008-14 Identification of reelin-induced sites of tyrosyl phosphorylation on disabled 1.

J. Biol. Chem. 274(53):37538-43 Substrate specificities and identification of putative substrates of ATM kinase family members.

J. Biol. Chem. 281(35):25447-56 Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization.

Cell 96(6):857-68 Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.

J. Biol. Chem. 277(19):16837-46 Regulation of arrestin-3 phosphorylation by casein kinase II.

The Journal of neuroscience : the official journal of the Society for Neuroscience 22(12):4869-77 Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of Reelin signaling.

FEBS letters 550(1-3):57-63 Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells.

J. Biol. Chem. 267(27):19258-65 Identification of the two major epidermal growth factor-induced tyrosine phosphorylation sites in the microvillar core protein ezrin.

Nature 424(6951):965-9 Transcription factor IIB acetylates itself to regulate transcription.

Neuron 47(3):407-21 PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking.

Molecular and cellular biology 25(18):7988-8000 Epidermal growth factor-dependent phosphorylation of the GGA3 adaptor protein regulates its recruitment to membranes.

The Journal of cell biology 173(2):279-89 Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning.

EMBO J. 16(19):6008-17 Induced N- and C-terminal cleavage of p53: a core fragment of p53, generated by interaction with damaged DNA, promotes cleavage of the N-terminus of full-length p53, whereas ssDNA induces C-terminal cleavage of p53.

J. Biol. Chem. 272(15):10240-7 Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes.

J. Biol. Chem. 276(16):13248-55 Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity.

J. Biol. Chem. 274(49):34932-9 Balance between activities of Rho kinase and type 1 protein phosphatase modulates turnover of phosphorylation and dynamics of desmin/vimentin filaments.

Molecular and cellular biology 24(5):2190-201 Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase.

Journal of protein chemistry 22(3):249-58 Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

European journal of biochemistry 269(12):3076-85 Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors.

J. Biol. Chem. 277(41):38021-8 Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase.

J. Biol. Chem. 278(15):13278-85 Phosphorylation of the Ras-GRF1 exchange factor at Ser916/898 reveals activation of Ras signaling in the cerebral cortex.

Leukemia research 31(4):541-5 Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes.

Biochem. Biophys. Res. Commun. 288(1):233-9 Phosphorylation of human N-myristoyltransferase by N-myristoylated SRC family tyrosine kinase members.

J. Biol. Chem. 274(49):34663-8 Functional interaction between SHPTP1 and the Lyn tyrosine kinase in the apoptotic response to DNA damage.

European journal of biochemistry 236(2):548-57 A comparative study of the phosphotyrosyl phosphatase specificity of protein phosphatase type 2A and phosphotyrosyl phosphatase type 1B using phosphopeptides and the phosphoproteins p50/HS1, c-Fgr and Lyn.

EMBO J. 9(8):2439-46 Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver.

The Journal of cell biology 164(7):1009-20 YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta.

Biochem. Biophys. Res. Commun. 338(1):660-7 Phosphorylation inhibits DNA-binding of alternatively spliced aryl hydrocarbon receptor nuclear translocator.

J. Biol. Chem. 270(46):27758-65 Differential sensitivity of interleukin-1 alpha and -beta precursor proteins to cleavage by calpain, a calcium-dependent protease.

Cardiovascular research 45(4):941-51 Human connexin40 gap junction channels are modulated by cAMP.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 17(3-4):137-44 DOCA-induced phosphorylation of glycogen synthase kinase 3beta.

Neuron 40(1):129-37 Carbon monoxide neurotransmission activated by CK2 phosphorylation of heme oxygenase-2.

Biological chemistry 377(11):721-30 Functional analysis of phosphorylation at serine 532 of human c-Myb by MAP kinase.

J. Biol. Chem. 277(38):35561-6 The role of Asp-462 in regulating Akt activity.

Biochem. Biophys. Res. Commun. 283(3):715-20 Identification of MUC1 proteolytic cleavage sites in vivo.

J. Biol. Chem. 275(41):32289-98 Cell volume-dependent phosphorylation of proteins of the cortical cytoskeleton and cell-cell contact sites. The role of Fyn and FER kinases.

J. Biol. Chem. 276(52):48631-6 Double prenylation by RabGGTase can proceed without dissociation of the mono-prenylated intermediate.

Nucleic acids research 25(4):877-82 Phosphorylation of ATF-1 enhances its DNA binding and transcription of the Na,K-ATPase alpha 1 subunit gene promoter.

Genes & development 11(8):984-95 The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.

Molecular and cellular biology 20(10):3655-66 IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity.

Journal of immunology (Baltimore, Md. : 1950) 161(2):859-67 Regulation of apoptosis by tyrosine-containing domains of IL-4R alpha: Y497 and Y713, but not the STAT6-docking tyrosines, signal protection from apoptosis.

Archives of biochemistry and biophysics 337(2):143-8 Phosphorylation of growth factor receptor binding protein-2 by pp60c-src tyrosine kinase.

Neuron 26(3):633-46 Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth.

Biochemistry 38(32):10344-51 Phosphorylation and activation of phospholipase D1 by protein kinase C in vivo: determination of multiple phosphorylation sites.

The Biochemical journal 375(Pt 3):769-75 Allowed N-glycosylation sites on the Kv1.2 potassium channel S1-S2 linker: implications for linker secondary structure and the glycosylation effect on channel function.

J. Biol. Chem. 277(45):43327-34 Post-translational modification of bone morphogenetic protein-1 is required for secretion and stability of the protein.

Biochim. Biophys. Acta 1332(2):M53-63 Cdc25 protein phosphatases in cell proliferation.

J. Biol. Chem. 274(18):12626-31 Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition.

The Journal of cell biology 140(3):647-57 Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association.

Biological & pharmaceutical bulletin 25(6):718-21 Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site.

J. Biol. Chem. 275(48):37645-50 Inactivation of plasminogen activator inhibitor-1 by specific proteolysis with stromelysin-1 (MMP-3).

"Science (New York, N.Y.)" 296(5574):1886-9 Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.

EMBO reports 4(12):1182-9 AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1.

Current biology : CB 12(14):1251-5 Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1.

Biochem. Biophys. Res. Commun. 292(2):415-21 Revised structure of the active form of human deoxyribonuclease IIalpha.

J. Biol. Chem. 271(28):16897-905 Phosphorylation of purified bovine bone sialoprotein and osteopontin by protein kinases.

Biochem. Biophys. Res. Commun. 266(1):28-35 A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression.

Biochem. Biophys. Res. Commun. 295(2):495-500 Modification of Daxx by small ubiquitin-related modifier-1.

J. Biol. Chem. 277(24):21639-42 Identification of 14-3-3zeta as a protein kinase B/Akt substrate.

J. Biol. Chem. 269(44):27240-5 Identification of tyrosine 620 as the major phosphorylation site of myelin-associated glycoprotein and its implication in interacting with signaling molecules.

EMBO J. 17(15):4426-41 Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.

J. Biol. Chem. 278(7):5163-71 Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac.

Genes & development 15(9):1067-77 ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.

J. Biol. Chem. 277(33):29643-53 Role of MAP kinases in the 1,25-dihydroxyvitamin D3-induced transactivation of the rat cytochrome P450C24 (CYP24) promoter. Specific functions for ERK1/ERK2 and ERK5.

Molecular biology of the cell 9(7):1661-74 Tyrosine phosphorylation of selected secretory carrier membrane proteins, SCAMP1 and SCAMP3, and association with the EGF receptor.

FEBS letters 532(1-2):52-6 Differential phosphorylation of SNAP-25 in vivo by protein kinase C and protein kinase A.

J. Biol. Chem. 264(13):7564-9 Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor.

J. Biol. Chem. 274(52):37400-6 Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Thr-412 as well as Thr-252.

Biochem. Biophys. Res. Commun. 270(3):927-31 Phosphorylation of the 105-kDa heat shock proteins, HSP105alpha and HSP105beta, by casein kinase II.

Biochem. Biophys. Res. Commun. 284(4):880-6 Nuclear extracellular signal-regulated kinase 2 phosphorylates p53 at Thr55 in response to doxorubicin.

Journal of neurochemistry 73(4):1765-8 Phosphorylation of serine-880 in GluR2 by protein kinase C prevents its C terminus from binding with glutamate receptor-interacting protein.

The Journal of investigative dermatology 127(5):1094-106 The role of proline-rich protein tyrosine kinase 2 in differentiation-dependent signaling in human epidermal keratinocytes.

J. Biol. Chem. 271(6):3265-71 Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells.

Journal of immunology (Baltimore, Md. : 1950) 150(1):96-105 Insulin regulates serine/threonine phosphorylation in activated human B lymphocytes.

FEBS letters 579(20):4309-16 Endosomal proteolysis of insulin-like growth factor-I at its C-terminal D-domain by cathepsin B.

EMBO J. 25(21):5094-104 Suppression of receptor interacting protein 140 repressive activity by protein arginine methylation.

J. Biol. Chem. 270(5):2082-91 Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase.

Molecular and cellular biology 22(16):5962-74 Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription.

Journal of medicinal chemistry 48(3):671-9 Mechanism of CDK5/p25 binding by CDK inhibitors.

Current biology : CB 13(10):797-806 TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function.

J. Biol. Chem. 276(33):31449-58 Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells.

Oncogene 22(38):5927-37 Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1.

EMBO J. 16(21):6426-38 Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins.

Nature 411(6833):102-7 Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase.

Molecular & cellular proteomics : MCP 5(4):686-701 Identification of sites of mannose 6-phosphorylation on lysosomal proteins.

Proceedings of the National Academy of Sciences of the United States of America 101(33):12130-5 Large-scale characterization of HeLa cell nuclear phosphoproteins.

J. Biol. Chem. 275(1):390-7 Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein.

J. Biol. Chem. 276(51):47877-85 Phosphorylation of cysteine string protein by protein kinase A. Implications for the modulation of exocytosis.

The Biochemical journal Endogenous cleavage of the Arg-379-Ala-380 bond in vitronectin results in a distinct conformational change which 'buries' Ser-378, its site of phosphorylation by protein kinase A.

The Journal of cell biology 141(4):875-85 Nuclear localization of cyclin B1 controls mitotic entry after DNA damage.

J. Biol. Chem. 273(34):21834-45 A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein.

J. Biol. Chem. 269(41):25849-55 Hydrolytic inactivation of a breast carcinoma cell-derived serpin by human stromelysin-3.

J. Biol. Chem. 275(37):28569-74 Properdin, the positive regulator of complement, is highly C-mannosylated.

Nature 416(6876):103-7 Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9.

Endocrinology 139(4):1708-14 Insulin-like growth factor-binding protein-5 is cleaved by physiological concentrations of thrombin.

J. Biol. Chem. 276(11):8516-23 Insulin suppresses transactivation by CAAT/enhancer-binding proteins beta (C/EBPbeta). Signaling to p300/CREB-binding protein by protein kinase B disrupts interaction with the major activation domain of C/EBPbeta.

J. Biol. Chem. 273(51):34087-97 Phosphorylation and O-glycosylation sites of human chromogranin A (CGA79-439) from urine of patients with carcinoid tumors.

Nature 431(7006):268-74 The DNA sequence and comparative analysis of human chromosome 5.

J. Biol. Chem. 272(16):10506-13 A 180-kDa protein kinase seems to be responsible for the phosphorylation of prothymosin alpha observed in proliferating cells.

"Science (New York, N.Y.)" 286(5440):735-41 Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.

Molecular & cellular proteomics : MCP 2(1):29-36 Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry.

Journal of molecular biology 290(4):839-50 Serine 32 and serine 36 of IkappaBalpha are directly phosphorylated by protein kinase CKII in vitro.

Oncogene 14(22):2619-31 Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site.

"Science (New York, N.Y.)" 278(5336):294-8 Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis.

European journal of biochemistry 213(2):659-71 Identification of novel phosphorylation sites in murine A-type lamins.

Proceedings of the National Academy of Sciences of the United States of America 82(15):4910-4 Cloning and sequence analysis of cDNA for human cathepsin D.

Peptides 17(8):1323-30 Identification of the site of glycation of human insulin.

Oncogene 19(29):3309-20 Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4.

J. Biol. Chem. 273(45):29367-72 Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2.

J. Biol. Chem. 274(1):335-44 The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells.

Proceedings of the National Academy of Sciences of the United States of America 107(24):10848-53 High-resolution human genome structure by single-molecule analysis.

Oncogene 18(22):3334-42 Regulation and function of protein kinase B and MAP kinase activation by the IL-5/GM-CSF/IL-3 receptor.

Molecular and cellular biology 20(21):8026-34 ets-2 is a target for an akt (Protein kinase B)/jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice.

Nature cell biology 7(7):665-74 S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding.

J. Biol. Chem. 273(40):25628-36 Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2.

J. Biol. Chem. 278(31):28462-9 Phosphorylation of threonine 10 on CKBBP1/SAG/ROC2/Rbx2 by protein kinase CKII promotes the degradation of IkappaBalpha and p27Kip1.

J. Biol. Chem. 268(34):25780-9 A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential.

Experimental cell research 255(2):135-43 Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9.

The Journal of experimental medicine 192(10):1403-14 Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

Journal of biochemistry 127(6):965-70 Studies on the phosphorylation of protein kinase B by Ca(2+)/calmodulin-dependent protein kinases.

Journal of cell science Membrane localization and biological activity of SNAP-25 cysteine mutants in insulin-secreting cells.

Proceedings of the National Academy of Sciences of the United States of America 98(12):6587-92 Phosphorylation sites of protein kinase C delta in H2O2-treated cells and its activation by tyrosine kinase in vitro.

J. Biol. Chem. 278(32):29667-75 Catalase activity is regulated by c-Abl and Arg in the oxidative stress response.

J. Biol. Chem. 273(46):30218-24 Differential control of the phosphorylation state of proline-juxtaposed serine residues Ser725 of Stat5a and Ser730 of Stat5b in prolactin-sensitive cells.

Nature structural & molecular biology 14(6):564-7 FANCI is a second monoubiquitinated member of the Fanconi anemia pathway.

Archives of biochemistry and biophysics 304(1):65-73 Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2.

J. Biol. Chem. 275(36):28139-43 Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells.

J. Biol. Chem. 277(32):29304-14 Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites.

Archives of biochemistry and biophysics 381(2):302-12 Regulation of DNA binding activity of the ligand-activated aryl hydrocarbon receptor by tyrosine phosphorylation.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1(1):3-7 Identification of autophosphorylation sites of HER2/neu.

Molecular biology of the cell 14(8):3325-41 Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis.

Journal of neurochemistry 71(3):1307-14 Endothelin induces a calcium-dependent phosphorylation of PEA-15 in intact astrocytes: identification of Ser104 and Ser116 phosphorylated, respectively, by protein kinase C and calcium/calmodulin kinase II in vitro.

J. Biol. Chem. 277(33):29737-44 Human mannose 6-phosphate-uncovering enzyme is synthesized as a proenzyme that is activated by the endoprotease furin.

J. Biol. Chem. 280(47):39058-66 Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation.

EMBO J. 14(8):1785-97 ATF-2 contains a phosphorylation-dependent transcriptional activation domain.

Nature genetics 45(9):1083-7 Independent specialization of the human and mouse X chromosomes for the male germ line.

