PROJECT INFORMATION | |
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GOLD Project ID
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Gp0013515
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Project Name
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Legionella pneumophila pneumonophila 570-CO-H, ATCC 43290
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Other Names
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Legacy ER Project ID
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20201
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Legacy GOLD ID
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Gc02062
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NCBI BioProject Name | Legionella pneumophila subsp. pneumophila ATCC 43290 |
NCBI BioProject ID
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78169 |
NCBI BioProject Accession
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PRJNA78169 |
NCBI Locus Tag
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LP12
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NCBI BioSample Accession
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PI | Shuman,H.A |
Added By |
Nikos Kyrpides
on 2011-12-23 |
Last Modified By |
JGI automated process
on 2014-05-20 |
Project Comments |
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Project Status
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Complete and Published
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Project Relevance
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Medical |
Sequencing Center
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University of Chicago
(USA)
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Collaborating Institute
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Funding Agency
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Project Description
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This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. Protozoans may act as bacterial reservoirs. The first outbreak of Legionnaire's disease occurred in 1976 at an American Legion convention and the resulting pneumonia-like disease resulted in 34 deaths. The cause of the disease was traced to Legionella bacteria. The disease greatly affects elderly patients and has a mortality rate of 5-30% of infected patients. Transmission occurs through contaminated water, sometimes in the form of aerosolized spray of standing or warm water. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Some of these include the Sid proteins (substrates of Icm/Dot transporter), which comprise a set of three protein families encoded by the genome, and the enhanced entry proteins. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.
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Project Information Visibility
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Public |
PROJECT TYPE | |
Specimen
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Organism |
Nucleic Acid
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DNA |
Sequencing Strategy
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Whole Genome Sequencing
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EXTERNAL PROJECT LINKS | |
Project Information
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Database
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Genome Publications
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Journal of bacteriology
194(6):1613-4
Whole-genome sequence of the human pathogen Legionella pneumophila serogroup 12 strain 570-CO-H.
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Other Publications
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PROJECT COMPOSITION | |
Study |
Legionella pneumophila pneumonophila 570-CO-H, ATCC 43290 |
Organism |
Legionella pneumophila pneumonophila 570-CO-H, ATCC 43290 |
Analysis Projects |
Legionella pneumophila pneumonophila 570-CO-H, ATCC 43290 |
Number of Analysis Projects |
1 |
Number of DAPs |
0
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SEQUENCING INFORMATION | |
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Sequencing Status
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Complete |
Sequencing Quality (MIGS-31) |
Level 6: Finished |
Finishing Goal
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Sequencing Comments
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Sequencing Technology
(MIGS-29)
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Illumina |
Library Method
(MIGS-28)
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Number Of Reads
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Read Size
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Vector
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GC Percent |
38
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Chromosome Count |
1
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Plasmid Count |
0
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ORGANISM NAME | |
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GOLD Organism ID |
Go0013515 |
Organism Name |
Legionella pneumophila pneumonophila 570-CO-H, ATCC 43290
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Other names (alias, synonyms, short names, common names) |
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Organism Domain |
BACTERIAL
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Phylogeny |
PROTEOBACTERIA-GAMMA
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Genus |
Legionella
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Genus Synonyms |
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Species |
Legionella pneumophila
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Subspecies |
pneumonophila
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Species Synonyms |
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Strain |
570-CO-H, ATCC 43290
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Strain Synonyms |
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Serovar-Biovar |
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Culture Collection ID |
CCUG 30661
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Type Strain |
Unknown
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Exemplar DOI |
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Exemplar Name |
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Taxon DOI |
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Biosafety Level |
2
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Organism Comments |
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Cultured |
Yes
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Culture Type |
Isolate
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Organism Type |
Natural
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Uncultured Type |
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Commercial Strain |
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Commercial Strain Comments |
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ORGANISM TAXONOMY
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NCBI Taxonomy ID |
933093 |
NCBI Superkingdom |
Bacteria
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NCBI Kingdom |
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NCBI Phylum |
Proteobacteria
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NCBI Class |
Gammaproteobacteria
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NCBI Order |
Legionellales
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NCBI Family |
Legionellaceae
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NCBI Genus |
Legionella
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NCBI Species |
Legionella pneumophila
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ISOLATION CLASSIFICATION | |
Ecosystem |
Host-associated
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Ecosystem Category |
Human
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Ecosystem Type |
Respiratory system
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Ecosystem Subtype |
Unclassified
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Specific Ecosystem |
Unclassified
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ORGANISM EXTERNAL REFERENCES | |
Strain Info ID |
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Genbank 16S ID |
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GENERAL PROPERTIES | |
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Oxygen Requirement |
Aerobe
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Cell Shape |
Rod-shaped
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Motility |
Motile
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Sporulation |
Nonsporulating
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Temperature Range |
Mesophile
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Temperature Optimum |
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Salinity |
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pH |
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Cell Diameter |
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Cell Length |
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Color |
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Gram Staining |
Gram-
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Biotic Relationships | Free living |
Symbiotic Physical Interaction |
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Symbiotic Relationship |
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Symbiont Name |
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Symbiont Taxon ID |
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Cell Arrangements |
Singles |
Diseases |
Pneumonia Respiratory disease |
Known Habitats |
Soil Host Fresh water Fresh meat Biofilm |
Metabolisms |
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Phenotypes |
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Energy Sources |
Chemoorganotroph |
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