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Study

Study Name: Human feces microbial communities from healthy individuals and ACVD patients in Guangdong General Hospital, Guangdong, China

Projects

Biosamples

Organisms

Biosamples: 405 Seq. Projects: 405
STUDY INFORMATION
GOLD Study ID Gs0141917
Study Name Human feces microbial communities from healthy individuals and ACVD patients in Guangdong General Hospital, Guangdong, China
Other Names
NCBI Umbrella Bioproject Name
NCBI Umbrella Bioproject ID
SRA Studies
SRA Study Id ERP023788
Study Title Here we performed a metagenome-wide association study (MWAS) on stools from 218 individuals with atherosclerotic cardiovascular disease (ACVD) and 187 healthy controls.
Study Abstract The gut microbiota has been linked to cardiovascular diseases, most notably through the production of trimethylamine and its hepatic conversion to the proatherogenic metabolite, trimethylamine-N-oxide. However, the composition and functional capacity of the gut microbiome in relation to cardiovascular diseases have not been systematically examined. Here we perform a metagenome-wide association study on stools from 218 individuals with atherosclerotic cardiovascular disease (ACVD) and 187 healthy controls. The ACVD gut microbiome deviates from the healthy status by increased abundance of Enterobacteriaceae and Streptococcus spp. and, functionally, in the potential for metabolism or transport of several molecules important for cardiovascular health. We further identify common themes by comparison with gut microbiome data associated with other cardiometabolic diseases (obesity and type 2 diabetes), liver cirrhosis, and an autoimmune disease, rheumatoid arthritis. Our data represent a comprehensive resource for further investigations on the role of the gut microbiome in promoting or preventing ACVD as well as other related diseases.
  
Legacy ER Study ID
Legacy GOLD ID
Added By JGI automated process on 2019-02-28
Last Modified By
PI
Description The goal of this study is to examine the composition and functional capacity of the gut microbiome in relation to cardiovascular disease (ACVD).
Relevance
Study Information Link
Study Information Visibility Public
Metagenomic Study Yes
Publication
Is GEBA
Is HMP
ECOSYSTEM CLASSIFICATION
Ecosystem Host-associated
Ecosystem Category Human
Ecosystem Type Digestive system
Ecosystem Subtype Large intestine
Specific Ecosystem Fecal
STUDY COMPOSITION
Number of Biosamples 405
Number of Organisms 0
Number of Seq Projects 405
Number of Analysis Projects 0
Number of Related Studies 0

 

 

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