J. Biol. Chem. 276(16):12774-80 Phosphorylation of Ser363, Thr370, and Ser375 residues within the carboxyl tail differentially regulates mu-opioid receptor internalization.

J. Biol. Chem. 273(43):28478-85 Association of GAP-43 with detergent-resistant membranes requires two palmitoylated cysteine residues.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 16(8):825-32 Phosphorylation status modulates Bcl-2 function during glucocorticoid-induced apoptosis in T lymphocytes.

Biochem. Biophys. Res. Commun. 297(4):722-8 M6a acts as a nerve growth factor-gated Ca(2+) channel in neuronal differentiation.

J. Biol. Chem. 276(16):13372-8 Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4.

Nature reviews. Molecular cell biology 1(3):179-86 The many substrates and functions of ATM.

Proceedings of the National Academy of Sciences of the United States of America 101(34):12479-84 A tagging-via-substrate technology for detection and proteomics of farnesylated proteins.

J. Biol. Chem. 270(49):29469-75 Primary structure of a gamma subunit of G protein, gamma 12, and its phosphorylation by protein kinase C.

J. Biol. Chem. 262(3):1037-43 Characterization of pure human renal renin. Evidence for a subunit structure.

J. Biol. Chem. 274(19):13271-80 Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway.

Biochem. Biophys. Res. Commun. 281(2):499-505 Caspase-cleaved TRAF1 negatively regulates the antiapoptotic signals of TRAF2 during TNF-induced cell death.

Journal of neurochemistry 66(2):779-86 Casein kinase II phosphorylates the neural cell adhesion molecule L1.

The Biochemical journal 366(Pt 2):399-404 Inducible nitric oxide synthase (NOS2) expressed in septic patients is nitrated on selected tyrosine residues: implications for enzymic activity.

Molecular cell 11(4):1055-66 Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties.

J. Biol. Chem. 274(43):31108-13 Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase.

Glycobiology 11(7):549-56 Complete analysis of the glycosylation and disulfide bond pattern of human beta-hexosaminidase B by MALDI-MS.

J. Biol. Chem. 277(45):42769-74 Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription.

J. Biol. Chem. 277(13):11352-61 AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival.

FEBS letters 279(2):243-8 Phorbol-ester-induced phosphorylation of the beta 2-adrenergic receptor decreases its coupling to Gs.

EMBO J. 25(13):3045-55 Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling.

Molecular and cellular biology 18(4):2089-99 SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain.

Molecular and cellular biology 24(2):651-61 Phosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activity.

Nature genetics 45(4):406-14, 414e1-2 Using population admixture to help complete maps of the human genome.

J. Biol. Chem. 279(3):2005-11 PIASgamma represses the transcriptional activation induced by the nuclear receptor Nurr1.

FEBS letters 262(2):356-8 Fatty acid acylation of lens fiber plasma membrane proteins. MP26 and alpha-crystallin are palmitoylated.

Biochemistry 39(45):13825-30 Role of tyrosine sulfation and serine phosphorylation in the processing of procholecystokinin to amidated cholecystokinin and its secretion in transfected AtT-20 cells.

FEBS letters 577(1-2):270-6 A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein.

Proceedings of the National Academy of Sciences of the United States of America 93(15):7464-9 In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

J. Biol. Chem. 273(33):21261-6 Cytotoxic T lymphocyte-assisted suicide. Caspase 3 activation is primarily the result of the direct action of granzyme B.

Molecular & cellular proteomics : MCP 3(3):279-86 Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line.

FEBS letters 579(6):1534-8 Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB.

Cellular signalling 13(7):475-81 Membrane-targeting is critical for the phosphorylation of Vav2 by activated EGF receptor.

"Science (New York, N.Y.)" 285(5429):886-91 Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3.

Nature 402(6761):489-95 The DNA sequence of human chromosome 22.

Archives of biochemistry and biophysics 423(1):136-47 Alkylation of protein disulfide isomerase by the episulfonium ion derived from the glutathione conjugate of 1,2-dichloroethane and mass spectrometric characterization of the adducts.

Biochem. Biophys. Res. Commun. 299(3):510-5 Phosphorylation of Bruton's tyrosine kinase by c-Abl.

The Journal of experimental medicine 193(4):497-507 Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor.

Journal of oral surgery (American Dental Association : 1965) 33(8):619-21 Antibiotic treatment of oral anaerobic infections.

J. Biol. Chem. 277(45):42669-79 Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A.

Proceedings of the National Academy of Sciences of the United States of America 78(2):848-51 Complete amino acid sequence of the catalytic subunit of bovine cardiac muscle cyclic AMP-dependent protein kinase.

J. Biol. Chem. 269(27):18062-71 The functions of the human insulin receptor are affected in different ways by mutation of each of the four N-glycosylation sites in the beta subunit.

European journal of biochemistry 271(4):809-20 Nonlysine-analog plasminogen modulators promote autoproteolytic generation of plasmin(ogen) fragments with angiostatin-like activity.

J. Biol. Chem. 276(24):21529-37 Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication.

The FEBS journal 272(15):3767-76 BCR kinase phosphorylates 14-3-3 Tau on residue 233.

J. Biol. Chem. 274(47):33287-95 Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor.

J. Biol. Chem. 252(5):1689-95 Complete covalent structure of statherin, a tyrosine-rich acidic peptide which inhibits calcium phosphate precipitation from human parotid saliva.

Molecular and cellular biology 24(11):4968-78 Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling.

J. Biol. Chem. 280(11):9985-93 Human S-nitroso oxymyoglobin is a store of vasoactive nitric oxide.

European journal of immunology 31(6):1825-36 Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein).

J. Biol. Chem. 272(16):10957-67 Autophosphorylation of activation loop tyrosines regulates signaling by the TRK nerve growth factor receptor.

J. Biol. Chem. 281(7):3764-72 The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6.

Nature 434(7031):325-37 The DNA sequence of the human X chromosome.

European journal of biochemistry 271(13):2615-23 Tyrosine phosphorylation of calponins. Inhibition of the interaction with F-actin.

Biochem. Biophys. Res. Commun. 297(2):353-60 Tyrosine phosphorylation of clathrin heavy chain under oxidative stress.

Oncogene 17(24):3157-67 Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK).

European journal of biochemistry 267(19):5977-82 Caspase-3 mediated cleavage of HsRad51 at an unconventional site.

Nature 405(6784):311-9 The DNA sequence of human chromosome 21.

Biochem. Biophys. Res. Commun. 246(1):238-42 Multiple phosphorylation of chicken protein tyrosine phosphatase 1 and human protein tyrosine phosphatase 1B by casein kinase II and p60c-src in vitro.

Archives of biochemistry and biophysics 410(1):7-15 Mechanism of Janus kinase 3-catalyzed phosphorylation of a Janus kinase 1 activation loop peptide.

Oncogene 15(17):2001-12 Inhibition of the DNA-binding and transcriptional repression activity of the Wilms' tumor gene product, WT1, by cAMP-dependent protein kinase-mediated phosphorylation of Ser-365 and Ser-393 in the zinc finger domain.

Nature 426(6966):574-9 Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2.

J. Biol. Chem. 273(19):11728-36 Phosphorylation of vimentin by Rho-associated kinase at a unique amino-terminal site that is specifically phosphorylated during cytokinesis.

J. Biol. Chem. 272(9):5371-4 Regulation of the low molecular weight phosphotyrosine phosphatase by phosphorylation at tyrosines 131 and 132.

Oncogene 21(15):2357-64 Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity.

Genes & development 16(5):571-82 SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint.

Proceedings of the National Academy of Sciences of the United States of America 95(16):9319-24 MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta.

EMBO J. 17(12):3372-84 PRAK, a novel protein kinase regulated by the p38 MAP kinase.

EMBO J. 18(2):420-32 Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation.

J. Biol. Chem. 267(23):16100-5 Specific phosphorylation of a COOH-terminal site on the full-length form of the alpha 1 subunit of the skeletal muscle calcium channel by cAMP-dependent protein kinase.

J. Biol. Chem. 265(24):14264-9 Phosphate groups as substrate determinants for casein kinase I action.

J. Biol. Chem. 270(16):9378-83 Expression, refolding, and autocatalytic proteolytic processing of the interleukin-1 beta-converting enzyme precursor.

J. Biol. Chem. 272(52):32972-8 Properties and phosphorylation sites of baculovirus-expressed nuclear inhibitor of protein phosphatase-1 (NIPP-1).

J. Biol. Chem. 270(43):25872-8 Phosphorylation of casein kinase II by p34cdc2. Identification of phosphorylation sites using phosphorylation site mutants in vitro.

EMBO J. 26(6):1511-21 Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex.

Nature genetics 34(3):274-85 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome.

Biochemistry 38(32):10361-70 Identification of the sites phosphorylated by cyclic AMP-dependent protein kinase on the beta 2 subunit of L-type voltage-dependent calcium channels.

Proceedings of the National Academy of Sciences of the United States of America 86(16):6047-51 Molecular cloning and expression of cDNA encoding a lumenal calcium binding glycoprotein from sarcoplasmic reticulum.

J. Biol. Chem. 276(26):23805-15 Modulation of the G protein regulator phosducin by Ca2+/calmodulin-dependent protein kinase II phosphorylation and 14-3-3 protein binding.

Molecular biology of the cell 11(3):929-39 Caspase-mediated cleavage of p130cas in etoposide-induced apoptotic Rat-1 cells.

Nucleic acids research 26(16):3854-61 Casein kinase II interacts with the bZIP domains of several transcription factors.

Molecular and cellular biology 21(15):5169-78 Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin.

Genes & development 19(7):827-39 Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4.

Biochemistry 29(12):3126-33 Substrate specificity of recombinant human renal renin: effect of histidine in the P2 subsite on pH dependence.

J. Biol. Chem. 268(25):18626-32 Identification of phosphorylation sites in the recombinant catalytic subunit of cAMP-dependent protein kinase.

Biochem. Biophys. Res. Commun. 178(2):430-7 A synthetic peptide substrate for initiation factor-2 kinases.

FEBS letters 569(1-3):249-55 The phosphorylation status and anti-apoptotic activity of Bcl-2 are regulated by ERK and protein phosphatase 2A on the mitochondria.

J. Steroid Biochem. Mol. Biol. 52(2):135-40 Hormone-induced hyperphosphorylation of specific phosphorylated sites in the mouse glucocorticoid receptor.

J. Biol. Chem. 279(14):14213-24 Identification of RET autophosphorylation sites by mass spectrometry.

Biochem. Biophys. Res. Commun. 241(2):355-62 PDGF-induced phosphorylation of Tyr28 in the N-terminus of Fyn affects Fyn activation.

Thrombosis and haemostasis 85(3):470-4 The amino acid sequence in fibrin responsible for high affinity thrombin binding.

Cell 90(4):595-606 Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain.

J. Biol. Chem. 270(24):14297-304 Mutagenesis studies of the phosphorylation sites of recombinant human pyruvate dehydrogenase. Site-specific regulation.

J. Virol. 77(4):2359-68 Conserved protein kinases encoded by herpesviruses and cellular protein kinase cdc2 target the same phosphorylation site in eukaryotic elongation factor 1delta.

J. Biol. Chem. 263(33):17243-6 An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing.

"Science (New York, N.Y.)" 235(4795):1504-8 Human CSF-1: molecular cloning and expression of 4-kb cDNA encoding the human urinary protein.

Cell 104(5):731-41 Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription.

J. Biol. Chem. 266(35):23521-4 A phosphorylation site located in the NH2-terminal domain of c-Myc increases transactivation of gene expression.

The Journal of cell biology 125(4):803-15 Biogenesis and transmembrane topology of the CHIP28 water channel at the endoplasmic reticulum.

Nature 428(6982):522-8 The DNA sequence and analysis of human chromosome 13.

J. Biol. Chem. 272(16):10341-4 Identification of protein kinase C phosphorylation sites on bovine rhodopsin.

Diabetes 50(3):534-9 The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site.

The Biochemical journal 363(Pt 1):137-45 Glycosylation and epitope mapping of the 5T4 glycoprotein oncofoetal antigen.

J. Biol. Chem. 275(51):40620-7 Activation of atypical protein kinase C zeta by caspase processing and degradation by the ubiquitin-proteasome system.

EMBO J. 22(14):3514-23 14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase.

EMBO J. 25(21):5159-70 C-terminal phosphorylation controls the stability and function of p27kip1.

FEBS letters 530(1-3):209-14 Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta.

FEBS letters 579(3):683-9 Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation.

J. Biol. Chem. 273(13):7717-24 Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3.

J. Biol. Chem. 275(35):27165-71 Activation of Ca2+/calmodulin-dependent protein kinase II within post-synaptic dendritic spines of cultured hippocampal neurons.

J. Biol. Chem. 264(18):10828-35 Mechanism of phosphorylation of the epidermal growth factor receptor at threonine 669.

J. Biol. Chem. 275(6):3835-40 Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells.

Thrombosis research 99(4):399-406 alpha(2)-plasmin inhibitor is a substrate for tissue transglutaminase: an in vitro study.

Analytical chemistry 76(10):2763-72 Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

J. Biol. Chem. 274(29):20597-602 Regulation of neuronal nitric-oxide synthase by calmodulin kinases.

Biochem. Biophys. Res. Commun. 197(2):457-64 Identification of the glycosylated sequons of human myelin-associated glycoprotein.

J. Biol. Chem. 276(3):1938-44 The SH2 domain containing tyrosine phosphatase-1 down-regulates activation of Lyn and Lyn-induced tyrosine phosphorylation of the CD19 receptor in B cells.

EMBO J. 25(22):5317-28 Regulation of MBD1-mediated transcriptional repression by SUMO and PIAS proteins.

J. Biol. Chem. 267(6):3561-4 The cytoplasmic domain of tissue factor is phosphorylated by a protein kinase C-dependent mechanism.

Molecular and cellular biology 25(17):7412-22 Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation.

The Biochemical journal Matrix metalloproteinases cleave at two distinct sites on human cartilage link protein.

Biochemistry 38(43):14396-408 Multiple in vivo tyrosine phosphorylation sites in EphB receptors.

The Biochemical journal Effects of phosphorylation on function of the Rad GTPase.

J. Biol. Chem. 279(50):52714-25 Inhibition of gap junction activity through the release of the C1B domain of protein kinase Cgamma (PKCgamma) from 14-3-3: identification of PKCgamma-binding sites.

Proceedings of the National Academy of Sciences of the United States of America 98(20):11598-603 A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus.

J. Biol. Chem. 276(9):6061-4 The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin.

Oncogene 16(1):141-6 Requirement of two specific tyrosine residues for the catalytic activity of Bcr serine/threonine kinase.

The Journal of neuroscience : the official journal of the Society for Neuroscience 23(7):2527-37 Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin.

Endocrinology 138(9):3797-803 Proteolysis of insulin-like growth factors (IGF) and IGF binding proteins by cathepsin D.

J. Biol. Chem. 278(1):124-30 Protein kinase A-mediated phosphorylation of the Galpha13 switch I region alters the Galphabetagamma13-G protein-coupled receptor complex and inhibits Rho activation.

J. Biol. Chem. 276(36):33345-52 Cathepsin B, L, and S cleave and inactivate secretory leucoprotease inhibitor.

J. Biol. Chem. 275(48):37382-9 Cross-linking of wild-type and mutant alpha 2-antiplasmins to fibrin by activated factor XIII and by a tissue transglutaminase.

