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Study

Study Name: Human stool microbial community from New York, USA

Projects

Biosamples

Organisms

Biosamples: 140 Seq. Projects: 140
STUDY INFORMATION
GOLD Study ID Gs0145276
Study Name Human stool microbial community from New York, USA
Other Names
NCBI Umbrella Bioproject Name
NCBI Umbrella Bioproject ID
SRA Studies
SRA Study Id ERP109376  (Link to NCBI )
Study Title Microbiome metagenome analysis of stool samples from individuals with low and high salivary amylase gene copy numbers
Study Abstract Human genetic variation influences the composition of the gut microbiome. Studies have focused on associations between components of the microbiome and single nucleotide polymorphisms in genes, but their copy number (CN) can also vary. Here, we relate oral and gut microbiome to CN variation at the AMY1 locus, encoding the salivary amylase gene active in starch degradation, in a study of human subjects including a 2-week standard diet. We show that diet standardization drove gut microbiome convergence, yet AMY1-CN influenced oral and gut microbiome composition and function. Low-AMY1-subject gut microbiomes showed an enhanced capacity for breakdown of complex carbohydrates, and high-AMY1 an enrichment of microbiota linked to resistant starch fermentation. High-AMY1-subject microbiomes were associated with higher fecal SCFAs, and drove higher adiposity when transferred to germfree mice. This study establishes AMY1-CN as a significant genetic factor patterning microbiome composition and function, with implications for personalized nutrition targeting microbiomes.
  
Legacy ER Study ID
Legacy GOLD ID
Added By JGI automated process on 2020-01-24
Last Modified By
PI
Description Human stool microbial community from New York, USA
Relevance
Study Information Link
Study Information Visibility Public
Metagenomic Study Yes
Publication
Is GEBA
Is HMP
ECOSYSTEM CLASSIFICATION
Ecosystem Host-associated
Ecosystem Category Human
Ecosystem Type Digestive system
Ecosystem Subtype Large intestine
Specific Ecosystem Fecal
STUDY COMPOSITION
Number of Biosamples 140
Number of Organisms 0
Number of Seq Projects 140
Number of Analysis Projects 138
Number of Related Studies 0

 

 

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