PROJECT INFORMATION
GOLD Project ID
Gp0010260  
Project Name
Clostridium botulinum H04402 065  
Other Names
  
Legacy ER Project ID
19021  
Legacy GOLD ID
Gi08921, Gc01687  
NCBI BioProject Name Clostridium botulinum H04402 065
NCBI BioProject ID 61511
NCBI BioProject Accession PRJEA61511
NCBI Locus Tag
H04402  
NCBI BioSample Accession
PI
Added By Ionna Pagani on 2011-02-11
Last Modified By Jon Bertsch on 2014-04-08
Project Comments
  
Project Status
Complete and Published  
Project Relevance Food industry
Pharmaceutical
Medical
Sequencing Center The Genome Analysis Centre (United Kingdom)
Collaborating Institute Institute of Food Research (United Kingdom)
Funding Agency
  
Project Description
This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin. This toxin finds its use in various applications requiring neuroparalitic intervention, including cosmetology (Botox).This strain has been implicated in wound botulism.  
Project Information Visibility Public
PROJECT TYPE
Specimen Organism
Nucleic Acid DNA
Sequencing Strategy
Whole Genome Sequencing  
EXTERNAL PROJECT LINKS
Project Information Wikipedia
Database
  
Genome Publications Journal of bacteriology 193(9):2351-2 Complete genome sequence of the proteolytic Clostridium botulinum type A5 (B3') strain H04402 065.
Other Publications
  
PROJECT COMPOSITION
Study Clostridium botulinum H04402 065
Analysis Projects Clostridium botulinum H04402 065
Number of Analysis Projects 1
Number of DAPs
0  
SEQUENCING INFORMATION
Sequencing Status Complete
Sequencing Quality (MIGS-31) Level 6: Finished
Finishing Goal
  
Sequencing Comments
  
Sequencing Technology (MIGS-29)
  
Library Method (MIGS-28)
  
Number Of Reads
  
Read Size
  
Vector
  
GC Percent
28  
Chromosome Count
1  
Plasmid Count
  
ORGANISM NAME
GOLD Organism ID Go0010260
Organism Name
Clostridium botulinum H04402 065  
Other names (alias, synonyms, short names, common names)
  
Organism Domain
BACTERIAL  
Phylogeny
FIRMICUTES  
Genus
Clostridium  
Genus Synonyms
  
Species
Clostridium botulinum  
Subspecies
  
Species Synonyms
  
Strain
H04402 065  
Strain Synonyms
  
Serovar-Biovar
  
Culture Collection ID
  
Type Strain
Unknown  
Exemplar DOI
  
Exemplar Name
  
Taxon DOI
  
Biosafety Level
  
Organism Comments
  
Cultured
Yes  
Culture Type
Isolate  
Organism Type
Natural  
Uncultured Type
  
Commercial Strain
  
Commercial Strain Comments
  
ORGANISM TAXONOMY
NCBI Taxonomy ID 941968
NCBI Superkingdom
Bacteria  
NCBI Kingdom
  
NCBI Phylum
Firmicutes  
NCBI Class
Clostridia  
NCBI Order
Clostridiales  
NCBI Family
Clostridiaceae  
NCBI Genus
Clostridium  
NCBI Species
Clostridium botulinum  
ISOLATION CLASSIFICATION
Ecosystem
Host-associated  
Ecosystem Category
Human  
Ecosystem Type
Unclassified  
Ecosystem Subtype
Unclassified  
Specific Ecosystem
Unclassified  
ORGANISM EXTERNAL REFERENCES
Strain Info ID
Genbank 16S ID
Synonym List
  
GENERAL PROPERTIES
Oxygen Requirement
Obligate anaerobe  
Cell Shape
Rod-shaped  
Motility
Motile  
Sporulation
Sporulating  
Temperature Range
Mesophile  
Temperature Optimum
37  
Salinity
  
pH
  
Cell Diameter
  
Cell Length
  
Color
  
Gram Staining
Gram+  
Biotic Relationships Free living
Symbiotic Physical Interaction
  
Symbiotic Relationship
  
Symbiont Name
  
Symbiont Taxon ID
  
Cell Arrangements Singles
Pairs
Diseases None
Known Habitats Host
Metabolisms
  
Phenotypes Non-Pathogen
Energy Sources Chemoorganotroph

 

 

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