J. Biol. Chem. 281(29):20450-63 Reversible post-translational modification of proteins by nitrated fatty acids in vivo.

Thrombosis and haemostasis 76(5):780-5 Thrombin-activated human platelets release two NAP-2 variants that stimulate polymorphonuclear leukocytes.

J. Biol. Chem. 275(19):14615-23 Hck enhances the adherence of lipopolysaccharide-stimulated macrophages via Cbl and phosphatidylinositol 3-kinase.

Molecular and cellular biology 14(10):6715-26 Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation.

J. Biol. Chem. 273(33):21232-8 Role of N-glycosylation in human angiotensinogen.

FEBS letters 528(1-3):145-53 Direct identification of PTEN phosphorylation sites.

EMBO J. 16(8):1909-20 Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2.

Protein expression and purification 23(2):301-10 Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia pastoris and Chinese hamster ovary cells.

J. Biol. Chem. 276(50):46878-86 Identification of sequences within the gamma-carboxylase that represent a novel contact site with vitamin K-dependent proteins and that are required for activity.

EMBO reports 7(5):512-8 Interaction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptor.

Molecular and cellular biology 21(10):3314-24 Common properties of nuclear body protein SP100 and TIF1alpha chromatin factor: role of SUMO modification.

Oncogene 19(37):4290-7 SPAK, a STE20/SPS1-related kinase that activates the p38 pathway.

J. Biol. Chem. 264(22):13165-70 Molecular cloning and sequencing of the cDNA for human membrane-bound carboxypeptidase M. Comparison with carboxypeptidases A, B, H, and N.

Molecular biology of the cell 14(5):1882-99 Membrane targeting of Rab GTPases is influenced by the prenylation motif.

J. Biol. Chem. 272(7):4600-5 Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA.

Molecular and cellular biology 16(7):3361-9 Identification of a binding site in c-Ab1 tyrosine kinase for the C-terminal repeated domain of RNA polymerase II.

Glycobiology 13(2):73-85 The underglycosylation of plasma alpha 1-antitrypsin in congenital disorders of glycosylation type I is not random.

EMBO J. 25(17):3955-65 Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation.

J. Biol. Chem. 274(25):17771-6 Structure and function of human prepro-orexin gene.

J. Biol. Chem. 275(45):35491-8 Phosphorylation of protein kinase Cdelta on distinct tyrosine residues regulates specific cellular functions.

Proceedings of the National Academy of Sciences of the United States of America 84(24):9204-8 Cloning, sequence analysis, and expression of the large subunit of the human lymphocyte activation antigen 4F2.

FEBS letters 436(1):28-34 Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase.

J. Biol. Chem. 275(22):17122-9 The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies.

Oncogene 9(9):2589-95 In vitro phosphorylation of caveolin-rich membrane domains: identification of an associated serine kinase activity as a casein kinase II-like enzyme.

J. Biol. Chem. 277(33):29973-82 Inhibition of JNK by cellular stress- and tumor necrosis factor alpha-induced AKT2 through activation of the NF kappa B pathway in human epithelial Cells.

J. Biol. Chem. 265(25):15294-9 Cloning and sequencing of a human pancreatic tumor mucin cDNA.

Genomics 62(3):417-26 Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins.

J. Biol. Chem. 271(49):31562-71 Src phosphorylates the insulin-like growth factor type I receptor on the autophosphorylation sites. Requirement for transformation by src.

J. Biol. Chem. 270(9):4775-83 Post-translational processing of membrane-associated neu differentiation factor proisoforms expressed in mammalian cells.

EMBO J. 21(13):3443-53 Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK.

EMBO J. 24(14):2634-45 HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses.

Chemical reviews 101(8):2527-40 Glycogen synthase kinase-3: properties, functions, and regulation.

J. Biol. Chem. 274(51):36741-9 Phosphorylation of B-Myb regulates its transactivation potential and DNA binding.

Molecular and cellular biology 19(1):526-36 Identification of the in vivo casein kinase II phosphorylation site within the homeodomain of the cardiac tisue-specifying homeobox gene product Csx/Nkx2.5.

International immunology 11(8):1357-62 IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases.

The Biochemical journal 367(Pt 3):825-32 Endogenous mono-ADP-ribosylation of the free Gbetagamma prevents stimulation of phosphoinositide 3-kinase-gamma and phospholipase C-beta2 and is activated by G-protein-coupled receptors.

J. Biol. Chem. 279(3):1585-93 Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis.

J. Biol. Chem. 280(46):38639-47 Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression.

J. Biol. Chem. 271(50):31885-93 Processing of beta-amyloid precursor protein by cathepsin D.

Cell 121(2):179-93 Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis.

The Biochemical journal Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase.

J. Biol. Chem. 276(18):14634-41 Phosphorylation regulates intracellular trafficking of beta-secretase.

J. Biol. Chem. 276(31):28767-73 CD44-initiated cell spreading induces Pyk2 phosphorylation, is mediated by Src family kinases, and is negatively regulated by CD45.

J. Biol. Chem. 261(34):15827-30 Identification of two sites of sulfation of human heparin cofactor II.

Biochim. Biophys. Acta 1592(2):205-11 Inhibition of histone acetyltransferase function of p300 by PKCdelta.

J. Biol. Chem. 277(33):30401-7 Multiple domains of MCIP1 contribute to inhibition of calcineurin activity.

Proceedings of the National Academy of Sciences of the United States of America 99(4):1990-5 Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathway.

Genes & development 7(11):2135-48 Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

Journal of neuroscience research 67(4):435-42 Nerve growth factor-mediated increases in protein methylation occur predominantly at type I arginine methylation sites and involve protein arginine methyltransferase 1.

FEBS letters 427(2):247-51 Proteolytic cleavage of HsRad51 during apoptosis.

The Journal of clinical investigation 108(9):1341-8 Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site.

Proceedings of the National Academy of Sciences of the United States of America 98(5):2582-6 BLNK mediates Syk-dependent Btk activation.

J. Biol. Chem. 278(4):2106-17 Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment.

Nature 429(6990):369-74 DNA sequence and analysis of human chromosome 9.

European journal of biochemistry 242(2):191-200 Biosynthesis and N-glycosylation of human interferon-gamma. Asn25 and Asn97 differ markedly in how efficiently they are glycosylated and in their oligosaccharide composition.

J. Biol. Chem. 277(45):42981-6 SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling.

Journal of cell science 114(Pt 15):2879-87 Phosphorylation of MAP4 affects microtubule properties and cell cycle progression.

J. Biol. Chem. 272(8):5298-304 In vitro assay and characterization of the farnesylation-dependent prelamin A endoprotease.

The Biochemical journal Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.

The Biochemical journal Activation of human prolegumain by cleavage at a C-terminal asparagine residue.

Biochemistry 41(32):10351-9 Characterization of PDK2 activity against protein kinase B gamma.

J. Biol. Chem. 277(4):2573-8 Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation.

Proceedings of the National Academy of Sciences of the United States of America 93(13):6626-30 A human axillary odorant is carried by apolipoprotein D.

Biochem. Biophys. Res. Commun. 292(4):841-7 Phytochemical inhibition of interleukin-4-activated Stat6 and expression of VCAM-1.

Proceedings of the National Academy of Sciences of the United States of America 82(7):1974-8 Tumor-promoting phorbol diesters cause the phosphorylation of epidermal growth factor receptors in normal human fibroblasts at threonine-654.

Current opinion in genetics & development 12(2):162-9 Histone H2A variants H2AX and H2AZ.

Thrombosis and haemostasis 88(2):298-306 Metalloproteases cleave the urokinase-type plasminogen activator receptor in the D1-D2 linker region and expose epitopes not present in the intact soluble receptor.

J. Biol. Chem. 272(47):29590-5 Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2.

Neuron 35(4):721-31 cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation.

Cell 82(2):241-50 Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation.

Biochemistry 37(14):5029-38 Structure/function analyses of recombinant variants of human factor Xa: factor Xa incorporation into prothrombinase on the thrombin-activated platelet surface is not mimicked by synthetic phospholipid vesicles.

Neuron 34(2):235-44 Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV.

Genome research 15(2):195-204 Interchromosomal segmental duplications of the pericentromeric region on the human Y chromosome.

J. Biol. Chem. 270(50):29825-30 Substrate specificities of the insulin and insulin-like growth factor 1 receptor tyrosine kinase catalytic domains.

Proceedings of the National Academy of Sciences of the United States of America 99(6):3974-9 Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis.

The Journal of cell biology 137(2):387-98 Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation.

Endocrinology 138(9):4034-7 Cholecystokinin (CCK) levels are greatly reduced in the brains but not the duodenums of Cpe(fat)/Cpe(fat) mice: a regional difference in the involvement of carboxypeptidase E (Cpe) in pro-CCK processing.

Molecular and cellular biology 20(11):3906-17 Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation.

J. Biol. Chem. 272(26):16414-20 Tyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptor.

Biochim. Biophys. Acta 1549(2):161-73 Delineation of the minimal catalytic domain of human Galbeta1-3GalNAc alpha2,3-sialyltransferase (hST3Gal I).

Biochemistry 42(6):1451-9 Mutational analysis of the complex of human RNase inhibitor and human eosinophil-derived neurotoxin (RNase 2).

Biochem. Soc. Trans. 31(Pt 1):266-9 Regulation of eukaryotic DNA replication at the initiation step.

J. Biol. Chem. 278(6):3897-902 Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival.

Neuron 31(1):87-101 Multiple phosphorylation of rhodopsin and the in vivo chemistry underlying rod photoreceptor dark adaptation.

Nature 384(6608):484-9 Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation.

Journal of neurochemistry 83(4):775-83 Regulation of tyrosine hydroxylase by stress-activated protein kinases.

J. Biol. Chem. 275(8):5453-9 Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs.

J. Biol. Chem. 276(26):23539-46 Membrane topology of the ATP binding cassette transporter ABCR and its relationship to ABC1 and related ABCA transporters: identification of N-linked glycosylation sites.

Molecular cell 19(3):321-32 Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities.

Immunity 13(1):47-57 CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification.

Journal of cell science 114(Pt 21):3823-35 FIGQY phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons.

Surgery 138(2):269-74 Direct phosphorylation of proliferative and survival pathway proteins by RET.

J. Biol. Chem. 263(30):15325-9 cAMP-dependent protein kinase rapidly phosphorylates serine- 687 of the skeletal muscle receptor for calcium channel blockers.

J. Biol. Chem. 279(23):24420-6 Formin homology domain protein (FHOD1) is a cyclic GMP-dependent protein kinase I-binding protein and substrate in vascular smooth muscle cells.

EMBO J. 24(19):3411-22 ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage.

J. Biol. Chem. 278(11):9267-75 Approaches to define antigen receptor-induced serine kinase signal transduction pathways.

The Biochemical journal 363(Pt 1):127-36 Protein kinase A enhances, whereas glycogen synthase kinase-3 beta inhibits, the activity of the exon 2-encoded transactivator domain of heterogeneous nuclear ribonucleoprotein D in a hierarchical fashion.

J. Biol. Chem. 278(14):12335-43 Sumoylation of the progesterone receptor and of the steroid receptor coactivator SRC-1.

J. Biol. Chem. 277(51):49134-42 Protein kinase C delta associates with the interleukin-6 receptor subunit glycoprotein (gp) 130 via Stat3 and enhances Stat3-gp130 interaction.

Brain research 709(1):51-8 Purification and characterization of human endopeptidase 3.4.24.16. Comparison with the porcine counterpart indicates a unique cleavage site on neurotensin.

Archives of biochemistry and biophysics 344(1):94-102 Glycosylation of bile-salt-stimulated lipase from human milk: comparison of native and recombinant forms.

Oncogene 19(3):444-51 c-Myb acetylation at the carboxyl-terminal conserved domain by transcriptional co-activator p300.

J. Biol. Chem. 281(8):4787-94 The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity.

Current biology : CB 8(13):779-82 The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136.

Nature immunology 4(2):145-53 Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A.

Biochemistry 37(1):408-16 Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2.

The Biochemical journal Molecular characterization of human stathmin expressed in Escherichia coli: site-directed mutagenesis of two phosphorylatable serines (Ser-25 and Ser-63).

J. Biol. Chem. 272(35):22300-6 Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity.

Journal of cellular physiology 191(1):95-104 Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer.

Proceedings of the National Academy of Sciences of the United States of America 89(6):2365-9 ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ.

J. Biol. Chem. 269(9):6859-65 Isolation and characterization of a novel acetyl-CoA carboxylase kinase from rat liver.

EMBO J. 15(8):1902-13 Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway.

Cell death and differentiation 5(9):729-34 Proteolytic cleavage of ras GTPase-activating protein during apoptosis.

J. Biol. Chem. 275(43):33836-43 Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies.

J. Biol. Chem. 271(13):7752-7 Identification of a consensus cyclin-dependent kinase phosphorylation site unique to the nuclear form of human deoxyuridine triphosphate nucleotidohydrolase.

J. Biol. Chem. 278(19):16908-15 Hypertonicity activates Na+/H+ exchange through Janus kinase 2 and calmodulin.

Molecular biology of the cell 13(3):767-81 Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology.

Molecular biology of the cell 17(8):3508-20 Phosphorylation of focal adhesion kinase (FAK) on Ser732 is induced by rho-dependent kinase and is essential for proline-rich tyrosine kinase-2-mediated phosphorylation of FAK on Tyr407 in response to vascular endothelial growth factor.

J. Biol. Chem. 275(43):33302-7 MAP kinases Erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro.

The Biochemical journal 365(Pt 3):757-63 Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase.

Journal of neurochemistry 89(4):928-38 N-linked glycosylation sites of the motor protein prestin: effects on membrane targeting and electrophysiological function.

J. Biol. Chem. 271(33):19641-4 Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function.

Molecular and cellular biology 24(9):4065-74 CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37.

J. Biol. Chem. 279(40):42072-81 Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth.

J. Biol. Chem. 277(11):9318-25 The hemopexin-like C-terminal domain of membrane type 1 matrix metalloproteinase regulates proteolysis of a multifunctional protein, gC1qR.

Blood 100(4):1160-7 Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo.

J. Biol. Chem. 273(48):31880-9 Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta.

J. Biol. Chem. 276(42):39037-45 Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon.

J. Biol. Chem. 276(13):9733-41 Kinase suppressor of Ras signals through Thr269 of c-Raf-1.

Molecular and cellular biology 21(22):7545-57 Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization.

J. Biol. Chem. 277(42):39102-11 Nopp140 is a mediator of the protein kinase A signaling pathway that activates the acute phase response alpha1-acid glycoprotein gene.

J. Biol. Chem. 270(23):14072-7 Structural basis for species-specific differences in the phosphorylation of Na,K-ATPase by protein kinase C.

Oncogene 8(12):3211-20 Identification of casein kinase II phosphorylation sites in Max: effects on DNA-binding kinetics of Max homo- and Myc/Max heterodimers.

Molecular and cellular biology 21(9):2981-90 Phosphorylation of nuclear phospholipase C beta1 by extracellular signal-regulated kinase mediates the mitogenic action of insulin-like growth factor I.

J. Biol. Chem. 277(25):23054-64 Interactions between protein kinase CK2 and Pin1. Evidence for phosphorylation-dependent interactions.

