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|NCBI BioProject Name||Homo sapiens|
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Whole Genome Sequencing
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Initial sequencing and analysis of the human genome.
Molecular biology of the cell
Insulin-induced stimulation of Na+,K(+)-ATPase activity in kidney proximal tubule cells depends on phosphorylation of the alpha-subunit at Tyr-10.
J. Biol. Chem. 262(7):3082-5 Sulfation of a tyrosine residue in the plasmin-binding domain of alpha 2-antiplasmin.
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J. Biol. Chem. 275(35):27123-8 Matrix metalloproteinases cleave tissue factor pathway inhibitor. Effects on coagulation.
J. Biol. Chem. 275(19):14590-7 Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling.
J. Biol. Chem. 269(44):27715-8 Requirement for negative charge on "activation loop" of protein kinase C.
J. Biol. Chem. 273(46):30097-103 p40(phox) is phosphorylated on threonine 154 and serine 315 during activation of the phagocyte NADPH oxidase. Implication of a protein kinase c-type kinase in the phosphorylation process.
J. Biol. Chem. 279(3):1739-46 Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity.
J. Biol. Chem. 281(1):626-37 Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein.
J. Biol. Chem. 271(45):28502-8 Cysteines 153 and 154 of transmembrane transforming growth factor-alpha are palmitoylated and mediate cytoplasmic protein association.
Molecular and cellular biology 24(2):765-73 Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A.
J. Biol. Chem. 278(18):15886-96 Profile-based data base scanning for animal L-type lectins and characterization of VIPL, a novel VIP36-like endoplasmic reticulum protein.
Nucleic acids research 29(5):1027-33 Sp1 phosphorylation regulates inducible expression of platelet-derived growth factor B-chain gene via atypical protein kinase C-zeta.
J. Biol. Chem. 265(1):538-45 The amino terminus of muscle tropomyosin is a major determinant for function.
Journal of biochemistry 126(3):475-84 Mutational analysis of the regulatory mechanism of PKN: the regulatory region of PKN contains an arachidonic acid-sensitive autoinhibitory domain.
Molecular pharmacology 61(3):569-77 Caspase-dependent cleavage of carbamoyl phosphate synthetase II during apoptosis.
Genes & development 15(18):2343-60 Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails.
Proceedings of the National Academy of Sciences of the United States of America 92(24):11259-63 Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination.
Oncogene 22(23):3589-97 v-Src induces Shc binding to tyrosine 63 in the cytoplasmic domain of the LDL receptor-related protein 1.
Molecular cell 5(6):905-15 Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation.
J. Biol. Chem. 279(13):12220-31 Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398.
The Journal of cell biology 163(4):825-35 S100C/A11 is a key mediator of Ca(2+)-induced growth inhibition of human epidermal keratinocytes.
J. Biol. Chem. 277(42):39360-7 Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3.
Molecular and cellular biology 16(4):1295-304 Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation.
Thrombosis and haemostasis 80(4):645-8 Platelet glycoprotein Ia* is the processed form of multimerin--isolation and determination of N-terminal sequences of stored and released forms.
J. Biol. Chem. 271(39):23842-5 Elimination of potential sites of glycosylation fails to abrogate complement regulatory function of cell surface CD59.
J. Biol. Chem. 276(28):26237-42 Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity.
EMBO J. 23(2):312-21 Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins.
The Biochemical journal 365(Pt 1):79-87 Integrin-linked kinase phosphorylates the myosin phosphatase target subunit at the inhibitory site in platelet cytoskeleton.
Proceedings of the National Academy of Sciences of the United States of America 100(17):10032-7 Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease.
EMBO J. 22(4):797-806 Mad2 phosphorylation regulates its association with Mad1 and the APC/C.
Journal of molecular biology 329(4):631-44 Functional domains of FOXJ2.
J. Biol. Chem. 274(15):10086-93 Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase.
J. Biol. Chem. 278(8):5728-35 Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1.
J. Biol. Chem. 278(28):25277-80 Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate.
FEBS letters 421(2):125-30 Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin.
Arteriosclerosis, thrombosis, and vascular biology 22(5):759-64 Role of isoprenylcysteine carboxyl methyltransferase in tumor necrosis factor-alpha stimulation of expression of vascular cell adhesion molecule-1 in endothelial cells.
J. Biol. Chem. 275(34):26515-22 Synucleins are a novel class of substrates for G protein-coupled receptor kinases.
Molecular and cellular biology 26(7):2728-35 Uncleaved TFIIA is a substrate for taspase 1 and active in transcription.
Molecular and cellular biology 20(5):1678-91 Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav.
J. Biol. Chem. 266(14):8784-9 Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme.
Proceedings of the National Academy of Sciences of the United States of America 74(12):5377-81 Chemical evidence that proteolytic cleavage causes the heterogeneity present in human ceruloplasmin preparations.
EMBO J. 20(24):7052-9 Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression.
J. Biol. Chem. 272(13):8207-14 Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptor.
FEBS letters 409(1):57-62 Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases.
"Science (New York, N.Y.)" 278(5338):687-9 Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt.
Molecular cell 15(6):937-49 Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways.
The Journal of cell biology 160(7):1115-27 Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol.
J. Biol. Chem. 275(33):25585-94 Localization of disulfide bonds in the cystine knot domain of human von Willebrand factor.
J. Biol. Chem. 272(46):28962-70 Butylated hydroxyanisole and its metabolite tert-butylhydroquinone differentially regulate mitogen-activated protein kinases. The role of oxidative stress in the activation of mitogen-activated protein kinases by phenolic antioxidants.
Biochemistry 33(19):5791-6 Fluorescence studies of the location and membrane accessibility of the palmitoylation sites of rhodopsin.
Nature 405(6785):473-7 Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products.
J. Biol. Chem. 266(19):12266-71 In vitro phosphorylation of the adipocyte lipid-binding protein (p15) by the insulin receptor. Effects of fatty acid on receptor kinase and substrate phosphorylation.
Investigative ophthalmology & visual science 40(3):657-67 Modifications to rat lens major intrinsic protein in selenite-induced cataract.
Nature 434(7029):113-8 Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.
FEBS letters 266(1-2):167-70 Location and characterization of the three carbohydrate prosthetic groups of human protein HC.
Proceedings of the National Academy of Sciences of the United States of America 94(6):2350-5 Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain.
J. Biol. Chem. 281(1):36-42 In vitro transport of membrane proteins to peroxisomes by shuttling receptor Pex19p.
FEBS letters 236(1):201-4 A discontinuous epitope on p36, the major substrate of src tyrosine-protein-kinase, brings the phosphorylation site into the neighbourhood of a consensus sequence for Ca2+/lipid-binding proteins.
Molecular cell 5(6):917-26 Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14.
Nature 420(6916):636-42 Structural basis of BMP signalling inhibition by the cystine knot protein Noggin.
Biochem. Biophys. Res. Commun. 288(3):564-72 Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase, and PKCdelta.
Journal of biochemistry 138(4):485-91 Regulation of intracellular localization and transcriptional activity of FOXO4 by protein kinase B through phosphorylation at the motif sites conserved among the FOXO family.
Cytogenetic and genome research 159(1):12-18 Epigenetic Coactivation of MAGEA6 and CT-GABRA3 Defines Orientation of a Segmental Duplication in the Human X Chromosome.
J. Biol. Chem. 277(47):44962-8 Casein kinase 1 regulates connexin-43 gap junction assembly.
FEBS letters 482(1-2):44-8 MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells.
J. Biol. Chem. 277(2):1031-9 Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway.
J. Biol. Chem. 276(42):38480-6 Protein kinase C regulates the phosphorylation and cellular localization of occludin.
J. Biol. Chem. 277(41):38486-93 ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner.
J. Biol. Chem. 278(26):24018-25 CK2 phosphorylation of the armadillo repeat region of beta-catenin potentiates Wnt signaling.
Molecular and cellular biology 19(7):4843-54 BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site.
The Journal of cell biology 160(6):823-31 The RasGAP-associated endoribonuclease G3BP assembles stress granules.
J. Biol. Chem. 274(17):12171-6 Dual specificity protein kinase activity of testis-specific protein kinase 1 and its regulation by autophosphorylation of serine-215 within the activation loop.
J. Biol. Chem. 278(44):43541-9 T cell receptor engagement leads to the recruitment of IBP, a novel guanine nucleotide exchange factor, to the immunological synapse.
Oncogene 25(1):70-8 The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs.
"Science (New York, N.Y.)" 286(5445):1741-4 Phosphorylation and regulation of Raf by Akt (protein kinase B).
J. Biol. Chem. 272(40):25401-8 Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity.
J. Biol. Chem. 272(23):14850-9 The type II transforming growth factor-beta receptor autophosphorylates not only on serine and threonine but also on tyrosine residues.
Gastroenterology 115(5):1154-62 Modulation of the cleavage of the gastrin precursor by prohormone phosphorylation.
Journal of proteome research 4(5):1661-71 Phosphoproteome analysis of HeLa cells using stable isotope labeling with amino acids in cell culture (SILAC).
European journal of biochemistry 231(2):491-7 Human topoisomerase II alpha is phosphorylated in a cell-cycle phase-dependent manner by a proline-directed kinase.
Biochem. Biophys. Res. Commun. 169(3):896-904 Ca2(+)-calmodulin-dependent protein kinase II phosphorylates various types of non-epithelial intermediate filament proteins.
The Biochemical journal 394(Pt 2):379-87 Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity.
J. Biol. Chem. 271(10):5309-12 Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities.
EMBO J. 13(7):1610-9 Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.
J. Biol. Chem. 278(22):19642-8 In vivo identification of inducible phosphoacceptors in the IKKgamma/NEMO subunit of human IkappaB kinase.
Molecular and cellular biology 16(3):998-1005 Inhibition of Bcr serine kinase by tyrosine phosphorylation.
J. Biol. Chem. 271(38):23588-93 Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells.
J. Biol. Chem. 266(17):10820-4 Inactivation of DNA polymerase beta by in vitro phosphorylation with protein kinase C.
Molecular and cellular biology 20(6):2043-54 Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation.
Immunity 5(4):353-63 Protein kinase C mu (PKC mu) associates with the B cell antigen receptor complex and regulates lymphocyte signaling.
Endocrine journal 47(4):373-81 The functional significance of Shc in insulin signaling as a substrate of the insulin receptor.
Proceedings of the National Academy of Sciences of the United States of America 88(14):6142-6 Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation.
Nature 394(6694):697-700 Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta.
J. Biol. Chem. 280(42):35337-45 Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway.
Journal of immunology (Baltimore, Md. : 1950) 170(8):4170-7 Threonine phosphorylation sites in the beta 2 and beta 7 leukocyte integrin polypeptides.
Molecular cell 17(2):215-24 Regulation of Raf-1 by direct feedback phosphorylation.
Oncogene 21(43):6633-40 Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways.
J. Biol. Chem. 277(17):14408-16 Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727.
The Journal of cell biology 167(3):469-78 The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone.
European journal of biochemistry 175(2):331-8 Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase.
Oncogene 21(34):5335-45 Caspase-3 mediated cleavage of BRCA1 during UV-induced apoptosis.
Biochemistry 41(52):15845-53 Site-specific dephosphorylation of endothelial nitric oxide synthase by protein phosphatase 2A: evidence for crosstalk between phosphorylation sites.
Molecular cell 14(2):175-82 Gene-specific modulation of TAF10 function by SET9-mediated methylation.
J. Biol. Chem. 269(21):15337-43 Direct interaction between Shc and the platelet-derived growth factor beta-receptor.
J. Biol. Chem. 270(37):21765-71 Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits.
Molecular cancer research : MCR 1(8):598-609 Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation.
Cancer research 63(22):7619-23 Inactivation of a histone methyltransferase by mutations in human cancers.
The Biochemical journal 361(Pt 2):255-65 Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction.
J. Biol. Chem. 279(8):7048-54 Phosphorylation of vanilloid receptor 1 by Ca2+/calmodulin-dependent kinase II regulates its vanilloid binding.
Pharmacological reviews 51(1):7-61 The glutamate receptor ion channels.
J. Biol. Chem. 279(14):14391-7 Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor.
Molecular and cellular biology 21(4):1024-35 Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha.
J. Biol. Chem. 271(18):10816-20 Processing and activation of CMH-1 by granzyme B.
Biochim. Biophys. Acta 1477(1-2):90-7 S-nitrosylated human alpha(1)-protease inhibitor.
Molecular and cellular biology 16(3):1247-55 MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.
J. Biol. Chem. 278(19):17509-14 Phosphorylation-dependent regulation of Kv2.1 Channel activity at tyrosine 124 by Src and by protein-tyrosine phosphatase epsilon.
Proceedings of the National Academy of Sciences of the United States of America 94(24):12957-62 The phosphorylation state of the FIGQY tyrosine of neurofascin determines ankyrin-binding activity and patterns of cell segregation.
Oncogene 24(4):714-23 17beta-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo.
J. Biol. Chem. 273(3):1496-505 Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK.
J. Biol. Chem. 275(26):19567-76 Regulation of protein kinase D by multisite phosphorylation. Identification of phosphorylation sites by mass spectrometry and characterization by site-directed mutagenesis.
Nature 432(7020):988-94 The sequence and analysis of duplication-rich human chromosome 16.
J. Biol. Chem. 275(46):36143-51 cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains.
J. Biol. Chem. 277(30):27081-7 The presence of a single tyrosine residue at the carboxyl domain of vascular endothelial growth factor receptor-2/FLK-1 regulates its autophosphorylation and activation of signaling molecules.
J. Biol. Chem. 268(33):25001-8 Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha.
Biochemistry 31(17):4254-62 Recombinant human complement subcomponent C1s lacking beta-hydroxyasparagine, sialic acid, and one of its two carbohydrate chains still reassembles with C1q and C1r to form a functional C1 complex.
J. Biol. Chem. 275(31):24047-51 Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo.
Biochemistry 25(24):8089-94 A new acylphosphatase isoenzyme from human erythrocytes: purification, characterization, and primary structure.
European journal of biochemistry 196(3):743-50 Primary structure of a new actin-binding protein from human seminal plasma.
FEBS letters 536(1-3):203-8 Novel insights into cadherin processing by subtilisin-like convertases.
Journal of neurochemistry 86(6):1450-7 Physiological regulation of Munc18/nSec1 phosphorylation on serine-313.
J. Biol. Chem. 281(45):34009-20 Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF.
FEBS letters 492(3):204-9 A new family of small, palmitoylated, membrane-associated proteins, characterized by the presence of a cysteine-rich hydrophobic motif.
The Journal of cell biology 129(6):1677-89 The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion.
The Journal of social psychology 95(Second half):165-72 Symptoms of stress in four societies.
EMBO J. 18(1):270-9 Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.
Thrombosis and haemostasis 90(2):206-17 Biochemical importance of glycosylation of plasminogen activator inhibitor-1.
British journal of cancer 81(8):1269-73 Generation of angiostatin-like fragments from plasminogen by prostate-specific antigen.
Molecular carcinogenesis 22(2):110-9 Formation of a stable src-AFAP-110 complex through either an amino-terminal or a carboxy-terminal SH2-binding motif.
J. Biol. Chem. 275(44):34359-64 CREB-binding protein/p300 activates MyoD by acetylation.
J. Biol. Chem. 265(25):15341-5 Identification of membrane anchoring site of human renal dipeptidase and construction and expression of a cDNA for its secretory form.
Protein science : a publication of the Protein Society 4(4):791-803 Site-specific detection and structural characterization of the glycosylation of human plasma proteins lecithin:cholesterol acyltransferase and apolipoprotein D using HPLC/electrospray mass spectrometry and sequential glycosidase digestion.
Clinical cancer research : an official journal of the American Association for Cancer Research 9(2):594-600 Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis.
EMBO J. 22(1):47-59 Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor.
Biochem. Biophys. Res. Commun. 329(3):1108-17 Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain.
The Biochemical journal Human alpha-galactosidase A: glycosylation site 3 is essential for enzyme solubility.
American journal of human genetics 86(3):364-77 Worldwide population analysis of the 4q and 10q subtelomeres identifies only four discrete interchromosomal sequence transfers in human evolution.
Genes & development 12(19):2973-83 The complexity of p53 modulation: emerging patterns from divergent signals.
Molecular human reproduction 2(3):177-84 Cell-to-cell transfer of glycosylphosphatidylinositol-anchored membrane proteins during sperm maturation.
Molecular endocrinology (Baltimore, Md.) 16(2):367-77 Requirement of Ca(2+) and PKCdelta for Janus kinase 2 activation by angiotensin II: involvement of PYK2.
The Biochemical journal N-glycosylation of human acetylcholinesterase: effects on activity, stability and biosynthesis.
FEBS letters 549(1-3):105-9 S-nitrosation of Cys-800 of HIF-1alpha protein activates its interaction with p300 and stimulates its transcriptional activity.
Biochem. Biophys. Res. Commun. 291(5):1146-50 Nuclear receptor and apoptosis initiator NGFI-B is a substrate for kinase ERK2.
Nature 412(6844):346-51 TAK1 is a ubiquitin-dependent kinase of MKK and IKK.
Genes & development 16(8):919-32 SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.
J. Biol. Chem. 273(15):8691-8 Physical and functional interactions between receptor-like protein-tyrosine phosphatase alpha and p59fyn.
J. Biol. Chem. 277(1):528-34 Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway.
Proceedings of the National Academy of Sciences of the United States of America 87(19):7541-5 Identification and preliminary characterization of protein-cysteine farnesyltransferase.
Oncogene 18(39):5413-22 Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity.
J. Biol. Chem. 278(37):34897-909 A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases.
J. Biol. Chem. 276(43):39600-7 Dual regulation of mammalian myosin VI motor function.
Free radical biology & medicine 13(3):205-10 The site of nonenzymic glycation of human extracellular-superoxide dismutase in vitro.
Biochem. Biophys. Res. Commun. 178(2):764-72 Novel serine phosphorylation occurs in the fibroblast form of pp60c-src from Y79 retinoblastoma cells.
J. Biol. Chem. 271(34):20845-52 Cytoplasmic O-GlcNAc modification of the head domain and the KSP repeat motif of the neurofilament protein neurofilament-H.
J. Biol. Chem. 271(43):27099-106 The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32.
Nature 414(6859):36 Effect of DNA damage on a BRCA1 complex.
Biochemistry 35(6):1745-52 Mutagenesis of N-glycosylation sites in the human vasoactive intestinal peptide 1 receptor. Evidence that asparagine 58 or 69 is crucial for correct delivery of the receptor to plasma membrane.
The Biochemical journal 362(Pt 2):481-90 Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome.
Biophysical journal 64(3):792-802 Site-directed mutagenesis of alpha-tubulin. Reductive methylation studies of the Lys 394 region.
J. Biol. Chem. 277(35):32003-14 cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I.
EMBO J. 21(14):3694-703 Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition.
Biochem. Biophys. Res. Commun. 296(4):827-32 Functional analysis of calcium-binding EF-hand motifs of visinin-like protein-1.
EMBO J. 14(15):3679-86 Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase.
Nature 405(6784):360-4 Neurotoxicity induces cleavage of p35 to p25 by calpain.
The Biochemical journal 371(Pt 3):917-25 Protein kinase CK2 phosphorylates Hsp105 alpha at Ser509 and modulates its function.
Proceedings of the National Academy of Sciences of the United States of America 95(2):554-9 Modulation of cell death by Bcl-XL through caspase interaction.
Biochemistry 42(3):811-9 Phosphorylation of RGS14 by protein kinase A potentiates its activity toward G alpha i.
Protein expression and purification 22(2):258-66 [W206R]-procaspase 3: an inactivatable substrate for caspase 8.
J. Biol. Chem. 260(23):12492-9 Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3':5'-monophosphate-dependent protein kinase.
J. Biol. Chem. 273(27):16993-7 Human ADAM 12 (meltrin alpha) is an active metalloprotease.
FEBS letters 545(2-3):161-6 Occludin phosphorylation: identification of an occludin kinase in brain and cell extracts as CK2.
Molecular biology of the cell 18(4):1167-78 DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding.
Molecular and cellular biology 23(16):5526-39 p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD.
J. Biol. Chem. 277(41):38596-606 Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin.
EMBO J. 21(3):324-33 Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3.
J. Biol. Chem. 276(40):37529-36 The role of tyrosine residues in fibroblast growth factor receptor 1 signaling in PC12 cells. Systematic site-directed mutagenesis in the endodomain.
J. Biol. Chem. 267(1):555-63 Vertebrate lens alpha-crystallins are modified by O-linked N-acetylglucosamine.
FEBS letters 540(1-3):106-10 Stimulation of the alpha1A adrenergic receptor inhibits PDGF-induced PDGF beta receptor Tyr751 phosphorylation and PI 3-kinase activation.
J. Biol. Chem. 271(14):8075-81 Protein kinase A-dependent phosphorylation of GLUT2 in pancreatic beta cells.
European journal of immunology 23(10):2488-97 Association of the p56lck protein tyrosine kinase with the Fc gamma RIIIA/CD16 complex in human natural killer cells.
The Biochemical journal 358(Pt 1):185-92 Roles of the juxtamembrane and extracellular domains of angiotensin-converting enzyme in ectodomain shedding.
Journal of neurochemistry 67(2):699-707 In vitro phosphorylation of the cytoplasmic domain of the amyloid precursor protein by glycogen synthase kinase-3beta.
Nature cell biology 4(6):399-407 A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility.
J. Biol. Chem. 274(48):33851-4 Functional regulation of L-type calcium channels via protein kinase A-mediated phosphorylation of the beta(2) subunit.
J. Biol. Chem. 277(51):50131-6 Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes.
Journal of biochemistry 124(6):1237-44 Human erythrocyte bisphosphoglycerate mutase: inactivation by glycation in vivo and in vitro.
J. Biol. Chem. 274(49):34646-56 The novel kinase peptidylglycine alpha-amidating monooxygenase cytosolic interactor protein 2 interacts with the cytosolic routing determinants of the peptide processing enzyme peptidylglycine alpha-amidating monooxygenase.
Biochemistry 34(44):14594-600 Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal.
Cell 61(4):579-89 Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis.
Proceedings of the National Academy of Sciences of the United States of America 97(24):13103-7 Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin.
Nature 426(6966):579-84 Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly.
J. Biol. Chem. 269(1):588-92 Autocatalytic maturation of the prohormone convertase PC2.
Molecular and cellular biology 16(9):4710-6 A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9.
EMBO J. 26(1):209-20 Palmitoylation is required for efficient Fas cell death signaling.
J. Biol. Chem. 274(4):2097-106 Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase.
EMBO J. 25(5):932-42 Ubiquitylation of leptin receptor OB-Ra regulates its clathrin-mediated endocytosis.
J. Biol. Chem. 274(19):13229-34 Unusual sites of arginine methylation in Poly(A)-binding protein II and in vitro methylation by protein arginine methyltransferases PRMT1 and PRMT3.
Blood 77(3):644-8 Molecular characterization of erythrocyte glycophorin C variants.
J. Biol. Chem. 276(4):2544-50 Characterization of a prostate-specific tyrosine phosphatase by mutagenesis and expression in human prostate cancer cells.
Biochem. Biophys. Res. Commun. 294(2):324-8 Characterisation of the phosphorylation of beta-catenin at the GSK-3 priming site Ser45.
Cancer research 63(20):6758-62 Direct activation of pro-matrix metalloproteinase-2 by leukolysin/membrane-type 6 matrix metalloproteinase/matrix metalloproteinase 25 at the asn(109)-Tyr bond.
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Nucleic acids research 22(24):5173-6 Phosphorylation of the c-Fos and c-Jun HOB1 motif stimulates its activation capacity.
Biochim. Biophys. Acta 1593(1):45-55 Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase.
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Blood 91(3):930-9 The p85 and p110 subunits of phosphatidylinositol 3-kinase-alpha are substrates, in vitro, for a constitutively associated protein tyrosine kinase in platelets.
FEBS letters 543(1-3):76-80 Heregulin and HER2 signaling selectively activates c-Src phosphorylation at tyrosine 215.
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Biochim. Biophys. Acta 994(3):281-4 N-terminal sequence extension in the glycosylated forms of human pancreatic stone protein. The 5-oxoproline N-terminal chain is O-glycosylated on the 5th amino acid residue.
Genes & development 15(21):2852-64 Hierarchical phosphorylation of the translation inhibitor 4E-BP1.
Protein science : a publication of the Protein Society 11(10):2326-34 The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities.
Journal of neurochemistry 86(5):1181-8 Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B.
Journal of lipid research 37(8):1786-801 Functional and metabolic differences between elastase-generated fragments of human lipoprotein[a] and apolipoprotein[a].
Biochim. Biophys. Acta 1121(3):261-8 Human red cell acid phosphatase (ACP1): the primary structure of the two pairs of isozymes encoded by the ACP1*A and ACP1*C alleles.
Nucleic acids research 25(5):955-64 tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence.
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Oncogene 17(2):255-60 Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions.
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J. Biol. Chem. 277(33):29503-9 Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 signaling pathway.
Proceedings of the National Academy of Sciences of the United States of America 91(15):7335-9 Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.
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Nature 440(7087):1045-9 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
Molecular and cellular biology 16(3):899-906 Casein kinase II phosphorylates I kappa B alpha at S-283, S-289, S-293, and T-291 and is required for its degradation.
The Biochemical journal 353(Pt 1):69-77 Novel properties of the protein kinase CK2-site-regulated nuclear- localization sequence of the interferon-induced nuclear factor IFI 16.
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Nature 408(6808):106-11 Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation.
Molecular and cellular biology 14(10):6674-82 Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation.
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Experimental cell research 256(2):522-32 The RGG domain in hnRNP A2 affects subcellular localization.
Molecular and cellular biology 23(15):5376-87 Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding.
European journal of immunology 34(12):3690-701 IREM-1 is a novel inhibitory receptor expressed by myeloid cells.
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The Biochemical journal 254(2):531-7 Hydrolysis of alpha-human atrial natriuretic peptide in vitro by human kidney membranes and purified endopeptidase-24.11. Evidence for a novel cleavage site.
The Biochemical journal Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared with testis ACE despite cleavage at identical stalk sites.
Molecular cell 1(4):553-63 Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade.
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Cell 80(5):729-38 Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals.
European journal of biochemistry 252(3):542-52 Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation.
J. Biol. Chem. 278(35):32929-35 Threonine 391 phosphorylation of the human prolactin receptor mediates a novel interaction with 14-3-3 proteins.
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Biochem. Biophys. Res. Commun. 252(1):46-50 Calcium/calmodulin-dependent protein kinase II controls integrin alpha5beta1-mediated cell adhesion through the integrin cytoplasmic domain associated protein-1alpha.
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The Journal of neuroscience : the official journal of the Society for Neuroscience 18(11):4008-21 Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M.
EMBO J. 20(20):5692-702 PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization.
Molecular biology of the cell 13(6):2016-30 The RNA binding activity of a ribosome biogenesis factor, nucleophosmin/B23, is modulated by phosphorylation with a cell cycle-dependent kinase and by association with its subtype.
Proceedings of the National Academy of Sciences of the United States of America 95(7):3792-7 NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176.
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European journal of immunology 31(3):699-707 Rapid inactivation of stromal cell-derived factor-1 by cathepsin G associated with lymphocytes.
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European journal of immunology 30(12):3707-17 Induction, binding specificity and function of human ICOS.
EMBO J. 25(13):3078-88 FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2.
FEBS letters 364(2):223-8 Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells.
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EMBO reports 3(2):177-82 An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells.
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J. Biol. Chem. 269(49):31097-106 Visualization and function of vimentin phosphorylation by cdc2 kinase during mitosis.
J. Biol. Chem. 269(47):29746-51 Serine 1524 is a major site of phosphorylation on human topoisomerase II alpha protein in vivo and is a substrate for casein kinase II in vitro.
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J. Biol. Chem. 276(22):19469-82 Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.
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Cancer research 55(18):4000-3 Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein.
Molecular and cellular biology 24(7):2986-97 A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin.
