PROJECT INFORMATION
GOLD Project ID
Gp0013515  
Project Name
Legionella pneumophila pneumonophila 570-CO-H, ATCC 43290  
Other Names
  
Legacy ER Project ID
20201  
Legacy GOLD ID
Gc02062  
NCBI BioProject Name Legionella pneumophila subsp. pneumophila ATCC 43290
NCBI BioProject ID 78169
NCBI BioProject Accession PRJNA78169
NCBI Locus Tag
LP12  
NCBI BioSample Accession
PI Shuman,H.A
Added By Nikos Kyrpides on 2011-12-23
Last Modified By JGI automated process on 2014-05-20
Project Comments
  
Project Status
Complete and Published  
Project Relevance Medical
Sequencing Center University of Chicago (USA)
Collaborating Institute
  
Funding Agency
  
Project Description
This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. Protozoans may act as bacterial reservoirs. The first outbreak of Legionnaire's disease occurred in 1976 at an American Legion convention and the resulting pneumonia-like disease resulted in 34 deaths. The cause of the disease was traced to Legionella bacteria. The disease greatly affects elderly patients and has a mortality rate of 5-30% of infected patients. Transmission occurs through contaminated water, sometimes in the form of aerosolized spray of standing or warm water. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Some of these include the Sid proteins (substrates of Icm/Dot transporter), which comprise a set of three protein families encoded by the genome, and the enhanced entry proteins. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.   
Project Information Visibility Public
PROJECT TYPE
Specimen Organism
Nucleic Acid DNA
Sequencing Strategy
Whole Genome Sequencing  
EXTERNAL PROJECT LINKS
Project Information Wikipedia
Database
  
Genome Publications Journal of bacteriology 194(6):1613-4 Whole-genome sequence of the human pathogen Legionella pneumophila serogroup 12 strain 570-CO-H.
Other Publications
  
PROJECT COMPOSITION
Study Legionella pneumophila pneumonophila 570-CO-H, ATCC 43290
Analysis Projects Legionella pneumophila pneumonophila 570-CO-H, ATCC 43290
Number of Analysis Projects 1
Number of DAPs
0  
SEQUENCING INFORMATION
Sequencing Status Complete
Sequencing Quality (MIGS-31) Level 6: Finished
Finishing Goal
  
Sequencing Comments
  
Sequencing Technology (MIGS-29) Illumina
Library Method (MIGS-28)
  
Number Of Reads
  
Read Size
  
Vector
  
GC Percent
38  
Chromosome Count
1  
Plasmid Count
0  
ORGANISM NAME
GOLD Organism ID Go0013515
Organism Name
Legionella pneumophila pneumonophila 570-CO-H, ATCC 43290  
Other names (alias, synonyms, short names, common names)
  
Organism Domain
BACTERIAL  
Phylogeny
PROTEOBACTERIA-GAMMA  
Genus
Legionella  
Genus Synonyms
  
Species
Legionella pneumophila  
Subspecies
pneumonophila  
Species Synonyms
  
Strain
570-CO-H, ATCC 43290  
Strain Synonyms
  
Serovar-Biovar
  
Culture Collection ID
CCUG 30661  
Type Strain
Unknown  
Exemplar DOI
  
Exemplar Name
  
Taxon DOI
  
Biosafety Level
2  
Organism Comments
  
Cultured
Yes  
Culture Type
Isolate  
Organism Type
Natural  
Uncultured Type
  
Commercial Strain
  
Commercial Strain Comments
  
ORGANISM TAXONOMY
NCBI Taxonomy ID 933093
NCBI Superkingdom
Bacteria  
NCBI Kingdom
  
NCBI Phylum
Proteobacteria  
NCBI Class
Gammaproteobacteria  
NCBI Order
Legionellales  
NCBI Family
Legionellaceae  
NCBI Genus
Legionella  
NCBI Species
Legionella pneumophila  
ISOLATION CLASSIFICATION
Ecosystem
Host-associated  
Ecosystem Category
Human  
Ecosystem Type
Respiratory system  
Ecosystem Subtype
Unclassified  
Specific Ecosystem
Unclassified  
ORGANISM EXTERNAL REFERENCES
Strain Info ID
Genbank 16S ID
Synonym List
  
GENERAL PROPERTIES
Oxygen Requirement
Aerobe  
Cell Shape
Rod-shaped  
Motility
Motile  
Sporulation
Nonsporulating  
Temperature Range
Mesophile  
Temperature Optimum
  
Salinity
  
pH
  
Cell Diameter
  
Cell Length
  
Color
  
Gram Staining
Gram-  
Biotic Relationships Free living
Symbiotic Physical Interaction
  
Symbiotic Relationship
  
Symbiont Name
  
Symbiont Taxon ID
  
Cell Arrangements Singles
Diseases Pneumonia
Respiratory disease
Known Habitats Soil
Host
Fresh water
Fresh meat
Biofilm
Metabolisms
  
Phenotypes
  
Energy Sources Chemoorganotroph

 

 

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