FEBS letters 441(2):281-6 Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5.

J. Biol. Chem. 272(48):30447-54 Expression, purification, and regulation of two isoforms of the inositol 1,4,5-trisphosphate 3-kinase.

J. Biol. Chem. 280(28):26089-93 Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase.

Biochemistry 43(51):16348-55 Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop.

J. Biol. Chem. 276(24):21017-21 Tuberin phosphorylation regulates its interaction with hamartin. Two proteins involved in tuberous sclerosis.

Nature cell biology 3(4):331-8 Phosphorylation of Snapin by PKA modulates its interaction with the SNARE complex.

J. Biol. Chem. 273(36):23019-25 Regulation of erythroid Krüppel-like factor (EKLF) transcriptional activity by phosphorylation of a protein kinase casein kinase II site within its interaction domain.

J. Biol. Chem. 277(3):1845-54 MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor.

J. Biol. Chem. 279(40):41477-86 Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1.

Nature 387(6632):516-9 Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation.

J. Biol. Chem. 272(34):21113-9 Src kinase activity is regulated by the SHP-1 protein-tyrosine phosphatase.

Molecular and cellular biology 18(5):2965-75 Protein tyrosine phosphatase 1B antagonizes signalling by oncoprotein tyrosine kinase p210 bcr-abl in vivo.

Biochem. Biophys. Res. Commun. 316(1):39-47 Association of CPI-17 with protein kinase C and casein kinase I.

Schweizer Monatsschrift fur Zahnmedizin = Revue mensuelle suisse d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia 98(12):1367-71 [Root resorption. The maintenance for many years of an incisor almost devoid of root].

Molecular and cellular biology 21(4):1185-95 Identification of a major cyclic AMP-dependent protein kinase A phosphorylation site within the cytoplasmic tail of the low-density lipoprotein receptor-related protein: implication for receptor-mediated endocytosis.

EMBO J. 20(23):6793-804 Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: a novel regulatory mechanism for tyrosine kinase signaling.

Blood 99(3):957-65 Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation.

FEBS letters 562(1-3):160-4 The islet-specific glucose-6-phosphatase-related protein, implicated in diabetes, is a glycoprotein embedded in the endoplasmic reticulum membrane.

J. Biol. Chem. 269(16):11679-82 Transmembrane topology of the glutamate receptor subunit GluR6.

J. Biol. Chem. 271(18):10834-43 Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamics.

FEBS letters 578(1-2):90-4 Protein kinase Akt/PKB phosphorylates heme oxygenase-1 in vitro and in vivo.

J. Biol. Chem. 267(24):16911-21 Localization of O-GlcNAc modification on the serum response transcription factor.

Clinical chemistry 46(10):1610-8 Production and characterization of novel anti-prostate-specific antigen (PSA) monoclonal antibodies that do not detect internally cleaved Lys145-Lys146 inactive PSA.

Oncogene 22(28):4301-13 Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation.

J. Biol. Chem. 279(38):40209-19 Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation.

J. Biol. Chem. 272(47):29449-53 Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy.

J. Biol. Chem. 278(49):48570-9 Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I.

Molecular and cellular biology 25(2):854-64 Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation.

J. Biol. Chem. 272(36):22966-73 Proteolytic cleavage of the mdm2 oncoprotein during apoptosis.

FEBS letters 482(3):237-41 Crystal structure of S-glutathiolated carbonic anhydrase III.

Nature cell biology 1(5):253-9 Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics.

J. Biol. Chem. 276(12):8856-64 A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.

Cell 113(1):127-37 The polycomb protein Pc2 is a SUMO E3.

Molecular and cellular biology 23(1):186-94 Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization.

J. Biol. Chem. 276(45):42462-7 ATM phosphorylates histone H2AX in response to DNA double-strand breaks.

Journal of applied physiology (Bethesda, Md. : 1985) 89(5):1985-90 Mutagenesis analysis of human SM22: characterization of actin binding.

Biochem. Biophys. Res. Commun. 305(2):412-20 Expression and phosphorylation of the replication regulator protein geminin.

Clinica chimica acta; international journal of clinical chemistry 289(1-2):33-44 Process of carboxylation of glutamic acid residues in the gla domain of human des-gamma-carboxyprothrombin.

Biochem. Biophys. Res. Commun. 257(1):129-38 The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase.

Proceedings of the National Academy of Sciences of the United States of America 97(18):9943-8 Relative role of heme nitrosylation and beta-cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation.

J. Biol. Chem. 276(45):41856-61 Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2.

Nature 419(6903):135-41 RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

J. Biol. Chem. 264(26):15656-61 Platelet glycoprotein Ib beta is phosphorylated on serine 166 by cyclic AMP-dependent protein kinase.

Molecular and cellular biology 21(23):8225-35 Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451.

EMBO J. 21(19):5151-63 IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation.

European journal of immunology 33(2):287-96 T cell recognition and therapeutic effect of a phosphorylated synthetic peptide of the 70K snRNP protein administered in MR/lpr mice.

Nature 410(6825):215-20 Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase.

The Biochemical journal Phosphorylation of GAP-43 (growth-associated protein of 43 kDa) by conventional, novel and atypical isotypes of the protein kinase C gene family: differences between oligopeptide and polypeptide phosphorylation.

Prostate 45(2):132-9 Enzymatic action of prostate-specific antigen (PSA or hK3): substrate specificity and regulation by Zn(2+), a tight-binding inhibitor.

Biochemistry 38(20):6529-36 Proteolysis of blood coagulation factor VIII by the factor VIIa-tissue factor complex: generation of an inactive factor VIII cofactor.

Proceedings of the National Academy of Sciences of the United States of America 99(3):1182-7 Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex.

Physiological reviews 80(3):1083-105 Molecular analysis of the sodium/iodide symporter: impact on thyroid and extrathyroid pathophysiology.

J. Biol. Chem. 280(40):33756-65 B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity.

J. Biol. Chem. 277(22):19433-8 Regulation of TRAF2 signaling by self-induced degradation.

J. Biol. Chem. 280(11):10419-26 Differential regulation of phosphoglucose isomerase/autocrine motility factor activities by protein kinase CK2 phosphorylation.

The Journal of neuroscience : the official journal of the Society for Neuroscience 19(18):7770-80 Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein.

Molecular and cellular biology 24(3):966-75 Regulation of phosphoinositide 3-kinase by its intrinsic serine kinase activity in vivo.

Genome research 23(12):2003-12 The shared genomic architecture of human nucleolar organizer regions.

J. Biol. Chem. 273(1):215-21 Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro.

EMBO reports 7(2):192-8 DNA-damage-responsive acetylation of pRb regulates binding to E2F-1.

Proceedings of the National Academy of Sciences of the United States of America 93(23):12908-13 Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver.

J. Biol. Chem. 267(9):6171-7 Cell-associated episialin is a complex containing two proteins derived from a common precursor.

Cancer research 60(13):3504-13 A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells.

EMBO J. 25(12):2781-91 The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity.

J. Biol. Chem. 273(49):32377-9 CREB is a regulatory target for the protein kinase Akt/PKB.

Nature genetics 20(4):398-400 ATM associates with and phosphorylates p53: mapping the region of interaction.

FEBS letters 393(1):1-6 CPP32/Yama/apopain cleaves the catalytic component of DNA-dependent protein kinase in the holoenzyme.

"Science (New York, N.Y.)" 300(5626):1751-5 Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression.

J. Biol. Chem. 279(5):3245-53 Cells previously desensitized to type 1 interferons display different mechanisms of activation of stat-dependent gene expression from naïve cells.

J. Biol. Chem. 273(15):9148-57 Identification of a domain on the beta-subunit of the rod cGMP-gated cation channel that mediates inhibition by calcium-calmodulin.

Biochemistry 37(14):4699-702 Generation of an angiostatin-like fragment from plasminogen by stromelysin-1 (MMP-3).

J. Biol. Chem. 259(11):6790-7 Natural human interferon-gamma. Complete amino acid sequence and determination of sites of glycosylation.

J. Biol. Chem. 278(13):11182-9 STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif.

EMBO J. 26(7):1794-805 Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways.

Oncogene 20(8):951-61 Activation of the focal adhesion kinase signaling pathway by structural alterations in the carboxyl-terminal region of c-Crk II.

Proceedings of the National Academy of Sciences of the United States of America 98(11):6500-5 Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia.

Proceedings of the National Academy of Sciences of the United States of America 90(11):5292-6 The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase.

Biochemistry 36(50):15873-83 MAP4 is the in vivo substrate for CDC2 kinase in HeLa cells: identification of an M-phase specific and a cell cycle-independent phosphorylation site in MAP4.

Journal of biochemistry 130(4):503-13 Regulation of Ca(2+)/calmodulin-dependent protein kinase kinase alpha by cAMP-dependent protein kinase: I. Biochemical analysis.

Journal of receptor and signal transduction research 19(6):953-74 The TrkB receptor tyrosine kinase regulates cellular proliferation via signal transduction pathways involving SHC, PLCgamma, and CBL.

J. Biol. Chem. 277(30):27273-81 The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein family.

Biochemical pharmacology 64(2):257-66 Identification of two C-terminal amino acids, Ser(355) and Thr(357), required for short-term homologous desensitization of mu-opioid receptors.

Cell 85(7):1047-55 Tertiary structure of destrin and structural similarity between two actin-regulating protein families.

Immunity 9(1):13-24 FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation.

J. Biol. Chem. 271(51):32930-6 Co-expression with BCR induces activation of the FES tyrosine kinase and phosphorylation of specific N-terminal BCR tyrosine residues.

Oncogene 19(11):1369-78 Activation of NF-kappa B by the dsRNA-dependent protein kinase, PKR involves the I kappa B kinase complex.

Biochemistry 41(49):14524-31 Glycosylation of erythropoietin affects receptor binding kinetics: role of electrostatic interactions.

Journal of biochemistry 116(2):426-34 Identification of phosphorylation sites on glial fibrillary acidic protein for cdc2 kinase and Ca(2+)-calmodulin-dependent protein kinase II.

J. Biol. Chem. 265(11):6092-7 Interaction of heparin cofactor II with neutrophil elastase and cathepsin G.

FEBS letters 579(13):2883-90 The death domain-associated protein modulates activity of the transcription co-factor Skip/NcoA62.

FEBS letters 372(1):59-64 A novel tau-tubulin kinase from bovine brain.

J. Biol. Chem. 270(49):29498-506 Structural and functional consequences of mutations in 6-pyruvoyltetrahydropterin synthase causing hyperphenylalaninemia in humans. Phosphorylation is a requirement for in vivo activity.

J. Biol. Chem. 277(29):26530-9 In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents.

Molecular and cellular biology 6(7):2738-44 The protein-tyrosine kinase substrate p36 is also a substrate for protein kinase C in vitro and in vivo.

J. Biol. Chem. 276(22):19197-204 Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2.

Oncogene 18(27):3963-9 Cleavage and relocation of the tyrosine kinase P59FYN during Fas-mediated apoptosis in T lymphocytes.

Journal of toxicology and environmental health. Part B, Critical reviews 12(5-6):334-61 Genetic polymorphism in cytochrome P450 2D6 (CYP2D6): Population distribution of CYP2D6 activity.

J. Biol. Chem. 278(22):19667-73 Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor.

Molecular pharmacology 52(1):21-9 Palmitoylation of the V2 vasopressin receptor.

J. Biol. Chem. 271(29):17199-204 Phosphorylation of the MADS-Box transcription factor MEF2C enhances its DNA binding activity.

The Biochemical journal Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor.

J. Biol. Chem. 272(26):16152-7 Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart.

EMBO J. 22(20):5480-90 SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor.

J. Biol. Chem. 275(35):27354-9 Negative regulation of the serine/threonine kinase B-Raf by Akt.

Genome biology 9(5):R78 Finishing the finished human chromosome 22 sequence.

Nature 439(7078):811-6 Histone demethylation by a family of JmjC domain-containing proteins.

J. Biol. Chem. 246(9):3001-7 Human fetal hemoglobin F 1. Acetylation status.

Journal of cell science Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro: implications for microfilament reorganization during apoptosis.

EMBO J. 10(13):4279-90 The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.

J. Biol. Chem. 277(47):45473-9 Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin.

EMBO J. 26(4):1068-80 Death effector domain DEDa, a self-cleaved product of caspase-8/Mch5, translocates to the nucleus by binding to ERK1/2 and upregulates procaspase-8 expression via a p53-dependent mechanism.

Biochemistry 40(10):3167-73 S100A7, S100A10, and S100A11 are transglutaminase substrates.

J. Biol. Chem. 275(33):25805-13 Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells.

Proceedings of the National Academy of Sciences of the United States of America 90(11):5176-80 Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lck.

Nature methods 2(8):591-8 Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.

J. Biol. Chem. 277(19):16775-81 Caspase proteolysis of the cohesin component RAD21 promotes apoptosis.

Molecular and cellular biology 12(3):998-1006 Alteration of a cyclic AMP-dependent protein kinase phosphorylation site in the c-Fos protein augments its transforming potential.

J. Biol. Chem. 265(20):11740-5 Purification and characterization of catalytic fragments of phosphorylase kinase gamma subunit missing a calmodulin-binding domain.

J. Biol. Chem. 277(36):32799-806 cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b.

Journal of immunology (Baltimore, Md. : 1950) 170(2):913-21 Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling.

FEBS letters 580(5):1215-21 Repression of SOX6 transcriptional activity by SUMO modification.

J. Biol. Chem. 275(39):30677-82 Glycosylation of GIRK1 at Asn119 and ROMK1 at Asn117 has different consequences in potassium channel function.

J. Virol. 74(9):4404-13 N-linked glycosylation of CXCR4 masks coreceptor function for CCR5-dependent human immunodeficiency virus type 1 isolates.

Molecular and cellular biology 26(1):277-92 Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species.

J. Biol. Chem. 274(13):8797-805 MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells.

Advances in the biosciences Effect of delta 9-tetrahydrocannabinol (THC) on female reproductive function.

J. Biol. Chem. 271(19):11575-80 Identification of the site in the cGMP-inhibited phosphodiesterase phosphorylated in adipocytes in response to insulin and isoproterenol.

Proceedings of the National Academy of Sciences of the United States of America 90(13):6130-4 Characterization of site-specific mutants altered at protein kinase C beta 1 isozyme autophosphorylation sites.

Immunity 4(2):123-32 Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor.

J. Biol. Chem. 273(27):17227-35 Conserved in vivo phosphorylation of calnexin at casein kinase II sites as well as a protein kinase C/proline-directed kinase site.

Molecular and cellular biology 22(12):4419-32 Chk2 activation and phosphorylation-dependent oligomerization.

Genes & development 13(11):1422-37 Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism.

FEBS letters 297(1-2):112-8 Effective activation of the proenzyme form of the urokinase-type plasminogen activator (pro-uPA) by the cysteine protease cathepsin L.

J. Biol. Chem. 280(12):11147-51 c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage.

Nature methods 1(2):119-26 Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.

Biochem. Biophys. Res. Commun. 259(1):224-9 Overexpression of wild-type and catalytically inactive forms of GRK2 and GRK6 fails to alter the agonist-induced phosphorylation of the C5a receptor (CD88): evidence that GRK6 is autophosphorylated in COS-7 cells.