Growth regulation 4(4):164-72 Biochemical analysis of prostate specific antigen-proteolyzed insulin-like growth factor binding protein-3.
Immunogenetics 60(1):1-18 Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project.
Neuroscience 115(3):829-37 Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5.
Biochem. Biophys. Res. Commun. 315(2):471-6 Interaction of human MUC1 and beta-catenin is regulated by Lck and ZAP-70 in activated Jurkat T cells.
J. Biol. Chem. 267(7):5005-12 Proteolytic inactivation of alpha 1-proteinase inhibitor and alpha 1-antichymotrypsin by oxidatively activated human neutrophil metalloproteinases.
J. Biol. Chem. 279(3):1922-31 Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling.
Gut 47(2):242-50 Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells.
The Journal of cell biology 152(2):375-84 A novel chromatin protein, distantly related to histone H2A, is largely excluded from the inactive X chromosome.
J. Biol. Chem. 269(25):17311-9 Molecular structure of pulmonary surfactant protein D (SP-D).
J. Biol. Chem. 276(44):41237-44 Identification of a caspase-9 substrate and detection of its cleavage in programmed cell death during mouse development.
J. Biol. Chem. 273(8):4734-9 Transgenic approaches to define the functional role of dual site phospholamban phosphorylation.
Am. J. Pathol. 162(4):1183-90 Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer.
J. Biol. Chem. 270(32):19166-72 Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo.
The Biochemical journal 367(Pt 1):31-40 Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysis.
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Biochem. Biophys. Res. Commun. 296(4):911-7 Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation.
European journal of immunology 31(3):812-22 Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo.
Biochemistry 35(24):8035-44 Cell cycle-dependent phosphorylation of nucleoporins and nuclear pore membrane protein Gp210.
Oncogene 15(3):285-90 Involvement of caspase-4(-like) protease in Fas-mediated apoptotic pathway.
Biochem. Biophys. Res. Commun. 270(2):488-94 Skeletal muscle CaMKII enriches in nuclei and phosphorylates myogenic factor SRF at multiple sites.
Neuron 38(3):375-87 Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice.
Nature 428(6982):529-35 The DNA sequence and biology of human chromosome 19.
"Science (New York, N.Y.)" 286(5449):2514-7 Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation.
Genes to cells : devoted to molecular & cellular mechanisms 10(8):835-50 Transcriptional activity of megakaryoblastic leukemia 1 (MKL1) is repressed by SUMO modification.
FEBS letters 510(3):211-5 Decreased intracellular degradation of insulin-like growth factor binding protein-3 in cathepsin L-deficient fibroblasts.
EMBO J. 25(24):5670-82 GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome.
J. Biol. Chem. 278(42):40514-20 CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation.
Oncogene 19(7):858-69 The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP.
J. Biol. Chem. 282(22):16232-43 Biochemical and functional characterization of Orai proteins.
Molecular and cellular biology 13(2):801-8 Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1.
Proceedings of the National Academy of Sciences of the United States of America 103(9):3316-21 Proteinase 3 is an IL-32 binding protein.
Proceedings of the National Academy of Sciences of the United States of America 101(37):13489-94 Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.
J. Biol. Chem. 274(23):15971-4 Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases.
The Journal of cell biology 156(6):951-7 CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae.
J. Biol. Chem. 277(8):6490-6 Protein kinase C (PKC)eta-mediated PKC mu activation modulates ERK and JNK signal pathways.
J. Biol. Chem. 261(4):1868-72 Amino acid sequence of protein B23 phosphorylation site.
Nature 429(6990):375-81 The DNA sequence and comparative analysis of human chromosome 10.
Molecular and cellular biology 19(12):8469-78 BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.
FEBS letters 577(3):555-62 Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl.
Cell 122(6):887-900 Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR.
J. Biol. Chem. 269(16):12220-8 Insulin stimulates the phosphorylation of Tyr538 and the catalytic activity of PTP1C, a protein tyrosine phosphatase with Src homology-2 domains.
Molecular biology of the cell 9(2):301-9 Recognition signal for C-mannosylation of Trp-7 in RNase 2 consists of sequence Trp-x-x-Trp.
Molecular and cellular biology 19(4):2986-97 Role for caspase-mediated cleavage of Rad51 in induction of apoptosis by DNA damage.
Carcinogenesis 21(8):1537-46 A potential mechanism for fumonisin B(1)-mediated hepatocarcinogenesis: cyclin D1 stabilization associated with activation of Akt and inhibition of GSK-3beta activity.
European journal of biochemistry 209(3):945-50 Specific phosphorylation of the acidic central region of the N-myc protein by casein kinase II.
The Biochemical journal Post-translational processing of progastrin: inhibition of cleavage, phosphorylation and sulphation by brefeldin A.
J. Biol. Chem. 271(13):7265-8 Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin.
J. Biol. Chem. 261(4):1786-93 Identification of the site of sulfation of the fourth component of human complement.
Biochem. Biophys. Res. Commun. 279(3):744-50 Glycosylation effect on membrane domain (GEM) involved in cell adhesion and motility: a preliminary note on functional alpha3, alpha5-CD82 glycosylation complex in ldlD 14 cells.
J. Biol. Chem. 273(39):25436-42 A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis.
J. Biol. Chem. 274(33):23426-36 Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 80(10):2894-8 HLA-A2 and HLA-B7 antigens are phosphorylated in vitro by rous sarcoma virus kinase (pp60v-src) at a tyrosine residue encoded in a highly conserved exon of the intracellular domain.
The Biochemical journal 368(Pt 3):875-84 Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes.
Oncogene 18(5):1131-8 Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 91(25):12253-7 Amino-terminal basic residues of Src mediate membrane binding through electrostatic interaction with acidic phospholipids.
Oncogene 22(5):746-55 Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1).
FEBS letters 42(3):249-52 The amino acid sequences of the phosphorylated sites in troponin-I from rabbit skeletal muscle.
Nature immunology 4(1):44-8 Tyrosine phosphorylation of VHR phosphatase by ZAP-70.
J. Biol. Chem. 270(39):23119-25 Phosphorylation of Gz alpha by protein kinase C blocks interaction with the beta gamma complex.
Nature 420(6916):691-5 Signal-dependent regulation of splicing via phosphorylation of Sam68.
Journal of cell science 115(Pt 24):4787-99 Lasp-1 binds to non-muscle F-actin in vitro and is localized within multiple sites of dynamic actin assembly in vivo.
Archives of biochemistry and biophysics 327(1):61-70 Glycosylation in human thyroglobulin: location of the N-linked oligosaccharide units and comparison with bovine thyroglobulin.
Molecular and cellular biology 21(1):88-99 Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop.
Oncogene 9(10):3005-11 p56/p53lyn tyrosine kinase activation in mammalian cells treated with mitomycin C.
The Biochemical journal The regulation of AMP-activated protein kinase by phosphorylation.
J. Biol. Chem. 277(27):24809-17 Autophosphorylation of the mammalian multifunctional protein that initiates de novo pyrimidine biosynthesis.
Biochemistry 37(9):3196-202 Galpha12 requires acylation for its transforming activity.
Acta crystallographica. Section D, Biological crystallography 57(Pt 3):378-84 Structure of fibroblast growth factor 9 shows a symmetric dimer with unique receptor- and heparin-binding interfaces.
Current biology : CB 14(16):1425-35 aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity.
Journal of neurochemistry 75(3):1085-91 Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5.
FEBS letters 314(1):85-8 Natural human tumor necrosis factor beta (lymphotoxin). Variable O-glycosylation at Thr7, proteolytic processing, and allelic variation.
J. Biol. Chem. 273(27):17186-91 Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor.
The Biochemical journal 375(Pt 1):207-13 Adaptor signalling proteins Grb2 and Grb7 are recruited by human G6f, a novel member of the immunoglobulin superfamily encoded in the MHC.
J. Biol. Chem. 276(40):37223-9 Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase.
FEBS letters 506(3):207-10 Signalling of GPI-anchored CD157 via focal adhesion kinase in MCA102 fibroblasts.
Molecular and cellular biology 19(1):229-40 Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression.
J. Biol. Chem. 276(3):1911-5 Phosphorylation of GRK2 by protein kinase C abolishes its inhibition by calmodulin.
EMBO J. 22(12):3062-72 Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.
J. Biol. Chem. 269(27):18134-40 Activation of human interstitial procollagenase through direct cleavage of the Leu83-Thr84 bond by mast cell chymase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 22(16):6972-9 Protective role of phosphorylation in turnover of glial fibrillary acidic protein in mice.
Analytical chemistry 77(17):5693-9 Identification of phosphorylation sites in insulin receptor substrate-1 by hypothesis-driven high-performance liquid chromatography-electrospray ionization tandem mass spectrometry.
Molecular immunology 30(12):1089-96 Efficient complement-mediated lysis of cells containing the CAMPATH-1 (CDw52) antigen.
Circulation research 89(6):480-7 Proteomic analysis of pharmacologically preconditioned cardiomyocytes reveals novel phosphorylation of myosin light chain 1.
Developmental cell 2(6):831-7 The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.
J. Biol. Chem. 276(3):1961-7 The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation.
Biochemistry 30(9):2311-4 Tissue plasminogen activator has an O-linked fucose attached to threonine-61 in the epidermal growth factor domain.
Experimental cell research 299(2):343-55 Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1.
Cell 70(5):777-89 Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity.
Current biology : CB 9(10):522-9 Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex.
"Science (New York, N.Y.)" 281(5381):1360-3 Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate.
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The Biochemical journal The 50 kDa protein subunit of assembly polypeptide (AP) AP-2 adaptor from clathrin-coated vesicles is phosphorylated on threonine-156 by AP-1 and a soluble AP50 kinase which co-purifies with the assembly polypeptides.
J. Biol. Chem. 275(4):2513-9 Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase.
Oncogene 14(5):507-13 Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site.
Molecular biology of the cell 8(2):287-301 Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation.
FEBS letters 567(2-3):248-52 Suppression of the caspase cleavage of beta-amyloid precursor protein by its cytoplasmic phosphorylation.
Molecular and cellular biology 23(4):1239-50 Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle.
European journal of biochemistry 186(1-2):273-86 Carbohydrate structure of recombinant human uterine tissue plasminogen activator expressed in mouse epithelial cells.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 9(4):241-53 Inflammation-related neutrophil proteases, cathepsin G and elastase, function as insulin-like growth factor binding protein proteases.
J. Biol. Chem. 270(5):2092-8 Characterization of a mitochondrial metallopeptidase reveals neurolysin as a homologue of thimet oligopeptidase.
Oncogene 24(34):5333-43 Adhesion signaling by a novel mitotic substrate of src kinases.
Journal of immunology (Baltimore, Md. : 1950) 161(10):5276-83 Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B cell activation includes a site that negatively regulates signaling.
Nature 395(6705):863-9 Structural basis for activation of the titin kinase domain during myofibrillogenesis.
Archives of biochemistry and biophysics 314(1):99-106 Identification, assay, and purification of a Cdc2-activating threonine-161 protein kinase from human cells.
Stem cells (Dayton, Ohio) 16(5):322-8 Native thrombopoietin: structure and function.
J. Biol. Chem. 277(22):19521-9 Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity.
J. Virol. 65(1):170-9 Structural elements that regulate pp59c-fyn catalytic activity, transforming potential, and ability to associate with polyomavirus middle-T antigen.
J. Biol. Chem. 266(36):24249-52 CSK: a protein-tyrosine kinase involved in regulation of src family kinases.
Journal of lipid research 28(12):1405-9 Molecular cloning of a human apoC-III variant: Thr 74----Ala 74 mutation prevents O-glycosylation.
Journal of cell science 115(Pt 3):575-85 Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function.
J. Biol. Chem. 271(28):16526-34 Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation.
Journal of molecular biology 226(4):1051-72 Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine heart mitochondria. Application of a novel strategy for sequencing proteins using the polymerase chain reaction.
The Journal of experimental medicine 194(9):1263-76 Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling.
BMC biochemistry Phosphorylation-facilitated sumoylation of MEF2C negatively regulates its transcriptional activity.
J. Biol. Chem. 266(2):1250-7 Glycophospholipid membrane anchor attachment. Molecular analysis of the cleavage/attachment site.
FEBS letters 232(2):391-4 Role of N-linked oligosaccharides attached to human renin expressed in COS cells.
J. Biol. Chem. 272(11):7408-11 Evidence for a novel O-linked sialylated trisaccharide on Ser-248 of human plasminogen 2.
J. Biol. Chem. 272(18):11928-36 Phosphorylation and O-glycosylation sites of bovine chromogranin A from adrenal medullary chromaffin granules and their relationship with biological activities.
International journal of cancer 81(3):438-42 Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1.
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie 320(8):621-8 Proteolytic fragments of insulin-like growth factor binding protein-3: N-terminal sequences and relationships between structure and biological activity.
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The Biochemical journal Heterogeneity in utilization of N-glycosylation sites Asn624 and Asn138 in human lactoferrin: a study with glycosylation-site mutants.
Neuron 35(5):907-20 Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex.
Molecular cell 7(6):1221-31 Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300.
J. Biol. Chem. 278(5):3363-71 Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas.
Blood 94(6):1933-42 Identification of a 14-3-3 binding sequence in the common beta chain of the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors that is serine-phosphorylated by GM-CSF.
Nature genetics 23(2):147 Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA.
Oncogene 16(10):1229-39 Identification of Tyr-762 in the platelet-derived growth factor alpha-receptor as the binding site for Crk proteins.
Oncogene 19(25):2895-903 Identification of Grb10 as a direct substrate for members of the Src tyrosine kinase family.
J. Biol. Chem. 272(51):32547-50 The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus.
J. Biol. Chem. 265(26):15860-6 Protein kinase A phosphorylates retinal phosducin on serine 73 in situ.
J. Biol. Chem. 280(11):10264-76 SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.
J. Biol. Chem. 274(26):18821-6 ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix.
J. Biol. Chem. 277(2):1531-7 Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action.
J. Biol. Chem. 278(42):40973-9 Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites.
EMBO J. 16(8):1970-81 Positive and negative regulation of type II TGF-beta receptor signal transduction by autophosphorylation on multiple serine residues.
J. Biol. Chem. 274(45):32274-8 Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells.
Biochim. Biophys. Acta 1594(1):191-8 Mutational analysis of sites in sepiapterin reductase phosphorylated by Ca2+/calmodulin-dependent protein kinase II.
Molecular and cellular biology 18(6):3540-51 Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments.
Journal of cell science Role of glycosylation in the expression of human procathepsin D.
Cell 77(2):261-71 A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family.
Proceedings of the National Academy of Sciences of the United States of America 98(24):13631-6 Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription.
EMBO J. 21(8):1889-98 14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity.
FEBS letters 328(3):285-90 Determination of the disulphide bridge arrangement of bovine histidine-rich glycoprotein.
J. Biol. Chem. 276(21):18090-5 Identification of new JNK substrate using ATP pocket mutant JNK and a corresponding ATP analogue.
J. Biol. Chem. 259(12):7673-81 Amino acid sequence of the phosphorylation site of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
Molecular and cellular biochemistry Preparation and functional characterization of a catalytically active fragment of phosphorylase kinase.
The Journal of clinical endocrinology and metabolism 86(8):3675-85 Characterization of human FSH isoforms reveals a nonglycosylated beta-subunit in addition to the conventional glycosylated beta-subunit.
J. Biol. Chem. 276(29):26753-61 HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 ((3D)HSP27).
J. Biol. Chem. 278(48):47434-40 PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation.
J. Biol. Chem. 272(46):29238-42 Dentatorubral pallidoluysian atrophy (DRPLA) protein is cleaved by caspase-3 during apoptosis.
International journal of impotence research 17(4):320-5 3',5'-cyclic nucleotide phosphodiesterase 11A: localization in human tissues.
European journal of biochemistry 268(7):2099-106 Human phosphatidylinositol 4-kinase isoform PI4K92. Expression of the recombinant enzyme and determination of multiple phosphorylation sites.
BMC cell biology A p130Cas tyrosine phosphorylated substrate domain decoy disrupts v-crk signaling.
J. Biol. Chem. 262(22):10434-7 Phosphorylation site of eukaryotic initiation factor 4E.
Protein science : a publication of the Protein Society 3(5):822-30 Conserved phosphorylation of serines in the Ser-X-Glu/Ser(P) sequences of the vitamin K-dependent matrix Gla protein from shark, lamb, rat, cow, and human.
Biochemistry 38(12):3549-58 Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments.
Cell death and differentiation 7(9):843-50 Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis.
J. Biol. Chem. 277(35):32348-52 Natural truncation of the chemokine MIP-1 beta /CCL4 affects receptor specificity but not anti-HIV-1 activity.
Proceedings of the National Academy of Sciences of the United States of America 81(2):390-4 Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule.
FEBS letters 312(2-3):152-6 Prothymosin alpha is phosphorylated by casein kinase-2.
J. Biol. Chem. 275(46):36311-5 Phosphorylation of the beta-galactoside-binding protein galectin-3 modulates binding to its ligands.
J. Biol. Chem. 278(34):32227-35 Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways.
European journal of biochemistry 267(24):7170-5 Identification of IkappaBalpha as a substrate of Fas-associated phosphatase-1.
J. Biol. Chem. 268(9):6714-20 Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation.
Proceedings of the National Academy of Sciences of the United States of America 90(6):2207-11 Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.
European journal of biochemistry 107(2):529-37 Glycogen synthase from rabbit skeletal muscle. Amino acid sequence at the sites phosphorylated by glycogen synthase kinase-3, and extension of the N-terminal sequence containing the site phosphorylated by phosphorylase kinase.
Cell 94(4):481-90 Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors.
Biochemistry 43(20):6182-9 Protein phosphorylation of human brain glutamic acid decarboxylase (GAD)65 and GAD67 and its physiological implications.
Proceedings of the National Academy of Sciences of the United States of America 75(8):3588-92 Specific phosphorylation at serine-283 of alpha tropomyosin from frog skeletal and rabbit skeletal and cardiac muscle.
Urology 48(2):317-25 Alteration of the hormonal bioactivity of parathyroid hormone-related protein (PTHrP) as a result of limited proteolysis by prostate-specific antigen.
J. Biol. Chem. 275(27):20880-6 Selective attenuation of metabolic branch of insulin receptor down-signaling by high glucose in a hepatoma cell line, HepG2 cells.
Molecular cancer research : MCR 1(2):155-63 Regulation of Lck and Fyn tyrosine kinase activities by transmembrane protein tyrosine phosphatase leukocyte common antigen-related molecule.
J. Biol. Chem. 277(19):16733-43 ERK8, a new member of the mitogen-activated protein kinase family.
Biochemistry 36(13):3811-9 Characterization of prostate-specific antigen proteolytic activity on its major physiological substrate, the sperm motility inhibitor precursor/semenogelin I.
Blood 90(3):1065-74 Human neutrophil elastase activates human factor V but inactivates thrombin-activated human factor V.
J. Biol. Chem. 275(42):33008-13 Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XII.
J. Biol. Chem. 276(36):33665-74 SET-related cell division autoantigen-1 (CDA1) arrests cell growth.
J. Biol. Chem. 277(44):41835-42 Protein kinase A site-specific phosphorylation regulates ATP-binding cassette A1 (ABCA1)-mediated phospholipid efflux.
Oncogene 22(2):220-32 Protein kinase CK2 regulates CDC25B phosphatase activity.
J. Biol. Chem. 278(9):7390-6 Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells.
FEBS letters 403(3):254-8 Identification of Raf-1 Ser621 kinase activity from NIH 3T3 cells as AMP-activated protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 91(25):11963-7 Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A.
"Science (New York, N.Y.)" 296(5576):2215-8 Identification of signal peptide peptidase, a presenilin-type aspartic protease.
EMBO J. 19(20):5324-31 Post-translational hydroxylation at the N-terminus of the prion protein reveals presence of PPII structure in vivo.
Molecular and cellular biology 22(13):4535-43 c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs.
J. Biol. Chem. 273(12):7162-8 p125Fak focal adhesion kinase is a substrate for the insulin and insulin-like growth factor-I tyrosine kinase receptors.
EMBO J. 17(4):1087-95 Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300.
Rheumatology (Oxford, England) 42(1):154-61 Autoantibodies to dsDNA cross-react with the arginine-glycine-rich domain of heterogeneous nuclear ribonucleoprotein A2 (hnRNP A2) and promote methylation of hnRNP A2.
BMC cell biology Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL.
J. Biol. Chem. 277(27):24169-79 Inhibition of interleukin-1beta -induced NF-kappa B activation by calcium/calmodulin-dependent protein kinase kinase occurs through Akt activation associated with interleukin-1 receptor-associated kinase phosphorylation and uncoupling of MyD88.
J. Biol. Chem. 268(19):14294-300 Phosphorylation of connexin-32 by protein kinase C prevents its proteolysis by mu-calpain and m-calpain.
J. Biol. Chem. 281(8):4762-70 Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells.
J. Biol. Chem. 273(52):35273-81 Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323.
Molecular and cellular biology 24(11):4955-67 Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity.
J. Biol. Chem. 266(12):7549-55 Identification of phosphorylated sites in the mouse glucocorticoid receptor.
Proceedings of the National Academy of Sciences of the United States of America 101(8):2625-30 Regulation of canonical transient receptor potential isoform 3 (TRPC3) channel by protein kinase G.
J. Biol. Chem. 274(21):15101-9 Regulated interaction of protein kinase Cdelta with the heterogeneous nuclear ribonucleoprotein K protein.
International journal of molecular medicine 10(2):221-5 Molecular cloning and characterization of OSR1 on human chromosome 2p24.
J. Biol. Chem. 280(9):7581-7 Modulation of erythrocyte membrane mechanical function by protein 4.1 phosphorylation.
Molecular and cellular biology 16(3):977-89 Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction.
American journal of physiology. Heart and circulatory physiology 283(1):H77-84 Role of glycosylation in cell surface expression and stability of HERG potassium channels.
J. Biol. Chem. 276(40):37659-64 Acetylation of steroidogenic factor 1 protein regulates its transcriptional activity and recruits the coactivator GCN5.
European journal of biochemistry 268(17):4647-52 The role of Thr160 phosphorylation of Cdk2 in substrate recognition.
Molecular and cellular biology 17(11):6508-16 STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation.
J. Biol. Chem. 267(28):20317-25 Casein kinase II phosphorylates p34cdc2 kinase in G1 phase of the HeLa cell division cycle.
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Oncogene 9(1):49-57 Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor).
J. Biol. Chem. 279(51):53071-7 MUC1 membrane trafficking is modulated by multiple interactions.
American journal of physiology. Endocrinology and metabolism 290(3):E500-8 Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue.
J. Biol. Chem. 274(20):14376-81 Activation of C3G guanine nucleotide exchange factor for Rap1 by phosphorylation of tyrosine 504.
Cell 96(6):795-806 Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance.
J. Biol. Chem. 278(15):12737-44 Palmitoylated peptides from the cysteine-rich domain of SNAP-23 cause membrane fusion depending on peptide length, position of cysteines, and extent of palmitoylation.
J. Biol. Chem. 272(1):17-9 LSP1 is the major substrate for mitogen-activated protein kinase-activated protein kinase 2 in human neutrophils.
EMBO J. 19(24):6778-91 TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins.
J. Biol. Chem. 269(47):29520-9 Identification by electrospray ionization mass spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70.
Proceedings of the National Academy of Sciences of the United States of America 97(10):5261-6 5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases.
J. Biol. Chem. 276(18):14602-6 Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40.
EMBO J. 25(15):3618-26 A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics.
EMBO J. 21(1-2):72-82 PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2.
Neurobiology of disease 3(4):325-37 Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.
Proceedings of the National Academy of Sciences of the United States of America 98(12):6650-5 Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4.
Molecular biology of the cell 14(2):349-60 Integrin-mediated tyrosine phosphorylation of Shc in T cells is regulated by protein kinase C-dependent phosphorylations of Lck.
FEBS letters 447(1):87-90 The cleavage site specificity of human prostate specific antigen for insulin-like growth factor binding protein-3.
J. Biol. Chem. 278(38):36410-7 Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis.
Biochemical and molecular medicine 61(1):47-51 Comparison of the hydrolysis of the three types of natriuretic peptides by human kidney neutral endopeptidase 24.11.
Proceedings of the National Academy of Sciences of the United States of America 96(4):1321-6 Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization.
"Science (New York, N.Y.)" 289(5482):1202-6 Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3.
"Science (New York, N.Y.)" 255(5052):1705-7 An amino acid mutation in a potassium channel that prevents inhibition by protein kinase C.
Experimental cell research 287(2):219-27 Cofilin phosphorylation and actin polymerization by NRK/NESK, a member of the germinal center kinase family.
Biochim. Biophys. Acta 1380(2):177-82 Characterization of tau phosphorylation in glycogen synthase kinase-3beta and cyclin dependent kinase-5 activator (p23) transfected cells.
EMBO J. 22(6):1302-12 Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome.
Biochem. Biophys. Res. Commun. 323(4):1197-202 ATR-dependent phosphorylation of ATRIP in response to genotoxic stress.
J. Biol. Chem. 270(11):6338-44 Limited and defined truncation at the C terminus enhances receptor binding and degranulation activity of the neutrophil-activating peptide 2 (NAP-2). Comparison of native and recombinant NAP-2 variants.
Human molecular genetics 6(5):717-26 alpha-Mannosidosis: functional cloning of the lysosomal alpha-mannosidase cDNA and identification of a mutation in two affected siblings.
J. Biol. Chem. 265(30):18601-7 Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon.
J. Biol. Chem. 267(18):12742-52 Phosphorylation of the cystic fibrosis transmembrane conductance regulator.
J. Biol. Chem. 280(2):1037-43 Interleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR).
The Biochemical journal The low-density-lipoprotein receptor-related protein (LRP) is processed by furin in vivo and in vitro.
EMBO J. 19(16):4298-309 Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein.
J. Biol. Chem. 270(23):14192-200 Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells.
Molecular and cellular biology 25(6):2227-41 Removal of C-terminal SRC kinase from the immune synapse by a new binding protein.
J. Biol. Chem. 273(50):33443-8 Regulation of TFII-I activity by phosphorylation.
Biochem. Biophys. Res. Commun. 296(5):1215-21 Molecular cloning of a novel immunoglobulin superfamily gene preferentially expressed by brain and testis.
J. Biol. Chem. 273(25):15533-9 Identification and characterization of the major phosphorylation sites of the B-type natriuretic peptide receptor.
J. Biol. Chem. 276(6):4398-408 Caveolin-1 binding to endoplasmic reticulum membranes and entry into the regulated secretory pathway are regulated by serine phosphorylation. Protein sorting at the level of the endoplasmic reticulum.
The Journal of cell biology 117(3):583-93 PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18.
J. Biol. Chem. 276(21):18513-8 Sumo-1 modification regulates the DNA binding activity of heat shock transcription factor 2, a promyelocytic leukemia nuclear body associated transcription factor.
FEBS letters 392(3):209-14 A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress.
J. Biol. Chem. 273(10):5858-68 DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139.
Journal of cell science 117(Pt 12):2523-31 Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition.
J. Biol. Chem. 275(27):20754-61 Identification of p130cas as an in vivo substrate of receptor protein-tyrosine phosphatase alpha.
J. Biol. Chem. 278(35):32662-72 A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates.
J. Biol. Chem. 280(5):3414-25 Src phosphorylation of Alix/AIP1 modulates its interaction with binding partners and antagonizes its activities.
The Biochemical journal 355(Pt 3):597-607 The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site.
Proceedings of the National Academy of Sciences of the United States of America 99(12):7900-5 Shotgun identification of protein modifications from protein complexes and lens tissue.
Proceedings of the National Academy of Sciences of the United States of America 97(26):14400-5 Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5.
Proceedings of the National Academy of Sciences of the United States of America 97(17):9712-7 BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.
J. Biol. Chem. 282(3):1797-804 FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity.
Nature 396(6710):478-82 Functional interaction between InsP3 receptors and store-operated Htrp3 channels.
