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Study

Study Name: Fecal microbial communities from dogs in Nestle Purina Research, St. Louis, MO, USA

Projects

Biosamples

Organisms

Biosamples: 4 Seq. Projects: 4
STUDY INFORMATION
GOLD Study ID Gs0150696
Study Name Fecal microbial communities from dogs in Nestle Purina Research, St. Louis, MO, USA
Other Names
NCBI Umbrella Bioproject Name
NCBI Umbrella Bioproject ID
SRA Studies
SRA Study Id ERP022452  (Link to NCBI )
Study Title Similarity of the dog and human gut microbiomes in gene content and response to diet
Study Abstract Gut microbes influence their hosts, modulating the link between diet and obesity. Here we study the relationship between the gut metagenomes of dogs, humans, mice, and pigs. By building a gene catalog (containing 1,247,405 genes) we show that the dog microbiome is closer to the human microbiome than the pig or mice microbiomes in gene content. We further demonstrate the similarity of the dog microbiome to the human one with a randomized trial of two diets (high-protein/low-carbohydrate vs. lower-protein/higher-carbohydrate). Diet has a large, reproducible, effect on the microbiome, independent of dog breed or sex. Diet responses were in agreement with those observed in previous human studies, leading to the conclusion that findings in dogs may be predictive of human microbiome results. In particular, a novel finding is that overweight or obese dogs experience larger compositional shifts than lean dogs in response to a high protein diet.
  
Legacy ER Study ID
Legacy GOLD ID
Added By JGI automated process on 2020-12-02
Last Modified By
PI
Description Fecal microbial communities from dogs in Nestle Purina Research, St. Louis, MO, USA
Relevance
Study Information Link
Study Information Visibility Public
Metagenomic Study Yes
Publication
Is GEBA
Is HMP
ECOSYSTEM CLASSIFICATION
Ecosystem Host-associated
Ecosystem Category Mammals
Ecosystem Type Digestive system
Ecosystem Subtype Large intestine
Specific Ecosystem Fecal
STUDY COMPOSITION
Number of Biosamples 4
Number of Organisms 0
Number of Seq Projects 4
Number of Analysis Projects 4
Number of Related Studies 0

 

 

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