J. Biol. Chem. 274(7):4335-40 Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis.

Proceedings of the National Academy of Sciences of the United States of America 103(26):9773-8 Phosphoproteomic analysis of Her2/neu signaling and inhibition.

J. Biol. Chem. 268(30):22927-32 Activation of the zymogen of hepatocyte growth factor activator by thrombin.

Molecular & cellular proteomics : MCP 1(1):11-8 C-mannosylation and o-fucosylation of thrombospondin type 1 repeats.

Archives of biochemistry and biophysics 368(2):214-20 Distinct but dispensable N-glycosylation of human CD69 proteins.

Biochim. Biophys. Acta 1649(1):30-9 Identification of interleukin-8 converting enzyme as cathepsin L.

J. Biol. Chem. 276(14):10715-21 Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation.

Molecular and cellular biology 24(7):2649-61 Forkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivators.

J. Biol. Chem. 271(1):160-7 Effect of tyrosine mutations on the kinase activity and transforming potential of an oncogenic human insulin-like growth factor I receptor.

Nature cell biology 4(10):743-9 Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69.

J. Biol. Chem. 270(44):26146-51 Calpain cleavage of the cytoplasmic domain of the integrin beta 3 subunit.

J. Biol. Chem. 276(5):3098-105 Glutathiolation of proteins by glutathione disulfide S-oxide derived from S-nitrosoglutathione. Modifications of rat brain neurogranin/RC3 and neuromodulin/GAP-43.

J. Biol. Chem. 269(30):19578-84 Phosphorylation of Thr642 is an early event in the processing of newly synthesized protein kinase C beta 1 and is essential for its activation.

Molecular and cellular biology 23(6):2109-22 A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels.

Biochemistry 36(15):4643-9 Phosphorylation of Alzheimer beta-amyloid precursor-like proteins.

Endocrinology 144(4):1301-14 Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization.

J. Biol. Chem. 276(26):23322-8 Prodomain processing of Asp1 (BACE2) is autocatalytic.

Proceedings of the National Academy of Sciences of the United States of America 92(12):5361-5 Phosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation.

The Journal of urology 157(6):2166-70 Prostate specific antigen in benign prostatic hyperplasia: purification and characterization.

Biochemistry 44(37):12546-53 Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3.

Molecular and cellular biology 25(23):10543-55 Regulation of caspase 9 through phosphorylation by protein kinase C zeta in response to hyperosmotic stress.

Molecular endocrinology (Baltimore, Md.) 18(10):2451-62 Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9.

Neurobiology of aging 16(3):365-71; discussion 371-80 Hyperphosphorylation of tau in PHF.

European journal of biochemistry 270(6):1189-98 Disruption of structural and functional integrity of alpha 2-macroglobulin by cathepsin E.

FEBS letters 438(3):301-5 NADH:ubiquinone oxidoreductase from bovine heart mitochondria: sequence of a novel 17.2-kDa subunit.

J. Biol. Chem. 277(15):12491-4 ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation.

Biochem. Biophys. Res. Commun. 245(2):514-8 Regulation of the p53 protein by protein kinase C alpha and protein kinase C zeta.

Neuron 19(1):185-96 cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits.

EMBO reports 2(10):945-51 Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase.

The Biochemical journal 354(Pt 3):689-95 'Shed' furin: mapping of the cleavage determinants and identification of its C-terminus.

J. Biol. Chem. 263(27):13486-9 Ca2+/calmodulin-dependent protein kinase II. Identification of a regulatory autophosphorylation site adjacent to the inhibitory and calmodulin-binding domains.

Biochim. Biophys. Acta 1480(1-2):235-44 Phosphohexose isomerase/autocrine motility factor/neuroleukin/maturation factor is a multifunctional phosphoprotein.

Biochemistry 42(24):7381-9 Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis.

J. Biol. Chem. 276(42):39060-6 Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat axam, which is an axin-binding protein promoting beta-catenin degradation.

The Biochemical journal Degradation of decorin by matrix metalloproteinases: identification of the cleavage sites, kinetic analyses and transforming growth factor-beta1 release.

J. Biol. Chem. 278(10):7751-4 The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage.

J. Biol. Chem. 273(44):28691-9 Human leptin receptor. Determination of disulfide structure and N-glycosylation sites of the extracellular domain.

Biochemical pharmacology 62(8):997-1012 Sequestration and phosphorylation of the prostaglandin E2 EP4 receptor: dependence on the C-terminal tail.

J. Biol. Chem. 273(31):19495-501 Identification of amino acid residues critical for the Src-homology 2 domain-dependent docking of Stat2 to the interferon alpha receptor.

Nature cell biology 3(3):325-30 ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation.

J. Biol. Chem. 262(7):3086-91 Lecithin:cholesterol acyltransferase. Functional regions and a structural model of the enzyme.

J. Biol. Chem. 278(20):18440-7 Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2.

Biochemistry 39(35):10898-907 Identification of major tyrosine phosphorylation sites in the human insulin receptor substrate Gab-1 by insulin receptor kinase in vitro.

Journal of neurochemistry 77(4):1097-107 Interaction of phosphorylated tyrosine hydroxylase with 14-3-3 proteins: evidence for a phosphoserine 40-dependent association.

J. Biol. Chem. 277(50):48115-21 Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

J. Biol. Chem. 269(6):4458-66 Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity.

J. Biol. Chem. 267(28):20033-8 Post-translational modifications of p21rho proteins.

J. Biol. Chem. 270(50):29881-8 N-glycans modulate in vivo and in vitro thyroid hormone synthesis. Study at the N-terminal domain of thyroglobulin.

Biochem. Biophys. Res. Commun. 317(3):703-7 KIBRA is a novel substrate for protein kinase Czeta.

Proceedings of the National Academy of Sciences of the United States of America 93(14):7069-74 Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1.

EMBO J. 20(11):2768-78 A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells.

Genes & development 15(23):3088-103 PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies.

J. Biol. Chem. 277(9):7029-36 Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2.

J. Biol. Chem. 278(45):44745-52 CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction.

Glycobiology 15(5):541-7 Posttranslational N-glycosylation takes place during the normal processing of human coagulation factor VII.

Molecular and cellular biology 24(10):4557-70 Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta.

J. Biol. Chem. 268(27):20076-84 Multiple phosphorylation of stathmin. Identification of four sites phosphorylated in intact cells and in vitro by cyclic AMP-dependent protein kinase and p34cdc2.

Biochim. Biophys. Acta 1434(1):86-93 Carbohydrate moieties in human secretory component.

Molecular biology of the cell 12(4):1131-45 Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation.

Biochemistry 37(6):1613-22 Peroxynitrite-mediated inactivation of manganese superoxide dismutase involves nitration and oxidation of critical tyrosine residues.

J. Biol. Chem. 274(26):18559-66 Phosphorylation at the cyclin-dependent kinases site (Thr85) of parathyroid hormone-related protein negatively regulates its nuclear localization.

Nucleic acids research 13(14):5233-47 The structure and evolution of a 461 amino acid human protein C precursor and its messenger RNA, based upon the DNA sequence of cloned human liver cDNAs.

J. Biol. Chem. 274(32):22775-84 Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and Nck.

Cell 130(2):349-62 Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors.

Human molecular genetics 8(4):683-90 Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting.

Nature 425(6960):805-11 The DNA sequence and analysis of human chromosome 6.

Oncogene 14(19):2367-72 Bcr phosphorylated on tyrosine 177 binds Grb2.

Cell 119(1):61-74 The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.

Molecular cell 1(1):13-23 The discoidin domain receptor tyrosine kinases are activated by collagen.

The Journal of clinical investigation 110(5):659-69 Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface.

J. Biol. Chem. 271(12):6987-97 Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes.

J. Biol. Chem. 277(10):8217-25 The prosequence of human lactase-phlorizin hydrolase modulates the folding of the mature enzyme.

J. Biol. Chem. 276(49):45780-90 Phosphorylation of the CCAAT displacement protein (CDP)/Cux transcription factor by cyclin A-Cdk1 modulates its DNA binding activity in G(2).

Oncogene 20(14):1784-92 Constitutive c-Myb amino-terminal phosphorylation and DNA binding activity uncoupled during entry and passage through the cell cycle.

Genes & development 15(14):1833-44 Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation.

Genes to cells : devoted to molecular & cellular mechanisms 9(10):983-92 In vivo potentiation of human oestrogen receptor alpha by Cdk7-mediated phosphorylation.

FEBS letters 384(2):189-92 A potential site of functional modulation by protein kinase A in the cardiac Ca2+ channel alpha 1C subunit.

Proceedings of the National Academy of Sciences of the United States of America 94(26):14500-5 Phosphorylation of the immunosuppressant FK506-binding protein FKBP52 by casein kinase II: regulation of HSP90-binding activity of FKBP52.

The Journal of cell biology 135(6 Pt 1):1501-13 A role for N-myristoylation in protein targeting: NADH-cytochrome b5 reductase requires myristic acid for association with outer mitochondrial but not ER membranes.

Oncogene 19(44):5063-72 The ternary complex factor Net contains two distinct elements that mediate different responses to MAP kinase signalling cascades.

The international journal of biochemistry & cell biology 33(6):577-89 Phosphorylation of the Fas associated factor FAF1 by protein kinase CK2 and identification of serines 289 and 291 as the in vitro phosphorylation sites.

J. Biol. Chem. 268(10):7571-6 Interaction of the human insulin receptor tyrosine kinase from the baculovirus expression system with protein kinase C in a cell-free system.

Biochem. Biophys. Res. Commun. 341(2):343-50 CK2-dependent C-terminal phosphorylation at T300 directs the nuclear transport of TSPY protein.

Journal of biochemistry 110(4):648-54 Identification of full-sized forms of salivary (S-type) cystatins (cystatin SN, cystatin SA, cystatin S, and two phosphorylated forms of cystatin S) in human whole saliva and determination of phosphorylation sites of cystatin S.

J. Biol. Chem. 276(38):35239-42 The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin.

Biochim. Biophys. Acta 1281(2):205-12 Cyclic AMP-dependent protein kinase phosphorylates residues in the C-terminal domain of the cardiac L-type calcium channel alpha1 subunit.

J. Biol. Chem. 277(33):30144-52 Serine/threonine phosphorylation of ShcA. Regulation of protein-tyrosine phosphatase-pest binding and involvement in insulin signaling.

Genes to cells : devoted to molecular & cellular mechanisms 9(6):549-60 DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites.

J. Biol. Chem. 277(13):10775-82 Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization: modulation by a keratin 1-like disease causing mutation.

"Science (New York, N.Y.)" 272(5266):1347-9 Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase.

Blood 96(5):1674-80 Cleavage by CD26/dipeptidyl peptidase IV converts the chemokine LD78beta into a most efficient monocyte attractant and CCR1 agonist.

J. Biol. Chem. 277(30):26741-52 Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4.

J. Biol. Chem. 271(9):5101-11 Structural determinants in the platelet-derived growth factor alpha-receptor implicated in modulation of chemotaxis.

J. Biol. Chem. 271(23):13796-803 Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor.

J. Biol. Chem. 280(12):11528-34 Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation.

Nature cell biology 7(2):195-201 The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair.

J. Biol. Chem. 279(6):4507-14 p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells.

J. Biol. Chem. 278(27):24428-37 Phosphorylation of human Rad9 is required for genotoxin-activated checkpoint signaling.

J. Biol. Chem. 278(31):28694-702 Recruitment of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activation.

Nature cell biology 7(3):278-85 JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage.

Proceedings of the National Academy of Sciences of the United States of America 100(11):6376-81 Structural and biochemical studies of p21Ras S-nitrosylation and nitric oxide-mediated guanine nucleotide exchange.

Biochim. Biophys. Acta 1061(2):253-66 Phosphorylation sites in human erythrocyte band 3 protein.

J. Biol. Chem. 269(8):6026-30 Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of phosphatidylinositol (PI) 3-kinase and for c-kit-associated PI 3-kinase activity in COS-1 cells.

J. Biol. Chem. 270(25):15250-6 Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases.

Blood 79(7):1712-9 The effect of leukocyte elastase on tissue factor pathway inhibitor.

European journal of biochemistry 270(1):171-8 Kininogen-derived peptides for investigating the putative vasoactive properties of human cathepsins K and L.

Molecular and cellular biology 16(12):6926-36 Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation.

Blood 94(4):1440-50 Proteolytic processing of big endothelin-3 by the kell blood group protein.

EMBO J. 26(2):402-11 A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.

Blood 93(6):1809-16 Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors.

Cell 131(6):1190-203 Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.

Nature 364(6434):249-52 Protein kinase C alpha activates RAF-1 by direct phosphorylation.

Structure (London, England : 1993) 5(4):509-20 The crystal structure of an intact human Max-DNA complex: new insights into mechanisms of transcriptional control.

Biochemistry 39(11):3141-8 Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1.

The Journal of neuroscience : the official journal of the Society for Neuroscience 21(22):8842-53 Stimulation of endothelin B receptors in astrocytes induces cAMP response element-binding protein phosphorylation and c-fos expression via multiple mitogen-activated protein kinase signaling pathways.

EMBO J. 16(21):6325-36 Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination.

J. Biol. Chem. 271(9):4755-62 Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine.

J. Biol. Chem. 276(24):21209-16 Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton.

Journal of proteome research 4(4):1155-70 Extended Range Proteomic Analysis (ERPA): a new and sensitive LC-MS platform for high sequence coverage of complex proteins with extensive post-translational modifications-comprehensive analysis of beta-casein and epidermal growth factor receptor (EGFR).

J. Biol. Chem. 269(18):13637-43 Determination of structural requirements for the interaction of Rab6 with RabGDI and Rab geranylgeranyltransferase.

J. Biol. Chem. 273(16):9898-905 A role for the insulin-interleukin (IL)-4 receptor motif of the IL-4 receptor alpha-chain in regulating activation of the insulin receptor substrate 2 and signal transducer and activator of transcription 6 pathways. Analysis by mutagenesis.

Biochemistry 25(8):1988-96 Characterization of human platelet basic protein, a precursor form of low-affinity platelet factor 4 and beta-thromboglobulin.

J. Biol. Chem. 275(20):15207-19 Interactions between the exocytic and endocytic pathways in polarized Madin-Darby canine kidney cells.

Biochemistry 41(30):9680-7 ADP-ribosylation and functional effects of Pseudomonas exoenzyme S on cellular RalA.

J. Biol. Chem. 276(7):4972-80 Cleavage and shedding of E-cadherin after induction of apoptosis.

J. Biol. Chem. 266(31):20619-25 Human red cell acid phosphatase (ACP1). The amino acid sequence of the two isozymes Bf and Bs encoded by the ACP1*B allele.

J. Biol. Chem. 269(19):14159-64 A transmembrane model for an ionotropic glutamate receptor predicted on the basis of the location of asparagine-linked oligosaccharides.

Genes & development 11(23):3168-81 Mediation of NGF signaling by post-translational inhibition of HES-1, a basic helix-loop-helix repressor of neuronal differentiation.

Hepatology (Baltimore, Md.) 38(4):879-89 p38 MAPK mediates fibrogenic signal through Smad3 phosphorylation in rat myofibroblasts.

Biochemistry 34(37):11910-8 Binding of prenylated and polybasic peptides to membranes: affinities and intervesicle exchange.