Thrombosis research 33(5):487-98 The location of a second in vivo phosphorylation site in the A alpha-chain of human fibrinogen.
Proceedings of the National Academy of Sciences of the United States of America 85(17):6337-41 Ca2+/calmodulin-dependent protein kinase II: identification of threonine-286 as the autophosphorylation site in the alpha subunit associated with the generation of Ca2+-independent activity.
EMBO J. 22(9):2091-103 Cdc2-mediated phosphorylation of Kid controls its distribution to spindle and chromosomes.
European journal of biochemistry 268(23):6076-82 ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3).
J. Biol. Chem. 277(29):25904-13 Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor.
J. Biol. Chem. 275(10):7416-23 FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions.
J. Biol. Chem. 277(33):29484-9 The role of post-translational modifications of the CXCR4 amino terminus in stromal-derived factor 1 alpha association and HIV-1 entry.
American journal of physiology. Lung cellular and molecular physiology 280(5):L983-90 Regulation of endothelial cell barrier function by calcium/calmodulin-dependent protein kinase II.
J. Biol. Chem. 274(46):32580-7 Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase.
Nature 421(6923):601-7 The DNA sequence and analysis of human chromosome 14.
Genes to cells : devoted to molecular & cellular mechanisms 7(2):91-7 Phosphorylation and reorganization of vimentin by p21-activated kinase (PAK).
Nature neuroscience 1(3):185-91 Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition.
Biochemistry 34(45):14693-702 Isolation and structural characterization of different isoforms of the hypusine-containing protein eIF-5A from HeLa cells.
Proceedings of the National Academy of Sciences of the United States of America 92(26):12090-4 Palmitoylation of the GluR6 kainate receptor.
Molecular cell 9(3):481-91 Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication.
J. Biol. Chem. 274(52):37385-90 Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase.
Biochemistry 35(12):3704-11 Phosphorylation of beta III-tubulin.
Molecular and cellular biology 16(4):1305-15 Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk.
Molecular pharmacology 58(5):1050-6 Identification of G protein-coupled receptor kinase 2 phosphorylation sites responsible for agonist-stimulated delta-opioid receptor phosphorylation.
J. Biol. Chem. 276(23):19770-7 Phosphorylation and regulation of G-protein-activated phospholipase C-beta 3 by cGMP-dependent protein kinases.
Nature 416(6878):345-7 TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2.
European journal of biochemistry 166(3):565-74 Amino-acid sequence of human alpha 2-antiplasmin.
EMBO J. 20(4):792-801 Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis.
Proceedings of the National Academy of Sciences of the United States of America 95(7):4007-12 Mechanism of nicotinic acetylcholine receptor cluster formation by rapsyn.
Protein expression and purification 9(3):363-71 Purification, characterization, and in vitro phosphorylation of the neuron-specific membrane-associated protein SCG10.
Proceedings of the National Science Council, Republic of China. Part B, Life sciences 23(4):175-80 Arginine methylation of a glycine and arginine rich peptide derived from sequences of human FMRP and fibrillarin.
J. Biol. Chem. 279(30):31251-8 BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage.
FEBS letters 318(3):331-4 Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr-15 by human cdc25B phosphatase.
Am. J. Pathol. 163(1):243-51 ASK1 associates with troponin T and induces troponin T phosphorylation and contractile dysfunction in cardiomyocytes.
Nature neuroscience 6(6):564-71 AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists.
J. Biol. Chem. 277(20):17616-22 Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling.
J. Biol. Chem. 279(26):27542-8 Proteolysis of the mismatch repair protein MLH1 by caspase-3 promotes DNA damage-induced apoptosis.
Immunity 9(3):377-83 The structure of HLA-DM, the peptide exchange catalyst that loads antigen onto class II MHC molecules during antigen presentation.
J. Biol. Chem. 275(7):5031-6 Apoptotic cleavage of scaffold attachment factor A (SAF-A) by caspase-3 occurs at a noncanonical cleavage site.
J. Biol. Chem. 272(8):5175-82 Targeting of SCG10 to the area of the Golgi complex is mediated by its NH2-terminal region.
Cell 107(2):149-59 hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 354(1389):1601-9 Control of NF-kappa B transcriptional activation by signal induced proteolysis of I kappa B alpha.
J. Biol. Chem. 278(22):19579-82 Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX.
J. Biol. Chem. 276(5):3310-8 Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases.
EMBO J. 22(23):6299-309 Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene.
EMBO reports 8(3):265-70 Interferons induce tyrosine phosphorylation of the eIF2alpha kinase PKR through activation of Jak1 and Tyk2.
Current biology : CB 9(8):393-404 PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.
J. Biol. Chem. 276(3):1865-72 Regulation of apoptosis by phosphatidylinositol 4,5-bisphosphate inhibition of caspases, and caspase inactivation of phosphatidylinositol phosphate 5-kinases.
Protein science : a publication of the Protein Society 9(1):170-9 Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry.
J. Biol. Chem. 277(38):35168-75 Peptide substrate specificities and protein cleavage sites of human endometase/matrilysin-2/matrix metalloproteinase-26.
The Biochemical journal Dynamic palmitoylation of lymphoma proprotein convertase prolongs its half-life, but is not essential for trans-Golgi network localization.
Molecular and cellular biology 18(12):7499-509 Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control.
Molecular and cellular biology 11(7):3652-9 Mutation of serum response factor phosphorylation sites and the mechanism by which its DNA-binding activity is increased by casein kinase II.
EMBO J. 15(11):2760-70 Selective interaction of JNK protein kinase isoforms with transcription factors.
Brain research. Molecular brain research 47(1-2):59-66 Molecular characterization and pharmacological properties of the human P2X3 purinoceptor.
European journal of biochemistry 253(1):67-75 Activation of the precursor of human stromelysin 2 and its interactions with other matrix metalloproteinases.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 19(1):89-99 Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts.
J. Biol. Chem. 271(5):2769-75 Identification of important regions in the cytoplasmic juxtamembrane domain of type I receptor that separate signaling pathways of transforming growth factor-beta.
European journal of biochemistry 198(1):13-20 Nuclear transition protein 1 from ram elongating spermatids. Mass spectrometric characterization, primary structure and phosphorylation sites of two variants.
J. Biol. Chem. 273(7):3799-802 Regulation of Rad51 function by c-Abl in response to DNA damage.
Molecular and cellular biology 11(5):2511-6 The epidermal growth factor receptor phosphorylates GTPase-activating protein (GAP) at Tyr-460, adjacent to the GAP SH2 domains.
The Biochemical journal 374(Pt 2):423-31 Phosphorylation of BATF regulates DNA binding: a novel mechanism for AP-1 (activator protein-1) regulation.
American journal of human genetics 93(3):411-21 Mapping the human reference genome's missing sequence by three-way admixture in Latino genomes.
J. Biol. Chem. 271(37):22315-20 CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails.
J. Biol. Chem. 276(50):47460-7 The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism.
Carcinogenesis 17(12):2661-71 Structural characterization by mass spectrometry of hemoglobin adducts formed after in vivo exposure to methyl bromide.
Experimental cell research 257(2):245-54 Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization.
The Biochemical journal 353(Pt 3):621-6 Phosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+/calmodulin-independent activity.
J. Biol. Chem. 277(36):33501-8 p38 kinase regulates nitric oxide-induced apoptosis of articular chondrocytes by accumulating p53 via NFkappa B-dependent transcription and stabilization by serine 15 phosphorylation.
Biochemistry 23(16):3701-7 Tissue plasminogen activator: peptide analyses confirm an indirectly derived amino acid sequence, identify the active site serine residue, establish glycosylation sites, and localize variant differences.
J. Biol. Chem. 272(39):24550-5 Identification of serine 643 of protein kinase C-delta as an important autophosphorylation site for its enzymatic activity.
The Journal of cell biology 142(2):485-97 Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons.
Gene 302(1-2):21-9 Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1).
Lymphokine research 9(1):67-79 Closely related glycosylation patterns of recombinant human IL-2 expressed in a CHO cell line and natural IL-2.
Biochem. Biophys. Res. Commun. 262(1):198-205 The DNA-binding and transcriptional activities of MAZ, a myc-associated zinc finger protein, are regulated by casein kinase II.
The Biochemical journal Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase.
The Journal of cell biology 154(6):1111-6 S-Nitrosylation of mitochondrial caspases.
J. Biol. Chem. 279(49):50850-6 Arginine 260 of the amino-terminal domain of NR1 subunit is critical for tissue-type plasminogen activator-mediated enhancement of N-methyl-D-aspartate receptor signaling.
J. Biol. Chem. 278(21):19023-31 Serine phosphorylation negatively regulates RhoA in vivo.
Journal of immunology (Baltimore, Md. : 1950) 166(8):5058-67 Identification of novel functional regions important for the activity of HOXB7 in mammalian cells.
J. Biol. Chem. 268(36):27363-70 Iron-responsive element-binding protein. Phosphorylation by protein kinase C.
Oncogene 24(13):2218-28 Cooperation and selectivity of the two Grb2 binding sites of p52Shc in T-cell antigen receptor signaling to Ras family GTPases and Myc-dependent survival.
Nature 442(7104):814-7 Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology.
J. Biol. Chem. 278(4):2731-9 Oligomerization and trafficking of the human dopamine transporter. Mutational analysis identifies critical domains important for the functional expression of the transporter.
Biochemistry 38(20):6699-705 Regulation of PTP1B via glutathionylation of the active site cysteine 215.
J. Biol. Chem. 277(49):46852-7 Acyl-enzyme complexes between tissue-type plasminogen activator and neuroserpin are short-lived in vitro.
J. Biol. Chem. 278(13):11536-45 Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma.
Biochim. Biophys. Acta 996(1-2):82-8 Degradation of human gastrin and CCK by endopeptidase 24.11: differential behaviour of the sulphated and unsulphated peptides.
J. Biol. Chem. 277(25):22798-805 c-Src-dependent transcriptional activation of TFII-I.
"Science (New York, N.Y.)" 284(5411):147-51 Two distinct cytokines released from a human aminoacyl-tRNA synthetase.
J. Biol. Chem. 275(34):26477-83 Src-mediated tyrosine phosphorylation of NR2 subunits of N-methyl-D-aspartate receptors protects from calpain-mediated truncation of their C-terminal domains.
Proteomics 4(3):587-98 Identification and characterization of phosphorylated proteins in the human pituitary.
Journal of cell science 117(Pt 25):6085-94 PKA phosphorylation of Src mediates Rap1 activation in NGF and cAMP signaling in PC12 cells.
Proceedings of the National Academy of Sciences of the United States of America 100(26):16006-11 Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3.
Nature medicine 5(5):577-81 Enhanced inhibition of hepatitis B virus production by asialoglycoprotein receptor-directed interferon.
Oncogene 12(8):1727-36 A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn.
"Science (New York, N.Y.)" 277(5331):1497-501 Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25.
Journal of molecular biology 337(1):115-28 Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1.
The Biochemical journal Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor.
J. Biol. Chem. 275(49):38633-9 Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways.
FEBS letters 447(2-3):241-6 Biochemical analysis of interleukin-2 receptor beta chain phosphorylation by p56(lck).
J. Biol. Chem. 271(40):24880-4 Regulation of the Lck SH2 domain by tyrosine phosphorylation.
Molecular and cellular biology 17(4):1824-31 Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation.
Proceedings of the National Academy of Sciences of the United States of America 96(11):6193-8 Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6.
Nature 399(6736):601-5 Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation.
European journal of biochemistry 194(2):541-7 Amino acid sequence of in vivo phosphorylation sites in the main intrinsic protein (MIP) of lens membranes.
J. Biol. Chem. 275(39):30451-7 Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules.
Circulation research 87(5):E1-9 A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9.
J. Biol. Chem. 272(46):29083-90 Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates.
FEBS letters 547(1-3):145-50 Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif.
J. Biol. Chem. 271(20):11831-7 Phosphorylation of eIF-4E on serine 209 by protein kinase C is inhibited by the translational repressors, 4E-binding proteins.
Nature 393(6687):809-12 Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization.
Proceedings of the National Academy of Sciences of the United States of America 101(13):4419-24 M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.
Cell 89(5):693-702 A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway.
J. Biol. Chem. 275(14):10379-87 Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4.
J. Biol. Chem. 271(7):3863-8 Phosphorylation of caveolin by src tyrosine kinases. The alpha-isoform of caveolin is selectively phosphorylated by v-Src in vivo.
J. Biol. Chem. 276(48):45456-61 Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathway.
J. Biol. Chem. 276(10):7366-75 Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling.
J. Biol. Chem. 271(17):10183-7 A novel Ca2+-binding protein, p22, is required for constitutive membrane traffic.
Biochem. Biophys. Res. Commun. 229(3):845-51 Casein kinase 2 phosphorylates recombinant human spermidine/spermine N1-acetyltransferase on both serine and threonine residues.
J. Biol. Chem. 274(13):8539-45 Correlations in palmitoylation and multiple phosphorylation of rat bradykinin B2 receptor in Chinese hamster ovary cells.
Molecular and cellular biology 17(9):5648-55 Dual requirement for a newly identified phosphorylation site in p70s6k.
Endocrinology 142(5):1835-40 The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II.
The Biochemical journal The C-terminus of NIPP1 (nuclear inhibitor of protein phosphatase-1) contains a novel binding site for protein phosphatase-1 that is controlled by tyrosine phosphorylation and RNA binding.
J. Biol. Chem. 274(19):13085-90 Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit.
Proceedings of the National Academy of Sciences of the United States of America 100(16):9185-90 Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product.
J. Biol. Chem. 276(46):42714-21 Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids.
Biochemistry 34(50):16456-66 In vitro phosphorylation of the epidermal growth factor receptor autophosphorylation domain by c-src: identification of phosphorylation sites and c-src SH2 domain binding sites.
Proceedings of the National Academy of Sciences of the United States of America 97(19):10389-94 Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.
Bone 31(3):359-65 Calcitonin induces dephosphorylation of Pyk2 and phosphorylation of focal adhesion kinase in osteoclasts.
J. Biol. Chem. 275(13):9314-23 Identification of caspase 3-mediated cleavage and functional alteration of eukaryotic initiation factor 2alpha in apoptosis.
Molecular cell 10(1):151-62 Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.
Human molecular genetics 11(8):961-9 Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder.
Molecular and cellular biology 25(18):8273-84 Rapid estrogen-induced phosphorylation of the SRC-3 coactivator occurs in an extranuclear complex containing estrogen receptor.
Experimental hematology 31(5):398-405 Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway.
J. Biol. Chem. 275(19):14046-55 Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-alpha convertase activity but does not activate pro-MMP2.
J. Biol. Chem. 278(19):17218-27 Signal transduction pathways regulated by prolactin and Src result in different conformations of activated Stat5b.
Oncogene 23(31):5301-15 MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol.
Journal of neurochemistry 76(4):1221-32 Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry.
J. Biol. Chem. 281(3):1692-7 DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM.
J. Biol. Chem. 273(43):28524-32 Differential and cooperative polysialylation of the neural cell adhesion molecule by two polysialyltransferases, PST and STX.
J. Biol. Chem. 269(21):14853-6 Dephosphorylation of osteopontin and bone sialoprotein by osteoclastic tartrate-resistant acid phosphatase. Modulation of osteoclast adhesion in vitro.
J. Biol. Chem. 275(52):40946-51 Phosphorylation of p300 at serine 89 by protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America 87(22):8960-4 Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine.
Cell 42(3):849-57 Protein kinase C phosphorylates pp60src at a novel site.
The Journal of experimental medicine 189(11):1747-56 BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.
Molecular and cellular biology 20(11):4149-58 Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer.
Biochemistry 41(50):14645-51 S-methylated cysteines in human lens gamma S-crystallins.
Cellular and molecular life sciences : CMLS 60(1):198-211 Regulation of caldesmon activity by Cdc2 kinase plays an important role in maintaining membrane cortex integrity during cell division.
Neuroscience 96(1):121-9 The neuronal EF-hand calcium-binding protein visinin-like protein-3 is expressed in cerebellar Purkinje cells and shows a calcium-dependent membrane association.
Molecular systems biology Phosphotyrosine interactome of the ErbB-receptor kinase family.
Nature 443(7108):230-3 Orai1 is an essential pore subunit of the CRAC channel.
J. Biol. Chem. 275(5):3577-82 Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop.
FEBS letters 302(3):223-6 Phosphorylation sequences in h-caldesmon from phorbol ester-stimulated canine aortas.
Journal of molecular biology 282(1):195-208 A model of Cdc25 phosphatase catalytic domain and Cdk-interaction surface based on the presence of a rhodanese homology domain.
Journal of biomedical science 10(6 Pt 1):617-24 Identification and functional analysis of truncated human glutamic acid decarboxylase 65.
J. Biol. Chem. 275(52):41439-46 Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines.
J. Biol. Chem. 267(36):25660-3 Function of the alpha 1 beta 2 gamma 2S gamma-aminobutyric acid type A receptor is modulated by protein kinase C via multiple phosphorylation sites.
J. Biol. Chem. 270(46):27653-60 Characterization of the mitotic specific phosphorylation site of histone H1. Absence of a consensus sequence for the p34cdc2/cyclin B kinase.
J. Biol. Chem. 276(11):8118-24 Identification of internal autoproteolytic cleavage sites within the prosegments of recombinant procathepsin B and procathepsin S. Contribution of a plausible unimolecular autoproteolytic event for the processing of zymogens belonging to the papain family.
Molecular and cellular biology 21(18):6181-8 Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBP.
J. Biol. Chem. 278(28):26265-74 Ca2+-dependent phosphorylation of syntaxin-1A by the death-associated protein (DAP) kinase regulates its interaction with Munc18.
J. Biol. Chem. 279(35):36192-200 Argininosuccinate synthetase is reversibly inactivated by S-nitrosylation in vitro and in vivo.
Biochemistry 44(16):6286-92 Phosphorylation of the human Fhit tumor suppressor on tyrosine 114 in Escherichia coli and unexpected steady state kinetics of the phosphorylated forms.
J. Biol. Chem. 276(13):10025-31 Phosphorylation of tau is regulated by PKN.
EMBO J. 16(12):3563-71 Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.
J. Biol. Chem. 275(29):22574-82 Phosphorylation of human gp130 at Ser-782 adjacent to the Di-leucine internalization motif. Effects on expression and signaling.
Journal of cell science Retargeting of cytosolic proteins to the plasma membrane by the Lck protein tyrosine kinase dual acylation motif.
The Biochemical journal 14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation.
J. Biol. Chem. 277(24):21922-9 Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation.
J. Biol. Chem. 274(34):24392-400 Protein kinase C delta associates with and phosphorylates Stat3 in an interleukin-6-dependent manner.
Proceedings of the National Academy of Sciences of the United States of America 88(12):5222-6 Phosphorylation of protein 4.1 on tyrosine-418 modulates its function in vitro.
Nature 396(6707):180-3 The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338.
FEBS letters 463(3):312-6 Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15.
Biochim. Biophys. Acta 1541(3):231-8 Caspase 7 can cleave tumor necrosis factor receptor-I (p60) at a non-consensus motif, in vitro.
J. Biol. Chem. 277(49):46871-6 Ca2+-stimulated Ca2+ oscillations produced by the Ca2+-sensing receptor require negative feedback by protein kinase C.
J. Biol. Chem. 271(48):30847-57 Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1.
The Journal of physiology 546(Pt 3):879-89 Phosphorylation of the myosin phosphatase targeting subunit and CPI-17 during Ca2+ sensitization in rabbit smooth muscle.
J. Biol. Chem. 278(10):8468-75 Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody.
Blood 101(7):2804-9 Felic (CIP4b), a novel binding partner with the Src kinase Lyn and Cdc42, localizes to the phagocytic cup.
J. Biol. Chem. 273(18):10914-8 Regulation of syndecan-4 phosphorylation in vivo.
Molecular and cellular biology 23(5):1546-57 The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation.
EMBO J. 22(21):5780-92 Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities.
J. Biol. Chem. 269(47):29943-8 Tyrosine 1356 in the carboxyl-terminal tail of the HGF/SF receptor is essential for the transduction of signals for cell motility and morphogenesis.
J. Biol. Chem. 276(46):43305-12 Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.
Proceedings of the National Academy of Sciences of the United States of America 101(16):5898-903 Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress.
J. Biol. Chem. 267(35):25282-8 Unique autolytic cleavage of human myeloperoxidase. Implications for the involvement of active site MET409.
Archives of biochemistry and biophysics 304(1):144-53 N-linked sugar chain structure of recombinant human lymphotoxin produced by CHO cells: the functional role of carbohydrate as to its lectin-like character and clearance velocity.
Molecular and cellular biology 18(4):2282-97 Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2.
Blood 88(11):4159-65 CD10/neutral endopeptidase 24.11 is phosphorylated by casein kinase II and coassociates with other phosphoproteins including the lyn src-related kinase.
EMBO J. 18(15):4280-91 Residues phosphorylated by TFIIH are required for E2F-1 degradation during S-phase.
J. Biol. Chem. 266(30):20380-9 Phosphorylation of the beta subunit of casein kinase II in human A431 cells. Identification of the autophosphorylation site and a site phosphorylated by p34cdc2.
J. Biol. Chem. 268(2):1125-31 Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101.
American journal of physiology. Endocrinology and metabolism 285(4):E854-63 Potential role of leucine metabolism in the leucine-signaling pathway involving mTOR.
Biochem. Biophys. Res. Commun. 191(3):1028-33 In vitro tyrosine phosphorylation of PLC-gamma 1 and PLC-gamma 2 by src-family protein tyrosine kinases.
EMBO reports 5(2):154-60 p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 17(8):1401-7 Induction of transcriptional activity of the cyclic adenosine monophosphate response element binding protein by parathyroid hormone and epidermal growth factor in osteoblastic cells.
Oncogene 12(4):863-73 Differential phosphorylations of Spi-B and Spi-1 transcription factors.
Molecular and cellular biology 18(1):130-40 Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization.
Molecular and cellular biology 18(10):5899-907 Molecular determinants of NF-kappaB-inducing kinase action.
EMBO J. 16(2):332-42 Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factors.
EMBO J. 25(20):4784-94 The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression.
J. Biol. Chem. 259(23):14537-43 The enzyme that cleaves apolipoprotein A-II upon in vitro incubation of human plasma high-density lipoprotein-3 with blood polymorphonuclear cells is an elastase.
J. Biol. Chem. 275(36):28222-9 Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha.
J. Biol. Chem. 269(2):1437-48 Dominant inhibitory mutants of ARF1 block endoplasmic reticulum to Golgi transport and trigger disassembly of the Golgi apparatus.
J. Biol. Chem. 275(37):29042-52 Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks.
J. Biol. Chem. 278(52):52021-31 SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/degradation downstream of the prolactin receptor.
Oncogene 18(30):4287-94 Evidence for an important role of serine 16 and its phosphorylation in the stabilization of c-Mos.
EMBO J. 15(22):6231-40 Phosphorylation of Ser165 in TGF-beta type I receptor modulates TGF-beta1-induced cellular responses.
J. Biol. Chem. 271(35):21108-13 Site-specific phosphorylation of synapsin I by mitogen-activated protein kinase and Cdk5 and its effects on physiological functions.
J. Biol. Chem. 273(44):28733-9 Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity.
J. Biol. Chem. 274(15):10505-10 Regulation of the transcriptional activity of the peroxisome proliferator-activated receptor alpha by phosphorylation of a ligand-independent trans-activating domain.
J. Biol. Chem. 272(46):28823-5 Angiostatin-converting enzyme activities of human matrilysin (MMP-7) and gelatinase B/type IV collagenase (MMP-9).
Biochem. Biophys. Res. Commun. 250(3):635-41 Gustin from human parotid saliva is carbonic anhydrase VI.
J. Biol. Chem. 279(7):5405-12 Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP).
Journal of neurochemistry 61(2):451-6 Purification and chemical characterization of beta-trace protein from human cerebrospinal fluid: its identification as prostaglandin D synthase.
Nature cell biology 4(12):993-7 DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.
Molecular endocrinology (Baltimore, Md.) 10(10):1249-60 Identification of growth hormone receptor (GHR) tyrosine residues required for GHR phosphorylation and JAK2 and STAT5 activation.
American journal of physiology. Cell physiology 285(4):C823-30 Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-beta-induced nuclear accumulation.
Experimental eye research 77(3):383-5 Expression of betaA2-crystallin in human lenses.
Nature neuroscience 4(5):457-8 Beam me up, Scottie! TREK channels swing both ways.
J. Biol. Chem. 275(51):40048-56 Identification and cloning of Kidins220, a novel neuronal substrate of protein kinase D.
J. Biol. Chem. 273(33):21267-75 Protein kinase C phosphorylation of threonine at position 888 in Ca2+o-sensing receptor (CaR) inhibits coupling to Ca2+ store release.
J. Biol. Chem. 276(40):37472-81 Actin cytoskeletal association of cytohesin-1 is regulated by specific phosphorylation of its carboxyl-terminal polybasic domain.
Molecular and cellular biology 16(11):6295-302 Autophosphorylation sites participate in the activation of the double-stranded-RNA-activated protein kinase PKR.
Leukemia 13(9):1374-82 SHC and SHIP phosphorylation and interaction in response to activation of the FLT3 receptor.
Blood 99(7):2418-26 Adducin in platelets: activation-induced phosphorylation by PKC and proteolysis by calpain.
J. Biol. Chem. 278(14):12530-6 Nuclear localization of the cell cycle regulator CDH1 and its regulation by phosphorylation.
EMBO reports 7(7):727-33 c-Abl acetylation by histone acetyltransferases regulates its nuclear-cytoplasmic localization.
Proceedings of the National Academy of Sciences of the United States of America 83(8):2363-7 Amino acid sequence of human plasma alpha 1B-glycoprotein: homology to the immunoglobulin supergene family.
Journal of cell science 118(Pt 23):5661-73 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.
Oncogene 18(4):1033-40 Phosphorylation of the DNA repair protein APE/REF-1 by CKII affects redox regulation of AP-1.
The Biochemical journal Structural elements within the methylation loop (residues 112-117) and EF hands III and IV of calmodulin are required for Lys(115) trimethylation.
J. Biol. Chem. 268(22):16679-87 Glycosylation of mammalian neurofilaments. Localization of multiple O-linked N-acetylglucosamine moieties on neurofilament polypeptides L and M.
Journal of immunology (Baltimore, Md. : 1950) 160(12):5922-8 HLA-G isoforms produced by placental cytotrophoblasts and found in amniotic fluid are due to unusual glycosylation.
EMBO J. 22(4):893-904 STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPbeta.
Journal of neurochemistry 68(5):2220-3 Phosphorylation and activation of brain tryptophan hydroxylase: identification of serine-58 as a substrate site for protein kinase A.
Life sciences 64(6-7):471-7 Muscarinic cholinergic signaling in cardiac myocytes: dynamic targeting of M2AChR to sarcolemmal caveolae and eNOS activation.
J. Biol. Chem. 270(29):17616-21 Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation.
Biol. Reprod. 66(2):407-14 Proteolytic processing of human zona pellucida proteins.
J. Biol. Chem. 269(29):19074-80 Identification of nuclear beta II protein kinase C as a mitotic lamin kinase.
The Journal of experimental medicine 192(8):1165-74 FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation.
J. Biol. Chem. 274(13):8875-85 Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus.
J. Biol. Chem. 276(37):34458-64 Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme.
Circulation 111(15):1946-53 Phosphorylation of GATA2 by Akt increases adipose tissue differentiation and reduces adipose tissue-related inflammation: a novel pathway linking obesity to atherosclerosis.
J. Biol. Chem. 271(21):12632-8 Phosphorylation of human fascin inhibits its actin binding and bundling activities.
European journal of biochemistry 175(2):347-54 Analysis of sites phosphorylated on acetyl-CoA carboxylase in response to insulin in isolated adipocytes. Comparison with sites phosphorylated by casein kinase-2 and the calmodulin-dependent multiprotein kinase.
Canadian journal of physiology and pharmacology 75(6):757-61 Characterization of kininogenase activity of an acidic proteinase isolated from human kidney.
J. Biol. Chem. 272(32):20291-8 Phosphorylation and calmodulin binding of the metabotropic glutamate receptor subtype 5 (mGluR5) are antagonistic in vitro.
J. Biol. Chem. 273(8):4449-58 Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells.
Oncogene 17(9):1097-108 The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R.
Molecular and cellular biology 25(20):8834-43 Abl kinases regulate actin comet tail elongation via an N-WASP-dependent pathway.
The Biochemical journal Protein kinase C and cyclic AMP-dependent protein kinase phosphorylate phospholemman, an insulin and adrenaline-regulated membrane phosphoprotein, at specific sites in the carboxy terminal domain.
J. Biol. Chem. 278(15):12813-9 Specific nitration at tyrosine 430 revealed by high resolution mass spectrometry as basis for redox regulation of bovine prostacyclin synthase.
Molecular and cellular biology 23(21):7875-86 Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling.
J. Biol. Chem. 261(28):13333-41 Sequence analysis of phospholamban. Identification of phosphorylation sites and two major structural domains.
J. Biol. Chem. 275(36):27933-9 Torsin A and its torsion dystonia-associated mutant forms are lumenal glycoproteins that exhibit distinct subcellular localizations.
J. Biol. Chem. 277(13):10767-74 The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase.
J. Biol. Chem. 272(9):5647-58 Sequence-specific DNA binding and transcription factor phosphorylation by Ku Autoantigen/DNA-dependent protein kinase. Phosphorylation of Ser-527 of the rat glucocorticoid receptor.
Molecular cell 7(2):401-9 NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100.
The Biochemical journal 370(Pt 2):567-78 Effect of mutation of two critical glutamic acid residues on the activity and stability of human carboxypeptidase M and characterization of its signal for glycosylphosphatidylinositol anchoring.
Molecular and cellular biology 16(10):5674-82 Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2.
J. Biol. Chem. 275(5):3603-9 Regulation of protein kinase Ctheta function during T cell activation by Lck-mediated tyrosine phosphorylation.
J. Biol. Chem. 275(31):23973-80 Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse.
Cell cycle (Georgetown, Tex.) 1(6):424-9 Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2.
Oncogene 21(46):6992-7000 Tyr-863 phosphorylation enhances focal adhesion kinase autophosphorylation at Tyr-397.
Nature neuroscience 7(11):1204-12 Focal adhesion kinase in netrin-1 signaling.
J. Biol. Chem. 273(41):26675-82 Identification of three major sentrinization sites in PML.
J. Biol. Chem. 278(35):33029-38 Regulation of A + U-rich element-directed mRNA turnover involving reversible phosphorylation of AUF1.
J. Biol. Chem. 268(5):3494-8 Analysis of Gz alpha by site-directed mutagenesis. Sites and specificity of protein kinase C-dependent phosphorylation.
European journal of biochemistry 246(2):433-9 Sequence specificity of C-terminal Src kinase (CSK)--a comparison with Src-related kinases c-Fgr and Lyn.
Proceedings of the National Academy of Sciences of the United States of America 88(19):8425-9 Endocytosis by the asialoglycoprotein receptor is independent of cytoplasmic serine residues.
J. Biol. Chem. 276(9):6485-98 C-mannosylation and O-fucosylation of the thrombospondin type 1 module.
Journal of biochemistry 133(2):165-71 Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells.
The international journal of biochemistry & cell biology 35(12):1645-57 Inhibition of the catalytic activity of rhodanese by S-nitrosylation using nitric oxide donors.
J. Biol. Chem. 267(26):18991-8 Identification of the autophosphorylation sites in rhodopsin kinase.
Proceedings of the National Academy of Sciences of the United States of America 103(1):63-8 Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase.
Biochemistry 16(16):3507-13 Primary structure of human J chain: alignment of peptides from chemical and enzymatic hydrolyses.
J. Biol. Chem. 274(38):27168-76 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.
J. Biol. Chem. 264(16):9638-42 Phosphorylation modulates the activity of glycine N-methyltransferase, a folate binding protein. In vitro phosphorylation is inhibited by the natural folate ligand.
J. Biol. Chem. 276(11):8087-93 TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis.
Molecular and cellular biology 21(22):7747-60 RasGAP-associated endoribonuclease G3Bp: selective RNA degradation and phosphorylation-dependent localization.
Molecular and cellular biology 22(13):4851-62 Caspase processing and nuclear export of CTP:phosphocholine cytidylyltransferase alpha during farnesol-induced apoptosis.
Molecular and cellular biology 23(19):7030-43 Phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by extracellular signal-regulated kinase mediates the transcriptional activation of AP-1 and cellular transformation induced by platelet-derived growth factor.
FEBS letters 351(1):35-7 Identification and hypotensive activity of proadrenomedullin N-terminal 20 peptide (PAMP).
The Biochemical journal 357(Pt 3):843-50 Ca(2+)/calmodulin-dependent protein kinase mediates the phosphorylation of CD44 required for cell migration on hyaluronan.
EMBO J. 25(6):1207-18 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation.
Immunity 4(5):515-25 Regulation of Btk function by a major autophosphorylation site within the SH3 domain.
Archives of biochemistry and biophysics 356(2):187-96 Caspase-mediated fragmentation of calpain inhibitor protein calpastatin during apoptosis.
Protein and peptide letters 16(10):1244-8 Glycosylation of tetraspanin Tspan-1 at four distinct sites promotes its transition through the endoplasmic reticulum.
Oncogene 17(12):1587-95 Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation.
Radiation research 160(3):309-17 Dephosphorylation of histone gamma-H2AX during repair of DNA double-strand breaks in mammalian cells and its inhibition by calyculin A.
Cell 128(2):295-308 PRAK is essential for ras-induced senescence and tumor suppression.
J. Biol. Chem. 275(26):19831-8 Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells.
J. Biol. Chem. 273(52):34850-6 Characterization of human glycogenin-2, a self-glucosylating initiator of liver glycogen metabolism.
J. Biol. Chem. 274(47):33654-60 The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family.
EMBO J. 22(8):1790-800 PKA phosphorylates the p75 receptor and regulates its localization to lipid rafts.
Biochemistry 42(47):13909-18 Functional diversity of endothelin pathways in human lung fibroblasts may be based on structural diversity of the endothelin receptors.
Hepatology (Baltimore, Md.) 40(2):459-66 Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease.
Molecular cell 1(7):949-57 Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization.
FEBS letters 434(3):431-6 Tyrosine phosphorylation of the Wiskott-Aldrich syndrome protein by Lyn and Btk is regulated by CDC42.
J. Biol. Chem. 281(2):782-91 Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding.
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J. Biol. Chem. 276(37):35150-8 Palmitoylation of caveolin-1 at a single site (Cys-156) controls its coupling to the c-Src tyrosine kinase: targeting of dually acylated molecules (GPI-linked, transmembrane, or cytoplasmic) to caveolae effectively uncouples c-Src and caveolin-1 (TYR-14).
J. Biol. Chem. 276(19):16456-63 Mitotic reorganization of the intermediate filament protein nestin involves phosphorylation by cdc2 kinase.
Molecular cell 7(2):249-62 Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway.
J. Biol. Chem. 273(32):20487-93 Tyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activation.
J. Biol. Chem. 277(4):2973-86 PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASP.
Biochemistry 34(26):8433-40 Partial glycosylation of antithrombin III asparagine-135 is caused by the serine in the third position of its N-glycosylation consensus sequence and is responsible for production of the beta-antithrombin III isoform with enhanced heparin affinity.
Cell 129(5):903-14 Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity.
The Biochemical journal 367(Pt 2):475-81 Evidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulin.
J. Biol. Chem. 275(12):9047-54 The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307).
J. Biol. Chem. 276(1):729-37 Regulation of Cbl molecular interactions by the co-receptor molecule CD43 in human T cells.
J. Biol. Chem. 276(13):9817-24 Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance.
Proceedings of the National Academy of Sciences of the United States of America 100(3):928-33 The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation.
Journal of cellular biochemistry 78(2):241-50 Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4.
EMBO J. 16(11):3133-44 IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase.
J. Biol. Chem. 277(35):31988-93 Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35.
The Journal of experimental medicine 176(2):587-92 Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils.
Pituitary 9(2):109-20 Phosphoproteomic analysis of the human pituitary.
Molecular cell 7(3):551-8 CREB binding protein recruitment to the transcription complex requires growth factor-dependent phosphorylation of its GF box.
Biol. Reprod. 66(3):735-44 SAMP32, a testis-specific, isoantigenic sperm acrosomal membrane-associated protein.
Biochem. Biophys. Res. Commun. 211(3):928-34 Phorbol ester stimulates rapid intracellular phosphorylation of glia maturation factor.
Oncogene 25(6):827-37 Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA.
Biochemistry 41(17):5613-24 Identification of in vivo phosphorylation sites of MLK3 by mass spectrometry and phosphopeptide mapping.
Biochem. Biophys. Res. Commun. 307(3):459-65 Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C.
Blood 99(6):1894-901 Processing of the lipocalin alpha(1)-microglobulin by hemoglobin induces heme-binding and heme-degradation properties.
Molecular and cellular biology 13(10):6260-73 A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity.
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EMBO J. 24(2):294-304 Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK.
European journal of biochemistry 220(2):359-68 Cell-cycle-regulated phosphorylation of oncoprotein 18 on Ser16, Ser25 and Ser38.
Neuroreport 11(16):3479-84 Postsynaptic targeting of MAGUKs mediated by distinct N-terminal domains.
Proceedings of the National Academy of Sciences of the United States of America 89(13):5779-83 Identification of Tyr-185 as the site of tyrosine autophosphorylation of recombinant mitogen-activated protein kinase p42mapk.
Nature 431(7011):931-45 Finishing the euchromatic sequence of the human genome.
Journal of immunology (Baltimore, Md. : 1950) 162(5):2906-11 Mutations of the type A domain of complement factor B that promote high-affinity C3b-binding.
Molecular and cellular biology 22(2):567-77 PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells.
European journal of biochemistry 250(2):354-63 Human amyloid precursor-like protein 1--cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid.
Nature cell biology 1(5):305-11 Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase.
Analytical chemistry 81(1):94-104 Profiling of endogenous serum phosphorylated peptides by titanium (IV) immobilized mesoporous silica particles enrichment and MALDI-TOFMS detection.
Endocrinology 140(11):5102-11 Role of N-linked glycosylation on the function and expression of the human secretin receptor.
Cell 84(6):853-62 Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity.
Proceedings of the National Academy of Sciences of the United States of America 80(3):765-9 Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor.
The Biochemical journal 368(Pt 2):507-16 Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.
Experimental cell research 288(1):110-8 Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk.
J. Biol. Chem. 279(37):38649-57 Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk.
Biochemistry 26(2):338-43 Functional role of proteolytic cleavage at arginine-275 of human tissue plasminogen activator as assessed by site-directed mutagenesis.
The Journal of experimental medicine 179(6):1809-21 Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular "heads" of C1q.
J. Biol. Chem. 274(20):13933-7 The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate.
J. Biol. Chem. 271(8):4273-9 The sequence of human betaB1-crystallin cDNA allows mass spectrometric detection of betaB1 protein missing portions of its N-terminal extension.
EMBO J. 13(18):4361-9 Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription.
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Leukemia 11(4):497-503 Antisense src expression inhibits tyrosine phosphorylation of Shc and its association with Grb2 and Sos which leads to MAP kinase activation in U937 human leukemia cells.
Current biology : CB 10(11):671-4 Cyclic AMP regulates the HERG K(+) channel by dual pathways.
J. Biol. Chem. 273(27):17102-8 Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide.
The Biochemical journal 368(Pt 1):243-51 Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase.
International archives of allergy and immunology 118(2-4):422-5 Novel autocrine and paracrine loops of the stem cell factor/chymase network.
The Biochemical journal 368(Pt 2):495-505 Glycosylation of human proteinase-activated receptor-2 (hPAR2): role in cell surface expression and signalling.
J. Biol. Chem. 264(36):21748-59 Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase II.
Molecular pharmacology 57(4):778-83 Agonist-dependent modulation of G protein-coupled receptor kinase 2 by mitogen-activated protein kinases.
FEBS letters 506(3):196-200 The AP-1 repressor, JDP2, is a bona fide substrate for the c-Jun N-terminal kinase.
J. Biol. Chem. 278(41):39609-14 Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases.
J. Biol. Chem. 272(7):4043-9 Interactions of mast cell tryptase with thrombin receptors and PAR-2.
Protein science : a publication of the Protein Society 11(4):862-74 Mass spectrometric analysis of the kinetics of in vivo rhodopsin phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 94(25):13850-5 Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity.
Molecular carcinogenesis 43(1):1-12 Involvement of protein kinase PKN1 in G2/M delay caused by arsenite.
Genes & development 16(9):1066-76 Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway.
J. Biol. Chem. 278(17):15056-64 Activation of pro-gelatinase B by endometase/matrilysin-2 promotes invasion of human prostate cancer cells.
J. Biol. Chem. 265(8):4722-9 Phosphorylation sites linked to glial filament disassembly in vitro locate in a non-alpha-helical head domain.
Journal of protein chemistry 16(8):747-53 The unusual amino acid triplet Asn-Ile-Cys is a glycosylation consensus site in human alpha-lactalbumin.
Molecular and cellular biology 23(23):8528-41 Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain.
J. Biol. Chem. 275(27):20374-81 Thrombocidins, microbicidal proteins from human blood platelets, are C-terminal deletion products of CXC chemokines.
FEBS letters 489(2-3):254-8 Identification of the main ubiquitination site in human erythroid alpha-spectrin.
Biochemistry 39(20):6012-21 Effects of the N-linked glycans on the 3D structure of the free alpha-subunit of human chorionic gonadotropin.
Molecular and cellular biology 17(3):1129-43 Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes.
"Science (New York, N.Y.)" 256(5060):1217-21 Heteromeric NMDA receptors: molecular and functional distinction of subtypes.
J. Biol. Chem. 272(43):27116-23 Biosynthesis, distinct post-translational modifications, and functional characterization of lymphoma proprotein convertase.
J. Biol. Chem. 274(38):26705-12 Protein phosphatase 2C inactivates F-actin binding of human platelet moesin.
The Biochemical journal 361(Pt 3):587-95 The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis.
American journal of human genetics 92(4):530-46 Complete haplotype sequence of the human immunoglobulin heavy-chain variable, diversity, and joining genes and characterization of allelic and copy-number variation.
Immunity 6(2):155-64 Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2.
Neuron 22(3):497-509 Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifs.
Proceedings of the National Academy of Sciences of the United States of America 92(7):2597-601 Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells.
Current biology : CB 9(20):1173-6 Regulation of ARNO nucleotide exchange by a PH domain electrostatic switch.
Biochemistry 44(14):5420-9 N-Linked glycosylation of the human ABC transporter ABCG2 on asparagine 596 is not essential for expression, transport activity, or trafficking to the plasma membrane.
FEBS letters 470(2):161-6 Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors.
Genes & development 13(7):804-16 A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras.
J. Biol. Chem. 276(38):35368-74 Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.
J. Biol. Chem. 277(15):13312-20 KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine.
J. Biol. Chem. 277(35):31818-25 The specificity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphatases.
Molecular cell 31(3):371-82 Ubc9 sumoylation regulates SUMO target discrimination.
Blood 80(4):942-52 Role of individual gamma-carboxyglutamic acid residues of activated human protein C in defining its in vitro anticoagulant activity.
Molecular & cellular proteomics : MCP 5(9):1610-27 Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation by epidermal growth factor using Extended Range Proteomic Analysis (ERPA).
J. Biol. Chem. 277(16):14227-37 Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2+ signal transduction.
EMBO J. 22(7):1676-87 Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint.
FEBS letters 412(1):161-4 Multiple tyrosine residues in the intracellular domain of the common beta subunit of the interleukin 5 receptor are involved in activation of STAT5.
Archives of biochemistry and biophysics 420(1):55-67 Functional characterization of Narc 1, a novel proteinase related to proteinase K.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 12(3):447-55 Identification of peptide fragments generated by digestion of bovine and human osteocalcin with the lysosomal proteinases cathepsin B, D, L, H, and S.
EMBO reports 3(1):39-44 Methylation at arginine 17 of histone H3 is linked to gene activation.
J. Biol. Chem. 279(36):37716-25 Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B.
Proteomics 4(2):454-65 Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.
J. Biol. Chem. 264(15):9094-101 Glycosylation of human apolipoprotein E. The carbohydrate attachment site is threonine 194.
Proceedings of the National Academy of Sciences of the United States of America 100(4):2029-34 cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1.
Molecular and cellular biology 15(2):835-42 Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS.
J. Biol. Chem. 269(8):6016-25 Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution.
Oncogene 10(8):1647-51 B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222.
Biochem. Biophys. Res. Commun. 333(3):742-9 TSSK5, a novel member of the testis-specific serine/threonine kinase family, phosphorylates CREB at Ser-133, and stimulates the CRE/CREB responsive pathway.
Current biology : CB 5(9):986-9 Cell signalling. Receptor orphans find a family.
Journal of cell science 114(Pt 5):987-98 Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97.
Proceedings of the National Academy of Sciences of the United States of America 94(20):10669-74 Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells.
EMBO J. 21(8):2009-18 Regulation of the ubiquitin-conjugating enzyme hHR6A by CDK-mediated phosphorylation.
Genes to cells : devoted to molecular & cellular mechanisms 7(8):835-50 MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation.
J. Biol. Chem. 277(51):49417-21 Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding.
Proceedings of the National Academy of Sciences of the United States of America 90(10):4616-20 Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast.
J. Biol. Chem. 277(28):25583-91 Intracellular activation of human adamalysin 19/disintegrin and metalloproteinase 19 by furin occurs via one of the two consecutive recognition sites.
J. Biol. Chem. 278(32):30028-36 Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA).
Biochem. Biophys. Res. Commun. 214(3):888-94 Development of a rapid approach to identification of tyrosine phosphorylation sites: application to PKC delta phosphorylated upon activation of the high affinity receptor for IgE in rat basophilic leukemia cells.
J. Biol. Chem. 274(20):14229-37 Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck.
J. Biol. Chem. 272(48):30491-7 Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta.
Molecular cell 21(6):749-60 Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1.
Proceedings of the National Academy of Sciences of the United States of America 82(14):4673-7 The nucleotide sequence of the gene for human protein C.
J. Biol. Chem. 270(1):66-72 Hepsin, a putative membrane-associated serine protease, activates human factor VII and initiates a pathway of blood coagulation on the cell surface leading to thrombin formation.
Oncogene 19(43):4961-9 The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function.
Biochemistry 42(5):1301-8 Basal and hydrogen peroxide stimulated sites of phosphorylation in heterogeneous nuclear ribonucleoprotein C1/C2.
Molecular and cellular biology 22(7):2099-110 Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway.
J. Biol. Chem. 266(30):20198-204 Thyroglobulin processing by thyroidal proteases. Major sites of cleavage by cathepsins B, D, and L.
Experimental cell research 230(1):84-93 Inhibition of protein dephosphorylation results in the accumulation of splicing snRNPs and coiled bodies within the nucleolus.
The Journal of cell biology 154(4):815-27 v-Src phosphorylation of connexin 43 on Tyr247 and Tyr265 disrupts gap junctional communication.
Molecular biology of the cell 13(8):2881-93 The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells.
Nature biotechnology 21(6):660-6 Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.
J. Biol. Chem. 282(2):888-96 Phosphorylation of a threonine unique to the short C-terminal isoform of betaII-spectrin links regulation of alpha-beta spectrin interaction to neuritogenesis.
Proceedings of the National Academy of Sciences of the United States of America 99(8):5567-72 IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase.
Nature 361(6413):637-41 Phosphorylation and modulation of recombinant GluR6 glutamate receptors by cAMP-dependent protein kinase.
Endocrinology 139(10):4182-8 A protease-resistant form of insulin-like growth factor (IGF) binding protein 4 inhibits IGF-1 actions.
J. Biol. Chem. 274(11):7207-15 Disulfide bond structure and N-glycosylation sites of the extracellular domain of the human interleukin-6 receptor.
Molecular and cellular biology 23(13):4598-610 Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707.
Cancer research 60(1):56-9 A novel form of prostate-specific antigen transcript produced by alternative splicing.
Journal of immunology (Baltimore, Md. : 1950) 163(3):1321-6 CD45 negatively regulates lyn activity by dephosphorylating both positive and negative regulatory tyrosine residues in immature B cells.
J. Biol. Chem. 272(36):22377-80 Phosphorylation of the PEST domain of IkappaBbeta regulates the function of NF-kappaB/IkappaBbeta complexes.
Current biology : CB 8(2):69-81 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro.
Biochemistry 35(20):6267-75 Identification of insulin-stimulated phosphorylation sites on calmodulin.
Receptor 5(1):71-80 Glycosylation sites encoded by exon 2 of the human insulin receptor gene are not required for the oligomerization, ligand binding, or kinase activity of the insulin receptor.
Biochemistry 39(11):3023-33 Detailed analysis of the phosphorylation of the human La (SS-B) autoantigen. (De)phosphorylation does not affect its subcellular distribution.
J. Biol. Chem. 274(45):31981-6 The role of DOC-2/DAB2 protein phosphorylation in the inhibition of AP-1 activity. An underlying mechanism of its tumor-suppressive function in prostate cancer.
J. Biol. Chem. 269(35):22162-8 Critical phosphorylation sites for acetyl-CoA carboxylase activity.
EMBO J. 20(16):4360-9 A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta.
Molecular and cellular biology 22(6):1693-703 Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells.
FEBS letters 461(3):323-8 Kinetic mechanism and ATP-binding site reactivity of p38gamma MAP kinase.
Biochem. Biophys. Res. Commun. 310(2):612-8 Proteolytic processing of IGFBP-related protein-1 (TAF/angiomodulin/mac25) modulates its biological activity.
Proceedings of the National Academy of Sciences of the United States of America 101(29):10578-83 Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13.
Biology of the cell 96(7):509-17 Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit.
EMBO J. 20(21):5919-28 Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak.
Molecular and cellular biology 20(5):1886-96 Posttranslational modification of Bcl-2 facilitates its proteasome-dependent degradation: molecular characterization of the involved signaling pathway.
J. Biol. Chem. 277(28):24967-75 Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor.
Molecular and cellular biology 19(11):7539-48 JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway.
Blood 97(1):130-8 Posttranslational modifications of recombinant myotube-synthesized human factor IX.
EMBO J. 22(11):2788-97 MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14.
EMBO J. 21(21):5911-20 Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability.
Blood 102(1):254-61 Ser727/Tyr701-phosphorylated Stat1 is required for the regulation of c-Myc, cyclins, and p27Kip1 associated with ATRA-induced G0/G1 arrest of U-937 cells.
J. Biol. Chem. 274(6):3531-40 Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity.
The Journal of endocrinology 160(3):379-87 Characterisation of recombinant glycosylation variants of insulin-like growth factor binding protein-3.
European journal of biochemistry 262(3):781-9 Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors.
Gut 46(4):454-9 The human two domain trefoil protein, TFF2, is glycosylated in vivo in the stomach.
J. Biol. Chem. 278(47):46533-40 Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells.
Oncogene 18(44):6029-36 The physical association and phosphorylation of Cdc25C protein phosphatase by Prk.
Blood 93(6):2003-12 Involvement of wiskott-aldrich syndrome protein in B-cell cytoplasmic tyrosine kinase pathway.
The Journal of cell biology 155(7):1147-57 CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis.
Biochemistry 41(2):603-8 The Protein-tyrosine-phosphatase SHP2 is phosphorylated on serine residues 576 and 591 by protein kinase C isoforms alpha, beta 1, beta 2, and eta.
Oncogene 18(51):7370-7 Caspase-mediated cleavage and functional changes of hematopoietic progenitor kinase 1 (HPK1).
Prostate 57(2):140-51 Effect of carbohydrate moieties on the folate hydrolysis activity of the prostate specific membrane antigen.
Journal of immunology (Baltimore, Md. : 1950) 164(6):3123-31 Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines.
J. Biol. Chem. 276(29):27709-15 Sequential activation of Rac-1, SEK-1/MKK-4, and protein kinase Cdelta is required for interleukin-6-induced STAT3 Ser-727 phosphorylation and transactivation.
Journal of neurochemistry 73(1):12-20 Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain.
Journal of immunology (Baltimore, Md. : 1950) 169(1):286-91 Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation.
J. Biol. Chem. 278(39):37223-30 Oxidative damage to mitochondrial complex I due to peroxynitrite: identification of reactive tyrosines by mass spectrometry.
FEBS letters 416(1):45-50 Disturbed progastrin processing in carboxypeptidase E-deficient fat mice.
J. Biol. Chem. 272(8):5183-6 Protein kinase A (PKA)- and protein kinase C-phosphorylated glia maturation factor promotes the catalytic activity of PKA.
FEBS letters 313(3):307-13 Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins.
FEBS letters 407(3):257-60 Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association.
Molecular cell 8(5):971-82 Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1.
Nature 372(6508):786-91 Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase.
"Science (New York, N.Y.)" 292(5516):464-8 HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.
J. Biol. Chem. 278(4):2654-60 The cytokine-inducible Scr homology domain-containing protein negatively regulates signaling by promoting apoptosis in erythroid progenitor cells.
International journal of oncology 19(5):977-82 Molecular cloning and characterization of human WNT3.
Canadian journal of biochemistry 55(7):755-60 Human pituitary thyrotropin. The primary structure of the alpha and beta subunits.
J. Biol. Chem. 255(7):3120-7 Sites of nonenzymatic glycosylation of human hemoglobin A.
J. Biol. Chem. 274(26):18173-80 CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells.
J. Biol. Chem. 276(40):37459-71 Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity.
Oncogene 19(12):1509-18 Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis.
J. Biol. Chem. 276(40):37520-8 Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1.
J. Biol. Chem. 276(42):38940-8 In vivo tyrosine phosphorylation sites of activated ephrin-B1 and ephB2 from neural tissue.
Journal of immunology (Baltimore, Md. : 1950) 162(4):1879-83 Cutting edge: the CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes.
Oncogene 19(42):4906-16 The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation.
Cancer biology & therapy 1(3):277-83 p53 Antiproliferative function is enhanced by aspartate substitution at threonine 18 and serine 20.
Journal of cell science 119(Pt 14):2847-50 Identification of phosphorylation sites in GIT1.
Proceedings of the National Academy of Sciences of the United States of America 93(9):4170-4 The phosphatase activity of carbonic anhydrase III is reversibly regulated by glutathiolation.
J. Biol. Chem. 272(34):21067-74 Activation of type IV procollagenases by human tumor-associated trypsin-2.
The Biochemical journal 356(Pt 2):461-71 Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells.
Proceedings of the National Academy of Sciences of the United States of America 100(11):6529-34 Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate.
Biochem. Biophys. Res. Commun. 303(2):700-6 Transcriptional activity and DNA binding of heat shock factor-1 involve phosphorylation on threonine 142 by CK2.
J. Biol. Chem. 277(17):14838-43 Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase.
Journal of pharmaceutical sciences 72(4):432-5 Kinetics of the rapid modification of human serum albumin with trinitrobenzenesulfonate and localization of its site.
Genes & development 11(11):1464-78 Cyclin E-CDK2 is a regulator of p27Kip1.
European journal of cell biology 86(2):111-23 Modulation of beta-catenin by cyclin-dependent kinase 6 in Wnt-stimulated cells.
The Journal of cell biology 157(1):149-60 Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling.
Cell 128(2):281-94 p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2.
Proceedings of the National Academy of Sciences of the United States of America 102(14):5056-61 Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage.
Human molecular genetics 9(1):125-32 Ser298 of MITF, a mutation site in Waardenburg syndrome type 2, is a phosphorylation site with functional significance.