Nature biotechnology 21(5):532-8 A method for the comprehensive proteomic analysis of membrane proteins.

Oncogene 20(43):6188-95 Involvement of Jak2 tyrosine phosphorylation in Bcr-Abl transformation.

J. Biol. Chem. 274(23):16168-73 Ca2+/calmodulin-dependent kinase II phosphorylates the epidermal growth factor receptor on multiple sites in the cytoplasmic tail and serine 744 within the kinase domain to regulate signal generation.

Biochemistry 34(4):1433-8 In vivo glycation of aldehyde reductase, a major 3-deoxyglucosone reducing enzyme: identification of glycation sites.

J. Biol. Chem. 277(37):34208-16 The germ cell-specific transcription factor ALF. Structural properties and stabilization of the TATA-binding protein (TBP)-DNA complex.

Journal of chromatography. A 1106(1-2):181-9 Analysis on heat stress-induced hyperphosphorylation of stathmin at serine 37 in Jurkat cells by means of two-dimensional gel electrophoresis and tandem mass spectrometry.

Biochem. Biophys. Res. Commun. 171(1):375-83 The purification and characterization of recombinant human renin expressed in the human kidney cell line 293.

Cell 86(5):787-98 Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha.

J. Biol. Chem. 271(14):8203-8 Identification of plectin as a substrate of p34cdc2 kinase and mapping of a single phosphorylation site.

J. Biol. Chem. 277(46):44525-30 Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau.

J. Biol. Chem. 265(34):20887-92 Site-directed mutagenesis of the m2 muscarinic acetylcholine receptor. Analysis of the role of N-glycosylation in receptor expression and function.

EMBO J. 19(2):273-81 A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK.

Cell 127(4):775-88 E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation.

EMBO J. 9(6):1769-76 Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment.

J. Biol. Chem. 271(41):25107-16 Site-directed mutagenesis of nm23-H1. Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells.

EMBO J. 12(10):3789-98 Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation.

Molecular biology of the cell 11(12):4159-71 Self-association of coilin reveals a common theme in nuclear body localization.

Journal of molecular biology 330(5):955-66 Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14.

Molecular endocrinology (Baltimore, Md.) 10(9):1055-65 Characterization and determination of the biological activities of noncleavable high molecular weight forms of inhibin A and activin A.

The Journal of experimental medicine 171(2):449-54 Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases.

J. Biol. Chem. 277(37):34634-41 Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition.

J. Biol. Chem. 280(39):33687-92 Dephosphorylation of Ser-226 facilitates plasma membrane retention of Ntcp.

Molecular and cellular biology 20(19):7273-81 Regulation of STAT1 nuclear export by Jak1.

J. Biol. Chem. 278(9):6947-58 Palmitoylation of the human prostacyclin receptor. Functional implications of palmitoylation and isoprenylation.

EMBO J. 18(7):1891-9 Phosphorylation by G1-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF.

J. Biol. Chem. 276(29):26792-8 Effect of mutation and phosphorylation of type I keratins on their caspase-mediated degradation.

EMBO J. 11(1):97-105 Casein kinase II phosphorylation increases the rate of serum response factor-binding site exchange.

J. Biol. Chem. 278(18):16433-42 Mitotic regulation of ribosomal S6 kinase 1 involves Ser/Thr, Pro phosphorylation of consensus and non-consensus sites by Cdc2.

J. Biol. Chem. 276(9):6640-4 Essential tyrosine residues for interaction of the non-receptor protein-tyrosine phosphatase PTP1B with N-cadherin.

Nature 440(7083):497-500 Human chromosome 11 DNA sequence and analysis including novel gene identification.

J. Biol. Chem. 271(8):4230-5 Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20(12):4535-44 Phosphorylated syntaxin 1 is localized to discrete domains along a subset of axons.

J. Biol. Chem. 272(11):7229-44 The glycosylation of the complement regulatory protein, human erythrocyte CD59.

Molecular & cellular proteomics : MCP 4(6):721-30 Phosphotyrosine proteomic study of interferon alpha signaling pathway using a combination of immunoprecipitation and immobilized metal affinity chromatography.

Journal of cell science Hyaluronan-dependent cell migration can be blocked by a CD44 cytoplasmic domain peptide containing a phosphoserine at position 325.

J. Biol. Chem. 278(42):40764-70 Cleavage of syndecan-1 by membrane type matrix metalloproteinase-1 stimulates cell migration.

Journal of neurochemistry 69(5):1864-9 Characterization of the palmitoylation domain of SNAP-25.

J. Biol. Chem. 271(7):3779-86 Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein.

Molecular and cellular biology 21(24):8414-27 Nerve growth factor stimulates multisite tyrosine phosphorylation and activation of the atypical protein kinase C's via a src kinase pathway.

J. Biol. Chem. 276(11):8104-10 Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2.

Nature 443(7108):222-5 Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo.

J. Biol. Chem. 273(13):7222-7 Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection.

EMBO J. 22(12):3015-26 The B cell-specific major raft protein, Raftlin, is necessary for the integrity of lipid raft and BCR signal transduction.

Nature 407(6800):102-6 TFIIH is negatively regulated by cdk8-containing mediator complexes.

Journal of cell science 115(Pt 5):1059-72 Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling.

The American journal of physiology 271(3 Pt 1):E465-70 IGFBP-3 proteolysis by plasmin, thrombin, serum: heparin binding, IGF binding, and structure of fragments.

Biochemistry 31(17):4232-8 Sequential dephosphorylation of a multiply phosphorylated insulin receptor peptide by protein tyrosine phosphatases.

Blood 102(9):3311-3 PIAS proteins promote SUMO-1 conjugation to STAT1.

Journal of cell science 117(Pt 8):1339-50 EGFR signaling to p120-catenin through phosphorylation at Y228.

J. Biol. Chem. 279(40):42095-105 Complexity of translationally controlled transcription factor Sp3 isoform expression.

Biochemistry 35(11):3578-86 Dynamic O-GlcNAcylation of the small heat shock protein alpha B-crystallin.

Journal of neurochemistry 81(2):307-13 Cdk5 phosphorylates p53 and regulates its activity.

Cancer research 60(13):3631-7 Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells.

J. Biol. Chem. 275(28):21444-52 Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the early endosome.

J. Biol. Chem. 279(45):46614-20 Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor.

Nature 378(6554):307-10 Phosphorylation of Raf by ceramide-activated protein kinase.

American journal of human genetics 83(3):337-46 Adaptive evolution of UGT2B17 copy-number variation.

Neuron 21(3):495-504 Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in Neurons: a mechanism for attenuation of olfactory signals.

J. Biol. Chem. 275(4):2410-4 The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53.

EMBO J. 16(8):1921-33 MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates.

J. Biol. Chem. 266(19):12633-8 Identification of renal cathepsin B as a human prorenin-processing enzyme.

J. Biol. Chem. 276(32):30537-41 The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation.

J. Biol. Chem. 278(29):26773-9 The activation of matriptase requires its noncatalytic domains, serine protease domain, and its cognate inhibitor.

Molecular cell 10(2):247-58 Phosphorylation by protein kinase CK2: a signaling switch for the caspase-inhibiting protein ARC.

Molecular cell 11(5):1215-27 Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP.

J. Biol. Chem. 263(2):696-700 Botulinum C2 toxin ADP-ribosylates cytoplasmic beta/gamma-actin in arginine 177.

Oncogene 15(25):3103-11 Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential.

J. Biol. Chem. 277(20):18191-7 Glucocorticoids inhibit cell cycle progression in differentiating osteoblasts via glycogen synthase kinase-3beta.

FEBS letters 580(1):107-14 P70 S6 kinase mediates tau phosphorylation and synthesis.

The Biochemical journal 372(Pt 2):465-71 Post-synaptic density-95 promotes calcium/calmodulin-dependent protein kinase II-mediated Ser847 phosphorylation of neuronal nitric oxide synthase.

Molecular and cellular neurosciences 20(1):13-20 Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability.

Proceedings of the National Academy of Sciences of the United States of America 102(30):10454-9 Regulation of human methylenetetrahydrofolate reductase by phosphorylation.

Nature 441(7091):315-21 The DNA sequence and biological annotation of human chromosome 1.

J. Biol. Chem. 277(40):37414-21 Identification of threonine 66 as a functionally critical residue of the interleukin-1 receptor-associated kinase.

PLoS genetics 3(3):e41 Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome.

J. Biol. Chem. 252(21):7555-67 Carbohydrate moiety of HLA antigens. Antigenic properties and amino acid sequences around the site of glycosylation.

Molecular and cellular biology 14(3):1824-34 Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells.

Molecular and cellular biology 19(5):3466-73 Specific acetylation of chromosomal protein HMG-17 by PCAF alters its interaction with nucleosomes.

Journal of biochemistry 121(5):890-5 HSDJ, a human homolog of DnaJ, is farnesylated and is involved in protein import into mitochondria.

Journal of biochemistry 130(1):157-65 Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system.

J. Biol. Chem. 276(48):45175-83 Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules.

J. Biol. Chem. 275(4):2349-58 Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20(19):7258-67 Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins.

Nature immunology 6(3):253-60 Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase.

Biochim. Biophys. Acta 1480(1-2):245-57 Angiotensin II generation by mast cell alpha- and beta-chymases.

The Journal of experimental medicine 193(9):1059-66 Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a anaphylatoxin receptor.

Nature genetics 30(3):270-6 CEACAM1 regulates insulin clearance in liver.

Journal of proteome research 6(3):1165-75 A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis.

Proceedings of the National Academy of Sciences of the United States of America 93(25):14486-91 Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases.

Biochem. Biophys. Res. Commun. 282(2):387-93 Identification of Ser(1275) and Ser(1309) as autophosphorylation sites of the human insulin receptor in intact cells.

J. Biol. Chem. 279(4):2697-703 Secretion of heparanase protein is regulated by glycosylation in human tumor cell lines.

J. Biol. Chem. 277(29):26372-8 Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen.

J. Biol. Chem. 279(44):45304-7 Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101).

European journal of biochemistry 240(3):747-50 Replacement of Ser657 of protein kinase C-alpha by alanine leads to premature down regulation after phorbol-ester-induced translocation to the membrane.

Proceedings of the National Academy of Sciences of the United States of America 97(22):11960-5 Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A.

Molecular cancer research : MCR 3(8):453-61 Molecular characterization of ring finger protein 11.

Journal of neurochemistry 71(6):2465-76 New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry.

Nature 402(6762):656-60 Ghrelin is a growth-hormone-releasing acylated peptide from stomach.

EMBO J. 25(15):3504-14 Involvement of novel autophosphorylation sites in ATM activation.

The Biochemical journal Changes in protein kinase C epsilon phosphorylation status and intracellular localization as 3T3 and 3T6 fibroblasts grow to confluency and quiescence: a role for phosphorylation at ser-729?

The Journal of cell biology 132(3):299-310 Role of CD3 gamma in T cell receptor assembly.

Biochemistry 29(9):2330-5 Identification of the protein kinase C phosphorylation site in neuromodulin.

Neuroscience research 24(1):75-86 Antibody specific for phosphorylated AMPA-type glutamate receptors at GluR2 Ser-696.

Molecular and cellular biology 20(5):1537-45 Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation.

European journal of biochemistry 243(1-2):493-501 Phosphorylation of vitronectin on Ser362 by protein kinase C attenuates its cleavage by plasmin.

Genes to cells : devoted to molecular & cellular mechanisms 4(7):401-14 Changes in nuclear morphology during apoptosis correlate with vimentin cleavage by different caspases located either upstream or downstream of Bcl-2 action.

FEBS letters 516(1-3):265-9 Dephosphorylation of PKCdelta by protein phosphatase 2Ac and its inhibition by nucleotides.

Archives of biochemistry and biophysics 283(2):447-57 Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels.

Proceedings of the National Academy of Sciences of the United States of America 89(23):11627-31 Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein.

J. Biol. Chem. 278(29):27301-11 Src-CrkII-C3G-dependent activation of Rap1 switches growth hormone-stimulated p44/42 MAP kinase and JNK/SAPK activities.

J. Biol. Chem. 267(3):1786-91 Functional and structural analysis of VLA-4 integrin alpha 4 subunit cleavage.

Journal of immunology (Baltimore, Md. : 1950) 153(6):2369-80 Activation and serine phosphorylation of the p56lck protein tyrosine kinase in response to antigen receptor cross-linking in B lymphocytes.

Developmental cell 5(1):113-25 Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation.

The Journal of physiology 553(Pt 1):303-9 Exercise increases Ca2+-calmodulin-dependent protein kinase II activity in human skeletal muscle.

J. Biol. Chem. 278(20):18376-83 14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity.

J. Biol. Chem. 273(45):29417-23 Tumor necrosis factor-alpha activation of nuclear transcription factor-kappaB in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa Balpha.

J. Biol. Chem. 272(42):26595-603 Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells.

Cell 113(4):457-68 Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

FEBS letters 170(2):281-9 Acetyl-blocked N-terminal structures of sorbitol and aldehyde dehydrogenases.

Biochem. Biophys. Res. Commun. 227(3):810-5 Ser-27, Tyr-10 and Tyr-7 in the alpha-chain of pig stomach H+,K(+)-ATPase as Ca(2+)-dependent phosphorylatable sites by intrinsic and extrinsic protein kinases.

Developmental cell 9(3):389-402 Akt/PKB regulates actin organization and cell motility via Girdin/APE.

Cellular signalling 9(2):131-9 T cell signalling through CD73.

"Science (New York, N.Y.)" 329(5999):1650-3 A unifying genetic model for facioscapulohumeral muscular dystrophy.

EMBO J. 26(4):1140-9 Subcellular localization of Grb2 by the adaptor protein Dok-3 restricts the intensity of Ca2+ signaling in B cells.

EMBO J. 15(16):4182-93 Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E.

Electrophoresis 17(5):925-31 Mass spectrometric characterization of glycosylated interferon-gamma variants separated by gel electrophoresis.

J. Biol. Chem. 275(6):4484-91 Polysialyltransferase-1 autopolysialylation is not requisite for polysialylation of neural cell adhesion molecule.

EMBO J. 18(16):4549-59 Phosphorylation of splicing factor SF1 on Ser20 by cGMP-dependent protein kinase regulates spliceosome assembly.

Molecular biology of the cell 15(9):4234-47 The phosphorylation of vinculin on tyrosine residues 100 and 1065, mediated by SRC kinases, affects cell spreading.

Molecular and cellular biology 18(5):2545-52 Stat3 activation by Src induces specific gene regulation and is required for cell transformation.

Molecular & cellular proteomics : MCP 5(12):2298-310 Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics.

J. Biol. Chem. 277(27):24252-7 Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activation.

J. Biol. Chem. 277(16):13539-47 Interactions of beta and gamma ENaC with Nedd4 can be facilitated by an ERK-mediated phosphorylation.

J. Biol. Chem. 268(11):7874-84 The adipocyte lipid-binding protein at 1.6-A resolution. Crystal structures of the apoprotein and with bound saturated and unsaturated fatty acids.

Nature 401(6748):82-5 NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase.

Proceedings of the National Academy of Sciences of the United States of America 80(7):1802-6 beta-Hydroxyaspartic acid in vitamin K-dependent protein C.