Nature 398(6728):630-4 Direct control of the Forkhead transcription factor AFX by protein kinase B.
Nature 364(6432):70-3 Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain.
J. Biol. Chem. 276(18):15369-77 Unique disulfide bond structures found in ST8Sia IV polysialyltransferase are required for its activity.
The international journal of biochemistry & cell biology 31(11):1327-37 In vitro processing of amyloid precursor protein by cathepsin D.
Seminars in cell & developmental biology 11(4):235-42 Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic beta-cell.
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Proceedings of the National Academy of Sciences of the United States of America 97(10):5450-5 Molecular basis for a link between complement and the vascular complications of diabetes.
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Journal of neurochemistry 92(1):93-102 Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin.
Cell cycle (Georgetown, Tex.) 5(5):519-21 CDK9 phosphorylates p53 on serine residues 33, 315 and 392.
J. Biol. Chem. 281(38):28387-96 STOP-like protein 21 is a novel member of the STOP family, revealing a Golgi localization of STOP proteins.
Journal of neurochemistry 70(2):540-9 Peripherin is tyrosine-phosphorylated at its carboxyl-terminal tyrosine.
Current biology : CB 15(9):815-23 RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration.
J. Biol. Chem. 277(22):20104-12 Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site.
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Journal of neurochemistry 74(4):1587-95 Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta.
American journal of human genetics 90(4):599-613 Resolving the breakpoints of the 17q21.31 microdeletion syndrome with next-generation sequencing.
The Biochemical journal 358(Pt 1):137-45 Polyamine analogues inhibit the ubiquitination of spermidine/spermine N1-acetyltransferase and prevent its targeting to the proteasome for degradation.
The Journal of experimental medicine 189(8):1181-94 SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation.
J. Biol. Chem. 276(10):7609-13 Protein kinase C activation modulates alpha-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor complex.
Genome biology 10(6):R60 Closing gaps in the human genome using sequencing by synthesis.
EMBO J. 19(24):6792-803 P/CAF-mediated acetylation regulates the function of the basic helix-loop-helix transcription factor TAL1/SCL.
European journal of biochemistry 267(16):4998-5004 Processing of synthetic pro-islet amyloid polypeptide (proIAPP) 'amylin' by recombinant prohormone convertase enzymes, PC2 and PC3, in vitro.
Oncogene 14(21):2553-61 Recognition of activated CSF-1 receptor in breast carcinomas by a tyrosine 723 phosphospecific antibody.
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J. Biol. Chem. 272(38):23896-904 Sites of UV-induced phosphorylation of the p34 subunit of replication protein A from HeLa cells.
Biochemistry 38(41):13584-91 Partial glycosylation of Asn2181 in human factor V as a cause of molecular and functional heterogeneity. Modulation of glycosylation efficiency by mutagenesis of the consensus sequence for N-linked glycosylation.
Thrombosis and haemostasis 89(1):122-31 Plasma membrane Ca2+-ATPase isoform 4b is phosphorylated on tyrosine 1176 in activated human platelets.
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Molecular and cellular biology 18(4):1978-84 pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167.
Journal of immunology (Baltimore, Md. : 1950) 163(11):5753-7 Cutting edge: SLP-76 cooperativity with FYB/FYN-T in the Up-regulation of TCR-driven IL-2 transcription requires SLP-76 binding to FYB at Tyr595 and Tyr651.
J. Biol. Chem. 266(8):5147-52 Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (Pro-uPA).
Journal of cell science 115(Pt 17):3479-90 Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells.
The Journal of cell biology 161(6):1067-79 The localization and phosphorylation of p47 are important for Golgi disassembly-assembly during the cell cycle.
Nature 437(7058):551-5 DNA sequence and analysis of human chromosome 18.
EMBO J. 25(23):5614-25 MDMX regulation of p53 response to ribosomal stress.
Oncogene 22(28):4398-405 Lats2, a putative tumor suppressor, inhibits G1/S transition.
Molecular cell 2(6):877-85 PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis.
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FEBS letters 531(2):132-6 Identification and functional analysis of novel phosphorylation sites in Cx43 in rat primary granulosa cells.
Neuron 37(1):7-10 Pathways to Parkinsonism.
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J. Biol. Chem. 278(13):11032-40 Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex.
Oncogene 13(7):1379-85 Proline-rich sequences mediate the interaction of the Arg protein tyrosine kinase with Crk.
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Molecular and cellular biology 21(10):3534-46 Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.
Molecular and cellular biology 17(10):5771-83 Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation.
"Science (New York, N.Y.)" 281(5376):572-5 Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation.
FEBS letters 579(3):615-20 Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells.
Molecular and cellular biology 21(14):4441-52 Phosphorylation of MafA is essential for its transcriptional and biological properties.
J. Biol. Chem. 282(10):7522-31 Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1.
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Nature 440(7082):346-51 The finished DNA sequence of human chromosome 12.
Biochem. Biophys. Res. Commun. 244(3):756-62 Mutations which abolish phosphorylation of the TRAF-binding domain of TNF receptor 2 enhance receptor-mediated NF-kappa B activation.
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Molecular and cellular biology 23(8):2953-68 Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1.
J. Biol. Chem. 269(23):16311-7 The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo.
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J. Biol. Chem. 276(21):17672-8 Proteolytic activation of ETK/Bmx tyrosine kinase by caspases.
Biochemistry 36(26):8100-6 Serine-578 is a major phosphorylation locus in human plasma plasminogen.
Naunyn-Schmiedeberg's archives of pharmacology 369(1):23-37 Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry.
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American journal of physiology. Cell physiology 285(5):C1188-96 Mutagenesis of the N-glycosylation site of hNaSi-1 reduces transport activity.
Cell 92(4):573-85 Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.
Biochim. Biophys. Acta 1492(2-3):369-76 Functional cloning and mutational analysis of the human cDNA for phosphoacetylglucosamine mutase: identification of the amino acid residues essential for the catalysis.
Journal of biochemistry 114(4):473-7 Determination of carboxyl-terminal residue and disulfide bonds of MACIF (CD59), a glycosyl-phosphatidylinositol-anchored membrane protein.
Biochemistry 41(30):9462-9 The tumor necrosis factor-alpha converting enzyme (TACE): a unique metalloproteinase with highly defined substrate selectivity.
Electrophoresis 19(10):1803-7 Rab11a is modified in vivo by isoprenoid geranylgeranyl.
Molecular and cellular biology 14(4):2713-21 Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase.
EMBO J. 25(19):4423-35 A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking.
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BMC cell biology Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity.
Biochim. Biophys. Acta 1066(1):70-6 Three regions of erythrocyte band 3 protein are phosphorylated on tyrosines: characterization of the phosphorylation sites by solid phase sequencing combined with capillary electrophoresis.
J. Biol. Chem. 273(38):24805-13 Phosphorylation of vitronectin by casein kinase II. Identification of the sites and their promotion of cell adhesion and spreading.
"Science (New York, N.Y.)" 227(4685):427-9 Amino terminal myristylation of the protein kinase p60src, a retroviral transforming protein.
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Molecular and cellular biology 17(5):2497-501 Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop.
EMBO J. 21(20):5457-66 Control of CBP co-activating activity by arginine methylation.
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Genes & development 18(5):512-27 Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells.
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Oncogene 23(9):1645-55 Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation.
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J. Biol. Chem. 274(7):3988-93 Truncation of macrophage-derived chemokine by CD26/ dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction.
Nature methods 9(11):1107-12 DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution.
Nature 411(6840):969-74 ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses.
Molecular and cellular biology 21(16):5591-604 SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis.
J. Biol. Chem. 272(40):24961-5 Agonist-induced desensitization of the mu opioid receptor is determined by threonine 394 preceded by acidic amino acids in the COOH-terminal tail.
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Proceedings of the National Academy of Sciences of the United States of America 96(20):11156-60 Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation.
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EMBO J. 20(21):6095-103 A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300.
Molecular and cellular biology 21(5):1854-65 HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression.
Cancer science 96(2):134-41 Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage.
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J. Biol. Chem. 276(17):14400-6 Inhibition of insulin-induced activation of Akt by a kinase-deficient mutant of the epsilon isozyme of protein kinase C.
Biochemistry 35(20):6450-9 Amino acid sequence and carbohydrate structure of a recombinant human tissue factor pathway inhibitor expressed in Chinese hamster ovary cells: one N-and two O-linked carbohydrate chains are located between Kunitz domains 2 and 3 and one N-linked carbohydrate chain is in Kunitz domain 2.
Genome biology 8(6):R114 Detailed analysis of 15q11-q14 sequence corrects errors and gaps in the public access sequence to fully reveal large segmental duplications at breakpoints for Prader-Willi, Angelman, and inv dup(15) syndromes.
EMBO J. 20(13):3484-94 Rsk2 allosterically activates estrogen receptor alpha by docking to the hormone-binding domain.
Nature genetics 42(9):745-50 A large and complex structural polymorphism at 16p12.1 underlies microdeletion disease risk.
Journal of neurochemistry 73(1):418-28 Glycosylation sites flank phosphorylation sites on synapsin I: O-linked N-acetylglucosamine residues are localized within domains mediating synapsin I interactions.
Molecular biology of the cell 14(9):3664-74 Spy1 interacts with p27Kip1 to allow G1/S progression.
Biochemistry 32(30):7818-23 Specific glycosylation site mutations of the insulin receptor alpha subunit impair intracellular transport.
Biochem. Biophys. Res. Commun. 252(1):14-9 Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4.
J. Biol. Chem. 276(13):10556-63 The angiotensin II-dependent nuclear translocation of Stat1 is mediated by the Jak2 protein motif 231YRFRR.
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Archives of biochemistry and biophysics 357(2):299-309 Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules.
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Biochemistry 38(6):1829-37 Factor VIIa/tissue factor generates a form of factor V with unchanged specific activity, resistance to activation by thrombin, and increased sensitivity to activated protein C.
Molecular and cellular biology 26(1):63-76 Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation.
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J. Biol. Chem. 274(46):32786-94 The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues.
J. Biol. Chem. 277(17):14793-800 Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2).
J. Biol. Chem. 272(3):1777-85 The regulatory Ser262 of microtubule-associated protein tau is phosphorylated by phosphorylase kinase.
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The Journal of cell biology 161(5):911-21 BMPs signal alternately through a SMAD or FRAP-STAT pathway to regulate fate choice in CNS stem cells.
FEBS letters 304(2-3):170-8 Heterogeneous expression of four MAP kinase isoforms in human tissues.
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J. Biol. Chem. 275(2):1247-60 Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin.
Oncogene 21(25):3978-87 CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation.
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J. Biol. Chem. 266(30):19945-52 Phosphorylation by cdc2 kinase modulates DNA binding activity of high mobility group I nonhistone chromatin protein.
Oncogene 15(7):817-26 Ligand-independent activation of fibroblast growth factor receptor-2 by carboxyl terminal alterations.
Molecular and cellular biology 17(11):6472-80 O glycosylation of an Sp1-derived peptide blocks known Sp1 protein interactions.
J. Biol. Chem. 278(40):38980-90 Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo.
J. Biol. Chem. 265(16):8975-8 Phosphorylation of smooth myosin light chain kinase by smooth muscle Ca2+/calmodulin-dependent multifunctional protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 87(2):728-32 G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells.
Nature 367(6460):243-9 The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1.
Biochemistry 39(36):11084-91 N-terminal sequences direct the autophosphorylation states of the FER tyrosine kinases in vivo.
Biochemistry 39(5):1169-79 Phosphorylation of recombinant human ATP:citrate lyase by cAMP-dependent protein kinase abolishes homotropic allosteric regulation of the enzyme by citrate and increases the enzyme activity. Allosteric activation of ATP:citrate lyase by phosphorylated sugars.
Proceedings of the National Academy of Sciences of the United States of America 100(5):2328-33 The C-terminal domain phosphatase and transcription elongation activities of FCP1 are regulated by phosphorylation.
J. Biol. Chem. 259(11):7224-9 A vascular smooth muscle alpha-isoactin biosynthetic intermediate in BC3H1 cells. Identification of acetylcysteine at the NH2 terminus.
J. Biol. Chem. 269(25):17056-61 Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766.
Biochim. Biophys. Acta 1117(2):207-15 Site-specific glycation of lens crystallins by ascorbic acid.
EMBO J. 26(8):2115-26 A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis.
FEBS letters 464(3):164-8 Phosphorylation of the Spi-B transcription factor reduces its intrinsic stability.
Nature 446(7133):333-7 A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate.
EMBO J. 25(20):4752-62 Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2.
The Journal of clinical investigation 97(3):761-8 Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage.
J. Biol. Chem. 270(32):19173-80 Truncated forms of the human prion protein in normal brain and in prion diseases.
J. Biol. Chem. 258(23):14521-6 Phosphorylation of human choriogonadotropin. Stoichiometry and sites of phosphate incorporation.
Structure (London, England : 1993) 7(3):319-30 Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis.
Molecular cell 16(1):93-105 Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin.
"Science (New York, N.Y.)" 273(5277):959-63 Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase.
Nature 386(6622):296-9 Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation.
J. Biol. Chem. 270(38):22208-17 Identification of a putative Syp substrate, the PDGF beta receptor.
The Journal of experimental medicine 194(11):1661-73 Sialylated O-glycans and sulfated tyrosines in the NH2-terminal domain of CC chemokine receptor 5 contribute to high affinity binding of chemokines.
J. Biol. Chem. 251(23):7593-9 Post-proline cleaving enzyme. Purification of this endopeptidase by affinity chromatography.
Human immunology 61(12):1202-18 N-linked carbohydrate on human leukocyte antigen-C and recognition by natural killer cell inhibitory receptors.
J. Biol. Chem. 277(38):35176-82 Nuclear localization of CDC25B1 and serine 146 integrity are required for induction of mitosis.
Glycobiology 1(4):393-404 Site-specific N-glycosylation of human chorionic gonadotrophin--structural analysis of glycopeptides by one- and two-dimensional 1H NMR spectroscopy.
J. Biol. Chem. 269(37):23185-91 Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes.
The Biochemical journal Phosphorylation by protein kinase C and cyclic AMP-dependent protein kinase of synthetic peptides derived from the linker region of human P-glycoprotein.
J. Biol. Chem. 276(15):12356-61 Phosphorylation of the oncofetal variant of the human bile salt-dependent lipase. identification of phosphorylation site and relation with secretion process.
J. Biol. Chem. 270(29):17582-7 Reactivation of phosphorylated actin depolymerizing factor and identification of the regulatory site.
Proceedings of the National Academy of Sciences of the United States of America 98(13):7200-5 Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.
J. Biol. Chem. 266(16):10544-51 Phosphorylation of neuromodulin (GAP-43) by casein kinase II. Identification of phosphorylation sites and regulation by calmodulin.
J. Biol. Chem. 276(32):29839-45 Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family.
Genes & development 12(18):2831-41 DNA damage activates p53 through a phosphorylation-acetylation cascade.
J. Biol. Chem. 267(2):1129-40 Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase.
Molecular and cellular biology 23(6):2096-108 Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP.
EMBO J. 20(12):3101-13 Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation.
Blood 96(5):1844-52 Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity.
Nature cell biology 8(8):803-14 FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling.
J. Biol. Chem. 280(14):13304-14 Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types.
J. Biol. Chem. 270(11):5706-9 14-3-3 alpha and delta are the phosphorylated forms of raf-activating 14-3-3 beta and zeta. In vivo stoichiometric phosphorylation in brain at a Ser-Pro-Glu-Lys MOTIF.
Journal of lipid research 43(9):1496-507 The N-linked oligosaccharides at the amino terminus of human apoB are important for the assembly and secretion of VLDL.
American journal of human genetics 81(5):884-94 Specific sequence variations within the 4q35 region are associated with facioscapulohumeral muscular dystrophy.
J. Biol. Chem. 268(14):10425-32 Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase.
Cell 98(1):69-80 Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi.
J. Biol. Chem. 276(20):17387-94 Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi network.
J. Biol. Chem. 278(38):35979-87 M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex.
European journal of biochemistry 191(3):563-9 Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form.
Molecular & cellular proteomics : MCP 3(5):456-65 Improved detection of hydrophilic phosphopeptides using graphite powder microcolumns and mass spectrometry: evidence for in vivo doubly phosphorylated dynamin I and dynamin III.
Journal of cell science 119(Pt 14):2851-3 Cortactin phosphorylation sites mapped by mass spectrometry.
The Journal of physiology 537(Pt 3):659-65 Phosphorylation of Ser(982) in the sodium bicarbonate cotransporter kNBC1 shifts the HCO(3)(-) : Na(+) stoichiometry from 3 : 1 to 2 : 1 in murine proximal tubule cells.
J. Biol. Chem. 278(20):18658-63 The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor.
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The Journal of neuroscience : the official journal of the Society for Neuroscience 24(7):1561-4 Decreased phosphorylation of NMDA receptor type 1 at serine 897 in brains of patients with Schizophrenia.
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The Biochemical journal Evaluation of the extent of the binding site in human tissue kallikrein by synthetic substrates with sequences of human kininogen fragments.
Molecular cell 11(5):1163-76 Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype.
Endocrinology 141(2):564-70 The effect of phosphorylation by casein kinase 2 on the activity of insulin-like growth factor-binding protein-3.
Molecular and cellular biology 22(11):3892-904 Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases.
Journal of molecular biology 300(3):503-18 The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A.
Biochemistry 24(22):6185-90 Ia-associated invariant chain is fatty acylated before addition of sialic acid.
Cell 96(5):667-76 Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry.
Cancer cell 3(3):247-58 Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.
J. Biol. Chem. 276(30):28261-7 Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin).
European journal of immunology 24(9):2168-74 Interleukin-7 induces the association of phosphatidylinositol 3-kinase with the alpha chain of the interleukin-7 receptor.
Biochem. Biophys. Res. Commun. 174(2):735-41 Mapping of carbohydrate sites on the human insulin receptor.
J. Biol. Chem. 278(34):32448-56 Activation of ERK induces phosphorylation of MAPK phosphatase-7, a JNK specific phosphatase, at Ser-446.
J. Biol. Chem. 271(19):11222-7 Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action.
Biochem. Biophys. Res. Commun. 285(2):235-43 A novel secreted tumor antigen with a glycosylphosphatidylinositol-anchored structure ubiquitously expressed in human cancers.
Genes & development 13(19):2514-26 Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis.
EMBO J. 20(21):6028-36 Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress.
Molecular and cellular biology 21(7):2373-83 p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression.
Biochemistry 32(22):5773-80 Insulin receptor autophosphorylation. II. Determination of autophosphorylation sites by chemical sequence analysis and identification of the juxtamembrane sites.
Diabetes 42(7):966-74 Glycosylation of Asn397 or Asn418 is required for normal insulin receptor biosynthesis and processing.
J. Biol. Chem. 277(23):21007-16 p59Hck isoform induces F-actin reorganization to form protrusions of the plasma membrane in a Cdc42- and Rac-dependent manner.
J. Biol. Chem. 266(6):3968-72 Phosphorylation and subcellular distribution of calpastatin in human hematopoietic system cells.
J. Biol. Chem. 278(13):11579-89 Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation.
The Biochemical journal 382(Pt 3):957-66 The plasma membrane translocation of diacylglycerol kinase delta1 is negatively regulated by conventional protein kinase C-dependent phosphorylation at Ser-22 and Ser-26 within the pleckstrin homology domain.
FEBS letters 378(3):227-31 Processing of pro-islet amyloid polypeptide (proIAPP) by the prohormone convertase PC2.
Circulation research 78(4):635-42 Removal of Arg141 from the alpha chain of human hemoglobin by carboxypeptidases N and M.
J. Biol. Chem. 281(39):28919-31 CFBP is a novel tyrosine-phosphorylated protein that might function as a regulator of CIN85/CD2AP.
Journal of immunology (Baltimore, Md. : 1950) 173(6):3962-71 Phosphorylation of Grb2-associated binder 2 on serine 623 by ERK MAPK regulates its association with the phosphatase SHP-2 and decreases STAT5 activation.
FEBS letters 579(21):4635-41 The role of PKCalpha and RLIP76 in transport-mediated doxorubicin-resistance in lung cancer.
FEBS letters 579(21):4763-8 Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.
Blood 101(11):4423-9 A predominant role for cAMP-dependent protein kinase in the cGMP-induced phosphorylation of vasodilator-stimulated phosphoprotein and platelet inhibition in humans.
Biochemistry 43(49):15494-502 Requirements for pYXXM motifs in Cbl for binding to the p85 subunit of phosphatidylinositol 3-kinase and Crk, and activation of atypical protein kinase C and glucose transport during insulin action in 3T3/L1 adipocytes.
J. Biol. Chem. 277(51):49408-16 Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation.
J. Biol. Chem. 271(45):28533-40 Antibacterial activity of glycosylated and phosphorylated chromogranin A-derived peptide 173-194 from bovine adrenal medullary chromaffin granules.
Molecular and cellular biology 23(5):1590-601 Phosphorylation of stem-loop binding protein (SLBP) on two threonines triggers degradation of SLBP, the sole cell cycle-regulated factor required for regulation of histone mRNA processing, at the end of S phase.
Biochemistry 38(8):2377-85 Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization.
Nature 353(6342):361-3 Myc rescue of a mutant CSF-1 receptor impaired in mitogenic signalling.
Blood 96(4):1550-7 Sequential phosphorylation of protein band 3 by Syk and Lyn tyrosine kinases in intact human erythrocytes: identification of primary and secondary phosphorylation sites.
EMBO J. 17(8):2224-34 Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1.
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Molecular and cellular biology 18(12):7336-43 Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.
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Journal of immunology (Baltimore, Md. : 1950) 158(2):580-90 Analysis of CD28 cytoplasmic tail tyrosine residues as regulators and substrates for the protein tyrosine kinases, EMT and LCK.
Molecular human reproduction 8(12):1117-24 Expression and subcellular distribution of the active form of c-Src tyrosine kinase in differentiating human endometrial stromal cells.
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Molecular and cellular biology 20(4):1140-8 Extracellular signal-regulated kinase binds to TFII-I and regulates its activation of the c-fos promoter.
Proceedings of the National Academy of Sciences of the United States of America 93(21):11681-6 The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner.
Archives of biochemistry and biophysics 320(2):315-22 Carbonic anhydrase IV: role of removal of C-terminal domain in glycosylphosphatidylinositol anchoring and realization of enzyme activity.
The Biochemical journal 373(Pt 2):505-13 Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes.
Proceedings of the National Academy of Sciences of the United States of America 96(15):8511-5 Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins.
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Molecular and cellular biology 21(13):4292-301 Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family.
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The Journal of experimental medicine 194(4):529-39 B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1.
Proceedings of the National Academy of Sciences of the United States of America 95(16):9214-9 Autoregulation of the Raf-1 serine/threonine kinase.
J. Biol. Chem. 278(18):15601-7 Actin binding of human LIM and SH3 protein is regulated by cGMP- and cAMP-dependent protein kinase phosphorylation on serine 146.
J. Biol. Chem. 269(42):26259-66 Phorbol ester stimulates phosphorylation on serine 1327 of the human insulin receptor.
Molecular and cellular biology 21(3):952-65 Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a).
Molecular pharmacology 62(2):379-88 Oxidative stress decreases G protein-coupled receptor kinase 2 in lymphocytes via a calpain-dependent mechanism.
The Biochemical journal 213(2):467-71 Action of human liver cathepsin B on the oxidized insulin B chain.
Klinische Wochenschrift Relationships between structure and function of tissue-type plasminogen activator.
Proceedings of the National Academy of Sciences of the United States of America 99(23):14795-800 Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.
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European journal of biochemistry 127(3):473-81 Phosphorylation of the type-II regulatory subunit of cyclic-AMP-dependent protein kinase by glycogen synthase kinase 3 and glycogen synthase kinase 5.
Biochem. Biophys. Res. Commun. 291(3):628-34 Phosphorylation of Fanconi anemia protein, FANCA, is regulated by Akt kinase.
J. Biol. Chem. 276(33):30987-94 Heterogeneous fatty acylation of Src family kinases with polyunsaturated fatty acids regulates raft localization and signal transduction.
EMBO J. 16(9):2342-51 Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets.
EMBO J. 19(23):6427-39 Transmembrane transforming growth factor-alpha tethers to the PDZ domain-containing, Golgi membrane-associated protein p59/GRASP55.
J. Biol. Chem. 279(18):18392-400 p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor.
The Biochemical journal 357(Pt 2):563-7 Autocatalytic tyrosine-phosphorylation of protein kinase CK2 alpha and alpha' subunits: implication of Tyr182.
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Cell death and differentiation 9(3):322-8 Yeast two-hybrid screening using constitutive-active caspase-7 as bait in the identification of PA28gamma as an effector caspase substrate.
J. Biol. Chem. 273(40):25937-43 Two forms of collagen XVII in keratinocytes. A full-length transmembrane protein and a soluble ectodomain.
Molecular and cellular biology 19(6):4200-8 Expression of the p56(Lck) Y505F mutation in CD45-deficient mice rescues thymocyte development.
J. Biol. Chem. 281(3):1746-54 Phosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase x Src complex and promote cell migration.
Molecular and cellular biology 19(12):8433-41 Glycogen synthase kinase 3 is an insulin-regulated C/EBPalpha kinase.
Proceedings of the National Academy of Sciences of the United States of America 96(24):13813-8 An Eph receptor regulates integrin activity through R-Ras.
The Biochemical journal 397(1):223-31 Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.
Proceedings of the National Academy of Sciences of the United States of America 102(9):3489-94 Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5).
EMBO J. 26(4):1105-16 Role of activation of PIP5Kgamma661 by AP-2 complex in synaptic vesicle endocytosis.
J. Biol. Chem. 269(49):31034-40 Identification of phosphorylation sites unique to the B form of human progesterone receptor. In vitro phosphorylation by casein kinase II.
Cell 71(7):1181-94 FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains.
Neuron 36(3):493-505 Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning.
"Science (New York, N.Y.)" 171(3971):579-81 Specific enzymic methylation of an arginine in the experimental allergic encephalomyelitis protein from human myelin.
J. Biol. Chem. 275(43):33321-8 Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes. Cross-talk via trans-activation of the tyrosine kinase c-kit receptor.
Molecular human reproduction 3(11):957-63 The role of N-terminal glycosylation in the human oxytocin receptor.
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J. Biol. Chem. 270(13):7679-88 Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262.
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The Biochemical journal 368(Pt 1):317-24 N-glycosylation is required for full enzymic activity of the murine galactosylceramide sulphotransferase.
Journal of cellular biochemistry 80(3):346-52 Differences in phosphorylation of human and chicken stathmin by MAP kinase.
Molecular cell 16(3):387-97 Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint.
J. Biol. Chem. 266(1):380-5 Multisite phosphorylation of a synthetic peptide derived from the carboxyl terminus of the ribosomal protein S6.
J. Biol. Chem. 261(21):9614-21 Clathrin-coated vesicles contain two protein kinase activities. Phosphorylation of clathrin beta-light chain by casein kinase II.
Journal of immunology (Baltimore, Md. : 1950) 171(7):3734-41 Eosinophil major basic protein stimulates neutrophil superoxide production by a class IA phosphoinositide 3-kinase and protein kinase C-zeta-dependent pathway.
Cell 129(5):969-82 The tumor suppressor PP2A Abeta regulates the RalA GTPase.
Archives of biochemistry and biophysics 394(1):54-60 Purification and characterization of the human PDE4A catalytic domain (PDE4A330-723) expressed in Sf9 cells.
The Journal of pharmacology and experimental therapeutics 304(3):1120-8 Selective tryptic cleavage at the tethered ligand site of the amino terminal domain of proteinase-activated receptor-2 in intact cells.
Molecular and cellular biology 22(1):270-85 Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2.
Nature 378(6559):785-9 Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.
Oncogene 21(46):7067-76 The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn).
Biochemistry 42(34):10333-41 N-Glycosylation and conserved cysteine residues in RAMP3 play a critical role for the functional expression of CRLR/RAMP3 adrenomedullin receptor.
"Science (New York, N.Y.)" 291(5506):1040-3 An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome.
FEBS letters 535(1-3):6-10 Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells.
Journal of immunology (Baltimore, Md. : 1950) 171(1):267-73 Activation of protein kinase C delta by IFN-gamma.
Oncogene 8(12):3199-209 Phosphorylation sites mapping in the N-terminal domain of c-myc modulate its transforming potential.
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J. Biol. Chem. 275(24):18534-40 Big mitogen-activated kinase regulates multiple members of the MEF2 protein family.
J. Biol. Chem. 280(1):146-55 Sumoylation of MITF and its related family members TFE3 and TFEB.
Genes to cells : devoted to molecular & cellular mechanisms 3(12):789-800 Tip60 acetylates six lysines of a specific class in core histones in vitro.
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Amino acids 15(4):291-306 Recent advances in protein methylation: enzymatic methylation of nucleic acid binding proteins.
Biochemistry 33(19):5759-65 Glycosylation of human corticosteroid-binding globulin. Differential processing and significance of carbohydrate chains at individual sites.
Nature genetics 29(3):279-86 The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men.
Molecular cell 6(3):539-50 Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity.
Molecular and cellular biology 22(11):3599-609 APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes.
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Proceedings of the National Academy of Sciences of the United States of America 99(15):9745-9 Glutathionylation of human thioredoxin: a possible crosstalk between the glutathione and thioredoxin systems.
Nature genetics 46(12):1293-302 Palindromic GOLGA8 core duplicons promote chromosome 15q13.3 microdeletion and evolutionary instability.
J. Biol. Chem. 271(29):17124-31 Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme.
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Cancer research 63(7):1458-63 The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity.
J. Biol. Chem. 280(8):7080-7 BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan.
Oncogene 9(9):2733-6 Protein kinase A phosphorylates cyclin D1 at three distinct sites within the cyclin box and at the C-terminus.
J. Biol. Chem. 274(18):12748-52 Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl.
Molecular and cellular biology 19(9):6286-96 Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt.
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J. Biol. Chem. 275(48):37542-51 Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases.
Biochim. Biophys. Acta 1583(1):99-107 Early-glycation of apolipoprotein E: effect on its binding to LDL receptor, scavenger receptor A and heparan sulfates.
J. Biol. Chem. 277(6):3943-9 Phosphorylation of beta3 integrin controls ligand binding strength.
J. Biol. Chem. 279(49):50643-6 Phosphorylation of annexin I by TRPM7 channel-kinase.
Biochemistry 35(40):13040-6 Disulfide structure and N-glycosylation sites of an extracellular domain of granulocyte-colony stimulating factor receptor.
J. Biol. Chem. 277(11):9437-46 Endosomal proteolysis of internalized insulin at the C-terminal region of the B chain by cathepsin D.
EMBO J. 12(5):1937-46 Multi-site phosphorylation of the protein tyrosine phosphatase, PTP1B: identification of cell cycle regulated and phorbol ester stimulated sites of phosphorylation.
J. Biol. Chem. 267(4):2190-9 The predominant form of secreted colony stimulating factor-1 is a proteoglycan.
J. Biol. Chem. 278(11):9134-41 A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3.
J. Biol. Chem. 269(3):1668-73 Membrane topology of aquaporin CHIP. Analysis of functional epitope-scanning mutants by vectorial proteolysis.
J. Biol. Chem. 277(49):47572-80 SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei.
"Science (New York, N.Y.)" 256(5055):370-3 Calcium-regulated phosphorylation within the leucine zipper of C/EBP beta.
Journal of neurochemistry 68(6):2514-22 Functional role of amino-terminal serine16 and serine27 of G alphaZ in receptor and effector coupling.
Nucleic acids research 34(1):217-31 Functional role of NF-IL6beta and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene.
Genes & development 12(22):3499-511 Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
EMBO J. 25(4):739-51 P38MAPK-dependent phosphorylation and degradation of SRC-3/AIB1 and RARalpha-mediated transcription.
Molecular and cellular biology 22(8):2673-86 SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription.
Biochemistry 39(21):6459-65 Monoclonal antibody light chain with prothrombinase activity.
Nature medicine 8(10):1145-52 PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
Oncogene 17(21):2787-98 Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins.
Circulation research 88(11):E68-75 Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity.
The Journal of experimental medicine 176(4):1053-62 Myristyl acylation of the tumor necrosis factor alpha precursor on specific lysine residues.
FEBS letters 581(8):1542-8 Modulation of p300 binding by posttranslational modifications of the C-terminal activation domain of hypoxia-inducible factor-1alpha.
Journal of biochemistry 107(2):292-7 Structure of recombinant human interleukin 5 produced by Chinese hamster ovary cells.
"Science (New York, N.Y.)" 275(5308):1930-4 Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3.
Biochim. Biophys. Acta 1448(3):363-71 Ribonucleotide reductase R2 protein is phosphorylated at serine-20 by P34cdc2 kinase.
J. Biol. Chem. 275(30):23065-73 Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta.
The Journal of cell biology 153(5):893-904 Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration.
Molecular and cellular biology 18(12):7216-24 Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin.
J. Biol. Chem. 267(3):1517-21 Patterns of prohormone processing. Order revealed by a new procholecystokinin-derived peptide.
J. Biol. Chem. 271(30):18217-23 Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1.
Nature 421(6922):499-506 DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.
The Journal of experimental medicine 199(4):503-14 N-linked glycosylation is required for optimal function of Kaposi's sarcoma herpesvirus-encoded, but not cellular, interleukin 6.
Nature 405(6785):477-82 ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response.
Molecular biology of the cell 12(6):1811-7 Mitotic phosphorylation of Golgi reassembly stacking protein 55 by mitogen-activated protein kinase ERK2.
Biological chemistry 383(1):93-9 Apolipoprotein(a): structure-function relationship at the lysine-binding site and plasminogen activator cleavage site.
The Biochemical journal 358(Pt 1):69-77 Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites.
J. Biol. Chem. 278(28):25568-76 Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305.
J. Biol. Chem. 270(9):4805-12 Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity.
Oncogene 23(39):6581-9 The M-CSF receptor substrate and interacting protein FMIP is governed in its subcellular localization by protein kinase C-mediated phosphorylation, and thereby potentiates M-CSF-mediated differentiation.
Journal of inflammation 45(3):152-60 Phosphorylation of the 26 kDa TNF precursor in monocytic cells and in transfected HeLa cells.
Biochem. Biophys. Res. Commun. 268(2):249-54 Evidence for the carboxyl methylation of nuclear lamin-B in the pancreatic beta cell.
J. Biol. Chem. 265(20):11682-91 Phosphorylation of tyrosine hydroxylase in situ at serine 8, 19, 31, and 40.
EMBO J. 25(14):3323-34 Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation.
Proceedings of the National Academy of Sciences of the United States of America 97(8):4040-5 Membrane-associated GAIP is a phosphoprotein and can be phosphorylated by clathrin-coated vesicles.
Oncogene 21(6):867-77 MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts.
Molecular biology of the cell 9(6):1495-512 The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 96(17):9677-82 Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction.
Blood 100(2):467-73 Prostaglandin-E2 enhances EPO-mediated STAT5 transcriptional activity by serine phosphorylation of CREB.
FEBS letters 443(1):48-52 Prorenin processing by cathepsin B in vitro and in transfected cells.
Molecular and cellular biology 22(8):2810-20 HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A.
Molecular cell 10(3):483-93 Control of Smad7 stability by competition between acetylation and ubiquitination.
FEBS letters 178(2):213-6 Amino acid sequence of the N-terminal region of human hemopexin.
Journal of immunology (Baltimore, Md. : 1950) 176(6):3603-10 Signaling through mutants of the IgA receptor CD89 and consequences for Fc receptor gamma-chain interaction.
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Proceedings of the National Academy of Sciences of the United States of America 100(5):2432-7 JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis.
J. Biol. Chem. 273(15):9158-67 Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.
J. Biol. Chem. 278(38):36966-72 Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway.
EMBO J. 18(8):2137-48 Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation.
J. Biol. Chem. 281(3):1495-505 Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase.
Biochemistry 37(8):2291-8 Human mast cell tryptase fibrinogenolysis: kinetics, anticoagulation mechanism, and cell adhesion disruption.
Molecular cell 6(1):127-37 Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7.
The Journal of cell biology 116(2):405-22 A strategy for isolation of cDNAs encoding proteins affecting human intestinal epithelial cell growth and differentiation: characterization of a novel gut-specific N-myristoylated annexin.
Molecular and cellular biology 23(16):5692-705 The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization.
Current biology : CB 10(8):467-70 Acetylation of importin-alpha nuclear import factors by CBP/p300.
J. Biol. Chem. 277(29):26642-51 Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor.
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Molecular and cellular biology 24(19):8374-85 Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5.
J. Biol. Chem. 271(41):25157-66 Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C.
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J. Biol. Chem. 276(22):19656-63 Cdc42 is a substrate for caspases and influences Fas-induced apoptosis.
J. Biol. Chem. 278(7):4713-8 Tip60 acetyltransferase activity is controlled by phosphorylation.
J. Biol. Chem. 268(35):26712-8 L-29, a soluble lactose-binding lectin, is phosphorylated on serine 6 and serine 12 in vivo and by casein kinase I.
The Journal of neuroscience : the official journal of the Society for Neuroscience 22(18):7948-58 A new activity of doublecortin in recognition of the phospho-FIGQY tyrosine in the cytoplasmic domain of neurofascin.
Human mutation 18(5):397-410 Mutation screening at the RNA level of the STK11/LKB1 gene in Peutz-Jeghers syndrome reveals complex splicing abnormalities and a novel mRNA isoform (STK11 c.597(insertion mark)598insIVS4).
Biochem. Biophys. Res. Commun. 286(2):322-7 The N-terminal internal region of BLM is required for the formation of dots/rod-like structures which are associated with SUMO-1.
Cancer research 62(22):6475-80 14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s).
Structure (London, England : 1993) 8(11):1105-13 Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail.
Cell 105(2):257-67 Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation.
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J. Biol. Chem. 278(15):13061-8 Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein.
Immunity 9(2):239-46 LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation.
J. Biol. Chem. 278(16):13663-71 The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.
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Physiological reviews 83(3):731-801 The calpain system.
J. Biol. Chem. 264(34):20320-5 Identification of a disaccharide (Xyl-Glc) and a trisaccharide (Xyl2-Glc) O-glycosidically linked to a serine residue in the first epidermal growth factor-like domain of human factors VII and IX and protein Z and bovine protein Z.
J. Biol. Chem. 281(16):11002-10 Identification of substrates of human protein-tyrosine phosphatase PTPN22.
Immunogenetics 50(1-2):1-7 Cloning of a new lectin-like receptor expressed on human NK cells.
Immunity 8(4):451-60 Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis.
J. Biol. Chem. 277(29):26573-80 Deciphering the phosphorylation "code" of the glucocorticoid receptor in vivo.
J. Biol. Chem. 271(16):9313-9 Phosphorylation of the ATP-sensitive, inwardly rectifying K+ channel, ROMK, by cyclic AMP-dependent protein kinase.
Journal of biochemistry 102(5):1113-20 Phosphorylation sites of bovine brain myelin basic protein phosphorylated with Ca2+-calmodulin-dependent protein kinase from rat brain.
J. Biol. Chem. 277(48):45793-802 Bi-functional, substrate mimicking RNA inhibits MSK1-mediated cAMP-response element-binding protein phosphorylation and reveals magnesium ion-dependent conformational changes of the kinase.
American journal of physiology. Endocrinology and metabolism 286(3):E411-7 5'-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle.
J. Biol. Chem. 276(34):31620-6 Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf.
J. Biol. Chem. 278(10):8184-9 Nitric oxide, NOC-12, and S-nitrosoglutathione modulate the skeletal muscle calcium release channel/ryanodine receptor by different mechanisms. An allosteric function for O2 in S-nitrosylation of the channel.
Journal of immunology (Baltimore, Md. : 1950) 162(8):4438-46 Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase.
J. Biol. Chem. 266(1):559-66 Phosphorylation of the 48-kDa subunit of the glycine receptor by protein kinase C.
European journal of pharmacology 386(2-3):305-12 Palmitoylation occurs at cysteine 347 and cysteine 351 of the dopamine D(1) receptor.
Journal of immunology (Baltimore, Md. : 1950) 165(3):1197-209 FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells.
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Biochim. Biophys. Acta 1269(1):69-78 The protein kinase from mitotic human cells that phosphorylates Ser-209 on the casein kinase II beta-subunit is p34cdc2.
Proceedings of the National Academy of Sciences of the United States of America 103(14):5391-6 Phosphoproteome analysis of the human mitotic spindle.
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EMBO J. 12(1):75-85 Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15.
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Protein science : a publication of the Protein Society 13(6):1627-35 Identification of the N-glycosylation sites on glutamate carboxypeptidase II necessary for proteolytic activity.
The Biochemical journal Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2.
Journal of lipid research 34(8):1355-66 Fatty acid-binding protein from rat heart is phosphorylated on Tyr19 in response to insulin stimulation.
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The FEBS journal 273(6):1224-39 Site-specific phosphorylation of MCM4 during the cell cycle in mammalian cells.
The Journal of urology 156(2 Pt 1):526-31 Prostate specific antigen cleaves parathyroid hormone-related protein in the PTH-like domain: inactivation of PTHrP-stimulated cAMP accumulation in mouse osteoblasts.
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Proceedings of the National Academy of Sciences of the United States of America 100(15):8776-81 Protein kinase A phosphorylation modulates transport of the polypyrimidine tract-binding protein.
FEBS letters 474(2-3):141-5 Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1.
Molecular cell 12(2):381-92 Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation.
American journal of physiology. Cell physiology 279(1):C266-73 VACM-1, a cullin gene family member, regulates cellular signaling.
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Current biology : CB 7(10):776-89 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.
Biology of the cell 96(2):125-32 Alpha- and beta- cleavages of the amino-terminus of the cellular prion protein.
J. Biol. Chem. 277(26):23658-63 SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities.
The Biochemical journal 371(Pt 1):15-27 Positive and negative regulation of T-cell activation through kinases and phosphatases.
Nature structural & molecular biology 13(2):140-6 Structural basis for the methylation site specificity of SET7/9.
Journal of neurochemistry 70(5):1839-49 Palmitoylation of neurofascin at a site in the membrane-spanning domain highly conserved among the L1 family of cell adhesion molecules.
FEBS letters 385(3):241-3 Site-directed mutagenesis but not gamma-carboxylation of Glu-35 in factor VIIa affects the association with tissue factor.
FEBS letters 576(3):401-7 N-glycosylation is required for efficient secretion of a novel human secreted glycoprotein, hPAP21.
Molecular biology of the cell 18(3):1107-17 Aurora-B regulates RNA methyltransferase NSUN2.
Biochem. Biophys. Res. Commun. 280(4):1085-92 Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125.
The Journal of cell biology 145(2):347-61 Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility.
Proceedings of the National Academy of Sciences of the United States of America 95(15):8532-7 A cloning method for caspase substrates that uses the yeast two-hybrid system: cloning of the antiapoptotic gene gelsolin.
Oncogene 20(23):2918-26 Sequential two-step cleavage of the retinoblastoma protein by caspase-3/-7 during etoposide-induced apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 165(12):6872-9 The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19.
Cell 76(6):1025-37 JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain.
European journal of biochemistry 257(1):242-8 Caspase 3 specifically cleaves p21WAF1/CIP1 in the earlier stage of apoptosis in SK-HEP-1 human hepatoma cells.
J. Biol. Chem. 276(33):31216-28 Transcription factor STAT5A is a substrate of Bruton's tyrosine kinase in B cells.
Molecular and cellular biology 18(9):5229-38 14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity.
Cell 128(1):59-70 Modeling of a human circadian mutation yields insights into clock regulation by PER2.
Biochemistry 36(21):6270-82 Structure and assembly of the catalytic region of human complement protease C1r: a three-dimensional model based on chemical cross-linking and homology modeling.
Molecular endocrinology (Baltimore, Md.) 16(10):2382-92 Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation.
J. Biol. Chem. 277(22):19389-95 Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain.
J. Biol. Chem. 276(25):23173-8 Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase.
J. Biol. Chem. 276(34):31858-62 Regulation of Akt/PKB activation by tyrosine phosphorylation.
Molecular and cellular biochemistry 221(1-2):147-54 Phosphorylation and activation of protein tyrosine phosphatase (PTP) 1B by insulin receptor.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 9(3):197-208 C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding.
Molecular biology of the cell 11(9):2901-14 Exposure at the cell surface is required for gas3/PMP22 To regulate both cell death and cell spreading: implication for the Charcot-Marie-Tooth type 1A and Dejerine-Sottas diseases.
EMBO J. 20(11):2723-41 Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility.
Cell 108(6):837-47 Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism.
Journal of cell science 120(Pt 17):3034-44 Calcineurin is essential for depolarization-induced nuclear translocation and tyrosine phosphorylation of PYK2 in neurons.
Biochemistry 27(10):3682-90 Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C.
Cell 93(5):851-61 Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1.
J. Biol. Chem. 274(17):11693-700 Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP).
J. Biol. Chem. 275(27):20436-43 Histone deacetylases specifically down-regulate p53-dependent gene activation.
Biochemistry 32(20):5472-9 Expression of glycosylated and nonglycosylated human transferrin in mammalian cells. Characterization of the recombinant proteins with comparison to three commercially available transferrins.
Proceedings of the National Academy of Sciences of the United States of America 97(23):12577-82 Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein.
Biochemistry 41(42):12850-7 Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2.
Molecular & cellular proteomics : MCP 1(8):567-78 Mapping and structural dissection of human 20 S proteasome using proteomic approaches.
The international journal of biochemistry & cell biology 32(8):805-15 Structure-function and biological role of betacellulin.
EMBO J. 20(14):3716-27 Positive and negative regulation of Raf kinase activity and function by phosphorylation.
Journal of cell science 115(Pt 18):3609-18 A novel chk1-dependent G1/M checkpoint in fission yeast.
Nucleic acids research 21(5):1289-95 c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif.
Proceedings of the National Academy of Sciences of the United States of America 98(6):3416-21 The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation.
EMBO J. 21(14):3715-27 Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation.
Proceedings of the National Academy of Sciences of the United States of America 100(16):9470-5 A Ras activation pathway dependent on Syk phosphorylation of protein kinase C.
Cell cycle (Georgetown, Tex.) 2(5):473-8 Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint.
J. Biol. Chem. 276(29):27462-9 Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343.
J. Biol. Chem. 280(45):37623-33 Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties.
J. Biol. Chem. 279(44):45603-12 Protein kinase Cdelta regulates apoptosis via activation of STAT1.
Molecular and cellular biology 17(2):571-83 The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex.
Cell 78(5):799-811 Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa protein.
PloS one 5(12):e15115 Different patterns of evolution in the centromeric and telomeric regions of group A and B haplotypes of the human killer cell Ig-like receptor locus.
Molecular & cellular proteomics : MCP 5(1):194-203 Mapping post-translational modifications of the histone variant MacroH2A1 using tandem mass spectrometry.
"Science (New York, N.Y.)" 286(5442):1162-6 Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.
J. Biol. Chem. 272(50):31865-71 Regulation of leukotriene A4 hydrolase activity in endothelial cells by phosphorylation.
J. Steroid Biochem. Mol. Biol. 75(2-3):147-58 Glycosylation of the murine estrogen receptor-alpha.
European journal of biochemistry 225(1):29-41 A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex.
FEBS letters 453(3):387-90 Mutational analysis of sites in the translational regulator, PHAS-I, that are selectively phosphorylated by mTOR.
EMBO J. 25(13):3179-90 Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange.
FEBS letters 280(2):211-5 Inactivation of human cystatin C and kininogen by human cathepsin D.
The Biochemical journal Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7.
Nature structural & molecular biology 11(4):308-15 Regulation of the p300 HAT domain via a novel activation loop.
Nature genetics 30(3):285-9 BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage.
J. Biol. Chem. 269(24):16589-96 Phosphorylation of the erythroid transcription factor GATA-1.
EMBO J. 17(21):6250-62 Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation.
The Biochemical journal 358(Pt 3):705-15 Targeting of the transcription factor Max during apoptosis: phosphorylation-regulated cleavage by caspase-5 at an unusual glutamic acid residue in position P1.
Neuron 24(2):377-87 A phospho-switch controls the dynamic association of synapsins with synaptic vesicles.
Molecular cancer research : MCR 2(3):170-82 The interaction of specific peptide aptamers with the DNA binding domain and the dimerization domain of the transcription factor Stat3 inhibits transactivation and induces apoptosis in tumor cells.
J. Biol. Chem. 270(41):24116-26 Structural analysis of the oligosaccharides derived from glycodelin, a human glycoprotein with potent immunosuppressive and contraceptive activities.
Neurology 56(2):207-14 Cognitive impairment in Coffin-Lowry syndrome correlates with reduced RSK2 activation.
The Biochemical journal 370(Pt 3):881-9 The N-terminus of the human copper transporter 1 (hCTR1) is localized extracellularly, and interacts with itself.
Biochim. Biophys. Acta 1539(1-2):131-9 Glycosylation of human CRLR at Asn123 is required for ligand binding and signaling.
J. Biol. Chem. 271(17):10379-84 Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane.
J. Biol. Chem. 277(23):20367-71 Protein kinase C (PKC) delta regulates PKCalpha activity in a Syndecan-4-dependent manner.
J. Biol. Chem. 264(34):20526-31 Structure of human lysosomal membrane glycoprotein 1. Assignment of disulfide bonds and visualization of its domain arrangement.
J. Biol. Chem. 278(17):14926-35 Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs.
J. Biol. Chem. 275(44):34710-8 Mitotic phosphorylation of DNA topoisomerase II alpha by protein kinase CK2 creates the MPM-2 phosphoepitope on Ser-1469.
Biochim. Biophys. Acta 1151(2):149-52 Identification of the phosphorylation site on human erythrocyte band 7 integral membrane protein: implications for a monotopic protein structure.
J. Biol. Chem. 272(34):21010-7 Activation of caspase-2 in apoptosis.
J. Biol. Chem. 268(10):7107-17 The alpha-type 85-kDa subunit of phosphatidylinositol 3-kinase is phosphorylated at tyrosines 368, 580, and 607 by the insulin receptor.
The American journal of physiology 263(2 Pt 1):L249-56 Generation of the neutrophil-activating peptide-2 by cathepsin G and cathepsin G-treated human platelets.
The Journal of cell biology 136(5):1023-35 Rapid plasma membrane anchoring of newly synthesized p59fyn: selective requirement for NH2-terminal myristoylation and palmitoylation at cysteine-3.
J. Biol. Chem. 279(16):16394-402 Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase.
J. Biol. Chem. 269(47):29351-4 Phosphorylation of the desmoplakin COOH terminus negatively regulates its interaction with keratin intermediate filament networks.
J. Biol. Chem. 277(16):13430-7 Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria.
The Biochemical journal Stat1 associates with c-kit and is activated in response to stem cell factor.
Molecular and cellular biology 13(8):4679-90 Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1.
Current biology : CB 5(12):1394-1403 Protein kinase C is regulated in vivo by three functionally distinct phosphorylations.
J. Biol. Chem. 268(24):18234-42 N-glycosylation of prostaglandin endoperoxide synthases-1 and -2 and their orientations in the endoplasmic reticulum.
Molecular and cellular endocrinology 175(1-2):149-56 KN-93 inhibition of G protein signaling is independent of the ability of Ca2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser.
The Journal of cell biology 142(6):1547-58 Active MAP kinase in mitosis: localization at kinetochores and association with the motor protein CENP-E.
J. Biol. Chem. 276(15):11939-48 Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor.
J. Biol. Chem. 278(46):45994-8 Phosphorylation of serine 337 of NF-kappaB p50 is critical for DNA binding.
"Science (New York, N.Y.)" 278(5343):1638-41 Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway.
Cell 115(3):293-303 Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression.
Biochemistry 39(44):13551-7 Mutations of serine 236-237 and tyrosine 302 residues in the human lipoxin A4 receptor intracellular domains result in sustained signaling.
Archives of biochemistry and biophysics 298(1):150-8 Post-translational processing of membrane-associated recombinant human stem cell factor expressed in Chinese hamster ovary cells.
Molecular endocrinology (Baltimore, Md.) 12(4):544-55 N-glycosylation of the prolactin receptor is not required for activation of gene transcription but is crucial for its cell surface targeting.
J. Biol. Chem. 269(16):11962-6 Identification of the phosphorylation site in vitro for cAMP-dependent protein kinase on the rat adipocyte cGMP-inhibited cAMP phosphodiesterase.
EMBO J. 20(24):7008-21 Polarized trafficking and surface expression of the AQP4 water channel are coordinated by serial and regulated interactions with different clathrin-adaptor complexes.
Molecular cell 11(2):437-44 The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.
J. Biol. Chem. 277(2):883-6 p21-activated kinase links Rac/Cdc42 signaling to merlin.
J. Biol. Chem. 271(11):5961-4 Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction.
J. Biol. Chem. 276(18):14909-15 Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis.
Molecular biology of the cell 13(6):2031-44 Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding.
EMBO J. 12(10):3903-11 Multiple and cooperative phosphorylation events regulate the CREM activator function.
J. Biol. Chem. 274(11):6823-6 Nitric oxide inhibits caspase-3 by S-nitrosation in vivo.
Nature 391(6668):703-7 Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells.
The Biochemical journal Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor 4E-binding protein 1 on the rapamycin-insensitive site (serine-111).
Biochemistry 44(50):16475-90 Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase.
J. Biol. Chem. 281(5):2551-61 Binding of manumycin A inhibits IkappaB kinase beta activity.
The Journal of cell biology 150(4):905-12 Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis.
J. Biol. Chem. 276(34):31738-44 Gas6 anti-apoptotic signaling requires NF-kappa B activation.
J. Biol. Chem. 280(15):15340-7 Protein kinase CK1alpha regulates mRNA binding by heterogeneous nuclear ribonucleoprotein C in response to physiologic levels of hydrogen peroxide.
EMBO J. 4(13B):3735-42 Phosphorylation and activation of hamster carbamyl phosphate synthetase II by cAMP-dependent protein kinase. A novel mechanism for regulation of pyrimidine nucleotide biosynthesis.
J. Biol. Chem. 276(7):4709-16 Heterologous activation of protein kinase C stimulates phosphorylation of delta-opioid receptor at serine 344, resulting in beta-arrestin- and clathrin-mediated receptor internalization.
Gene 186(2):189-95 The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals.
"Science (New York, N.Y.)" 282(5392):1318-21 Regulation of cell death protease caspase-9 by phosphorylation.
FEBS letters 580(21):5096-104 CRM1 mediates nuclear export of HDAC7 independently of HDAC7 phosphorylation and association with 14-3-3s.
J. Biol. Chem. 279(30):31164-70 Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function.
Journal of cell science 115(Pt 23):4433-45 A developmentally regulated ARF-like 5 protein (ARL5), localized to nuclei and nucleoli, interacts with heterochromatin protein 1.
EMBO reports 4(4):412-8 Proteolytic cleavage of PDZD2 generates a secreted peptide containing two PDZ domains.
J. Biol. Chem. 278(51):51479-83 Modification of promyelocytic leukemia zinc finger protein (PLZF) by SUMO-1 conjugation regulates its transcriptional repressor activity.
J. Biol. Chem. 281(10):6236-45 Phosphorylation of serine 526 is required for MEKK3 activity, and association with 14-3-3 blocks dephosphorylation.
J. Biol. Chem. 252(12):4326-9 Limited pepsin digestion of human plasma albumin.
FEBS letters 580(15):3624-30 Polo-like kinase 1 regulates mitotic arrest after UV irradiation through dephosphorylation of p53 and inducing p53 degradation.