J. Biol. Chem. 265(33):20488-95 The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones.

J. Biol. Chem. 278(9):6710-8 Mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase.

Proceedings of the National Academy of Sciences of the United States of America 97(10):5089-94 Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton.

"Science (New York, N.Y.)" 292(5516):468-72 Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.

The Biochemical journal 380(Pt 3):845-57 Structural analysis and tissue localization of human C4.4A: a protein homologue of the urokinase receptor.

Glycobiology 9(1):21-30 Glycosylation sites and site-specific glycosylation in human Tamm-Horsfall glycoprotein.

J. Biol. Chem. 277(3):1974-80 Transforming growth factor-beta 1 regulates Kir2.3 inward rectifier K+ channels via phospholipase C and protein kinase C-delta in reactive astrocytes from adult rat brain.

J. Biol. Chem. 278(11):9195-202 JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis.

FEBS letters 455(1-2):92-6 Cathepsin L is capable of truncating cystatin C of 11 N-terminal amino acids.

Biochemistry 30(27):6689-96 Structures of the asparagine-289-linked oligosaccharides assembled on recombinant human plasminogen expressed in a Mamestra brassicae cell line (IZD-MBO503).

Molecular biology of the cell 17(8):3705-16 Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1.

EMBO J. 13(13):3020-32 Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo.

J. Biol. Chem. 275(6):4475-83 Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway.

J. Biol. Chem. 266(17):11317-27 Cooperative activation of human factor IX by the human extrinsic pathway of blood coagulation.

Neuron 41(2):215-27 Cdk5 phosphorylation of doublecortin ser297 regulates its effect on neuronal migration.

J. Biol. Chem. 279(41):42410-21 ZNF76, a novel transcriptional repressor targeting TATA-binding protein, is modulated by sumoylation.

Molecular and cellular biology 19(5):3246-56 Cumulative effect of phosphorylation of pRB on regulation of E2F activity.

Molecular and cellular biology 20(11):3951-64 p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps.

Biochemistry 39(35):10799-805 Posttranslationally processed forms of the human chemokine HCC-1.

J. Biol. Chem. 280(6):4279-88 NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori lipopolysaccharide-stimulated macrophages.

Biochemistry 22(4):923-7 Amino acid sequence analysis of the asparagine-288 region of the carbohydrate variants of human plasminogen.

Proceedings of the National Academy of Sciences of the United States of America 100(11):6511-6 The phosphorylation of caveolin-2 on serines 23 and 36 modulates caveolin-1-dependent caveolae formation.

European journal of biochemistry 231(3):754-60 Site-specific and complete enzymic deglycosylation of the native human chorionic gonadotropin alpha-subunit.

American journal of physiology. Cell physiology 284(2):C349-64 Regulation of the mammalian cell cycle: a model of the G1-to-S transition.

European journal of biochemistry 245(3):684-92 The in vitro phosphorylation of p53 by calcium-dependent protein kinase C--characterization of a protein-kinase-C-binding site on p53.

Journal of molecular biology 361(2):312-26 A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases.

Biochemistry 18(25):5711-20 Complete amino acid sequence of a papain-solubilized human histocompatibility antigen, HLA-B7. 2. Sequence determination and search for homologies.

Biochemistry 37(15):5258-66 Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis.

J. Biol. Chem. 273(41):26908-14 The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling.

Molecular and cellular biology 18(9):4994-9 Phosphorylation of nuclear MyoD is required for its rapid degradation.

J. Biol. Chem. 272(38):23503-14 Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3.

J. Biol. Chem. 277(10):7882-8 Cell surface glycoprotein PZR is a major mediator of concanavalin A-induced cell signaling.

Molecular and cellular biology 20(15):5665-79 Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor-mediated apoptosis.

Biochem. Biophys. Res. Commun. 288(2):313-20 Heterogeneity in the phosphorylation of human death receptors by p42(mapk/erk2).

J. Biol. Chem. 272(38):23769-74 Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor subtype 3 is crucial for its desensitization and internalization.

J. Biol. Chem. 274(24):16741-6 Negative regulation of the forkhead transcription factor FKHR by Akt.

J. Biol. Chem. 276(26):23632-8 Post-translational processing of bovine chondromodulin-I.

J. Biol. Chem. 277(28):25562-7 Acetylation of beta-catenin by CREB-binding protein (CBP).

J. Biol. Chem. 279(2):970-9 Role of p38alpha Map kinase in Type I interferon signaling.

Biochemistry 30(6):1515-23 Disulfide assignments in recombinant mouse and human interleukin 4.

European journal of biochemistry 261(1):269-74 Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis.

Cancer research 60(24):6841-5 HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway.

European journal of biochemistry 270(18):3739-49 Gelatinase B/MMP-9 and neutrophil collagenase/MMP-8 process the chemokines human GCP-2/CXCL6, ENA-78/CXCL5 and mouse GCP-2/LIX and modulate their physiological activities.

J. Biol. Chem. 278(20):18671-81 Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A.

Proceedings of the National Academy of Sciences of the United States of America 98(24):13710-5 Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein.

Oncogene 20(36):4935-41 Cleavage of Fyn and Lyn in their N-terminal unique regions during induction of apoptosis: a new mechanism for Src kinase regulation.

J. Biol. Chem. 271(45):28485-91 Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by alpha9beta1 integrin.

EMBO J. 25(15):3556-64 The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf.

J. Biol. Chem. 277(1):502-8 RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth muscle cells into S-phase.

J. Biol. Chem. 275(47):36514-22 The neuropeptide processing enzyme EC 3.4.24.15 is modulated by protein kinase A phosphorylation.

J. Biol. Chem. 274(25):17806-12 Identification of the cell cycle regulator VCP (p97/CDC48) as a substrate of the band 4.1-related protein-tyrosine phosphatase PTPH1.

Molecular endocrinology (Baltimore, Md.) 13(1):15-23 Roles of pathway-specific and inhibitory Smads in activin receptor signaling.

Genes & development 14(23):2989-3002 Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.

European journal of immunology 28(8):2265-75 Roles of Lck, Syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation of the adapter protein Shc.

Nature cell biology 5(4):363-9 PKCepsilon is a permissive link in integrin-dependent IFN-gamma signalling that facilitates JAK phosphorylation of STAT1.

Biochem. Biophys. Res. Commun. 331(1):1-14 Src kinase regulation by phosphorylation and dephosphorylation.

J. Biol. Chem. 272(33):20317-20 Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis.

Endocrine reviews 19(3):225-68 Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice.

Oncogene 20(46):6784-93 UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts.

American journal of physiology. Endocrinology and metabolism 286(2):E239-44 AMPK activity and isoform protein expression are similar in muscle of obese subjects with and without type 2 diabetes.

The Biochemical journal 349(Pt 2):547-57 Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.

Molecular and cellular biology 21(4):1077-88 SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF.

Cellular signalling 19(3):600-9 The N-terminal SH2 domain of the tyrosine phosphatase, SHP-2, is essential for Jak2-dependent signaling via the angiotensin II type AT1 receptor.

Molecular cell 10(6):1269-81 Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation.

FEBS letters 496(1):60-5 Phosphorylation of murine homeodomain protein Dlx3 by protein kinase C.

Chem. Biol. 9(12):1329-35 Nitrosopeptide mapping: a novel methodology reveals s-nitrosylation of dexras1 on a single cysteine residue.

J. Biol. Chem. 277(48):46576-85 The aryl hydrocarbon receptor nuclear transporter is modulated by the SUMO-1 conjugation system.

J. Biol. Chem. 277(14):12359-63 Phosphorylation of stargazin by protein kinase A regulates its interaction with PSD-95.

J. Biol. Chem. 278(18):15461-4 The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif.

Molecular and cellular biology 21(15):4856-67 Transcription factor AP-2alpha is preferentially cleaved by caspase 6 and degraded by proteasome during tumor necrosis factor alpha-induced apoptosis in breast cancer cells.

J. Biol. Chem. 263(8):4023-8 The precursor of interleukin-1 alpha is phosphorylated at residue serine 90.

EMBO J. 12(2):803-8 Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation.

EMBO J. 26(2):468-80 aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb.

Proceedings of the National Academy of Sciences of the United States of America 86(14):5252-6 Human placenta protein-tyrosine-phosphatase: amino acid sequence and relationship to a family of receptor-like proteins.

Proceedings of the National Academy of Sciences of the United States of America 100(21):12480-5 Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1).

J. Biol. Chem. 276(12):9460-7 Differential effects of leukocyte common antigen-related protein on biochemical and biological activities of RET-MEN2A and RET-MEN2B mutant proteins.

Nucleic acids research 29(15):3172-80 Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIalpha.

J. Biol. Chem. 274(17):11505-12 The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2.

Molecular endocrinology (Baltimore, Md.) 17(4):534-49 Protein tyrosine phosphatase PTP20 induces actin cytoskeleton reorganization by dephosphorylating p190 RhoGAP in rat ovarian granulosa cells stimulated with follicle-stimulating hormone.

The Journal of experimental zoology 285(1):76-84 Phylogenetically conserved CK-II phosphorylation site of the murine homeodomain protein Hoxb-6.

J. Biol. Chem. 271(12):7113-9 Metalloproteinase activity secreted by fibrogenic cells in the processing of prolysyl oxidase. Potential role of procollagen C-proteinase.

J. Biol. Chem. 278(7):4668-74 The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation.

Nucleic acids research 32(10):3033-9 Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity.

Proceedings of the National Academy of Sciences of the United States of America 95(19):11211-6 Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.

J. Biol. Chem. 275(21):16219-26 Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1.

European journal of biochemistry 267(13):4054-62 Mutational analysis of arginine 177 in the nucleotide binding site of beta-actin.

J. Biol. Chem. 277(47):44623-30 Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase.

J. Biol. Chem. 274(49):34531-4 Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases.

J. Biol. Chem. 278(40):38117-20 Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37.

J. Biol. Chem. 270(50):30075-83 Phosphorylation of the cytosolic domain of peptidylglycine alpha-amidating monooxygenase.

J. Biol. Chem. 274(34):23707-18 The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling.

Biochemistry 28(7):2974-9 Domain- and sequence-specific phosphorylation of vimentin induces disassembly of the filament structure.

J. Biol. Chem. 274(34):24328-34 G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction.

Journal of neurochemistry 71(5):2220-8 Brain beta-spectrin phosphorylation: phosphate analysis and identification of threonine-347 as a heparin-sensitive protein kinase phosphorylation site.

American journal of physiology. Endocrinology and metabolism 279(5):E1202-6 AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation.

Cell 109(4):459-72 Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways.

Nature 390(6655):91-6 Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone.

Journal of immunology (Baltimore, Md. : 1950) 145(8):2730-6 Rapid nonlysosomal degradation of assembled HLA class II glycoproteins incorporating a mutant DR alpha-chain.

J. Biol. Chem. 276(19):16580-6 ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation.

The Journal of cell biology 135(6 Pt 1):1441-55 Lamin proteolysis facilitates nuclear events during apoptosis.

EMBO J. 19(5):964-78 A phosphotyrosine displacement mechanism for activation of Src by PTPalpha.

FEBS letters 445(1):149-54 Identification of caspases that cleave presenilin-1 and presenilin-2. Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1 to caspases.

Nature 419(6909):849-53 The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.

J. Biol. Chem. 278(19):16809-19 Sterol regulatory element-binding proteins are negatively regulated through SUMO-1 modification independent of the ubiquitin/26 S proteasome pathway.

J. Biol. Chem. 274(18):12861-6 Characterization of the major physiologic phosphorylation site of human keratin 19 and its role in filament organization.

J. Biol. Chem. 276(20):17276-80 Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies.

Molecular biology of the cell 10(3):551-65 The multisubstrate docking site of the MET receptor is dispensable for MET-mediated RAS signaling and cell scattering.

Proceedings of the National Academy of Sciences of the United States of America 98(16):8991-6 PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase.

J. Biol. Chem. 277(46):43933-41 The extracellular N terminus of the endothelin B (ETB) receptor is cleaved by a metalloprotease in an agonist-dependent process.

Molecular and cellular biology 23(20):7391-402 Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription.

J. Biol. Chem. 280(36):31913-23 Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.

J. Biol. Chem. 274(1):48-51 Effect of phosphorylation on activities of Rap1A to interact with Raf-1 and to suppress Ras-dependent Raf-1 activation.

J. Biol. Chem. 276(45):42153-61 Heregulin-dependent activation of phosphoinositide 3-kinase and Akt via the ErbB2/ErbB3 co-receptor.

J. Biol. Chem. 278(5):3403-9 Cell cycle-dependent regulation of pyrimidine biosynthesis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 16(13):1823-5 Induction of cancer cell migration by epidermal growth factor is initiated by specific phosphorylation of tyrosine 1248 of c-erbB-2 receptor via EGFR.

Biochim. Biophys. Acta 1763(10):1098-107 An ITIM-like motif within the CCK2 receptor sequence required for interaction with SHP-2 and the activation of the AKT pathway.

EMBO J. 26(1):221-31 Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling.

J. Biol. Chem. 272(4):2527-33 Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin.

J. Biol. Chem. 273(8):4478-84 Autocatalytic processing of recombinant human procathepsin L. Contribution of both intermolecular and unimolecular events in the processing of procathepsin L in vitro.

Cell structure and function 30(2):69-80 Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1.

The New England journal of medicine 333(21):1386-90 Brief report: impaired processing of prohormones associated with abnormalities of glucose homeostasis and adrenal function.

Experimental cell research 253(1):117-30 Signaling via vascular endothelial growth factor receptors.

Biochemistry 28(2):635-43 The single-chain form of tissue-type plasminogen activator has catalytic activity: studies with a mutant enzyme that lacks the cleavage site.

J. Biol. Chem. 277(30):26904-11 Palmitoylation of KChIP splicing variants is required for efficient cell surface expression of Kv4.3 channels.

Biochim. Biophys. Acta 1596(1):131-7 Stromal interaction molecule 1 (STIM1), a transmembrane protein with growth suppressor activity, contains an extracellular SAM domain modified by N-linked glycosylation.

European journal of biochemistry 260(2):421-9 Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms.

J. Biol. Chem. 274(29):20693-703 PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway.

J. Biol. Chem. 270(32):18961-5 c-Myc is glycosylated at threonine 58, a known phosphorylation site and a mutational hot spot in lymphomas.

FEBS letters 517(1-3):27-31 Primary sequence determinants responsible for site-selective dephosphorylation of the PDGF beta-receptor by the receptor-like protein tyrosine phosphatase DEP-1.

The Biochemical journal Caspase-mediated cleavage of eukaryotic translation initiation factor subunit 2alpha.

J. Biol. Chem. 278(19):16706-12 Activation of cGMP-dependent protein kinase by protein kinase C.

Molecular and cellular biology 18(5):2986-96 Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation.

Nature 406(6792):210-5 Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response.

Nature genetics 40(9):1076-83 Evolutionary toggling of the MAPT 17q21.31 inversion region.

Biochim. Biophys. Acta 1645(2):123-32 Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases.

Biochem. Biophys. Res. Commun. 201(3):1279-88 Identification of novel phosphorylation sites in the beta-subunit of translation initiation factor eIF-2.

Human molecular genetics 14(15):2209-19 LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes.

J. Biol. Chem. 269(52):33116-22 A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP formation.

Journal of cellular physiology 183(1):129-39 Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases.