J. Biol. Chem. 275(1):423-8 Akt protein kinase inhibits Rac1-GTP binding through phosphorylation at serine 71 of Rac1.
J. Biol. Chem. 275(33):25723-32 Regulation of human endothelial cell focal adhesion sites and migration by cGMP-dependent protein kinase I.
Molecular cell 8(5):1063-73 An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF.
Molecular and cellular biology 16(10):5623-33 Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases.
Molecular and cellular biology 18(1):616-28 Pex19p, a farnesylated protein essential for peroxisome biogenesis.
Glycobiology 11(11):997-1008 The polysialyltransferase ST8Sia II/STX: posttranslational processing and role of autopolysialylation in the polysialylation of neural cell adhesion molecule.
J. Biol. Chem. 277(16):13840-7 IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2.
J. Biol. Chem. 278(37):35702-9 Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival.
British journal of cancer 82(12):1938-45 ATM protein and p53-serine 15 phosphorylation in ataxia-telangiectasia (AT) patients and at heterozygotes.
J. Biol. Chem. 271(40):24408-12 Stimulation of tumor cell motility linked to phosphodiesterase catalytic site of autotaxin.
Genomics 47(1):125-30 Sequence characterization of a newly identified human alpha-tubulin gene (TUBA2).
Molecular and cellular biology 23(4):1379-89 Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling.
Journal of andrology 16(1):64-74 Secretory leucocyte protease inhibitor in the male genital tract: PSA-induced proteolytic processing in human semen and tissue localization.
J. Biol. Chem. 277(46):44115-20 Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase.
Journal of biochemistry 107(3):486-92 Structural characterization of natural and recombinant human granulocyte colony-stimulating factors.
J. Biol. Chem. 281(2):915-26 Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling.
Nature 444(7119):629-32 Repression of p53 activity by Smyd2-mediated methylation.
J. Biol. Chem. 274(12):8022-8 Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation.
J. Biol. Chem. 275(36):27845-50 SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells.
Developmental biology 213(2):283-300 Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis.
J. Biol. Chem. 277(33):29792-802 The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation.
J. Biol. Chem. 270(47):28357-63 Cell cycle phase-specific phosphorylation of human topoisomerase II alpha. Evidence of a role for protein kinase C.
J. Biol. Chem. 272(51):32221-9 Separate domains of the human fas ligand dictate self-association and receptor binding.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 16(2):210-2 Multiple phosphorylation of alpha-synuclein by protein tyrosine kinase Syk prevents eosin-induced aggregation.
Cell death and differentiation 8(5):443-50 Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis.
J. Biol. Chem. 268(32):23933-9 Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases.
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Molecular and cellular biology 19(8):5523-34 Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.
Molecular and cellular biology 22(8):2871-81 MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts.
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Molecular and cellular biology 25(20):9063-72 Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination.
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Nature 389(6651):618-22 Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1.
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The Biochemical journal The two forms of bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase result from alternative splicing.
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Proceedings of the National Academy of Sciences of the United States of America 98(7):3690-4 Akt phosphorylates and regulates the orphan nuclear receptor Nur77.
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J. Biol. Chem. 273(13):7594-603 Protein kinase C-theta phosphorylation of moesin in the actin-binding sequence.
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Biochemistry 35(12):3782-9 Phosphorylation of C8 and C9 subunits of the multicatalytic proteinase by casein kinase II and identification of the C8 phosphorylation sites by direct mutagenesis.
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FEBS letters 449(2-3):101-4 Cysteine 29 is the major palmitoylation site on stomatin.
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The Biochemical journal 374(Pt 1):199-206 Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization.
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Molecular cell 6(1):41-51 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation.
American journal of hematology 54(1):1-11 Lineage- and differentiation stage-specific expression of LSM-1 (LPAP), a possible substrate for CD45, in human hematopoietic cells.
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The Biochemical journal The m3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase.
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Molecular and cellular biology 20(14):5010-8 Phosphorylation of the PTEN tail regulates protein stability and function.
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Biochemistry 39(35):10812-22 Proteolysis of the exodomain of recombinant protease-activated receptors: prediction of receptor activation or inactivation by MALDI mass spectrometry.
Molecular cell 8(5):995-1004 Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein.
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Biochem. Biophys. Res. Commun. 293(4):1191-6 Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction.
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Molecular cell 4(5):725-34 Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program.
Journal of cell science 116(Pt 20):4169-79 The UIM domain of Hrs couples receptor sorting to vesicle formation.
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FEBS letters 267(2):181-2 Two phosphorylation sites on eIF-2 alpha.
Genome research 26(11):1453-1467 Interchromosomal core duplicons drive both evolutionary instability and disease susceptibility of the Chromosome 8p23.1 region.
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FEBS letters 499(1-2):127-32 Proposed lipocalin fold for apolipoprotein M based on bioinformatics and site-directed mutagenesis.
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Molecular and cellular biology 23(7):2287-97 p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction.
Proceedings of the National Academy of Sciences of the United States of America 99(9):5971-6 Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma.
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J. Biol. Chem. 277(7):5094-100 Different domains of the mitogen-activated protein kinases ERK3 and ERK2 direct subcellular localization and upstream specificity in vivo.
European journal of cell biology 62(2):237-47 Functional analysis of phosphorylation sites in human lamin A controlling lamin disassembly, nuclear transport and assembly.
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Nature structural biology 8(7):593-6 Structure of GSK3beta reveals a primed phosphorylation mechanism.
Molecular biology of the cell 14(2):600-10 Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexes.
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Nature 414(6866):865-71 The DNA sequence and comparative analysis of human chromosome 20.
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FEBS letters 535(1-3):82-6 Ezrin is a substrate for Lck in T cells.
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The Journal of cell biology 149(7):1503-12 Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication.
Oncogene 9(5):1437-46 Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity.
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Molecular cell 11(5):1389-96 Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding.
Molecular and cellular biology 21(3):743-54 The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.
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European journal of biochemistry 217(2):715-22 Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2.
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European journal of biochemistry 260(2):384-91 Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb.
Molecular and cellular biology 16(9):4735-43 In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation.
Molecular and cellular biology 20(14):5285-99 The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR.
FEBS letters 521(1-3):190-4 Activation of Pyk2/RAFTK induces tyrosine phosphorylation of alpha-synuclein via Src-family kinases.
Molecular and cellular biology 19(7):4819-24 Tyrosine phosphorylation of the proto-oncoprotein Raf-1 is regulated by Raf-1 itself and the phosphatase Cdc25A.
Human molecular genetics 10(3):179-88 Congenital insensitivity to pain with anhidrosis (CIPA): effect of TRKA (NTRK1) missense mutations on autophosphorylation of the receptor tyrosine kinase for nerve growth factor.
Molecular and cellular biology 19(2):1202-9 p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage.
J. Biol. Chem. 279(21):21866-72 Phosphorylation of histone H2A inhibits transcription on chromatin templates.
J. Biol. Chem. 271(47):30077-82 Threonine 1342 in human topoisomerase IIalpha is phosphorylated throughout the cell cycle.
Endocrine reviews 20(2):189-206 The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family.
Molecular and cellular biology 22(17):6209-21 Plk phosphorylation regulates the microtubule-stabilizing protein TCTP.
Nature 399(6738):814-7 p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage.
Cell 111(5):709-20 Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation.
J. Biol. Chem. 275(16):11610-7 Phosphorylation of dynamin I on Ser-795 by protein kinase C blocks its association with phospholipids.
J. Biol. Chem. 276(45):42070-6 G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2.
Biochem. Biophys. Res. Commun. 299(5):880-5 Identification and characterization of P15RS, a novel P15(INK4b) related gene on G1/S progression.
J. Biol. Chem. 277(45):42987-96 Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation.
EMBO J. 14(9):1878-91 Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle.
J. Biol. Chem. 278(11):9019-26 Phosphorylation of tyrosine 319 of the angiotensin II type 1 receptor mediates angiotensin II-induced trans-activation of the epidermal growth factor receptor.
J. Biol. Chem. 278(13):11221-6 Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition.
Life sciences 72(7):747-57 Biosynthesis and processing of pro CCK: recent progress and future challenges.
Chemistry 7(5):1129-32 Chemical synthesis of lymphotactin: a glycosylated chemokine with a C-terminal mucin-like domain.
Journal of neurochemistry 68(5):2129-39 The neuronal calcium-sensor protein VILIP modulates cyclic AMP accumulation in stably transfected C6 glioma cells: amino-terminal myristoylation determines functional activity.
Cell 127(3):635-48 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
J. Biol. Chem. 270(21):12665-9 Components of a new human protein kinase signal transduction pathway.
Nature cell biology 5(8):701-10 Cdk5 is essential for synaptic vesicle endocytosis.
Progress in brain research Molecular pharmacology and modeling of vasopressin receptors.
J. Biol. Chem. 269(2):944-54 Molecular mechanism of the synergistic phosphorylation of phosphatase inhibitor-2. Cloning, expression, and site-directed mutagenesis of inhibitor-2.
Current biology : CB 12(6):446-53 The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3.
FEBS letters 230(1-2):1-5 Two adjacent cysteine residues in the C-terminal cytoplasmic fragment of bovine rhodopsin are palmitylated.
J. Biol. Chem. 277(44):41361-8 Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase.
Molecular and cellular biology 19(3):2180-8 Activation of IkappaB kinase beta by protein kinase C isoforms.
Cell 129(5):915-28 L3MBTL1, a histone-methylation-dependent chromatin lock.
J. Biol. Chem. 275(40):30996-1000 The low pH in trans-Golgi triggers autocatalytic cleavage of pre-alpha -inhibitor heavy chain precursor.
The Biochemical journal 347(Pt 2):501-9 The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells.
Journal of chromatography. B, Biomedical sciences and applications 759(1):1-15 Characterization of glycated hemoglobin in diabetic patients: usefulness of electrospray mass spectrometry in monitoring the extent and distribution of glycation.
The Biochemical journal 368(Pt 3):939-45 Differential targeting of the stress mitogen-activated protein kinases to the c-Jun dimerization protein 2.
FEBS letters 570(1-3):133-7 Calcium/calmodulin-dependent protein kinase I inhibits neuronal nitric-oxide synthase activity through serine 741 phosphorylation.
FEBS letters 579(25):5473-80 HIPK2 inhibits both MDM2 gene and protein by, respectively, p53-dependent and independent regulations.
EMBO J. 14(23):5920-30 Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2.
Oncogene 23(20):3580-8 Phosphorylation of p53 on Thr55 by ERK2 is necessary for doxorubicin-induced p53 activation and cell death.
Biulleten' eksperimental'noi biologii i meditsiny 82(8):961-2 [Study of the heterogenetic antigens in vaccinal preparations of V. cholerae].
Molecular cancer research : MCR 5(4):393-401 Growth stimulation of non-small cell lung cancer cell lines by antibody against epidermal growth factor receptor promoting formation of ErbB2/ErbB3 heterodimers.
Cell 101(4):365-76 PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.
EMBO J. 23(24):4835-46 Phosphorylation of XPB helicase regulates TFIIH nucleotide excision repair activity.
Molecular & cellular proteomics : MCP 3(11):1093-101 Phosphoproteomic analysis of the developing mouse brain.
Molecular and cellular biology 22(11):3717-28 Cyclic AMP blocks cell growth through Raf-1-dependent and Raf-1-independent mechanisms.
The Biochemical journal 355(Pt 3):609-15 The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase.
Molecular biology of the cell 13(12):4497-507 Calcium regulation of GM-CSF by calmodulin-dependent kinase II phosphorylation of Ets1.
Cell 30(1):153-61 Alpha chain of HLA-DR transplantation antigens is a member of the same protein superfamily as the immunoglobulins.
EMBO J. 17(7):1892-906 Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins.
J. Biol. Chem. 279(16):15719-22 Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status.
The Biochemical journal Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1.
Oncogene 8(1):117-24 Phosphorylation of Src mutants at Tyr 527 in fibroblasts does not correlate with in vitro phosphorylation by CSK.
Proceedings of the National Academy of Sciences of the United States of America 100(8):4574-9 Processing, localization, and requirement of human separase for normal anaphase progression.
Journal of molecular biology 355(3):590-603 Phosphorylation on Ser106 modulates the cellular functions of the SHOX homeodomain protein.
Oncogene 14(18):2175-88 ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)
"Science (New York, N.Y.)" 284(5412):309-13 Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.
Genes & development 17(24):3048-61 SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression.
J. Biol. Chem. 275(7):4897-905 Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha.
Biochemistry 40(14):4372-80 Posttranslational modifications of microfibril associated glycoprotein-1 (MAGP-1).
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Circulation research 92(4):411-8 Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle.
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Cancer cell 10(6):473-86 Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint.
Molecular endocrinology (Baltimore, Md.) 9(1):24-33 Phosphorylation of the human estrogen receptor on tyrosine 537 in vivo and by src family tyrosine kinases in vitro.
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Biochemistry 44(24):8890-7 Phosphorylation of Grb10 by mitogen-activated protein kinase: identification of Ser150 and Ser476 of human Grb10zeta as major phosphorylation sites.
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The Biochemical journal Mechanisms of platelet activation by a stimulatory antibody: cross-linking of a novel platelet receptor for monoclonal antibody F11 with the Fc gamma RII receptor.
Cancer research 64(19):7156-68 Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence.
British journal of cancer 87(6):645-53 Biological activity of the thyroid TRK-T3 oncogene requires signalling through Shc.
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J. Biol. Chem. 280(21):20793-803 Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of TRPM7/ChaK1.
Oncogene 19(22):2664-77 Interaction between protein tyrosine phosphatase and protein tyrosine kinase is involved in androgen-promoted growth of human prostate cancer cells.
Molecular cell 8(3):693-704 Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis.
Oncogene 21(16):2555-63 Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain.
Zoological science 22(2):169-75 Receptor-type protein tyrosine phosphatase epsilon (PTPepsilonM) is a negative regulator of insulin signaling in primary hepatocytes and liver.
J. Biol. Chem. 270(13):7773-81 Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors.
Molecular and cellular biology 22(19):6719-25 Cdc42/Rac1-mediated activation primes PAK2 for superactivation by tyrosine phosphorylation.
Molecular and cellular biology 15(1):505-16 Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27.
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J. Biol. Chem. 276(45):41898-905 DNA damage-dependent and -independent phosphorylation of the hRad9 checkpoint protein.
"Science (New York, N.Y.)" 295(5556):858-61 Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch.
Biochem. Biophys. Res. Commun. 223(3):539-43 Proadrenomedullin N-terminal 20 peptide is rapidly cleaved by neutral endopeptidase.
J. Biol. Chem. 275(49):38885-90 Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites.
FEBS letters 571(1-3):74-80 hOLF44, a secreted glycoprotein with distinct expression pattern, belongs to an uncharacterized olfactomedin-like subfamily newly identified by phylogenetic analysis.
Molecular and cellular biology 23(19):6922-35 Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms.
Carcinogenesis 25(7):1165-75 Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1.
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Cell 120(1):137-49 GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity.
Molecular cell 15(4):511-21 Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation.
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Nature immunology 4(2):106-8 Granzyme A: the road less traveled.
Oncogene 18(26):3919-22 Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma.
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Oncogene 22(19):2897-909 ARHI is a Ras-related small G-protein with a novel N-terminal extension that inhibits growth of ovarian and breast cancers.
Biochem. Biophys. Res. Commun. 185(2):524-30 Phosphorylation of interleukin-6 at serine54: an early event in the secretory pathway in human fibroblasts.
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J. Biol. Chem. 278(21):18714-9 Activation of transforming growth factor-beta signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4.
Molecular and cellular biology 18(12):6951-61 Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity.
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J. Biol. Chem. 268(33):24808-12 The phosphorylation and DNA binding of the DNA-binding domain of the orphan nuclear receptor NGFI-B.
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The Biochemical journal Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo.
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J. Biol. Chem. 268(15):11256-64 Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor.
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Cell 119(4):517-28 Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases.
Journal of protein chemistry 22(2):177-81 Thr94 in bovine myelin basic protein is a second phosphorylation site for 42-kDa mitogen-activated protein kinase (ERK2).
Proceedings of the National Academy of Sciences of the United States of America 94(2):604-9 BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement.
J. Biol. Chem. 276(31):28676-85 The cytoskeletal/non-muscle isoform of alpha-actinin is phosphorylated on its actin-binding domain by the focal adhesion kinase.
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The Biochemical journal The principal site of glycation of human complement factor B.
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Journal of cell science Ubiquitin-activating enzyme, E1, is phosphorylated in mammalian cells by the protein kinase Cdc2.
J. Biol. Chem. 271(30):17896-902 An activated epidermal growth factor receptor/Lck chimera restores early T cell receptor-mediated calcium response in a CD45-deficient T cell line.
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Biochemistry 40(6):1671-8 Human recombinant pro-dipeptidyl peptidase I (cathepsin C) can be activated by cathepsins L and S but not by autocatalytic processing.
Nature 409(6818):349-54 CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling.
J. Biol. Chem. 279(31):32586-91 VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX.
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J. Biol. Chem. 276(4):2459-65 Domain-dependent function of the rasGAP-binding protein p62Dok in cell signaling.
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Proceedings of the National Academy of Sciences of the United States of America 98(13):7218-23 Mutations within a furin consensus sequence block proteolytic release of ectodysplasin-A and cause X-linked hypohidrotic ectodermal dysplasia.
Proceedings of the National Academy of Sciences of the United States of America 97(4):1456-60 Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein.
The Biochemical journal LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo.
The Journal of cell biology 149(6):1193-206 Relationship between contact inhibition and intranuclear S100C of normal human fibroblasts.
J. Biol. Chem. 276(26):24422-31 Inhibition of the catalytic activity of cell adhesion kinase beta by protein-tyrosine phosphatase-PEST-mediated dephosphorylation.
J. Biol. Chem. 274(43):31055-61 Serine phosphorylation and negative regulation of Stat3 by JNK.
The Biochemical journal Palmitoylation of the recombinant human A1 adenosine receptor: enhanced proteolysis of palmitoylation-deficient mutant receptors.
J. Biol. Chem. 276(44):40903-9 Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding.
Molecular and cellular biology 25(16):7092-106 WW domains provide a platform for the assembly of multiprotein networks.
Nature genetics 32(2):235-6 Facioscapulohumeral muscular dystrophy is uniquely associated with one of the two variants of the 4q subtelomere.
J. Biol. Chem. 266(14):9078-85 Protein kinase C phosphorylates the carboxyl terminus of the plasma membrane Ca(2+)-ATPase from human erythrocytes.
Molecular cell 4(6):1029-40 Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1.
Molecular and cellular biology 21(3):893-901 Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1.
"Science (New York, N.Y.)" 283(5410):2083-5 Inhibition of myosin light chain kinase by p21-activated kinase.
Biochem. Biophys. Res. Commun. 299(5):857-62 Characterization of the cysteine-rich calcium-binding S100A3 protein from human hair cuticles.
The Biochemical journal Complex formation between deoxyhypusine synthase and its protein substrate, the eukaryotic translation initiation factor 5A (eIF5A) precursor.
J. Biol. Chem. 272(21):13489-95 Casein kinase II-mediated phosphorylation of the C terminus of Sp1 decreases its DNA binding activity.
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Journal of cell science 115(Pt 24):4743-53 Protein kinase CKII regulates the interaction of beta-catenin with alpha-catenin and its protein stability.
Molecular and cellular biology 23(13):4511-21 Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action.
J. Biol. Chem. 273(33):20996-1002 Mutation of a Shc binding site tyrosine residue in ErbB3/HER3 blocks heregulin-dependent activation of mitogen-activated protein kinase.
FEBS letters 528(1-3):246-50 Anaphase specific auto-cleavage of separase.
Biochem. Biophys. Res. Commun. 296(4):870-6 Interaction of the developmental regulator SALL1 with UBE2I and SUMO-1.
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The Biochemical journal Characterization of iduronate sulphatase mutants affecting N-glycosylation sites and the cysteine-84 residue.
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J. Biol. Chem. 275(15):11514-20 Acetylation of novel sites in the nucleosomal binding domain of chromosomal protein HMG-14 by p300 alters its interaction with nucleosomes.
Molecular and cellular biology 20(24):9391-8 Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination.
J. Biol. Chem. 279(15):14961-6 Role of glycosylation in the organic anion transporter OAT1.
Molecular and cellular biology 21(10):3387-97 JAK2 activates TFII-I and regulates its interaction with extracellular signal-regulated kinase.
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Nature 430(6996):226-31 Cyclin-dependent kinases regulate the antiproliferative function of Smads.
FEBS letters 580(26):6269-74 PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners.
Nature 424(6945):157-64 The DNA sequence of human chromosome 7.
Archives of biochemistry and biophysics 397(1):77-83 Release and degradation of angiotensin I and angiotensin II from angiotensinogen by neutrophil serine proteinases.
Developmental cell 5(1):33-43 Fertility and taxon-specific sperm binding persist after replacement of mouse sperm receptors with human homologs.
J. Biol. Chem. 275(24):18210-8 c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity.
FEBS letters 580(1):305-10 Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon.
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J. Biol. Chem. 271(42):26395-403 Beta1,4-N-acetylgalactosaminyltransferase (GM2 synthase) is released from Golgi membranes as a neuraminidase-sensitive, disulfide-bonded dimer by a cathepsin D-like protease.
The Biochemical journal PC8 [corrected], a new member of the convertase family.
Journal of immunology (Baltimore, Md. : 1950) 147(3):921-6 Proteolysis of C3 on U937 cell plasma membranes. Purification of cathepsin G.
Nature 405(6783):195-200 ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation.
J. Biol. Chem. 276(1):670-6 Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase.
Nucleic acids research 30(5):1154-62 Phosphorylation of mammalian translation initiation factor 5 (eIF5) in vitro and in vivo.
Molecular and cellular biology 23(14):5090-106 Cdk5 regulates the organization of Nestin and its association with p35.
The Biochemical journal Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor.
Nature 402(6762):669-71 Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons.
Molecular cell 6(6):1413-23 Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation.
J. Biol. Chem. 267(19):13593-7 Identification of palmitoylation sites on CD4, the human immunodeficiency virus receptor.
Annual review of genomics and human genetics Apolipoprotein E: far more than a lipid transport protein.
J. Biol. Chem. 252(16):5864-70 Effects of altered thyroid function on galactosyl diacylglycerol metabolism in myelinating rat brain.
FEBS letters 529(2-3):319-24 WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis.
Oncogene 16(20):2657-70 Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region.
BMC biochemistry The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site.
Oncogene 15(11):1247-53 Phosphorylation of the Src substrate Sam68 by Cdc2 during mitosis.
Biochim. Biophys. Acta 1175(2):193-206 Phosphorylation of serine 2843 in ryanodine receptor-calcium release channel of skeletal muscle by cAMP-, cGMP- and CaM-dependent protein kinase.
Genes & development 14(3):289-300 The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.
J. Biol. Chem. 277(27):24220-4 Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP).
Molecular biology of the cell 10(11):3607-22 Mechanisms of G2 arrest in response to overexpression of p53.
J. Biol. Chem. 277(24):22093-102 Mitosis-specific activation of LIM motif-containing protein kinase and roles of cofilin phosphorylation and dephosphorylation in mitosis.
Nature cell biology 5(7):647-54 Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK.
EMBO J. 18(17):4766-78 NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes.
Molecular and cellular biology 23(17):6243-54 Acetylation-mediated transcriptional activation of the ETS protein ER81 by p300, P/CAF, and HER2/Neu.
Cancer cell 5(6):575-85 Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes.
Biochemistry 43(43):13694-706 Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27).
Molecular and cellular biology 14(3):1680-8 Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src.
J. Biol. Chem. 279(12):11354-63 Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response.
J. Biol. Chem. 262(35):16969-72 Glycation and inactivation of human Cu-Zn-superoxide dismutase. Identification of the in vitro glycated sites.
Nature cell biology 4(1):11-9 Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.
J. Biol. Chem. 277(40):36955-61 A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta.
EMBO J. 20(16):4349-59 Eukaryotic initiation factor 2B: identification of multiple phosphorylation sites in the epsilon-subunit and their functions in vivo.
J. Biol. Chem. 277(41):38087-94 Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells.
J. Biol. Chem. 278(20):18617-27 Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide.
Molecular biology of the cell 11(2):721-34 Palmitoylation of apolipoprotein B is required for proper intracellular sorting and transport of cholesteroyl esters and triglycerides.
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J. Biol. Chem. 270(35):20775-80 Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor.
J. Biol. Chem. 276(23):20774-80 Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplication.
Molecular & cellular proteomics : MCP 6(3):537-47 Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America 93(5):2077-82 Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation.
J. Biol. Chem. 275(28):21099-106 Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties.
J. Biol. Chem. 276(26):24380-7 Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2.
Nature 439(7074):331-5 DNA sequence and analysis of human chromosome 8.
J. Biol. Chem. 272(16):10333-6 Phosphorylation of glial fibrillary acidic protein at the same sites by cleavage furrow kinase and Rho-associated kinase.
Proceedings of the National Academy of Sciences of the United States of America 95(22):12906-11 Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics.
J. Biol. Chem. 280(34):30175-84 Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels.
Molecular and cellular biology 15(2):954-63 Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases.
Proceedings of the National Academy of Sciences of the United States of America 101(13):4401-6 Functional association between Wwox tumor suppressor protein and p73, a p53 homolog.
Molecular and cellular biology 17(8):4509-16 Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling.
Molecular and cellular biology 20(21):8103-11 Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II.
Proceedings of the National Academy of Sciences of the United States of America 84(21):7518-22 Amino acid sequences surrounding the cAMP-dependent and calcium/calmodulin-dependent phosphorylation sites in rat and bovine synapsin I.
FEBS letters 478(1-2):173-7 Acylation of Galpha(13) is important for its interaction with thrombin receptor, transforming activity and actin stress fiber formation.
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J. Biol. Chem. 274(53):37538-43 Substrate specificities and identification of putative substrates of ATM kinase family members.
J. Biol. Chem. 281(35):25447-56 Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization.
Cell 96(6):857-68 Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.
J. Biol. Chem. 277(19):16837-46 Regulation of arrestin-3 phosphorylation by casein kinase II.
The Journal of neuroscience : the official journal of the Society for Neuroscience 22(12):4869-77 Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of Reelin signaling.
FEBS letters 550(1-3):57-63 Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells.
J. Biol. Chem. 267(27):19258-65 Identification of the two major epidermal growth factor-induced tyrosine phosphorylation sites in the microvillar core protein ezrin.
Nature 424(6951):965-9 Transcription factor IIB acetylates itself to regulate transcription.
Neuron 47(3):407-21 PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking.
Molecular and cellular biology 25(18):7988-8000 Epidermal growth factor-dependent phosphorylation of the GGA3 adaptor protein regulates its recruitment to membranes.
The Journal of cell biology 173(2):279-89 Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning.
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J. Biol. Chem. 276(16):13248-55 Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity.
J. Biol. Chem. 274(49):34932-9 Balance between activities of Rho kinase and type 1 protein phosphatase modulates turnover of phosphorylation and dynamics of desmin/vimentin filaments.
Molecular and cellular biology 24(5):2190-201 Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase.
Journal of protein chemistry 22(3):249-58 Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.
European journal of biochemistry 269(12):3076-85 Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors.
J. Biol. Chem. 277(41):38021-8 Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase.
J. Biol. Chem. 278(15):13278-85 Phosphorylation of the Ras-GRF1 exchange factor at Ser916/898 reveals activation of Ras signaling in the cerebral cortex.
Leukemia research 31(4):541-5 Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes.
Biochem. Biophys. Res. Commun. 288(1):233-9 Phosphorylation of human N-myristoyltransferase by N-myristoylated SRC family tyrosine kinase members.
J. Biol. Chem. 274(49):34663-8 Functional interaction between SHPTP1 and the Lyn tyrosine kinase in the apoptotic response to DNA damage.
European journal of biochemistry 236(2):548-57 A comparative study of the phosphotyrosyl phosphatase specificity of protein phosphatase type 2A and phosphotyrosyl phosphatase type 1B using phosphopeptides and the phosphoproteins p50/HS1, c-Fgr and Lyn.
EMBO J. 9(8):2439-46 Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver.
The Journal of cell biology 164(7):1009-20 YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta.
Biochem. Biophys. Res. Commun. 338(1):660-7 Phosphorylation inhibits DNA-binding of alternatively spliced aryl hydrocarbon receptor nuclear translocator.
J. Biol. Chem. 270(46):27758-65 Differential sensitivity of interleukin-1 alpha and -beta precursor proteins to cleavage by calpain, a calcium-dependent protease.
Cardiovascular research 45(4):941-51 Human connexin40 gap junction channels are modulated by cAMP.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 17(3-4):137-44 DOCA-induced phosphorylation of glycogen synthase kinase 3beta.
Neuron 40(1):129-37 Carbon monoxide neurotransmission activated by CK2 phosphorylation of heme oxygenase-2.
Biological chemistry 377(11):721-30 Functional analysis of phosphorylation at serine 532 of human c-Myb by MAP kinase.
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Nature cell biology 7(7):665-74 S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding.
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Nature structural & molecular biology 14(6):564-7 FANCI is a second monoubiquitinated member of the Fanconi anemia pathway.
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Molecular and cellular biology 24(2):651-61 Phosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activity.
Nature genetics 45(4):406-14, 414e1-2 Using population admixture to help complete maps of the human genome.
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FEBS letters 262(2):356-8 Fatty acid acylation of lens fiber plasma membrane proteins. MP26 and alpha-crystallin are palmitoylated.
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FEBS letters 579(6):1534-8 Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB.
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Oncogene 15(17):2001-12 Inhibition of the DNA-binding and transcriptional repression activity of the Wilms' tumor gene product, WT1, by cAMP-dependent protein kinase-mediated phosphorylation of Ser-365 and Ser-393 in the zinc finger domain.
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Nature genetics 34(3):274-85 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome.
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Nature 428(6982):522-8 The DNA sequence and analysis of human chromosome 13.
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The Biochemical journal 363(Pt 1):137-45 Glycosylation and epitope mapping of the 5T4 glycoprotein oncofoetal antigen.
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The Biochemical journal Matrix metalloproteinases cleave at two distinct sites on human cartilage link protein.
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The Biochemical journal Effects of phosphorylation on function of the Rad GTPase.
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Proceedings of the National Academy of Sciences of the United States of America 98(20):11598-603 A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus.
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Endocrinology 138(9):3797-803 Proteolysis of insulin-like growth factors (IGF) and IGF binding proteins by cathepsin D.
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Molecular and cellular biology 14(10):6715-26 Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation.
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Molecular and cellular biology 21(10):3314-24 Common properties of nuclear body protein SP100 and TIF1alpha chromatin factor: role of SUMO modification.
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J. Biol. Chem. 275(45):35491-8 Phosphorylation of protein kinase Cdelta on distinct tyrosine residues regulates specific cellular functions.
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FEBS letters 436(1):28-34 Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase.
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The Biochemical journal Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase.
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The Journal of clinical investigation 108(9):1341-8 Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site.
Proceedings of the National Academy of Sciences of the United States of America 98(5):2582-6 BLNK mediates Syk-dependent Btk activation.
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The Biochemical journal Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.
The Biochemical journal Activation of human prolegumain by cleavage at a C-terminal asparagine residue.
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Cell 82(2):241-50 Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation.
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The Journal of cell biology 137(2):387-98 Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation.
Endocrinology 138(9):4034-7 Cholecystokinin (CCK) levels are greatly reduced in the brains but not the duodenums of Cpe(fat)/Cpe(fat) mice: a regional difference in the involvement of carboxypeptidase E (Cpe) in pro-CCK processing.
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Biochemistry 42(6):1451-9 Mutational analysis of the complex of human RNase inhibitor and human eosinophil-derived neurotoxin (RNase 2).
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Neuron 31(1):87-101 Multiple phosphorylation of rhodopsin and the in vivo chemistry underlying rod photoreceptor dark adaptation.
Nature 384(6608):484-9 Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation.
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Immunity 13(1):47-57 CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification.
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Nature immunology 4(2):145-53 Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A.
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The Biochemical journal Molecular characterization of human stathmin expressed in Escherichia coli: site-directed mutagenesis of two phosphorylatable serines (Ser-25 and Ser-63).
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The Biochemical journal 365(Pt 3):757-63 Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase.
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Molecular and cellular biology 24(9):4065-74 CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37.
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Molecular and cellular biology 21(22):7545-57 Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization.
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Molecular and cellular biology 21(9):2981-90 Phosphorylation of nuclear phospholipase C beta1 by extracellular signal-regulated kinase mediates the mitogenic action of insulin-like growth factor I.
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Biochemistry 43(51):16348-55 Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop.
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Nature cell biology 3(4):331-8 Phosphorylation of Snapin by PKA modulates its interaction with the SNARE complex.
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J. Biol. Chem. 277(3):1845-54 MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor.
J. Biol. Chem. 279(40):41477-86 Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1.
Nature 387(6632):516-9 Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation.
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FEBS letters 562(1-3):160-4 The islet-specific glucose-6-phosphatase-related protein, implicated in diabetes, is a glycoprotein embedded in the endoplasmic reticulum membrane.
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FEBS letters 578(1-2):90-4 Protein kinase Akt/PKB phosphorylates heme oxygenase-1 in vitro and in vivo.
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FEBS letters 482(3):237-41 Crystal structure of S-glutathiolated carbonic anhydrase III.
Nature cell biology 1(5):253-9 Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics.
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Cell 113(1):127-37 The polycomb protein Pc2 is a SUMO E3.
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Clinica chimica acta; international journal of clinical chemistry 289(1-2):33-44 Process of carboxylation of glutamic acid residues in the gla domain of human des-gamma-carboxyprothrombin.
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Proceedings of the National Academy of Sciences of the United States of America 97(18):9943-8 Relative role of heme nitrosylation and beta-cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation.
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Nature 419(6903):135-41 RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.
J. Biol. Chem. 264(26):15656-61 Platelet glycoprotein Ib beta is phosphorylated on serine 166 by cyclic AMP-dependent protein kinase.
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EMBO J. 21(19):5151-63 IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation.
European journal of immunology 33(2):287-96 T cell recognition and therapeutic effect of a phosphorylated synthetic peptide of the 70K snRNP protein administered in MR/lpr mice.
Nature 410(6825):215-20 Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase.
The Biochemical journal Phosphorylation of GAP-43 (growth-associated protein of 43 kDa) by conventional, novel and atypical isotypes of the protein kinase C gene family: differences between oligopeptide and polypeptide phosphorylation.
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Biochemistry 38(20):6529-36 Proteolysis of blood coagulation factor VIII by the factor VIIa-tissue factor complex: generation of an inactive factor VIII cofactor.
Proceedings of the National Academy of Sciences of the United States of America 99(3):1182-7 Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex.
Physiological reviews 80(3):1083-105 Molecular analysis of the sodium/iodide symporter: impact on thyroid and extrathyroid pathophysiology.
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The Journal of neuroscience : the official journal of the Society for Neuroscience 19(18):7770-80 Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein.
Molecular and cellular biology 24(3):966-75 Regulation of phosphoinositide 3-kinase by its intrinsic serine kinase activity in vivo.
Genome research 23(12):2003-12 The shared genomic architecture of human nucleolar organizer regions.
J. Biol. Chem. 273(1):215-21 Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro.
EMBO reports 7(2):192-8 DNA-damage-responsive acetylation of pRb regulates binding to E2F-1.
Proceedings of the National Academy of Sciences of the United States of America 93(23):12908-13 Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver.
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Nature genetics 20(4):398-400 ATM associates with and phosphorylates p53: mapping the region of interaction.
FEBS letters 393(1):1-6 CPP32/Yama/apopain cleaves the catalytic component of DNA-dependent protein kinase in the holoenzyme.
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Biochemistry 37(14):4699-702 Generation of an angiostatin-like fragment from plasminogen by stromelysin-1 (MMP-3).
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Oncogene 20(8):951-61 Activation of the focal adhesion kinase signaling pathway by structural alterations in the carboxyl-terminal region of c-Crk II.
Proceedings of the National Academy of Sciences of the United States of America 98(11):6500-5 Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia.
Proceedings of the National Academy of Sciences of the United States of America 90(11):5292-6 The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase.
Biochemistry 36(50):15873-83 MAP4 is the in vivo substrate for CDC2 kinase in HeLa cells: identification of an M-phase specific and a cell cycle-independent phosphorylation site in MAP4.
Journal of biochemistry 130(4):503-13 Regulation of Ca(2+)/calmodulin-dependent protein kinase kinase alpha by cAMP-dependent protein kinase: I. Biochemical analysis.
Journal of receptor and signal transduction research 19(6):953-74 The TrkB receptor tyrosine kinase regulates cellular proliferation via signal transduction pathways involving SHC, PLCgamma, and CBL.
J. Biol. Chem. 277(30):27273-81 The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein family.
Biochemical pharmacology 64(2):257-66 Identification of two C-terminal amino acids, Ser(355) and Thr(357), required for short-term homologous desensitization of mu-opioid receptors.
Cell 85(7):1047-55 Tertiary structure of destrin and structural similarity between two actin-regulating protein families.
Immunity 9(1):13-24 FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation.
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Oncogene 19(11):1369-78 Activation of NF-kappa B by the dsRNA-dependent protein kinase, PKR involves the I kappa B kinase complex.
Biochemistry 41(49):14524-31 Glycosylation of erythropoietin affects receptor binding kinetics: role of electrostatic interactions.
Journal of biochemistry 116(2):426-34 Identification of phosphorylation sites on glial fibrillary acidic protein for cdc2 kinase and Ca(2+)-calmodulin-dependent protein kinase II.
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FEBS letters 579(13):2883-90 The death domain-associated protein modulates activity of the transcription co-factor Skip/NcoA62.
FEBS letters 372(1):59-64 A novel tau-tubulin kinase from bovine brain.
J. Biol. Chem. 270(49):29498-506 Structural and functional consequences of mutations in 6-pyruvoyltetrahydropterin synthase causing hyperphenylalaninemia in humans. Phosphorylation is a requirement for in vivo activity.
J. Biol. Chem. 277(29):26530-9 In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents.
Molecular and cellular biology 6(7):2738-44 The protein-tyrosine kinase substrate p36 is also a substrate for protein kinase C in vitro and in vivo.
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Oncogene 18(27):3963-9 Cleavage and relocation of the tyrosine kinase P59FYN during Fas-mediated apoptosis in T lymphocytes.
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Molecular pharmacology 52(1):21-9 Palmitoylation of the V2 vasopressin receptor.
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The Biochemical journal Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor.
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Genome biology 9(5):R78 Finishing the finished human chromosome 22 sequence.
Nature 439(7078):811-6 Histone demethylation by a family of JmjC domain-containing proteins.
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Journal of cell science Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro: implications for microfilament reorganization during apoptosis.
EMBO J. 10(13):4279-90 The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.
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Biochemistry 40(10):3167-73 S100A7, S100A10, and S100A11 are transglutaminase substrates.
J. Biol. Chem. 275(33):25805-13 Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America 90(11):5176-80 Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lck.
Nature methods 2(8):591-8 Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.
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Molecular and cellular biology 12(3):998-1006 Alteration of a cyclic AMP-dependent protein kinase phosphorylation site in the c-Fos protein augments its transforming potential.
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J. Biol. Chem. 277(36):32799-806 cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b.
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FEBS letters 580(5):1215-21 Repression of SOX6 transcriptional activity by SUMO modification.
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Molecular and cellular biology 26(1):277-92 Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species.
J. Biol. Chem. 274(13):8797-805 MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells.
Advances in the biosciences Effect of delta 9-tetrahydrocannabinol (THC) on female reproductive function.
J. Biol. Chem. 271(19):11575-80 Identification of the site in the cGMP-inhibited phosphodiesterase phosphorylated in adipocytes in response to insulin and isoproterenol.
Proceedings of the National Academy of Sciences of the United States of America 90(13):6130-4 Characterization of site-specific mutants altered at protein kinase C beta 1 isozyme autophosphorylation sites.
Immunity 4(2):123-32 Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor.
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Molecular and cellular biology 22(12):4419-32 Chk2 activation and phosphorylation-dependent oligomerization.
Genes & development 13(11):1422-37 Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism.
FEBS letters 297(1-2):112-8 Effective activation of the proenzyme form of the urokinase-type plasminogen activator (pro-uPA) by the cysteine protease cathepsin L.
J. Biol. Chem. 280(12):11147-51 c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage.
Nature methods 1(2):119-26 Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.
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Proceedings of the National Academy of Sciences of the United States of America 103(26):9773-8 Phosphoproteomic analysis of Her2/neu signaling and inhibition.
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Molecular & cellular proteomics : MCP 1(1):11-8 C-mannosylation and o-fucosylation of thrombospondin type 1 repeats.
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Biochim. Biophys. Acta 1649(1):30-9 Identification of interleukin-8 converting enzyme as cathepsin L.
J. Biol. Chem. 276(14):10715-21 Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation.
Molecular and cellular biology 24(7):2649-61 Forkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivators.
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Nature cell biology 4(10):743-9 Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69.
J. Biol. Chem. 270(44):26146-51 Calpain cleavage of the cytoplasmic domain of the integrin beta 3 subunit.
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Molecular and cellular biology 23(6):2109-22 A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels.
Biochemistry 36(15):4643-9 Phosphorylation of Alzheimer beta-amyloid precursor-like proteins.
Endocrinology 144(4):1301-14 Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization.
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Proceedings of the National Academy of Sciences of the United States of America 92(12):5361-5 Phosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation.
The Journal of urology 157(6):2166-70 Prostate specific antigen in benign prostatic hyperplasia: purification and characterization.
Biochemistry 44(37):12546-53 Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3.
Molecular and cellular biology 25(23):10543-55 Regulation of caspase 9 through phosphorylation by protein kinase C zeta in response to hyperosmotic stress.
Molecular endocrinology (Baltimore, Md.) 18(10):2451-62 Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9.
Neurobiology of aging 16(3):365-71; discussion 371-80 Hyperphosphorylation of tau in PHF.
European journal of biochemistry 270(6):1189-98 Disruption of structural and functional integrity of alpha 2-macroglobulin by cathepsin E.
FEBS letters 438(3):301-5 NADH:ubiquinone oxidoreductase from bovine heart mitochondria: sequence of a novel 17.2-kDa subunit.
J. Biol. Chem. 277(15):12491-4 ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation.
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Neuron 19(1):185-96 cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits.
EMBO reports 2(10):945-51 Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase.
The Biochemical journal 354(Pt 3):689-95 'Shed' furin: mapping of the cleavage determinants and identification of its C-terminus.
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Biochim. Biophys. Acta 1480(1-2):235-44 Phosphohexose isomerase/autocrine motility factor/neuroleukin/maturation factor is a multifunctional phosphoprotein.
Biochemistry 42(24):7381-9 Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis.
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The Biochemical journal Degradation of decorin by matrix metalloproteinases: identification of the cleavage sites, kinetic analyses and transforming growth factor-beta1 release.
J. Biol. Chem. 278(10):7751-4 The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage.
J. Biol. Chem. 273(44):28691-9 Human leptin receptor. Determination of disulfide structure and N-glycosylation sites of the extracellular domain.
Biochemical pharmacology 62(8):997-1012 Sequestration and phosphorylation of the prostaglandin E2 EP4 receptor: dependence on the C-terminal tail.
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Nature cell biology 3(3):325-30 ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation.
J. Biol. Chem. 262(7):3086-91 Lecithin:cholesterol acyltransferase. Functional regions and a structural model of the enzyme.
J. Biol. Chem. 278(20):18440-7 Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2.
Biochemistry 39(35):10898-907 Identification of major tyrosine phosphorylation sites in the human insulin receptor substrate Gab-1 by insulin receptor kinase in vitro.
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J. Biol. Chem. 277(50):48115-21 Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.
J. Biol. Chem. 269(6):4458-66 Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity.
J. Biol. Chem. 267(28):20033-8 Post-translational modifications of p21rho proteins.
J. Biol. Chem. 270(50):29881-8 N-glycans modulate in vivo and in vitro thyroid hormone synthesis. Study at the N-terminal domain of thyroglobulin.
Biochem. Biophys. Res. Commun. 317(3):703-7 KIBRA is a novel substrate for protein kinase Czeta.
Proceedings of the National Academy of Sciences of the United States of America 93(14):7069-74 Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1.
EMBO J. 20(11):2768-78 A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells.
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Glycobiology 15(5):541-7 Posttranslational N-glycosylation takes place during the normal processing of human coagulation factor VII.
Molecular and cellular biology 24(10):4557-70 Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta.
J. Biol. Chem. 268(27):20076-84 Multiple phosphorylation of stathmin. Identification of four sites phosphorylated in intact cells and in vitro by cyclic AMP-dependent protein kinase and p34cdc2.
Biochim. Biophys. Acta 1434(1):86-93 Carbohydrate moieties in human secretory component.
Molecular biology of the cell 12(4):1131-45 Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation.
Biochemistry 37(6):1613-22 Peroxynitrite-mediated inactivation of manganese superoxide dismutase involves nitration and oxidation of critical tyrosine residues.
J. Biol. Chem. 274(26):18559-66 Phosphorylation at the cyclin-dependent kinases site (Thr85) of parathyroid hormone-related protein negatively regulates its nuclear localization.
Nucleic acids research 13(14):5233-47 The structure and evolution of a 461 amino acid human protein C precursor and its messenger RNA, based upon the DNA sequence of cloned human liver cDNAs.
J. Biol. Chem. 274(32):22775-84 Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and Nck.
Cell 130(2):349-62 Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors.
Human molecular genetics 8(4):683-90 Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting.
Nature 425(6960):805-11 The DNA sequence and analysis of human chromosome 6.
Oncogene 14(19):2367-72 Bcr phosphorylated on tyrosine 177 binds Grb2.
Cell 119(1):61-74 The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.
Molecular cell 1(1):13-23 The discoidin domain receptor tyrosine kinases are activated by collagen.
The Journal of clinical investigation 110(5):659-69 Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface.
J. Biol. Chem. 271(12):6987-97 Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes.
J. Biol. Chem. 277(10):8217-25 The prosequence of human lactase-phlorizin hydrolase modulates the folding of the mature enzyme.
J. Biol. Chem. 276(49):45780-90 Phosphorylation of the CCAAT displacement protein (CDP)/Cux transcription factor by cyclin A-Cdk1 modulates its DNA binding activity in G(2).
Oncogene 20(14):1784-92 Constitutive c-Myb amino-terminal phosphorylation and DNA binding activity uncoupled during entry and passage through the cell cycle.
Genes & development 15(14):1833-44 Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation.
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FEBS letters 384(2):189-92 A potential site of functional modulation by protein kinase A in the cardiac Ca2+ channel alpha 1C subunit.
Proceedings of the National Academy of Sciences of the United States of America 94(26):14500-5 Phosphorylation of the immunosuppressant FK506-binding protein FKBP52 by casein kinase II: regulation of HSP90-binding activity of FKBP52.
The Journal of cell biology 135(6 Pt 1):1501-13 A role for N-myristoylation in protein targeting: NADH-cytochrome b5 reductase requires myristic acid for association with outer mitochondrial but not ER membranes.
Oncogene 19(44):5063-72 The ternary complex factor Net contains two distinct elements that mediate different responses to MAP kinase signalling cascades.
The international journal of biochemistry & cell biology 33(6):577-89 Phosphorylation of the Fas associated factor FAF1 by protein kinase CK2 and identification of serines 289 and 291 as the in vitro phosphorylation sites.
J. Biol. Chem. 268(10):7571-6 Interaction of the human insulin receptor tyrosine kinase from the baculovirus expression system with protein kinase C in a cell-free system.
Biochem. Biophys. Res. Commun. 341(2):343-50 CK2-dependent C-terminal phosphorylation at T300 directs the nuclear transport of TSPY protein.
Journal of biochemistry 110(4):648-54 Identification of full-sized forms of salivary (S-type) cystatins (cystatin SN, cystatin SA, cystatin S, and two phosphorylated forms of cystatin S) in human whole saliva and determination of phosphorylation sites of cystatin S.
J. Biol. Chem. 276(38):35239-42 The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin.
Biochim. Biophys. Acta 1281(2):205-12 Cyclic AMP-dependent protein kinase phosphorylates residues in the C-terminal domain of the cardiac L-type calcium channel alpha1 subunit.
J. Biol. Chem. 277(33):30144-52 Serine/threonine phosphorylation of ShcA. Regulation of protein-tyrosine phosphatase-pest binding and involvement in insulin signaling.
Genes to cells : devoted to molecular & cellular mechanisms 9(6):549-60 DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites.
J. Biol. Chem. 277(13):10775-82 Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization: modulation by a keratin 1-like disease causing mutation.
"Science (New York, N.Y.)" 272(5266):1347-9 Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase.
Blood 96(5):1674-80 Cleavage by CD26/dipeptidyl peptidase IV converts the chemokine LD78beta into a most efficient monocyte attractant and CCR1 agonist.
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J. Biol. Chem. 271(9):5101-11 Structural determinants in the platelet-derived growth factor alpha-receptor implicated in modulation of chemotaxis.
J. Biol. Chem. 271(23):13796-803 Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor.
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Nature cell biology 7(2):195-201 The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair.
J. Biol. Chem. 279(6):4507-14 p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells.
J. Biol. Chem. 278(27):24428-37 Phosphorylation of human Rad9 is required for genotoxin-activated checkpoint signaling.
J. Biol. Chem. 278(31):28694-702 Recruitment of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activation.
Nature cell biology 7(3):278-85 JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage.
Proceedings of the National Academy of Sciences of the United States of America 100(11):6376-81 Structural and biochemical studies of p21Ras S-nitrosylation and nitric oxide-mediated guanine nucleotide exchange.
Biochim. Biophys. Acta 1061(2):253-66 Phosphorylation sites in human erythrocyte band 3 protein.
J. Biol. Chem. 269(8):6026-30 Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of phosphatidylinositol (PI) 3-kinase and for c-kit-associated PI 3-kinase activity in COS-1 cells.
J. Biol. Chem. 270(25):15250-6 Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases.
Blood 79(7):1712-9 The effect of leukocyte elastase on tissue factor pathway inhibitor.
European journal of biochemistry 270(1):171-8 Kininogen-derived peptides for investigating the putative vasoactive properties of human cathepsins K and L.
Molecular and cellular biology 16(12):6926-36 Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation.
Blood 94(4):1440-50 Proteolytic processing of big endothelin-3 by the kell blood group protein.
EMBO J. 26(2):402-11 A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.
Blood 93(6):1809-16 Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors.
Cell 131(6):1190-203 Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Nature 364(6434):249-52 Protein kinase C alpha activates RAF-1 by direct phosphorylation.
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Biochemistry 39(11):3141-8 Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 21(22):8842-53 Stimulation of endothelin B receptors in astrocytes induces cAMP response element-binding protein phosphorylation and c-fos expression via multiple mitogen-activated protein kinase signaling pathways.
EMBO J. 16(21):6325-36 Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination.
J. Biol. Chem. 271(9):4755-62 Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine.
J. Biol. Chem. 276(24):21209-16 Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton.
Journal of proteome research 4(4):1155-70 Extended Range Proteomic Analysis (ERPA): a new and sensitive LC-MS platform for high sequence coverage of complex proteins with extensive post-translational modifications-comprehensive analysis of beta-casein and epidermal growth factor receptor (EGFR).
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The Journal of experimental medicine 171(2):449-54 Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases.
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Nature 440(7083):497-500 Human chromosome 11 DNA sequence and analysis including novel gene identification.
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The American journal of physiology 271(3 Pt 1):E465-70 IGFBP-3 proteolysis by plasmin, thrombin, serum: heparin binding, IGF binding, and structure of fragments.
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Nature immunology 6(3):253-60 Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase.
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The Journal of experimental medicine 193(9):1059-66 Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a anaphylatoxin receptor.
Nature genetics 30(3):270-6 CEACAM1 regulates insulin clearance in liver.
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Proceedings of the National Academy of Sciences of the United States of America 93(25):14486-91 Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases.
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European journal of biochemistry 240(3):747-50 Replacement of Ser657 of protein kinase C-alpha by alanine leads to premature down regulation after phorbol-ester-induced translocation to the membrane.
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Nature 402(6762):656-60 Ghrelin is a growth-hormone-releasing acylated peptide from stomach.
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The Biochemical journal Changes in protein kinase C epsilon phosphorylation status and intracellular localization as 3T3 and 3T6 fibroblasts grow to confluency and quiescence: a role for phosphorylation at ser-729?
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European journal of biochemistry 243(1-2):493-501 Phosphorylation of vitronectin on Ser362 by protein kinase C attenuates its cleavage by plasmin.
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Developmental cell 5(1):113-25 Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation.
The Journal of physiology 553(Pt 1):303-9 Exercise increases Ca2+-calmodulin-dependent protein kinase II activity in human skeletal muscle.
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FEBS letters 170(2):281-9 Acetyl-blocked N-terminal structures of sorbitol and aldehyde dehydrogenases.
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Molecular and cellular biology 18(5):2545-52 Stat3 activation by Src induces specific gene regulation and is required for cell transformation.
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Nature 401(6748):82-5 NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase.
Proceedings of the National Academy of Sciences of the United States of America 80(7):1802-6 beta-Hydroxyaspartic acid in vitamin K-dependent protein C.
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Proceedings of the National Academy of Sciences of the United States of America 97(10):5089-94 Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton.
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The Biochemical journal 380(Pt 3):845-57 Structural analysis and tissue localization of human C4.4A: a protein homologue of the urokinase receptor.
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Biochemistry 30(27):6689-96 Structures of the asparagine-289-linked oligosaccharides assembled on recombinant human plasminogen expressed in a Mamestra brassicae cell line (IZD-MBO503).
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Molecular and cellular biology 20(11):3951-64 p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps.
Biochemistry 39(35):10799-805 Posttranslationally processed forms of the human chemokine HCC-1.
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Proceedings of the National Academy of Sciences of the United States of America 100(11):6511-6 The phosphorylation of caveolin-2 on serines 23 and 36 modulates caveolin-1-dependent caveolae formation.
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Biochemistry 18(25):5711-20 Complete amino acid sequence of a papain-solubilized human histocompatibility antigen, HLA-B7. 2. Sequence determination and search for homologies.
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J. Biol. Chem. 277(28):25562-7 Acetylation of beta-catenin by CREB-binding protein (CBP).
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Proceedings of the National Academy of Sciences of the United States of America 98(24):13710-5 Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein.
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J. Biol. Chem. 275(47):36514-22 The neuropeptide processing enzyme EC 18.104.22.168 is modulated by protein kinase A phosphorylation.
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Genes & development 14(23):2989-3002 Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.
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Nature cell biology 5(4):363-9 PKCepsilon is a permissive link in integrin-dependent IFN-gamma signalling that facilitates JAK phosphorylation of STAT1.
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Oncogene 20(46):6784-93 UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts.
American journal of physiology. Endocrinology and metabolism 286(2):E239-44 AMPK activity and isoform protein expression are similar in muscle of obese subjects with and without type 2 diabetes.
The Biochemical journal 349(Pt 2):547-57 Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.
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The Biochemical journal Glycosylation pattern of human inter-alpha-inhibitor heavy chains.
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Nature cell biology 7(8):785-96 Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis.
Nature 440(7084):671-5 Analysis of the DNA sequence and duplication history of human chromosome 15.
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Nature 434(7034):724-31 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
EMBO J. 18(2):396-410 Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
"Science (New York, N.Y.)" 284(5412):339-43 Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.
European journal of biochemistry 213(2):689-99 Regulation of elongation factor-2 by multisite phosphorylation.
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European journal of biochemistry 267(7):2105-12 Structural characterization of the oligosaccharide chains of human alpha1-microglobulin from urine and amniotic fluid.
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The Biochemical journal Identification of csk tyrosine phospho