Proceedings of the National Academy of Sciences of the United States of America 101(47):16612-7 Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation.

Molecular and cellular biology 22(10):3292-300 c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage.

Biochim. Biophys. Acta 1598(1-2):40-5 Sequence determinants on the NR2A and NR2B subunits of NMDA receptor responsible for specificity of phosphorylation by CaMKII.

Cell 75(3):487-93 MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo.

Oncogene 18(25):3696-702 SHP-2 binds to Tyr763 and Tyr1009 in the PDGF beta-receptor and mediates PDGF-induced activation of the Ras/MAP kinase pathway and chemotaxis.

The Journal of cell biology 144(6):1097-112 A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96.

Molecular biology of the cell 14(4):1489-500 Functional significance of the specific sites phosphorylated in desmin at cleavage furrow: Aurora-B may phosphorylate and regulate type III intermediate filaments during cytokinesis coordinatedly with Rho-kinase.

J. Biol. Chem. 276(21):18130-8 Interaction of hematopoietic progenitor kinase 1 and c-Abl tyrosine kinase in response to genotoxic stress.

EMBO J. 13(3):522-33 PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

The Journal of cell biology 158(1):165-74 Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells.

Molecular endocrinology (Baltimore, Md.) 17(1):11-26 A central role for Ets-2 in the transcriptional regulation and cyclic adenosine 5'-monophosphate responsiveness of the human chorionic gonadotropin-beta subunit gene.

J. Biol. Chem. 274(20):14434-43 MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo.

Nucleic acids research 31(8):2196-208 Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function.

Biochem. Biophys. Res. Commun. 325(3):997-1004 Characterization of a MAPKK-like protein kinase TOPK.

J. Biol. Chem. 275(15):11064-70 Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase.

J. Biol. Chem. 277(26):23216-22 Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor.

Neuron 38(6):899-914 JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis.

FEBS letters 581(8):1661-72 Cyclin B1/Cdk1 binds and phosphorylates Filamin A and regulates its ability to cross-link actin.

Molecular and cellular biology 11(4):1840-5 Biosynthesis of human fibroblast growth factor-5.

J. Biol. Chem. 271(25):14657-60 Degradation of interleukin 1beta by matrix metalloproteinases.

Oncogene 17(21):2679-89 The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties.

EMBO J. 11(12):4379-89 Reversible phosphorylation--dephosphorylation determines the localization of rab4 during the cell cycle.

J. Biol. Chem. 280(27):25409-15 Protein kinase C phosphorylation of the metabotropic glutamate receptor mGluR5 on Serine 839 regulates Ca2+ oscillations.

Nature genetics 21(2):187-90 Activating SRC mutation in a subset of advanced human colon cancers.

J. Biol. Chem. 275(43):33353-64 Modulation of the catalytic activity of the Src family tyrosine kinase Hck by autophosphorylation at a novel site in the unique domain.

The Biochemical journal 367(Pt 2):451-8 Structural and functional characterization of tissue factor pathway inhibitor following degradation by matrix metalloproteinase-8.

Nature 440(7083):528-34 The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production.

Journal of proteome research 7(9):4050-7 Phosphorylation of SUMO-1 occurs in vivo and is conserved through evolution.

Biochemistry 28(10):4253-8 Primary structure of the cAMP-dependent phosphorylation site of the plasma membrane calcium pump.

FEBS letters 312(1):95-9 p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected].

J. Biol. Chem. 276(42):38921-8 Multiple ErbB-2/Neu Phosphorylation Sites Mediate Transformation through Distinct Effector Proteins.

Nippon Ganka Gakkai zasshi 96(11):1418-22 [Topical timolol and blood-aqueous barrier permeability to protein in human eyes].

Proceedings of the National Academy of Sciences of the United States of America 99(18):11860-5 Essential myosin light chain as a target for caspase-3 in failing myocardium.

"Science (New York, N.Y.)" 279(5352):870-3 Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning.

J. Biol. Chem. 279(40):41815-21 Proteomic identification of Bcl2-associated athanogene 2 as a novel MAPK-activated protein kinase 2 substrate.

Biochem. Biophys. Res. Commun. 291(3):574-81 Phosphorylation of the N-terminal and C-terminal CD3-epsilon-ITAM tyrosines is differentially regulated in T cells.

J. Biol. Chem. 278(12):10538-45 Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis.

Biochemistry 43(38):12133-40 Identification of major ERK-related phosphorylation sites in Gab1.

Circulation research 97(7):645-54 Glycogen synthase kinase 3beta inhibits myocardin-dependent transcription and hypertrophy induction through site-specific phosphorylation.

DNA and cell biology 23(1):67-74 TIAF1 and p53 functionally interact in mediating apoptosis and silencing of TIAF1 abolishes nuclear translocation of serine 15-phosphorylated p53.

FEBS letters 330(3):323-8 Isoprenylation of Rab proteins possessing a C-terminal CaaX motif.

Journal of immunology (Baltimore, Md. : 1950) 172(10):5838-42 Cutting edge: TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2.

Proceedings of the National Academy of Sciences of the United States of America 95(12):6642-6 Cloning and characterization of human protease-activated receptor 4.

J. Biol. Chem. 273(50):33423-8 Role of asparagine-linked oligosaccharides in protein folding, membrane targeting, and thyrotropin and autoantibody binding of the human thyrotropin receptor.

J. Biol. Chem. 276(24):21849-53 Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase.

Biochim. Biophys. Acta 1395(2):202-8 cDNA cloning of a novel trypsin inhibitor with similarity to pathogenesis-related proteins, and its frequent expression in human brain cancer cells.

J. Biol. Chem. 275(1):599-604 Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation.

J. Biol. Chem. 270(39):23212-7 Role of N-linked glycosylation in human osteonectin. Effect of carbohydrate removal by N-glycanase and site-directed mutagenesis on structure and binding of type V collagen.

Molecular and cellular biology 21(8):2743-54 Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.

Proceedings of the National Academy of Sciences of the United States of America 100(19):10966-71 Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America 96(10):5458-63 From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells.

Archives of biochemistry and biophysics 344(1):67-74 Serine phosphorylation of syndecan-2 proteoglycan cytoplasmic domain.

Cell death and differentiation 9(9):915-25 Caspase cleavage of the nuclear autoantigen LEDGF/p75 abrogates its pro-survival function: implications for autoimmunity in atopic disorders.

Proceedings of the National Academy of Sciences of the United States of America 92(23):10531-4 Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein.

Biochem. Biophys. Res. Commun. 228(3):662-8 Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src.

Blood 103(10):3783-8 A novel plasma proteinase potentiates alpha2-antiplasmin inhibition of fibrin digestion.

Oncogene 18(36):5024-31 The transmembranal and cytoplasmic forms of protein tyrosine phosphatase epsilon physically associate with the adaptor molecule Grb2.

J. Biol. Chem. 267(20):14304-8 Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage.

Nature 404(6774):201-4 hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response.

J. Biol. Chem. 278(14):11760-7 Regulation of mammalian STE20-like kinase 2 (MST2) by protein phosphorylation/dephosphorylation and proteolysis.

EMBO J. 13(10):2341-51 c-Abl kinase regulates the protein binding activity of c-Crk.

J. Biol. Chem. 271(31):18803-9 A single N-linked glycosylation site is implicated in the regulation of ligand recognition by the I-type lectins CD22 and CD33.

EMBO J. 18(19):5252-63 Cathepsin D targeted by acid sphingomyelinase-derived ceramide.

EMBO reports 3(4):341-8 Plk1 promotes nuclear translocation of human Cdc25C during prophase.

Nature cell biology 8(2):163-9 Regulation of ubiquitin-binding proteins by monoubiquitination.

The Journal of cell biology 111(6 Pt 2):2939-49 cDNA cloning reveals the molecular structure of a sperm surface protein, PH-20, involved in sperm-egg adhesion and the wide distribution of its gene among mammals.

J. Biol. Chem. 273(7):3994-4000 Modification of phosphatidylinositol 3-kinase SH2 domain binding properties by Abl- or Lck-mediated tyrosine phosphorylation at Tyr-688.

J. Biol. Chem. 275(44):34744-9 Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms.

Proceedings of the National Academy of Sciences of the United States of America 92(8):3454-7 Phosphorylation of ubiquitin-activating enzyme in cultured cells.

Oncogene 19(32):3656-64 The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.

J. Biol. Chem. 277(47):45115-21 Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein.

The Biochemical journal Glycosylation pattern of human inter-alpha-inhibitor heavy chains.

EMBO J. 25(17):3943-54 Direct binding of p85 to sst2 somatostatin receptor reveals a novel mechanism for inhibiting PI3K pathway.

Nature biotechnology 21(5):566-9 Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

J. Biol. Chem. 265(7):3940-3 Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro.

J. Biol. Chem. 276(22):19276-85 MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation.

Biochemistry 42(30):9195-204 Adhesion-associated and PKC-modulated changes in serine/threonine phosphorylation of p120-catenin.

The Journal of neuroscience : the official journal of the Society for Neuroscience 21(2):423-33 Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin.

Biochim. Biophys. Acta 1564(2):333-42 Analysis of membrane topology of the human reduced folate carrier protein by hemagglutinin epitope insertion and scanning glycosylation insertion mutagenesis.

J. Biol. Chem. 269(14):10209-12 Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5.

Journal of molecular biology 259(5):995-1010 Crystal structure of human trypsin 1: unexpected phosphorylation of Tyr151.

J. Biol. Chem. 276(26):23816-24 Identification and characterization of S2V, a novel putative siglec that contains two V set Ig-like domains and recruits protein-tyrosine phosphatases SHPs.

J. Biol. Chem. 273(22):13524-30 Caspase-mediated cleavage of the ubiquitin-protein ligase Nedd4 during apoptosis.

J. Biol. Chem. 274(53):38260-7 Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10.

J. Biol. Chem. 281(5):2989-98 Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones.

Proceedings of the National Academy of Sciences of the United States of America 90(23):10952-6 Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase.

J. Biol. Chem. 275(27):20853-60 p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation.

J. Biol. Chem. 276(46):42843-50 Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt.

J. Biol. Chem. 277(34):30798-804 Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo.

Proceedings of the National Academy of Sciences of the United States of America 101(12):4100-5 DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity.

Nature cell biology 7(8):785-96 Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis.

Nature 440(7084):671-5 Analysis of the DNA sequence and duplication history of human chromosome 15.

European journal of biochemistry 192(2):515-21 Primary structure of the bovine analogues to human apolipoproteins CII and CIII. Studies on isoforms and evidence for proteolytic processing.

J. Biol. Chem. 277(52):50311-7 Definition of the nuclear encoded protein composition of bovine heart mitochondrial complex I. Identification of two new subunits.

"Science (New York, N.Y.)" 277(5330):1306-9 A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes.

J. Biol. Chem. 276(7):4894-900 Threonine 180 is required for G-protein-coupled receptor kinase 3- and beta-arrestin 2-mediated desensitization of the mu-opioid receptor in Xenopus oocytes.

J. Biol. Chem. 273(36):23258-66 Phosphorylation of the prostacyclin receptor during homologous desensitization. A critical role for protein kinase c.

J. Biol. Chem. 277(10):8693-701 Novel activation of STAT5b in response to epidermal growth factor.

Oncogene 23(1):109-21 H4(D10S170), a gene frequently rearranged with RET in papillary thyroid carcinomas: functional characterization.

Medicinski pregled 30(9-10):477-82 [Viscosimetry in clinical practice].

J. Biol. Chem. 275(7):5090-5 Casein kinase II phosphorylation of E-cadherin increases E-cadherin/beta-catenin interaction and strengthens cell-cell adhesion.

J. Biol. Chem. 276(3):2286-91 Cleavage of the amino terminus of the prion protein by reactive oxygen species.

J. Biol. Chem. 269(16):12304-9 Core protein structure and sequence determine the site and presence of heparan sulfate and chondroitin sulfate on syndecan-1.

J. Biol. Chem. 273(14):8459-66 Identification and partial characterization of factor Va heavy chain kinase from human platelets.

J. Biol. Chem. 268(24):17896-901 Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase by G protein and tyrosine kinase oncoproteins.

Archives of biochemistry and biophysics 347(1):62-8 Interaction of matrix metalloproteinases-2 and -9 with pregnancy zone protein and alpha2-macroglobulin.

J. Biol. Chem. 277(11):8810-6 Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation.

Methods (San Diego, Calif.) 35(1):44-53 Substrate-trapping techniques in the identification of cellular PTP targets.

EMBO J. 20(16):4370-9 Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

Proceedings of the National Academy of Sciences of the United States of America 90(14):6796-800 Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.

Biochim. Biophys. Acta 1208(2):332-7 Expression of rat alpha-fetoprotein cDNA and its mutants in cultured mouse fibroblasts and identification of glycosylation sites related to electrophoretic variants.

The Journal of cell biology 138(6):1379-94 Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis.

J. Biol. Chem. 271(21):12481-7 Modulation of the SH2 binding specificity and kinase activity of Src by tyrosine phosphorylation within its SH2 domain.

"Science (New York, N.Y.)" 310(5746):306-10 Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.

J. Biol. Chem. 271(29):17119-23 The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3.

J. Biol. Chem. 272(46):28882-8 14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction.

"Science (New York, N.Y.)" 293(5532):1133-6 Coordination of a transcriptional switch by HMGI(Y) acetylation.

Molecular and cellular biology 18(7):4131-40 Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt.

Molecular cell 3(4):521-6 Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress.

J. Biol. Chem. 279(38):39653-62 In vitro modification of human centromere protein CENP-C fragments by small ubiquitin-like modifier (SUMO) protein: definitive identification of the modification sites by tandem mass spectrometry analysis of the isopeptides.

J. Biol. Chem. 271(48):30942-9 Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors.

Protein science : a publication of the Protein Society 12(8):1762-74 Methylation and carbamylation of human gamma-crystallins.

J. Biol. Chem. 272(50):31235-40 Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I.

Proceedings of the National Academy of Sciences of the United States of America 98(22):12742-7 Regulation of NMDA receptors by cyclin-dependent kinase-5.

J. Biol. Chem. 277(9):7396-404 A lipid-regulated docking site on vinculin for protein kinase C.

Peptides 10(4):891-4 Endopeptidase-24.11 in human plasma degrades atrial natriuretic factor (ANF) to ANF(99-105/106-126).

J. Biol. Chem. 272(17):11457-62 Target-dependent effect of phosphorylation on the DNA binding activity of the TAL1/SCL oncoprotein.

Nucleic acids research 33(22):e186 New approaches to the analysis of palindromic sequences from the human genome: evolution and polymorphism of an intronic site at the NF1 locus.

Nature 434(7034):724-31 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

EMBO J. 18(2):396-410 Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.

"Science (New York, N.Y.)" 284(5412):339-43 Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.

European journal of biochemistry 213(2):689-99 Regulation of elongation factor-2 by multisite phosphorylation.

J. Biol. Chem. 274(39):27583-9 SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity.

J. Biol. Chem. 271(21):12517-24 Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification.

European journal of biochemistry 267(7):2105-12 Structural characterization of the oligosaccharide chains of human alpha1-microglobulin from urine and amniotic fluid.

Molecular and cellular biology 16(12):6887-99 A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion.

Oncogene 19(54):6324-33 NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation.

The Biochemical journal Identification of csk tyrosine phospho